Professor Matt Berriman

Professor (Parasitology)

telephone: 01413303689
email: Matt.Berriman@glasgow.ac.uk
pronouns: He/him/his

Biography

I received my Bachelor’s degree from the University of Manchester before completing a PhD on characterising a potential antimalarial drug target with Alan Fairlamb (first at the London School of Hygiene & Tropical Medicine, and later at the University of Dundee). Following this, I undertook a postdoctoral fellowship in New York, studying trypanosome telomeres with George Cross at Rockefeller University. I then moved to the Wellcome Sanger Institute in the UK to contribute to the emerging international initiatives to sequence the genomes of malaria parasites and trypanosomes. Over the next 20 years, I led comparative and functional genomics studies of major parasite species, including coordinating international projects that generated genomic resources for more than 30 parasites, and establishing the primary community portal for accessing helminth genomes. In 2022, I moved to the University of Glasgow, to focus on genome-scale functional studies in helminths.

Research interests

My lab is interested in the genomes and transcriptomics of developing parasites, with a particular focus on neglected tropical diseases like schistosomiasis. Having established reference genomes for many of the major parasite species, one strand of my work is the development of high-quality genome annotation and genomics resources. The other strand is to use large scale sequencing to investigate important aspects of parasite biology. For schistosomes (blood flukes) in particular, we are exploring genome variation in populations of parasites to reveal regions of the genome showing the effects of drug selection or subject to other evolutionary changes. In the lab, we are dissecting the parasite’s life cycle with single cell sequencing to reveal biological processes and mechanisms employed as the parasite radically changes its body plan throughout development. Through these approaches we hope to reveal potential vulnerabilities – aspects the parasite biology that can be exploited in the search for future interventions and control measures.

Publications

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Jump to: 2026 | 2025 | 2024 | 2023 | 2022 | 2020 | 2019 | 2018 | 2017 | 2016 | 2014 | 2013 | 2012

Number of items: 31.

2026

Rohr, C. M. et al. (2026) TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants. International Journal for Parasitology: Drugs and Drug Resistance, 30, 100639. (doi: 10.1016/j.ijpddr.2026.100639) (PMID:41865684)

2025

McIntyre, J. et al. (2025) Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta. PLoS Pathogens, 21(2), e1012820. (doi: 10.1371/journal.ppat.1012820) (PMID:39913358) (PMCID:PMC11801625)

2024

Attenborough, Teresa, Rawlinson, Kate A., Diaz Soria, Carmen L., Ambridge, Kirsty, Sankaranarayanan, Geetha, Graham, Jennie, Cotton, James A. ORCID: https://orcid.org/0000-0001-5475-3583, Doyle, Stephen R., Rinaldi, Gabriel and Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377 (2024) A single-cell atlas of the miracidium larva of the human blood fluke Schistosoma mansoni: cell types, developmental pathways and tissue architecture. eLife, 13, RP95628. (doi: 10.7554/eLife.95628) (PMID:39190022) (PMCID:PMC11349301)

Diaz Soria, C. L. et al. (2024) Single-cell transcriptomics of the human parasite Schistosoma mansoni first intra-molluscan stage reveals tentative tegumental and stem-cell regulators. Scientific Reports, 14(1), 5974. (doi: 10.1038/s41598-024-55790-3) (PMID:38472267) (PMCID:PMC10933418)

Chevalier, Frédéric D., Le Clec'h, Winka, Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377 and Anderson, Timothy J.C. (2024) A single locus determines praziquantel response in Schistosoma mansoni. Antimicrobial Agents and Chemotherapy, 68(3), e01432-23. (doi: 10.1128/aac.01432-23) (PMID:38289079) (PMCID:PMC10916369)

Brann, T., Beltramini, A., Chaparro, C., Berriman, M. ORCID: https://orcid.org/0000-0002-9581-0377, Doyle, S.R. and Protasio, A.V. (2024) Subtelomeric plasticity contributes to gene family expansion in the human parasitic flatworm Schistosoma mansoni. BMC Genomics, 25(1), 217. (doi: 10.1186/s12864-024-10032-8) (PMID:38413905) (PMCID:PMC10900676)

Herz, M. et al. (2024) Genome-wide transcriptome analysis of Echinococcus multilocularis larvae and germinative cell cultures reveals genes involved in parasite stem cell function. Frontiers in Cellular and Infection Microbiology, 14, 1335946. (doi: 10.3389/fcimb.2024.1335946) (PMID:38333034) (PMCID:PMC10850878)

2023

Padalino, Gilda, Coghlan, Avril, Pagliuca, Giampaolo, Forde-Thomas, Josephine E., Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377 and Hoffmann, Karl F. (2023) Using ChEMBL to complement schistosome drug discovery. Pharmaceutics, 15(5), 1359. (doi: 10.3390/pharmaceutics15051359) (PMID:37242601) (PMCID:PMC10220823)

2022

Rinaldi, Gabriel, Attenborough, Teresa, Rawlinson, Kate A. and Berriman, Matt ORCID: https://orcid.org/0000-0002-9581-0377 (2022) Schistosomes go single cell. Nature Reviews Microbiology, 20, p. 705. (doi: 10.1038/s41579-022-00810-0) (PMID:36229520)

Hoshizaki, Johanna, Adjalley, Sophie H., Thathy, Vandana, Judge, Kim, Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377, Reid, Adam J. and Lee, Marcus C. S. (2022) A manually curated annotation characterises genomic features of P. falciparum lncRNAs. BMC Genomics, 23, 780. (doi: 10.1186/s12864-022-09017-2) (PMID:36451097) (PMCID:PMC9710153)

Cortés, A. et al. (2022) The gut microbial metabolic capacity of microbiome-humanized vs. wild type rodents reveals a likely dual role of intestinal bacteria in hepato-intestinal schistosomiasis. PLoS Neglected Tropical Diseases, 16(10), e0010878. (doi: 10.1371/journal.pntd.0010878) (PMID:36279280) (PMCID:PMC9633004)

Vianney, T. J. et al. (2022) Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities. PLoS Neglected Tropical Diseases, 16(8), e0010188. (doi: 10.1371/journal.pntd.0010188) (PMID:35981002) (PMCID:PMC9426917)

Coghlan, Avril, Padalino, Gilda, O'Boyle, Noel M., Hoffmann, Karl F. and Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377 (2022) Identification of anti-schistosomal, anthelmintic and anti-parasitic compounds curated and text-mined from the scientific literature. Wellcome Open Research, 7, 193. (doi: 10.12688/wellcomeopenres.17987.1) (PMID:36003342) (PMCID:PMC9363976)

Costain, A. H. et al. (2022) Dynamics of host immune response development during Schistosoma mansoni infection. Frontiers in Immunology, 13, 906338. (doi: 10.3389/fimmu.2022.906338) (PMID:35958580) (PMCID:PMC9362740)

Aunin, Eerik, Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377 and Reid, Adam James (2022) Characterising genome architectures using genome decomposition analysis. BMC Genomics, 23, 398. (doi: 10.1186/s12864-022-08616-3) (PMID:35610562) (PMCID:PMC9131526)

2020

Imamura, Hideo, Monsieurs, Pieter, Jara, Marlene, Sanders, Mandy, Maes, Ilse, Vanaerschot, Manu, Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377, Cotton, James A. ORCID: https://orcid.org/0000-0001-5475-3583, Dujardin, Jean-Claude and Domagalska, Malgorzata A. (2020) Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level. Scientific Reports, 10, 15043. (doi: 10.1038/s41598-020-71882-2) (PMID:32929126) (PMCID:PMC7490275)

2019

Sallé, G., Doyle, S.R., Cortet, J., Cabaret, J., Berriman, M. ORCID: https://orcid.org/0000-0002-9581-0377, Holroyd, N. and Cotton, J.A. ORCID: https://orcid.org/0000-0001-5475-3583 (2019) The global diversity of Haemonchus contortus is shaped by human intervention and climate. Nature Communications, 10, 4811. (doi: 10.1038/s41467-019-12695-4) (PMID:31641125) (PMCID:PMC6805936)

2018

Cotton, James A. ORCID: https://orcid.org/0000-0001-5475-3583, Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377, Dalén, Love and Barnes, Ian (2018) Eradication genomics-lessons for parasite control. Science, 361(6398), pp. 130-131. (doi: 10.1126/science.aar6609) (PMID:30002241)

Sargison, Neil D., Redman, Elizabeth, Morrison, Alison A., Bartley, David J., Jackson, Frank, Naghra-van Gijzel, Hardeep, Holroyd, Nancy, Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377, Cotton, James A. ORCID: https://orcid.org/0000-0001-5475-3583 and Gilleard, John S. (2018) A method for single pair mating in an obligate parasitic nematode. International Journal for Parasitology, 48(2), pp. 159-165. (doi: 10.1016/j.ijpara.2017.08.010) (PMID:29111440)

2017

Iantorno, S. A. et al. (2017) Gene expression in Leishmania is regulated predominantly by gene dosage. mBio, 8(5), e01393-17. (doi: 10.1128/mBio.01393-17) (PMID:28900023) (PMCID:PMC5596349)

Dumetz, F. et al. (2017) Modulation of aneuploidy in leishmania donovani during adaptation to different in vitro and in vivo environments and its impact on gene expression. mBio, 8(3), e00599-17. (doi: 10.1128/mBio.00599-17) (PMID:28536289) (PMCID:PMC5442457)

2016

Bennuru, S. et al. (2016) Stage-specific transcriptome and proteome analyses of the filarial parasite Onchocerca volvulus and its Wolbachia endosymbiont. mBio, 7(6), e02028-16. (doi: 10.1128/mBio.02028-16) (PMID:27881553) (PMCID:PMC5137501)

Cotton, J. A. et al. (2016) The genome of Onchocerca volvulus, agent of river blindness. Nature Microbiology, 2, 16216. (doi: 10.1038/nmicrobiol.2016.216) (PMID:27869790) (PMCID:PMC5310847)

Hunt, V. L. et al. (2016) The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), pp. 299-307. (doi: 10.1038/ng.3495) (PMID:26829753) (PMCID:PMC4948059)

Crellen, T. et al. (2016) Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection. Scientific Reports, 6, 20954. (doi: 10.1038/srep20954) (PMID:26879532) (PMCID:PMC4754680)

2014

Foth, B. J. et al. (2014) Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction. Nature Genetics, 46(7), pp. 693-700. (doi: 10.1038/ng.3010) (PMID:24929830) (PMCID:PMC5012510)

Attardo, G. M. et al. (2014) Genome sequence of the Tsetse fly (Glossina morsitans): vector of African trypanosomiasis. Science, 344(6182), pp. 380-386. (doi: 10.1126/science.1249656) (PMID:24763584) (PMCID:PMC4077534)

Cotton, J. A. et al. (2014) The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode. Genome Biology, 15(3), R43. (doi: 10.1186/gb-2014-15-3-r43) (PMID:24580726) (PMCID:PMC4054857)

Rogers, Matthew B., Downing, Tim, Smith, Barbara A., Imamura, Hideo, Sanders, Mandy, Svobodova, Milena, Volf, Petr, Berriman, Matthew ORCID: https://orcid.org/0000-0002-9581-0377, Cotton, James A. ORCID: https://orcid.org/0000-0001-5475-3583 and Smith, Deborah F. (2014) Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population. PLoS Genetics, 10(1), e1004092. (doi: 10.1371/journal.pgen.1004092) (PMID:24453988) (PMCID:PMC3894156)

2013

Saunders, Gary Ian, Wasmuth, James David, Beech, Robin, Laing, Roz ORCID: https://orcid.org/0000-0002-6191-0759, Hunt, Martin, Naghra, Hardeep, Cotton, James A. ORCID: https://orcid.org/0000-0001-5475-3583, Berriman, Matt ORCID: https://orcid.org/0000-0002-9581-0377, Britton, Collette ORCID: https://orcid.org/0000-0002-5165-312X and Gilleard, John Stuart (2013) Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes. International Journal for Parasitology, 43(6), pp. 465-475. (doi: 10.1016/j.ijpara.2012.12.011) (PMID:23416426)

2012

Reid, A. J. et al. (2012) Comparative genomics of the apicomplexan parasites Toxoplasma gondii and neospora caninum: Coccidia differing in host range and transmission strategy. PLoS Pathogens, 8(3), e1002567. (doi: 10.1371/journal.ppat.1002567) (PMID:22457617) (PMCID:PMC3310773)

This list was generated on Wed Jun 3 18:21:11 2026 BST.

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