Professor Margaret Harnett

Professor of Immune Signalling (Immunology & Infection)

telephone: 01413308413
email: Margaret.Harnett@glasgow.ac.uk

RB418 Level B4, School of Infection and Immunity, SGDB, University Place, Glasgow G12 8TA

Biography

Professor Margaret Harnett's research career has been concerned with the study of immune system cell signalling.

For some 30 years, Professor Harnett has been working on the signalling mechanism underpinning development of the immune response in order to identify novel drug targets and immunomodulatory therapies to combat infection and inflammatory disease.

Margaret spent the opening years of her research career as a biochemist investigating pathogen (bacteria and helminth)-specific metabolic pathways in order to identify novel drug targets.

Follwing a PhD at the University of Glasgow, she then worked on innate cell, particularly neutrophil, responses and their dysfunction in diseases at University College London before switching to adaptive B and T cell Biology at the National Institute for Medicine, London.

Since returning to the University of Glasgow, her major focus has been to identify the targets of the anti-inflammatory actions of ES-62 in order to identify biomarkers of inflammatory disease and potential sites of intervention in Asthma, Rheumatoid arthritis, Systemic Lupus Erythematosus and Cardiovascular Disease.

Her major contributions to the field include:

Role of G-proteins in the immune system: for example, the identification of a novel site of G-protein-regulated exocytosis in neutrophil degranulation (Ge) that was the first step in our understanding of how GTPases regulate endocytic/secretory pathways.
The discovery that a defect in the respiratory burst of autosomal recessive patients with chronic granulomatous disease reflected their failure to phosphorylate a key component of the NADPH oxidase complex and this contributed to their immunodeficiency.
Discovery that differential lipid and kinase signalling provides functional checkpoints in B cell biology, potentially impacting on autoimmunity: for example, differential ERK kinetic signatures in immature B cells dictates either cell survival or negative selection (apoptosis), the latter via coupling to phospholipase A2 in a novel caspase-independent pathway.
Demonstration that remodelling of pulmonary, but not systemic, arteries under conditions of chronic hypoxia reflects enhanced p38 MAPK activation, providing a molecular mechanism underpinning pulmonary hypertension
Translation of the analysis of intracellular signalling mechanisms from the test-tube to the in situ physiological microenvironment of the immune response in animal models, exploiting Laser Scanning Cytometry.
Dissection of the molecular mechanisms underpinning evasion of the immune system by pathogens: in particular, the discovery that the parasitic worm product ES-62 subverts TLR4 signalling to induce hyporesponsiveness by downregulating MyD88 and this has identified novel targets for therapeutic intervention in inflammatory disease. This research has additionally led to the generation of ES-62-mimicking compounds that can potentially be developed as novel anti-inflammatory drugs.

Research interests

The major focus of Professor Harnett's laboratory is to understand the differential signalling mechanisms underlying functional maturation of the immune response and its evasion by pathogens in order to identify novel targets for therapeutic intervention in inflammatory disease and to promote healthy ageing.

A particular interest has been to translate the analysis of intracellular signalling mechanisms from the test tube to the in situ physiological environment of the immune response in animal models.

To follow the Harnett Lab's research progress and public engagement activities, please visit them on the following media platforms:

Publications

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Number of items: 105.

2024

Harnett, W. and Harnett, M. M. (2024) Epigenetic changes induced by parasitic worms and their excretory-secretory products. Biochemical Society Transactions, 52(1), pp. 55-63. (doi: 10.1042/BST20230087) (PMID:38334208) (PMCID:PMC10903456)

Harnett, M. M. , Doonan, J. , Tarafdar, A., Pineda, M. , Duncombe-Moore, J., Buitrago, G., Pan, P., Hoskisson, P., Selman, C. and Harnett, W. (2024) The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner. Frontiers in Tropical Diseases, 4, 1334705. (doi: 10.3389/fitd.2023.1334705)

2022

Harnett, M. M. et al. (2022) The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing. Frontiers in Immunology, 13, 953053. (doi: 10.3389/fimmu.2022.953053) (PMID:36105811) (PMCID:PMC9465317)

Oguegbulu, J. C., Khalaf, A. I., Suckling, C. J., Harnett, M. M. and Harnett, W. (2022) Lead optimisation efforts on a molecular prototype of the immunomodulatory parasitic protein ES-62. Physical Sciences Reviews, (doi: 10.1515/psr-2021-0235)

Wang, Y., Çil, Ç., Harnett, M. M. and Pineda, M. A. (2022) Cytohesin-2/ARNO: a novel bridge between cell migration and immunoregulation in synovial fibroblasts. Frontiers in Immunology, 12, 809896. (doi: 10.3389/fimmu.2021.809896) (PMID:35095899) (PMCID:PMC8790574)

2021

Buitrago, G., Duncombe-Moore, J., Harnett, M. M. and Harnett, W. (2021) Mini review: structure and function of nematode phosphorylcholine-containing glycoconjugates. Frontiers in Tropical Diseases, 2, 769000. (doi: 10.3389/fitd.2021.769000)

Corbet, M., Pineda, M. A. , Yang, K., Tarafdar, A., McGrath, S., NakagawaI, R., Lumb, F. E., Suckling, C. J., Harnett, W. and Harnett, M. M. (2021) Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts. PLoS Pathogens, 17(11), e1010069. (doi: 10.1371/journal.ppat.1010069) (PMID:34748611) (PMCID:PMC8601611)

Lumb, F. E., Doonan, J. , Corbet, M., Pineda, M. A. , Harnett, M. M. and Harnett, W. (2021) Development of Acanthocheilonema viteae in Meriones shawi : Absence of microfilariae and production of active ES‐62. Parasite Immunology, 43(3), e12803. (doi: 10.1111/pim.12803) (PMID:33091157) (PMCID:PMC7988569)

2020

Crowe, J. et al. (2020) The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing. PLoS Pathogens, 16(3), e1008391. (doi: 10.1371/journal.ppat.1008391) (PMID:32163524) (PMCID:PMC7108737)

2019

Lumb, F. E., Crowe, J., Doonan, J., Suckling, C. J., Selman, C. , Harnett, M. M. and Harnett, W. (2019) Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model. Molecular and Biochemical Parasitology, 111232. (doi: 10.1016/j.molbiopara.2019.111232) (PMID:31634505)

Doonan, J. , Tarafdar, A., Pineda, M. A. , Lumb, F. E., Crowe, J., Khan, A. M., Hoskisson, P. A., Harnett, M. M. and Harnett, W. (2019) The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. Nature Communications, 10, 1554. (doi: 10.1038/s41467-019-09361-0) (PMID:30952846) (PMCID:PMC6451002)

2018

Doonan, J. et al. (2018) Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease. Molecules, 23(10), 2669. (doi: 10.3390/molecules23102669) (PMID:30336585) (PMCID:PMC6222842)

Suckling, C. J., Mukherjee, S., Khalaf, A. I., Narayan, A., Scott, F. J., Khare, S., Dhakshinamoorthy, S., Harnett, M. M. and Harnett, W. (2018) Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis. Acta Tropica, 185, pp. 212-218. (doi: 10.1016/j.actatropica.2018.05.015) (PMID:29802846)

Doonan, J. , Lumb, F. E., Pineda, M. A. , Tarafdar, A., Crowe, J., Khan, A. M., Suckling, C. J., Harnett, M. M. and Harnett, W. (2018) Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis. Frontiers in Immunology, 9, 1016. (doi: 10.3389/fimmu.2018.01016) (PMID:29867986) (PMCID:PMC5967578)

Ball, D., Al-Riyami, L., Harnett, W. and Harnett, M. (2018) IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62. Scientific Reports, 8, 4497. (doi: 10.1038/s41598-018-22716-9) (PMID:29540770) (PMCID:PMC5852134)

Michie, A.M. , Paunovic, V. and Harnett, M.M. (2018) Cellular homeostasis: Cell growth and cancer. In: Baynes, J. and Dominiczak, M. (eds.) Medical Biochemistry, 5th Edition. Elsevier: New York, NY. ISBN 9780702072994

Suckling, C. J., Alam, S., Olson, M. A., Saikh, K. U., Harnett, M. M. and Harnett, W. (2018) Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling. Scientific Reports, 8, 2123. (doi: 10.1038/s41598-018-20388-z) (PMID:29391452) (PMCID:PMC5794923)

2017

Harnett, M. W. and Harnett, W. (2017) Can parasitic worms cure the modern world's ills? Trends in Parasitology, 33(9), pp. 694-705. (doi: 10.1016/j.pt.2017.05.007) (PMID:28606411)

Lumb, F. E., Doonan, J., Bell, K. S., Pineda, M. A. , Corbet, M., Suckling, C. J., Harnett, M. M. and Harnett, W. (2017) Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62. Scientific Reports, 7, 1704. (doi: 10.1038/s41598-017-01651-1) (PMID:28490801) (PMCID:PMC5431997)

Crowe, J., Lumb, F.E., Harnett, M.M. and Harnett, W. (2017) Parasite excretory-secretory products and their effects on metabolic syndrome. Parasite Immunology, 39(5), e12410. (doi: 10.1111/pim.12410) (PMID:28066896)

Harnett, M. M. , Pineda, M. A. , Latré de Laté, P., Eason, R. J., Besteiro, S., Harnett, W. and Langsley, G. (2017) From Christian de Duve to Yoshinori Ohsumi: more to autophagy than just dining at home. Biomedical Journal, 40(1), pp. 9-22. (doi: 10.1016/j.bj.2016.12.004) (PMID:28411887)

Laté de Laté, P., Pineda, M. , Harnett, M. , Harnett, W., Besteiro, S. and Langsley, G. (2017) Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells. Biomedical Journal, 40(1), pp. 23-30. (doi: 10.1016/j.bj.2017.01.001) (PMID:28411879)

2016

Eason, R. J., Bell, K. S., Marshall, F. A., Rodgers, D. T., Pineda, M. , Steiger, C. N., Al-Riyami, L., Harnett, W. and Harnett, M. M. (2016) The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosmal degradation of TLR-transducers, as exemplified by PKCδ. Scientific Reports, 6, 37276. (doi: 10.1038/srep37276) (PMID:27869138) (PMCID:PMC5116678)

Janicova, L., Rzepecka, J., Rodgers, D.T., Doonan, J., Bell, K.S., Lumb, F.E., Suckling, C.J., Harnett, M.M. and Harnett, W. (2016) Testing small molecule analogues of theAcanthocheilonema viteaeimmunomodulator ES-62 against clinically relevant allergens. Parasite Immunology, 38(6), pp. 340-351. (doi: 10.1111/pim.12322) (PMID:27059010) (PMCID:PMC4913752)

Coltherd, J. C., Rodgers, D. T., Lawrie, R. E., Al-Riyami, L., Suckling, C. J., Harnett, W. and Harnett, M. M. (2016) The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma. Scientific Reports, 6, 19224. (doi: 10.1038/srep19224) (PMID:26763929) (PMCID:PMC4725896)

2015

Al-Riyami, L., Rodgers, D. T., Rzepecka, J., Pineda, M. A. , Suckling, C. J., Harnett, M. M. and Harnett, W. (2015) Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation. Experimental Parasitology, 158, pp. 18-22. (doi: 10.1016/j.exppara.2015.03.025) (PMID:25836375) (PMCID:PMC4659540)

Bell, K. S., Al-Riyami, L., Lumb, F. E., Britton, G. J., Poole, A. W., Williams, C. M., Braun, U., Leitges, M., Harnett, M. and Harnett, W. (2015) The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62. Immunology Letters, 168(1), pp. 31-40. (doi: 10.1016/j.imlet.2015.09.001) (PMID:26343793) (PMCID:PMC464348)

Rodgers, D. T., Pineda, M. A. , Suckling, C. J., Harnett, W. and Harnett, M. M. (2015) Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus. Lupus, 24(13), pp. 1437-1442. (doi: 10.1177/0961203315591031) (PMID:26085597) (PMCID:PMC4616909)

Rzepecka, J. et al. (2015) Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. Journal of Autoimmunity, 60, pp. 59-73. (doi: 10.1016/j.jaut.2015.04.005) (PMID:25975491) (PMCID:PMC4459730)

Pineda, M.A. , Eason, R.J., Harnett, M.M. and Harnett, W. (2015) From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis. Lupus, 24(4-5), pp. 400-411. (doi: 10.1177/0961203314560004) (PMID:25801883)

Rodgers, D. T., McGrath, M. A., Pineda, M. A. , Al-Riyami, L., Rzepecka, J., Lumb, F., Harnett, W. and Harnett, M. M. (2015) The parasitic worm product, ES-62 targets MyD88-dependent effector mechanisms to suppress ANA production and proteinuria in MRL/Lpr mice. Arthritis and Rheumatology, 67(4), pp. 1023-1035. (doi: 10.1002/art.39004) (PMID:25546822) (PMCID:PMC4409857)

Aprahamian, T. R., Zhong, X., Amir, S., Binder, C. J., Chiang, L.-K., Al-Riyami, L., Gharakhanian, R., Harnett, M. M. , Harnett, W. and Rifkin, I. R. (2015) The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. International Journal for Parasitology, 45(4), pp. 203-207. (doi: 10.1016/j.ijpara.2014.12.006) (PMID:25666929) (PMCID:PMC4355381)

2014

Rzepecka, J. et al. (2014) Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. International Journal for Parasitology, 44(9), pp. 669-674. (doi: 10.1016/j.ijpara.2014.05.001)

Pineda, M. A. , Al-Riyami, L., Harnett, W. and Harnett, M. M. (2014) Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis. Clinical and Experimental Immunology, 177(1), pp. 13-23. (doi: 10.1111/cei.12252) (PMID:24666108) (PMCID:PMC4089150)

Pineda, M. A. , Rodgers, D. T., Al-Riyami, L., Harnett, W. and Harnett, M. M. (2014) ES-62 protects against collagen-induced arthritis by resetting IL-22 towards resolution of inflammation in the joints. Arthritis and Rheumatology, 66(6), pp. 1492-1503. (doi: 10.1002/art.38392) (PMID:24497523)

Pineda, M. A. , Lumb, F., Harnett, M. M. and Harnett, W. (2014) ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae. Molecular and Biochemical Parasitology, 194(1-2), pp. 1-8. (doi: 10.1016/j.molbiopara.2014.03.003)

Rodgers, D.T., Pineda, M.A. , McGrath, M.A., Al-Riyami, L., Harnett, W. and Harnett, M.M. (2014) Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints. Immunology, 141(3), pp. 457-466. (doi: 10.1111/imm.12208) (PMID:24708419) (PMCID:PMC3930382)

Harnett, M. , Harnett, W. and Pineda, M. A. (2014) The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of Collagen-Induced Arthritis. Inflammation and Cell Signaling, 1(5), e308. (doi: 10.14800/ics.308)

Michie, A.M. , Paunovic, V. and Harnett, M.M. (2014) Cellular homeostasis: cell growth and cancer. In: Baynes, J. and Dominiczak, M. (eds.) Medical Biochemistry, 4th Edition. Elsevier: New York, NY. ISBN 9781455745807

Salt, I.P. , Harnett, M.M. and Goodridge, H.S. (2014) Membrane receptors and signal transduction. In: Baynes, J. and Dominiczak, M. (eds.) Medical Biochemistry [4th Edition]. Saunders Elsevier. ISBN 9781455745807

2013

Al-Riyami, L., Pineda, M.A. , Rzepecka, J., Huggan, J.K., Khalaf, A.I., Suckling, C.J., Scott, F.J., Rodgers, D.T., Harnett, M.M. and Harnett, W. (2013) Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the acanthocheilonema viteae product es-62 prevents development of collagen-induced arthritis. Journal of Medicinal Chemistry, 56(24), pp. 9982-10002. (doi: 10.1021/jm401251p)

Harnett, W. and Harnett, M. M. (2013) Reply. Arthritis and Rheumatism, 65(5), pp. 1403-1404. (doi: 10.1002/art.37886) (PMID:23401057)

Rzepecka, J., Siebeke, I., Coltherd, J.C., Kean, D.E., Steiger, C.N., Al-Riyami, L., McSharry, C., Harnett, M.M. and Harnett, W. (2013) The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype. International Journal for Parasitology, 43(3-4), pp. 211-223. (doi: 10.1016/j.ijpara.2012.12.001)

Paunovic, V. and Harnett, M.M. (2013) Mitogen-activated protein kinases as therapeutic targets for rheumatoid arthritis. Drugs, 73(2), pp. 101-115. (doi: 10.1007/s40265-013-0014-6)

Ball, D. H., Tay, H. K., Bell, K. S., Coates, M. L., Al-Riyami, L., Rzepecka, J., Harnett, W. and Harnett, M. M. (2013) Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62. Journal of Parasitology Research, 2013, 961268. (doi: 10.1155/2013/961268)

2012

Paunovic, V., Carter, N. A., Thalhamer, T., Blair, D., Gordon, B., Lacey, E., Michie, A. M. and Harnett, M. M. (2012) Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus. Journal of Autoimmunity, 39(4), pp. 332-346. (doi: 10.1016/j.jaut.2012.04.006)

Pineda, M.A. , McGrath, M.A., Smith, P.C., Al-Riyami, L., Rzepecka, J., Gracie, J.A., Harnett, W. and Harnett, M.M. (2012) The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites. Arthritis and Rheumatism, 64(10), pp. 3168-3178. (doi: 10.1002/art.34581) (PMID:22729944)

Harnett, W., Goodridge, H.S., Allen, J.M. and Harnett, M. (2012) Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62. Experimental Parasitology, 132(1), pp. 97-102. (doi: 10.1016/j.exppara.2011.09.001)

2011

Norman, J.E., Yuan, M., Anderson, L., Howie, F., Harold, G., Young, A., Jordan, F., McInnes, I. and Harnett, M.M. (2011) Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels. Reproductive Sciences, 18(5), pp. 435-446. (doi: 10.1177/1933719110395404)

McGrath, M. A., Morton, A. M. and Harnett, M. M. (2011) Laser scanning cytometry: capturing the immune system in situ. Methods in Cell Biology, 102, pp. 231-260. (doi: 10.1016/B978-0-12-374912-3.00009-2)

2010

Harnett, M. M. , Melendez, A. J. and Harnett, W. (2010) The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clinical and Experimental Immunology, 159(3), pp. 256-267. (doi: 10.1111/j.1365-2249.2009.04064.x)

Harnett, W. and Harnett, M. M. (2010) Helminth-derived immunomodulators: can understanding the worm produce the pill? Nature Reviews Immunology, 10(4), pp. 278-284. (doi: 10.1038/nri2730)

2009

Leonardo, S. M., Harnett, M. M. , Lerch-Gaggl, A. F. and Gauld, S. B. (2009) Fluorescence-based assays as tools for understanding immunologic processes. Annals of Allergy, Asthma and Immunology, 102(1), pp. 84-90. (doi: 10.1016/S1081-1206(10)60113-5)

Harnett, W. and Harnett, M. (2009) Immunomodulatory Activity and Therapeutic Potential of the Filarial Nematode Secreted Product, ES-62. Pathogen-Derived Immunomodulatory Molecules, 666, pp. 88-94.

Yuan, M., Jordan, F., McInnes, I. , Harnett, M. and Norman, J. (2009) Leukocytes are primed in peripheral blood for activation during term and preterm labour. Molecular Human Reproduction, 15(11), pp. 713-724. (doi: 10.1093/molehr/gap054) (PMID:19628509)

2008

Marshall, F. A., Watson, K. A., Garside, P. , Harnett, M. M. and Harnett, W. (2008) Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo. Immunology, 123(3), pp. 411-425. (doi: 10.1111/j.1365-2567.2007.02706.x)

Harnett, M. et al. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Annals of the Rheumatic Diseases, 67(4), pp. 518-523. (doi: 10.1136/ard.2007.073502) (PMID:17704067)

Harnett, W. and Harnett, M. (2008) Lymphocyte hyporesponsiveness during filarial nematode infection. Parasite Immunology, 30(9), pp. 447-453.

Thalhamer, T., McGrath, M. and Harnett, M. (2008) MAPKs and their relevance to arthritis and inflammation. Rheumatology, 47(4), pp. 409-414.

2007

Harnett, M. M. (2007) Laser scanning cytometry: understanding the immune system in situ. Nature Reviews Immunology, 7(11), pp. 897-904. (doi: 10.1038/nri2188)

Harnett, M. M., Harnett, W., McSharry, C. P., Melendez, A. J., Pushparaj, P. N., Tay, H. K. and Wong, W. S. F. (2007) Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. Nature Medicine, 13(11), pp. 1375-1381. (doi: 10.1038/nm1654)

Goodridge, H., McGuiness, S., Houston, K., Egan, C., Al-Riyami, L., Alcocer, M., Harnett, M. and Harnett, W. (2007) Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells. Parasite Immunology, 29, pp. 127-137. (doi: 10.1111/j.1365-3024.2006.00926.x)

Morton, A., McManus, B., Garside, P., Mowat, A. and Harnett, M. (2007) Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4(+) T cells in vitro and in vivo. Journal of Immunology, 179(12), pp. 8026-8034.

2006

Harnett, W. and Harnett, M. (2006) Filarial nematode secreted product ES-62 is an anti-inflammatory agent: Therapeutic potential of small molecule derivatives and ES-62 peptide mimetics. Clinical and Experimental Pharmacology and Physiology, 33, pp. 511-518.

Harnett, W. and Harnett, M. (2006) Molecular basis of worm-induced immunomodulation. Parasite Immunology, 28, pp. 535-543. (doi: 10.1111/j.1365-3024.2006.00893.x)

Harnett, W. and Harnett, M. (2006) What causes lymphocyte hyporesponsiveness during filarial nematode infection? Trends in Parasitology, 22, pp. 105-110. (doi: 10.1016/j.pt.2006.01.010)

Kean, D., Goodridge, H., McGuinness, S., Harnett, M. , Alcocer, M. and Harnett, W. (2006) Differential polarization of immune responses by plant 2S seed albumins, ber e 1, and SFA8. Journal of Immunology, 177, pp. 1561-1566.

Kean, D., Ohtsuka, I., Sato, K., Hada, N., Takeda, T., Lochnit, G., Geyer, R., Harnett, M. and Harnett, W. (2006) Dissecting Ascaris glycosphingolipids for immunomodulatory moieties - the use of synthetic structural glycosphingolipid analogues. Parasite Immunology, 28, pp. 69-76. (doi: 10.1111/j.1365-3024.2005.00801.x)

2005

Al, R., Egan, C., Else, K., Goodridge, H., Harnett, M. , Harnett, W., Houston, K., Liew, F. and Marshall, F. (2005) Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. Journal of Immunology, 174, pp. 284-293.

Goodridge, H. and Harnett, M. (2005) Introduction to immune cell signalling. Parasitology, 130, S3-S9. (doi: 10.1017/S0031182005008115)

Goodridge, H., Stepek, G., Harnett, W. and Harnett, M. (2005) Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology, 115, pp. 296-304. (doi: 10.1111/j.1365-2567.2005.02167.x)

Goodrigde, H., Deehan, M., Harnett, W. and Harnett, M. (2005) Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product. Cellular Signalling, 17, pp. 11-16. (doi: 10.1016/j.cellsig.2004.05.014)

Grierson, A., Mitchell, P., Adams, C., Mowat, A., Brewer, J., Harnett, M. and Garside, P. (2005) Direct quantitation of T cell signaling by laser scanning cytometry. Journal of Immunological Methods, 301, pp. 140-153. (doi: 10.1016/j.jim.2005.04.011)

Harnett, M. , Katz, E. and Ford, C. (2005) Differential signalling during B-cell maturation. Immunology Letters, 98, pp. 33-44.

Harnett, W., Goodridge, H. and Harnett, M. (2005) Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62. Parasitology, 130, S63-S68. (doi: 10.1017/S0031182005008164)

Marshall, F., Grierson, A., Garside, P., Harnett, W. and Harnett, M. (2005) ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo. Journal of Immunology, 175, pp. 5817-5826.

2004

Welsh, D. J., Harnett, M. , Maclean, M. and Peacock, A. J. (2004) Proliferation and signaling in fibroblasts - Role of 5-hydroxytryptamine_2A receptor and transporter. American Journal of Respiratory and Critical Care Medicine, 170(3), pp. 252-259. (doi: 10.1164/rccm.200302-264OC)

Harnett, W., McInnes, I.B. and Harnett, M.M. (2004) ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential. Immunology Letters, 94(1-2), pp. 27-33. (doi: 10.1016/j.imlet.2004.04.008) (PMID:15234531)

Adams, C., Grierson, A., Mowat, A., Harnett, M. and Garside, P. (2004) Differences in the kinetics, amplitude, and localization of ERK activation in anergy and priming revealed at the level of individual primary T cells by laser scanning cytometry. Journal of Immunology, 173, pp. 1579-1586.

Brown, K., Blair, D., Reid, S., Nicholson, E. and Harnett, M. (2004) Fc gamma RIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3 '-inositol phosphatase, PTEN. Cellular Signalling, 16, pp. 71-80. (doi: 10.1016/S0898-6568(03)00113-X)

Carter, N. and Harnett, M. (2004) Dissection of the signalling mechanisms underlying Fc gamma RIIB-mediated apoptosis of mature B-cells. Biochemical Society Transactions, 32, pp. 973-975.

Goodridge, H., Harnett, M. , Harnett, W., Houston, K., Liew, F., Marshall, F. and Wilson, E. (2004) In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype. Immunology, 113, pp. 491-498. (doi: 10.1111/j.1365-2567.2004.01993.x)

Katz, E., Lord, C., Ford, C., Gauld, S., Carter, N. and Harnett, M. (2004) Bcl-x(L) antagonism of BCR-coupled mitochondrial phospholipase A(2) signaling correlates with protection from apoptosis in WEHI-231 B cells. Blood, 103, pp. 168-176. (doi: 10.1182/blood-2003-07-2473)

2003

McInnes, I. B. , Gracie, J.A., Harnett, M. , Harnett, W. and Liew, F.Y. (2003) New strategies to control inflammatory synovitis: interleukin 15 and beyond. Annals of the Rheumatic Diseases, 62(2), pp. 51-54. (doi: 10.1136/ard.62.suppl_2.ii51) (PMID:14532150) (PMCID:PMC1766739)

McInnes, I. B. , Leung, B.P., Harnett, M. , Gracie, J.A., Liew, F. and Harnett, W. (2003) A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. Journal of Immunology, 171(4), pp. 2127-2133. (doi: 10.4049/jimmunol.171.4.2127) (PMID:12902519)

Ackerman, C. J., Harnett, M. M. , Harnett, W., Kelly, S. M. , Svergun, D. I. and Byron, O. (2003) 19 angstrom solution structure of the filarial nematode immunomodulatory protein, ES-62. Biophysical Journal, 84(1), pp. 489-500. (doi: 10.1016/S0006-3495(03)74868-1) (PMID:12524301) (PMCID:PMC1302629)

Goodridge, H., Harnett, M. , Harnett, W. and Liew, F. (2003) Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology, 109, pp. 415-425.

Harnett, W., Harnett, M.M. and Byron, O. (2003) Structural/functional aspects of ES-62 - A secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein. Current Protein and Peptide Science, 4(1), pp. 59-71. (doi: 10.2174/1389203033380368) (PMID:12570785)

Smith, R. et al. (2003) A novel MyD-1 (SIRP-1 alpha) signaling pathway that inhibits LPS-induced TNF alpha production by monocytes. Blood, 102, pp. 2532-2540. (doi: 10.1182/blood-2002-11-3596)

Wilson, E., Deehan, M., Katz, E., Brown, K., Houston, K., OGrady, J., Harnett, M. and Harnett, W. (2003) Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivo. Immunology, 109, pp. 238-245.

2002

Cameron, A., McDonald, K., Harnett, M. and Allen, J. (2002) Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, Fc gamma RIIb. Immunology Letters, 83, pp. 171-179.

Deehan, M., Goodridge, H., Blair, D., Lochnit, G., Dennis, R., Geyer, R., Harnett, M. and Harnett, W. (2002) Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects. Parasite Immunology, 24, pp. 463-469.

Gauld, S., Blair, D., Moss, C., Reid, S. and Harnett, M. (2002) Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells. Journal of Immunology, 168, pp. 3855-3864.

2001

Welsh, D. J., Peacock, A. J., MacLean, M. and Harnett, M. (2001) Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries. American Journal of Respiratory and Critical Care Medicine, 164(2), pp. 282-289. (doi: 10.1164/ajrccm.164.2.2008054)

Cameron, A., Harnett, M. and Allen, J. (2001) Differential recruitment of accessory molecules by Fc gamma RI during monocyte differentiation. European Journal of Immunology, 31, pp. 2718-2725.

Campbell, C., Goodridge, H., Harnett, M. , Harnett, W., Liew, F. and Wilson, E. (2001) Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. Journal of Immunology, 167, pp. 940-945.

Deehan, M., Harnett, M. , Katz, E., Lord, C., Seatter, S. and Sturrock, R. (2001) B cell receptor-stimulated mitochondrial phospholipase A(2) activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells. Journal of Immunology, 166, pp. 137-147.

Deehan, M., Harnett, W. and Harnett, M. (2001) A filarial nematode-secreted phosphorylcholine-containing glycoprotein uncouples the B cell antigen receptor from extracellular signal-regulated kinase-mitogen-activated protein kinase by promoting the surface Ig-mediated recruitment of Src homology 2 dom. Journal of Immunology, 166, pp. 7462-7468.

Harnett, M. and Harnett, W. (2001) Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode. Archivum Immunologiae et Therapiae Experimentalis, 49, pp. 263-269.

Harnett, W. and Harnett, M.M. (2001) Modulation of the host immune system by phosphorylcholine-containing glycoproteins secreted by parasitic filarial nematodes. Biochimica et Biophysica Acta: Molecular Cell Research, 1539, pp. 7-15.

Melendez, A., Bruetschy, L., Floto, R., Harnett, M. and Allen, J. (2001) Functional coupling of Fc gamma RI to nicotinamide adenine dinucleotide phosphate (reduced form) oxidative burst and immune complex trafficking requires the activation of phospholipase D1. Blood, 98, pp. 3421-3428.

Siepmann, K., Skok, J., Van Essen, D., Harnett, M. and Gray, D. (2001) Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool. Immunology, 102, pp. 263-272.

1998

Michie, A. M. , Rena, G., Harnett, M. M. and Houslay, M. D. (1998) Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases. Cell Biochemistry and Biophysics, 28(2-3), pp. 161-185. (doi: 10.1007/BF02737810)

1997

Michie, A.M. , Harnett, M.M. and Houslay, M.D. (1997) Cyclic nucleotide signalling throughout T cell maturation. In: Harnett, M.M. and Rigley, K.P. (eds.) Lymphocyte Signalling: Mechanism, Subversion and Manipulation. John Wiley & Sons Ltd.: Chichester, p. 247. ISBN 9780471959038

1996

Michie, A. M. , Lobban, M., Müller, T., Harnett, M. M. and Houslay, M. D. (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cellular Signalling, 8(2), pp. 97-110. (doi: 10.1016/0898-6568(95)02032-2)

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