Dr Laura McCaughey

  • Lecturer in Biomolecular Sciences (Bacteriology)

telephone: 0141 330 2694
email: Laura.McCaughey@glasgow.ac.uk

B228 Sir Graeme Davies Building, School of Infection & Immunity, 120 University Place, University of Glasgow, G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-5897-0163

Biography

Laura obtained an MSci in Forensic and Analytical Chemistry from the University of Strathclyde, Scotland, in 2010.

During this degree, Laura undertook a one-year placement at GlaxoSmithKline, Stevenage, UK, where she worked as an analytical chemist.

She was then awarded a Wellcome Trust PhD scholarship at the University of Glasgow. During her PhD, and her successive Sir Henry Wellcome Postdoctoral Fellowship at the University of Technology in Sydney, Laura investigated the use of novel species-specific protein antibiotics, termed S-type pyocins, to kill the notoriously difficult-to-treat, and often multi-drug resistant, bacterium Pseudomonas aeruginosa. 

This research involved the discovery, and mechanistic, structural and biophysical characterisation of, pyocins, and the testing of these antibiotics in animal models.

Research interests

Research

Laura’s main research interests surround ‘How do bacteria develop resistance to antibiotics?' and 'How can we identify novel approaches to antibiotic development to overcome this problem?'

 

Public Engagement

Over the last ten years Laura has been actively involved in highlighting the problem of antibiotic resistance, and the interventions necessary to prevent the problem escalating further, to the public. Laura has a demonstrated ability at interpreting and conveying complex information to non-specialists and non-scientists through this active public engagement work. She has written articles & blogs, done radio interviews/podcasts and spoken at numerous public events on the topic of antibiotic resistance. She has also carried out an internship at the ABC (Australian Broadcast Corporation) working on their flagship science program Catalyst and has undertaken an intensive course 'strategies in science communication', at the Australian National University, Canberra.

Laura was also project manager for Soapbox Science Sydney 2019 & 2020, and has plans to bring it to Glasgow in 2022. Soapbox Science is a large scale public science event promoting female scientist and the science that they do (https://soapboxsciencesydney.com). Laura has a creative eye and does all of the artwork, website design and video editing for Soapbox Science Sydney.

Laura was awarded the Australian Institute for Policy and Science NSW Young Tall Poppy of the Year award in 2020 in recognition for her science communication endeavours.

 

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012 | 2010
Number of items: 21.

2024

Strange, N. et al. (2024) HtrA, fatty acids, and membrane protein interplay in Chlamydia trachomatis to impact stress response and trigger early cellular exit. Journal of Bacteriology, 206(4), e00371-23.. (doi: 10.1128/jb.00371-23) (PMID:38445896)

Donald, C. and McCaughey, L. (2024) Enhancing Student’s Mathematical Skills with Smart Worksheets. Microbiology Society Annual Conference 2024, Edinburgh, UK, 08-11 Apr 2024. (Unpublished)

McCaughey, L. , McGregor, A. , MacIver, K. and Aitken, R. (2024) Business in the biosciences: a compressed format entrepreneurship course with employability skills at its core. In: Norton, S., Phillips, M. and Ugiagbe-Green, I. (eds.) Lighting the Labyrinth: Enhancing Student Success through the 3Es. Advance HE: York, pp. 56-63. ISBN 9781738524204

McCaughey, L. , Mcgregor, A. and Hamilton, L. (2024) Formatively assessing competency in practical skills through direct observations and oral feedback in the Life Sciences. In: Elkington, S. and Irons, A. (eds.) Formative Assessment and Feedback in Post-Digital Environments: Disciplinary Case Studies in Higher Education. Routledge. (In Press)

McCaughey, L. , Mcgregor, A. , Hamilton, L. and McCombie, A. (2024) The Complete Graduate: Designing a VLE-based Skills and Knowledge Framework to Support Student Confidence and Awareness. AdvanceHE Student Engagement Conference 2024, Leeds, UK, 18th April 2024. (Accepted for Publication)

McCaughey, L. , Mcgregor, A. , Hamilton, L., Ranglani, S. and Charlton, S. (2024) Business in the Biosciences - Embedding Entrepreneurship into a Life Science Course to Create More Inclusive Interdisciplinary Curricula and Enhance Transferable Skill Development. 17th Annual University of Glasgow Learning and Teaching Conference, Glasgow, UK, 9th April 2024. (Accepted for Publication)

2023

McCaughey, L. , Hamilton, L., MacIver, K., Aitken, R. and Mcgregor, A. (2023) Evaluating Skills Attainment and Competency to Support Student Confidence and Awareness: Scaffolding a VLE-based Skills Tracker in Life Science Undergraduate Degrees. 16th Annual University of Glasgow Learning and Teaching Conference, Glasgow, UK, 13 Apr 2023.

McCaughey, L. , Mcgregor, A. , MacIver, K. and Aitken, R. (2023) Business in the Biosciences: A Compressed Format Entrepreneurship Course with Employability Skills at its Core. Employability Symposium 2023: Lighting the Labyrinth: Enhancing Student Success through the 3Es, Manchester, 25 April 2023.

2021

Hynen, A. L., Lazenby, J. J., Savva, G. M., McCaughey, L. C. , Turnbull, L., Nolan, L. M. and Whitchurch, C. B. (2021) Multiple holins contribute to extracellular DNA release in Pseudomonas aeruginosa biofilms. Microbiology, 167(2), 000990. (doi: 10.1099/mic.0.000990) (PMID:33400641) (PMCID:PMC8131026)

2020

Nolan, L. M., McCaughey, L. C. , Merjane, J., Turnbull, L. and Whitchurch, C. B. (2020) ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides. Microbiology, 166(7), pp. 669-678. (doi: 10.1099/mic.0.000911) (PMID:32478653) (PMCID:PMC7657506)

2019

Agbowuro, A. A., Hwang, J., Peel, E., Mazraani, R., Springwald, A., Marsh, J. W., McCaughey, L. , Gamble, A. B., Huston, W. M. and Tyndall, J. D.A. (2019) Structure-activity analysis of peptidic Chlamydia HtrA inhibitors. Bioorganic and Medicinal Chemistry, 27(18), pp. 4185-4199. (doi: 10.1016/j.bmc.2019.07.049) (PMID:31395511)

2018

Agbowuro, A. A., Mazraani, R., McCaughey, L. C. , Huston, W. M., Gamble, A. B. and Tyndall, J. D.A. (2018) Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron, 74(12), pp. 1184-1190. (doi: 10.1016/j.tet.2017.10.031)

2017

White, P. et al. (2017) Exploitation of an iron transporter for bacterial protein antibiotic import. Proceedings of the National Academy of Sciences of the United States of America, 114(45), pp. 12051-12056. (doi: 10.1073/pnas.1713741114) (PMID:29078392)

2016

Klein, A., Wojdyla, J. A., Joshi, A., Josts, I., McCaughey, L. C. , Housden, N. G., Kaminska, R., Byron, O. , Walker, D. and Kleanthous, C. (2016) Structural and biophysical analysis of nuclease protein antibiotics. Biochemical Journal, 473(18), pp. 2799-2812. (doi: 10.1042/bcj20160544) (PMID:27402794) (PMCID:PMC5264503)

McCaughey, L. C. , Josts, I., Grinter, R., White, P., Byron, O. , Tucker, N. P., Matthews, J. M., Kleanthous, C., Whitchurch, C. and Walker, D. (2016) Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa. Biochemical Journal, 473(15), pp. 2345-2358. (doi: 10.1042/bcj20160470) (PMID:27252387) (PMCID:PMC4964976)

McCaughey, L. C., Ritchie, N. D., Douce, G. R. , Evans, T. J. and Walker, D. (2016) Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection. Scientific Reports, 6, 30201. (doi: 10.1038/srep30201) (PMID:27444885) (PMCID:PMC4957109)

2015

Joshi, A. et al. (2015) Structures of the ultra-high-affinity protein–protein complexes of pyocins S2 and AP41 and their cognate immunity proteins from pseudomonas aeruginosa. Journal of Molecular Biology, 427(17), pp. 2852-2866. (doi: 10.1016/j.jmb.2015.07.014) (PMID:26215615) (PMCID:PMC4548480)

2014

Grinter, R., Josts, I., Zeth, K., Roszak, A. W., McCaughey, L. C. , Cogdell, R. J. , Milner, J. J. , Kelly, S. M., Byron, O. and Walker, D. (2014) Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Molecular Microbiology, 93(2), pp. 234-246. (doi: 10.1111/mmi.12655) (PMID:24865810) (PMCID:PMC4671253)

McCaughey, L. C. et al. (2014) Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor. PLoS Pathogens, 10(2), e1003898. (doi: 10.1371/journal.ppat.1003898) (PMID:24516380) (PMCID:PMC3916391)

2012

Brown, C. L., Smith, K., McCaughey, L. and Walker, D. (2012) Colicin-like bacteriocins as novel therapeutic agents for the treatment of chronic biofilm-mediated infection. Biochemical Society Transactions, 40(6), pp. 1549-1552. (doi: 10.1042/BST20120241) (PMID:23176515)

2010

Martin, L. C. , Larmour, I. A., Faulds, K. and Graham, D. (2010) Turning up the lights—fabrication of brighter SERRS nanotags. Chemical Communications, 46(29), pp. 5247-5249. (doi: 10.1039/C0CC00722F) (PMID:20567793)

This list was generated on Fri Jul 26 03:50:03 2024 BST.
Jump to: Articles | Book Sections | Conference or Workshop Item
Number of items: 21.

Articles

Strange, N. et al. (2024) HtrA, fatty acids, and membrane protein interplay in Chlamydia trachomatis to impact stress response and trigger early cellular exit. Journal of Bacteriology, 206(4), e00371-23.. (doi: 10.1128/jb.00371-23) (PMID:38445896)

Hynen, A. L., Lazenby, J. J., Savva, G. M., McCaughey, L. C. , Turnbull, L., Nolan, L. M. and Whitchurch, C. B. (2021) Multiple holins contribute to extracellular DNA release in Pseudomonas aeruginosa biofilms. Microbiology, 167(2), 000990. (doi: 10.1099/mic.0.000990) (PMID:33400641) (PMCID:PMC8131026)

Nolan, L. M., McCaughey, L. C. , Merjane, J., Turnbull, L. and Whitchurch, C. B. (2020) ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides. Microbiology, 166(7), pp. 669-678. (doi: 10.1099/mic.0.000911) (PMID:32478653) (PMCID:PMC7657506)

Agbowuro, A. A., Hwang, J., Peel, E., Mazraani, R., Springwald, A., Marsh, J. W., McCaughey, L. , Gamble, A. B., Huston, W. M. and Tyndall, J. D.A. (2019) Structure-activity analysis of peptidic Chlamydia HtrA inhibitors. Bioorganic and Medicinal Chemistry, 27(18), pp. 4185-4199. (doi: 10.1016/j.bmc.2019.07.049) (PMID:31395511)

Agbowuro, A. A., Mazraani, R., McCaughey, L. C. , Huston, W. M., Gamble, A. B. and Tyndall, J. D.A. (2018) Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron, 74(12), pp. 1184-1190. (doi: 10.1016/j.tet.2017.10.031)

White, P. et al. (2017) Exploitation of an iron transporter for bacterial protein antibiotic import. Proceedings of the National Academy of Sciences of the United States of America, 114(45), pp. 12051-12056. (doi: 10.1073/pnas.1713741114) (PMID:29078392)

Klein, A., Wojdyla, J. A., Joshi, A., Josts, I., McCaughey, L. C. , Housden, N. G., Kaminska, R., Byron, O. , Walker, D. and Kleanthous, C. (2016) Structural and biophysical analysis of nuclease protein antibiotics. Biochemical Journal, 473(18), pp. 2799-2812. (doi: 10.1042/bcj20160544) (PMID:27402794) (PMCID:PMC5264503)

McCaughey, L. C. , Josts, I., Grinter, R., White, P., Byron, O. , Tucker, N. P., Matthews, J. M., Kleanthous, C., Whitchurch, C. and Walker, D. (2016) Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa. Biochemical Journal, 473(15), pp. 2345-2358. (doi: 10.1042/bcj20160470) (PMID:27252387) (PMCID:PMC4964976)

McCaughey, L. C., Ritchie, N. D., Douce, G. R. , Evans, T. J. and Walker, D. (2016) Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection. Scientific Reports, 6, 30201. (doi: 10.1038/srep30201) (PMID:27444885) (PMCID:PMC4957109)

Joshi, A. et al. (2015) Structures of the ultra-high-affinity protein–protein complexes of pyocins S2 and AP41 and their cognate immunity proteins from pseudomonas aeruginosa. Journal of Molecular Biology, 427(17), pp. 2852-2866. (doi: 10.1016/j.jmb.2015.07.014) (PMID:26215615) (PMCID:PMC4548480)

Grinter, R., Josts, I., Zeth, K., Roszak, A. W., McCaughey, L. C. , Cogdell, R. J. , Milner, J. J. , Kelly, S. M., Byron, O. and Walker, D. (2014) Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Molecular Microbiology, 93(2), pp. 234-246. (doi: 10.1111/mmi.12655) (PMID:24865810) (PMCID:PMC4671253)

McCaughey, L. C. et al. (2014) Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor. PLoS Pathogens, 10(2), e1003898. (doi: 10.1371/journal.ppat.1003898) (PMID:24516380) (PMCID:PMC3916391)

Brown, C. L., Smith, K., McCaughey, L. and Walker, D. (2012) Colicin-like bacteriocins as novel therapeutic agents for the treatment of chronic biofilm-mediated infection. Biochemical Society Transactions, 40(6), pp. 1549-1552. (doi: 10.1042/BST20120241) (PMID:23176515)

Martin, L. C. , Larmour, I. A., Faulds, K. and Graham, D. (2010) Turning up the lights—fabrication of brighter SERRS nanotags. Chemical Communications, 46(29), pp. 5247-5249. (doi: 10.1039/C0CC00722F) (PMID:20567793)

Book Sections

McCaughey, L. , McGregor, A. , MacIver, K. and Aitken, R. (2024) Business in the biosciences: a compressed format entrepreneurship course with employability skills at its core. In: Norton, S., Phillips, M. and Ugiagbe-Green, I. (eds.) Lighting the Labyrinth: Enhancing Student Success through the 3Es. Advance HE: York, pp. 56-63. ISBN 9781738524204

McCaughey, L. , Mcgregor, A. and Hamilton, L. (2024) Formatively assessing competency in practical skills through direct observations and oral feedback in the Life Sciences. In: Elkington, S. and Irons, A. (eds.) Formative Assessment and Feedback in Post-Digital Environments: Disciplinary Case Studies in Higher Education. Routledge. (In Press)

Conference or Workshop Item

Donald, C. and McCaughey, L. (2024) Enhancing Student’s Mathematical Skills with Smart Worksheets. Microbiology Society Annual Conference 2024, Edinburgh, UK, 08-11 Apr 2024. (Unpublished)

McCaughey, L. , Mcgregor, A. , Hamilton, L. and McCombie, A. (2024) The Complete Graduate: Designing a VLE-based Skills and Knowledge Framework to Support Student Confidence and Awareness. AdvanceHE Student Engagement Conference 2024, Leeds, UK, 18th April 2024. (Accepted for Publication)

McCaughey, L. , Mcgregor, A. , Hamilton, L., Ranglani, S. and Charlton, S. (2024) Business in the Biosciences - Embedding Entrepreneurship into a Life Science Course to Create More Inclusive Interdisciplinary Curricula and Enhance Transferable Skill Development. 17th Annual University of Glasgow Learning and Teaching Conference, Glasgow, UK, 9th April 2024. (Accepted for Publication)

McCaughey, L. , Hamilton, L., MacIver, K., Aitken, R. and Mcgregor, A. (2023) Evaluating Skills Attainment and Competency to Support Student Confidence and Awareness: Scaffolding a VLE-based Skills Tracker in Life Science Undergraduate Degrees. 16th Annual University of Glasgow Learning and Teaching Conference, Glasgow, UK, 13 Apr 2023.

McCaughey, L. , Mcgregor, A. , MacIver, K. and Aitken, R. (2023) Business in the Biosciences: A Compressed Format Entrepreneurship Course with Employability Skills at its Core. Employability Symposium 2023: Lighting the Labyrinth: Enhancing Student Success through the 3Es, Manchester, 25 April 2023.

This list was generated on Fri Jul 26 03:50:03 2024 BST.

Teaching

Laura is involved in several aspects of teaching across L1-L4 for Biochemistry, Genetics and Molecular & Cellular Biology.

Professional activities & recognition

Prizes, awards & distinctions

  • 2020: NSW Young Tall Poppy of the Year award (Australian Institute of Policy & Science)
  • 2016: Travel grant for academic collaboration (Campus Travel)
  • 2016: ComBio Early Career Researcher award (Sydney Protein Group)
  • 2016: Young Investigators award (Lorne Conference on Protein Structure and Function)

Research fellowships

  • 2015 - 2021: Sir Henry Wellcome Postdoctoral Fellowship

Supplementary

  • Over the last ten years Laura has been actively involved in highlighting the problem of antibiotic resistance, and the interventions necessary to prevent the problem escalating further, to the public. Laura has a demonstrated ability at interpreting and conveying complex information to non-specialists and non-scientists through this active public engagement work. She has written articles & blogs, done radio interviews/podcasts and spoken at numerous public events on the topic of antibiotic resistance. She has also carried out an internship at the ABC (Australian Broadcast Corporation) working on their flagship science program Catalyst and has undertaken an intensive course 'strategies in science communication', at the Australian National University, Canberra. Laura was also project manager for Soapbox Science Sydney 2019 & 2020. Soapbox Science is a large scale public science event promoting female scientist and the science that they do (https://soapboxsciencesydney.com). Laura has a creative eye and does all of the artwork, website design and video editing for Soapbox Science Sydney. Laura was awarded the Australian Institute for Policy and Science NSW Young Tall Poppy of the Year award in 2020 in recognition for her science communication endeavours.

Dr Laura McCaughey smiling