Professor John McLauchlan

Affiliate (School of Infection & Immunity)

email: John.McLauchlan@glasgow.ac.uk

Centre for Virus Research, Sir Michael Stoker Building, 464 Bearsden Road, Glasgow

Research interests

Virus image CVR Supporting COVID-19 Research Response

Infection with hepatitis C virus (HCV) is a global public health problem. It is estimated that between 140-185 million people, are infected with the virus worldwide. Typically, HCV will establish a chronic infection that does not clear without intervention, leading to progressive liver disease and increased risk of hepatocellular cancer. It is now recognised that HCV infection is one of the leading causes of serious liver disease in many countries and is a growing burden on healthcare services. Previously, treatment consisted of a long course of interferon and ribavirin which was often poorly tolerated due to side effects, and had a low overall success rate. Although there are now new drugs available (called direct-acting antivirals; DAAs) that often do not require the use of interferon and give much higher cure rates even with reduced length of treatment, resistance to these drugs has been demonstrated which may limit their use in the future.

As well as being an important clinical pathogen, HCV is also interesting in terms of fundamental research as it is one of the most variable pathogens known to infect humans. It has been divided into 7 genotypes based on diversity at the nucleotide sequence level but there also many sub-types of each genotype. Even within an infected person, the virus is highly variable and exists as quasispecies, which is a population of diverse but closely-related variants. The extent of variability will depend on many factors; the amount of circulating virus, the genetics of the infected host and other external factors.

Publications

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Number of items: 114.

2023

Adeboyejo, K., King, B. J., Tsoleridis, T., Tarr, A. W., McLauchlan, J. , Irving, W. L., Ball, J. K. and McClure, P. (2023) Hepatitis C subtyping assay failure in UK patients born in sub‐Saharan Africa: implications for global treatment and elimination. Journal of Medical Virology, 95(1), e28178. (doi: 10.1002/jmv.28178) (PMID:36168235)

Nickbakhsh, S. , McWilliam Leitch, E. C., Smith, S., Davis, C. , Hutchinson, S., Irving, W. L., McLauchlan, J. and Thomson, E. C. (2023) Geographical variation in Hepatitis C-related severe liver disease and patient risk factors: a multicentre cross-sectional study. Epidemiology and Infection, 151, e59. (doi: 10.1017/S0950268823000377) (PMID:36915219) (PMCID:PMC10126891)

2022

Aranday-Cortes, E. et al. (2022) Real-world outcomes of direct-acting antiviral treatment and retreatment in United Kingdom–based patients infected with hepatitis C virus genotypes/subtypes endemic in Africa. Journal of Infectious Diseases, 226(6), pp. 995-1004. (doi: 10.1093/infdis/jiab110) (PMID:33668068) (PMCID:PMC9492310)

Bamford, C. G.C., Aranday-Cortes, E. , Sanchez-Velazquez, R., Mullan, C., Kohl, A. , Patel, A. H. , Wilson, S. J. and McLauchlan, J. (2022) A human and rhesus macaque interferon-stimulated gene screen shows that over-expression of ARHGEF3/XPLN inhibits replication of hepatitis C virus and other flavivirids. Viruses, 14(8), 1655. (doi: 10.3390/v14081655) (PMID:36016278) (PMCID:PMC9414520)

Xu, R., Rong, X., Aranday-Cortes, E., Vattipally, S. , Hughes, J. , McLauchlan, J. and Fu, Y. (2022) The transmission route and selection pressure in HCV subtype 3a and 3b Chinese infections: evolutionary kinetics and selective force analysis. Viruses, 14(7), 1514. (doi: 10.3390/v14071514) (PMID:35891494) (PMCID:PMC9324606)

Innes, H. et al. (2022) The rs429358 locus in apolipoprotein E is associated with hepatocellular carcinoma in patients with cirrhosis. Hepatology Communications, 6(5), pp. 1213-1226. (doi: 10.1002/hep4.1886) (PMID:34958182) (PMCID:PMC9035556)

Xu, R. et al. (2022) The evolutionary dynamics and epidemiological history of hepatitis C virus genotype 6, including unique strains from the Li community of Hainan Island, China. Virus Evolution, 8(1), veac012. (doi: 10.1093/ve/veac012) (PMID:35600095) (PMCID:PMC9115904)

2021

Niemi, M. E. K. et al. (2021) Mapping the human genetic architecture of COVID-19. Nature, 600(7889), pp. 472-477. (doi: 10.1038/s41586-021-03767-x) (PMID:34237774) (PMCID:PMC8674144)

Guo, C., Reuss, D., Coey, J. D., Sukumar, S., Lang, B., McLauchlan, J. , Boulant, S., Stanifer, M. L. and Bamford, C. G. G. (2021) Conserved induction of distinct antiviral signalling kinetics by primate interferon lambda 4 proteins. Frontiers in Immunology, 12, 772588. (doi: 10.3389/fimmu.2021.772588)

Smith, D. A. et al. (2021) Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure. Nature Communications, 12, 6105. (doi: 10.1038/s41467-021-25649-6) (PMID:34671027) (PMCID:PMC8528821)

Smith, D. A. et al. (2021) Real world SOF/VEL/VOX retreatment outcomes and viral resistance analysis for HCV patients with prior failure to DAA therapy. Journal of Viral Hepatitis, 28(9), pp. 1256-1264. (doi: 10.1111/jvh.13549) (PMID:34003556)

Bamford, C. G.G. and McLauchlan, J. (2021) An interferon lambda 4-associated variant in the hepatitis C virus RNA polymerase affects viral replication in infected cells. Journal of General Virology, 102(2), 001495. (doi: 10.1099/jgv.0.001495) (PMID:32897180)

2019

Bradshaw, D. et al. (2019) Consensus recommendations for resistance testing in the management of chronic hepatitis C virus infection: Public Health England HCV Resistance Group. Journal of Infection, 79(6), pp. 503-512. (doi: 10.1016/j.jinf.2019.10.007) (PMID:31629015)

Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi: 10.7554/eLife.42463) (PMID:31478835) (PMCID:PMC6721795)

Wing, P. A.C. et al. (2019) Amino acid substitutions in genotype 3a hepatitis C virus polymerase protein affect responses to sofosbuvir. Gastroenterology, 157(3), 692-704.e9. (doi: 10.1053/j.gastro.2019.05.007) (PMID:31078622)

Singer, J. B. et al. (2019) Interpreting viral deep sequencing data with GLUE. Viruses, 11(4), 323. (doi: 10.3390/v11040323) (PMID:30987147) (PMCID:PMC6520954)

Davis, C. et al. (2019) New highly diverse hepatitis C strains detected in sub‐Saharan Africa have unknown susceptibility to direct‐acting antiviral treatments. Hepatology, 69(4), pp. 1426-1441. (doi: 10.1002/hep.30342) (PMID:30387174) (PMCID:PMC6492010)

Bamford, C. G.G. and McLauchlan, J. (2019) Comparative host genomics: how has human evolution affected our immune defence against hepatitis C virus? Future Virology, 14(3), pp. 125-128. (doi: 10.2217/fvl-2019-0017)

Xu, R. et al. (2019) HCV genotype 6 prevalence, spontaneous clearance and diversity amongst elderly members of the Li ethnic minority in Baisha County, China. Journal of Viral Hepatitis, 26(5), pp. 529-540. (doi: 10.1111/jvh.13062) (PMID:30629794)

2018

Singer, J. B., Thomson, E. C. , McLauchlan, J. , Hughes, J. and Gifford, R. J. (2018) GLUE: a flexible software system for virus sequence data. BMC Bioinformatics, 19, 532. (doi: 10.1186/s12859-018-2459-9) (PMID:30563445) (PMCID:PMC6299651)

Nickbakhsh, S. , McLauchlan, J. and Leitch, E. C. M. (2018) Evaluating “treatment as prevention” on the road to hepatitis C virus elimination. Annals of Blood, 3, 44. (doi: 10.21037/aob.2018.10.05)

Pervolaraki, K. et al. (2018) Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. PLoS Pathogens, 14(11), e1007420. (doi: 10.1371/journal.ppat.1007420) (PMID:30485383) (PMCID:PMC6287881)

Bamford, C. G.G. et al. (2018) A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages. PLoS Pathogens, 14(10), e1007307. (doi: 10.1371/journal.ppat.1007307) (PMID:30308076) (PMCID:PMC6181419)

Karamitros, T. et al. (2018) Human Endogenous Retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model. Proceedings of the National Academy of Sciences of the United States of America, 115(41), pp. 10434-10439. (doi: 10.1073/pnas.1811940115) (PMID:30249655) (PMCID:PMC6187174)

da Silva Filipe, A. et al. (2018) Reply to: "Reply to: 'Response to DAA therapy in the NHS England Early Access Programme for rare HCV subtypes from low and middle income countries'". Journal of Hepatology, 68(4), pp. 864-866. (doi: 10.1016/j.jhep.2017.11.044) (PMID:29339112)

Knodel, M. M., Nägel, A., Reiter, S., Vogel, A., Targett-Adams, P., McLauchlan, J. , Herrmann, E. and Wittum, G. (2018) Quantitative analysis of hepatitis C NS5A viral protein dynamics on the ER surface. Viruses, 10(1), 28. (doi: 10.3390/v10010028) (PMID:29316722)

2017

da Silva Filipe, A. et al. (2017) Response to DAA therapy in the NHS England early access programme for rare HCV subtypes from low and middle income countries. Journal of Hepatology, 67(6), pp. 1348-1350. (doi: 10.1016/j.jhep.2017.06.035) (PMID:28789880)

McLauchlan, J. , Innes, H., Dillon, J.F., Foster, G., Holtham, E., McDonald, S. , Wilkes, B., Hutchinson, S.J. and Irving, W.L. (2017) Cohort profile: the hepatitis C virus (HCV) research UK clinical database and biobank. International Journal of Epidemiology, 46(5), 1391-1391h. (doi: 10.1093/ije/dyw362) (PMID:28338838)

Çevik, R. E., Cesarec, M., Da Silva Filipe, A. , Licastro, D., McLauchlan, J. and Marcello, A. (2017) Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response. Journal of Virology, 91(18), e00880-17. (doi: 10.1128/JVI.00880-17) (PMID:28659470)

Ansari, M. A. et al. (2017) Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus. Nature Genetics, 49(5), pp. 666-673. (doi: 10.1038/ng.3835) (PMID:28394351)

2016

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Cheung, M. C.M. et al. (2016) Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis. Journal of Hepatology, 65(4), pp. 741-747. (doi: 10.1016/j.jhep.2016.06.019) (PMID:27388925)

Thomson, E. et al. (2016) Comparison of next-generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes. Journal of Clinical Microbiology, 54(10), pp. 2470-2484. (doi: 10.1128/JCM.00330-16) (PMID:27385709) (PMCID:PMC5035407)

Swann, R.E. , Mandalou, P., Robinson, M.W., Ow, M.M., Foung, S.K.H., McLauchlan, J. , Patel, A.H. and Cramp, M.E. (2016) Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection. Journal of Viral Hepatitis, 23(11), pp. 873-880. (doi: 10.1111/jvh.12568) (PMID:27405885) (PMCID:PMC5244678)

Foster, G. R. et al. (2016) Cohort study of the impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis. Journal of Hepatology, 64(6), pp. 1224-1231. (doi: 10.1016/j.jhep.2016.01.029) (PMID:26829205)

Swann, R. E. , Cowton, V. M., Robinson, M. W., Cole, S. J., Barclay, S. T., Mills, P. R., Thomson, E. C. , McLauchlan, J. and Patel, A. (2016) Broad anti-hepatitis C virus (HCV) antibody responses are associated with improved clinical disease parameters in chronic HCV infection. Journal of Virology, 90(9), pp. 4530-4543. (doi: 10.1128/JVI.02669-15) (PMID:26912610) (PMCID:PMC4836347)

Bulteel, N., McGuinness, D., Shiels, P. G. and McLauchlan, J. (2016) Circulating micrornas as biomarkers for disease progression in chronic hepatitis C virus infection. EASL International Liver Congress 2016, Barcelona, Spain, 13-17 Apr 2016.

Robinson, M. W., Hughes, J. , Wilkie, G. S., Swann, R. , Barclay, S. T., Mills, P. R., Patel, A. H. , Thomson, E. C. and McLauchlan, J. (2016) Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region. Frontiers in Immunology, 7, 131. (doi: 10.3389/fimmu.2016.00131) (PMID:27092143) (PMCID:PMC4820669)

Lee, E. M., Alsagheir, A., Wu, X., Hammack, C., McLauchlan, J. , Watanabe, N., Wakita, T., Kneteman, N. M., Douglas, D. N. and Tang, H. (2016) Hepatitis C virus-induced degradation of cell death-inducing DFFA-like effector B leads to hepatic lipid dysregulation. Journal of Virology, 90(8), pp. 4174-4185. (doi: 10.1128/JVI.02891-15) (PMID:26865724)

Gomes, R., Isken, O., Tautz, N., McLauchlan, J. and McCormick, C. J. (2016) Polyprotein driven formation of two interdependent sets of complexes supporting hepatitis C virus genome replication. Journal of Virology, 90(6), pp. 2868-2883. (doi: 10.1128/JVI.01931-15) (PMID:26719260)

2015

Domingues, P., Bamford, C. G.G., Boutell, C. and McLauchlan, J. (2015) Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase. Journal of General Virology, 96(11), pp. 3236-3242. (doi: 10.1099/jgv.0.000283) (PMID:26361997) (PMCID:PMC4806579)

McNaughton, A. L., Cameron, I. D., Wignall-Fleming, E. B., Biek, R. , McLauchlan, J. , Gunson, R. N., Templeton, K., Tan, H. M.-L. and McWilliam Leitch, E. C. (2015) Spatiotemporal reconstruction of the introduction of hepatitis C virus into Scotland and its subsequent regional transmission. Journal of Virology, 89(22), pp. 11223-11232. (doi: 10.1128/JVI.02106-15) (PMID:26311892) (PMCID:PMC4645645)

Robinson, M. W. et al. (2015) Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection. Liver International, 35(10), pp. 2256-2264. (doi: 10.1111/liv.12830) (PMID:25800823) (PMCID:PMC4949513)

Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi: 10.1099/jgv.0.000241) (PMID:26315040)

Read, S. A., Tay, E. S., Shahidi, M., McLauchlan, J. , George, J. and Douglas, M. (2015) The mechanism of interferon refractoriness during hepatitis C virus Infection and Its reversal with a peroxisome proliferator-activated receptor α agonist. Journal of Interferon and Cytokine Research, 35(6), pp. 488-497. (doi: 10.1089/jir.2014.0209) (PMID:25734487)

Abdelrahman, T., Hughes, J. , Main, J., McLauchlan, J. , Thursz, M. and Thomson, E. (2015) Reply. Hepatology, 61(4), p. 1438. (doi: 10.1002/hep.27393) (PMID:25147121) (PMCID:PMC4407921)

Ardelrahman, T., Hughes, J. , Main, J., McLauchlan, J. , Thursz, M. and Thomson, E. (2015) Waiting time and transplantation for hepatocellular cancer: a balance between tempus fugit and carpe diem. Hepatology, 61(4), pp. 1438-1439. (doi: 10.1002/hep.27434)

Robinson, M.W., Swann, R. , Sigruener, A., Barclay, S.T., Mills, P.R., McLauchlan, J. and Patel, A. H. (2015) Elevated interferon-stimulated gene transcription in peripheral blood mononuclear cells occurs in patients infected with genotype 1 but not genotype 3 hepatitis C virus. Journal of Viral Hepatitis, 22(4), pp. 384-390. (doi: 10.1111/jvh.12310) (PMID:25200131) (PMCID:PMC4409080)

Abdelrahman, T., Hughes, J. , Main, J., McLauchlan, J. , Thursz, M. and Thomson, E. (2015) Next generation sequencing sheds light on the natural history of hepatitis C infection in patients that fail treatment. Hepatology, 61(1), pp. 88-97. (doi: 10.1002/hep.27192) (PMID:24797101) (PMCID:PMC4303934)

Filipe, A. and McLauchlan, J. (2015) Hepatitis C virus and lipid droplets: finding a niche. Trends in Molecular Medicine, 21(1), pp. 34-42. (doi: 10.1016/j.molmed.2014.11.003)

2014

Liefhebber, J. M.P., Hague, C. V., Zhang, Q., Wakelam, M. J.O. and McLauchlan, J. (2014) Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus. Journal of Biological Chemistry, 289(31), pp. 21276-21288. (doi: 10.1074/jbc.M114.582999)

Herod, M.R., Schregel, V., Hinds, C., Liu, M., McLauchlan, J. , McCormick, C.J. and Sandri-Goldin, R.M. (2014) Genetic complementation of hepatitis C virus nonstructural protein functions associated with replication exhibits requirements that differ from those for virion assembly. Journal of Virology, 88(5), pp. 2748-2762. (doi: 10.1128/JVI.03588-13)

2013

McWilliam Leitch, E. C. and McLauchlan, J. (2013) Determining the cellular diversity of hepatitis C virus quasispecies by single-cell viral sequencing. Journal of Virology, 87(23), pp. 12648-12655. (doi: 10.1128/JVI.01602-13) (PMID:24049174) (PMCID:PMC3838117)

Robinson, M. W., McGuinness, D., Swann, R. , Barclay, S., Mills, P. R., Patel, A. H. , McLauchlan, J. and Shiels, P. G. (2013) Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease. Aging Cell, 12(6), pp. 1141-1143. (doi: 10.1111/acel.12125) (PMID:23931242)

Jhaveri, R., Lyn, R.K., Hope, G., Sherratt, A.R., McLauchlan, J. and Pezacki, J.P. (2013) Bidirectional lipid droplet velocities are controlled by differential binding strengths of HCV Core DII protein. PLoS ONE, 8(11), e78065. (doi: 10.1371/journal.pone.0078065) (PMID:24223760) (PMCID:PMC3815211)

Mazumder, N. et al. (2013) Fluorescence lifetime imaging of alterations to cellular metabolism by domain 2 of the Hepatitis C virus core protein. PLoS ONE, 8(6), e66738. (doi: 10.1371/journal.pone.0066738) (PMID:23826122) (PMCID:PMC3691201)

2012

Herod, M. R., Jones, D. M., McLauchlan, J. and McCormick, C. J. (2012) Increasing rate of cleavage at boundary between non-structural proteins 4B and 5A inhibits replication of Hepatitis C virus. Journal of Biological Chemistry, 287(1), pp. 568-580. (doi: 10.1074/jbc.M111.311407) (PMID:22084249) (PMCID:PMC3249110)

Oehler, V., Filipe, A. , Montserret, R., da Costa, D., Brown, G., Penin, F. and McLauchlan, J. (2012) Structural analysis of Hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase. Journal of Virology, 86(15), pp. 7818-7828. (doi: 10.1128/JVI.00457-12) (PMID:22593157) (PMCID:PMC3421639)

2010

Felmlee, D. J. et al. (2010) Intravascular transfer contributes to postprandial increase in numbers of very-low-density hepatitis C virus particles. Gastroenterology, 139(5), pp. 1774-1783. (doi: 10.1053/j.gastro.2010.07.047) (PMID:20682323)

Jones, D.M., Domingues, P., Targett-Adams, P. and McLauchlan, J. (2010) Comparison of U2OS and Huh-7 cells for identifying host factors that affect hepatitis C virus RNA replication. Journal of General Virology, 91(9), pp. 2238-2248. (doi: 10.1099/vir.0.022210-0) (PMID:20505011)

Angus, A.G.N. et al. (2010) Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein. Journal of General Virology, 91(1), pp. 122-132. (doi: 10.1099/vir.0.015909-0) (PMID:19793905) (PMCID:PMC2885062)

Benga, W. J. A. et al. (2010) Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. Hepatology, 51(1), pp. 43-53. (doi: 10.1002/hep.23278) (PMID:20014138)

Jones, D.M. and McLauchlan, J. (2010) Hepatitis C virus: assembly and release of virus particles. Journal of Biological Chemistry, 285(30), pp. 22733-22739. (doi: 10.1074/jbc.R110.133017) (PMID:20457608) (PMCID:PMC2906262)

Tang, X., Wagoner, J., Negash, A., Austin, M., McLauchlan, J. , Hahn, Y. S., Rosen, H. R. and Polyak, S. J. (2010) Functional characterization of core genes from patients with acute hepatitis C virus infection. Journal of Infectious Diseases, 201(6), pp. 912-922. (doi: 10.1086/650699) (PMID:20170366) (PMCID:PMC2827820)

Targett-Adams, P., Boulant, S., Douglas, M. W. and McLauchlan, J. (2010) Lipid metabolism and HCV infection. Viruses, 2(5), pp. 1195-1217. (doi: 10.3390/v2051195) (PMID:21994676) (PMCID:PMC3187597)

2009

McLauchlan, J. (2009) Hepatitis C virus: viral proteins on the move. Biochemical Society Transactions, 37(5), p. 986. (doi: 10.1042/BST0370986) (PMID:19754437)

McLauchlan, J. (2009) Lipid droplets and hepatitis C virus infection. Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1791(6), pp. 552-559. (doi: 10.1016/j.bbalip.2008.12.012) (PMID:19167518)

Jones, D. M., Patel, A. H., Targett-Adams, P. and McLauchlan, J. (2009) The hepatitis c virus ns4b protein can trans-complement viral rna replication and modulates production of infectious virus. Journal of Virology, 83(5), pp. 2163-2177. (doi: 10.1128/JVI.01885-08) (PMID:19073716) (PMCID:PMC2643717)

Ratinier, M., Boulant, S., Crussard, S., McLauchlan, J. and Lavergne, J.-P. (2009) Subcellular localizations of the hepatitis C virus alternate reading frame proteins. Virus Research, 139(1), pp. 106-110. (doi: 10.1016/j.virusres.2008.09.011) (PMID:18996421)

Elliott, R.M., Armstrong, V.J. and McLauchlan, J. (2009) Structural and molecular virology. In: Karayiannis, P., Main, J. and Thomas, H. (eds.) Hepatitis C Virus. International Medical Press: London, UK, 2.1-2.13. ISBN 9781901769159

Roohvand, F. et al. (2009) Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein. Journal of Biological Chemistry, 284(20), pp. 13778-13791. (doi: 10.1074/jbc.M807873200) (PMID:19269968) (PMCID:PMC2679479)

2008

Ratinier, M., Boulant, S., Combet, C., Targett-Adams, P., McLauchlan, J. and Lavergne, J.-P. (2008) Transcriptional slippage prompts recoding in alternate reading frames in the hepatitis C virus (HCV) core sequence from strain HCV-1. Journal of General Virology, 89(7), pp. 1569-1578. (doi: 10.1099/vir.0.83614-0) (PMID:18559926)

Boulant, S., Douglas, M.W., Moody, L., Budkowska, A., Targett-Adams, P. and McLauchlan, J. (2008) Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner. Traffic, 9(8), pp. 1268-1282. (doi: 10.1111/j.1600-0854.2008.00767.x) (PMID:18489704)

Targett-Adams, P., Boulant, S. and McLauchlan, J. (2008) Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication. Journal of Virology, 82(5), pp. 2182-2195. (doi: 10.1128/JVI.01565-07) (PMID:18094154) (PMCID:PMC2258944)

Targett-Adams, P., Hope, G., Boulant, S. and McLauchlan, J. (2008) Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production. Journal of Biological Chemistry, 283(24), pp. 16850-16859. (doi: 10.1074/jbc.M802273200) (PMID:18424431)

2007

Shavinskaya, A., Boulant, S., Penin, F., McLauchlan, J. and Bartenschlager, R. (2007) The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. Journal of Biological Chemistry, 282(51), pp. 37158-37169. (doi: 10.1074/jbc.M707329200) (PMID:17942391)

Boulant, S., Targett-Adams, P. and McLauchlan, J. (2007) Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus. Journal of General Virology, 88(8), pp. 2204-2213. (doi: 10.1099/vir.0.82898-0) (PMID:17622624)

Jones, D.M., Gretton, S.N., McLauchlan, J. and Targett-Adams, P. (2007) Mobility analysis of an NS5A-GFP fusion protein in cells actively replicating hepatitis C virus subgenomic RNA. Journal of General Virology, 88(2), pp. 470-475. (doi: 10.1099/vir.0.82363-0) (PMID:17251564)

2006

Boulant, S., Montserret, R., Hope, R. G., Ratinier, M., Targett-Adams, P., Lavergne, J.-P., Penin, F. and McLauchlan, J. (2006) Structural determinants that target the hepatitis C virus core protein to lipid droplets. Journal of Biological Chemistry, 281(31), pp. 22236-22247. (doi: 10.1074/jbc.M601031200) (PMID:16704979)

Hope, R.G., McElwee, M.J. and McLauchlan, J. (2006) Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and E1 proteins of hepatitis C virus strain J1. Journal of General Virology, 87(3), pp. 623-627. (doi: 10.1099/vir.0.81371-0) (PMID:16476983)

Targett-Adams, P., Schaller, T., Hope, R.G., Lanford, R.E., Lemon, S.M., Martin, A. and McLauchlan, J. (2006) Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo. Journal of Biological Chemistry, 281(39), pp. 29221-29227. (doi: 10.1074/jbc.M605373200) (PMID:16882659)

2005

Targett-Adams, P. and McLauchlan, J. (2005) Development and characterization of a transient-replication assay for the genotype 2a hepatitis C virus subgenomic replicon. Journal of General Virology, 86(11), pp. 3075-3080. (doi: 10.1099/vir.0.81334-0)

Mouzakitis, G., McLauchlan, J. , Barreca, C., Kueltzo, L. and O'Hare, P. (2005) Characterization of VP22 in herpes simplex virus-infected cells. Journal of Virology, 79(19), pp. 12185-12198. (doi: 10.1128/JVI.79.19.12185-12198.2005)

Targett-Adams, P., McElwee, M.J., Ehrenborg, E., Gustafsson, M.C., Palmer, C.N. and McLauchlan, J. (2005) A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein. BBA: Gene Structure and Expression, 1728(1-2), pp. 95-104. (doi: 10.1016/j.bbaexp.2005.01.017)

2003

Shaw, M.L., McLauchlan, J. , Mills, P.R., Patel, A.H. and McCruden, E.A.B. (2003) Characterisation of the differences between hepatitis C virus genotype 3 and 1 glycoproteins. Journal of Medical Virology, 70(3), pp. 361-372. (doi: 10.1002/jmv.10404)

Targett-Adams, P., Chambers, D., Gledhill, S., Hope, R.G., Coy, J.F., Girod, A. and McLauchlan, J. (2003) Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein. Journal of Biological Chemistry, 278(18), pp. 15998-16007. (doi: 10.1074/jbc.M211289200)

2002

Martin, A., O'Hare, P., McLauchlan, J. and Elliott, G. (2002) Herpes simplex virus tegument protein VP22 contains overlapping domains for cytoplasmic localization, microtubule interaction, and chromatin binding. Journal of Virology, 76(10), pp. 4961-4970. (doi: 10.1128/JVI.76.10.4961-4970.2002)

McLauchlan, J. , Lemberg, M.K., Hope, G. and Martoglio, B. (2002) Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO Journal, 21(15), pp. 3980-3988. (doi: 10.1093/emboj/cdf414)

2001

Patel, J., Patel, A.H. and McLauchlan, J. (2001) The transmembrane domain of the hepatitis C virus E2 glycoprotein is required for correct folding of the E1 glycoprotein and native complex formation. Virology, 279(1), pp. 58-68. (doi: 10.1006/viro.2000.0693)

2000

Murphy, D.J., Hernendez-Pinzon, I., Patel, K., Hope, R.G. and McLauchlan, J. (2000) New insights into the mechanisms of lipid-body biogenesis in plants and other organisms. Biochemical Society Transactions, 28(6), pp. 710-1. (doi: 10.1042/bst0280713)

Hope, R.G. and McLauchlan, J. (2000) Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein. Journal of General Virology, 81(Pt 8), pp. 1913-25.

McLauchlan, J. (2000) Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. Journal of Viral Hepatitis, 7(1), pp. 2-14. (doi: 10.1046/j.1365-2893.2000.00201.x)

Verjans, G.M.G.M., Dings, M.E.M., McLauchlan, J. , van der Kooi, A., Hoogerhout, P., Brugghe, H.F., Timmermans, H.A.M., Baarsma, G.S. and Osterhaus, A.D.M.E. (2000) Intraocular T cells of patients with herpes simplex virus (HSV)–induced acute retinal necrosis recognize HSV tegument proteins VP11/12 and VP13/14. Journal of Infectious Diseases, 182(3), pp. 923-927. (doi: 10.1086/315759)

1999

Patel, J., Patel, A.H. and McLauchlan, J. (1999) Covalent interactions are not required to permit or stabilize the non-covalent association of hepatitis C virus glycoproteins E1 and E2. Journal of General Virology, 80(7), pp. 1681-1690.

1997

McLauchlan, J. (1997) The abundance of the herpes simplex virus type 1 UL37 tegument protein in virus particles is closely controlled. Journal of General Virology, 78(1), pp. 189-194.

1996

Leslie, J., Rixon, F.J. and McLauchlan, J. (1996) Overexpression of the herpes simplex virus type 1 tegument protein VP22 increases its incorporation into virus particles. Virology, 220(1), pp. 60-68. (doi: 10.1006/viro.1996.0286)

1994

McLauchlan, J. , Liefkens, K. and Stow, N.D. (1994) The herpes simplex virus type 1 UL37 gene product is a component of virus particles. Journal of General Virology, 75(8), pp. 2047-2052. (doi: 10.1099/0022-1317-75-8-2047)

Sinclair, M.C., McLauchlan, J. , Marsden, H. and Brown, S.M. (1994) Characterization of a herpes simplex virus type 1 deletion variant (1703) which under-produces Vmw63 during immediate early conditions of infection. Journal of General Virology, 75(5), pp. 1083-1089. (doi: 10.1099/0022-1317-75-5-1083)

1992

McLauchlan, J. , Phelan, A., Loney, C. , Sandri-Goldin, R.M. and Clements, J.B. (1992) Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing. Journal of Virology, 66(12), pp. 6939-6945.

McLauchlan, J. , Addison, C., Craigie, M.C. and Rixon, F.J. (1992) Noninfectious L-particles supply functions which can facilitate infection by HSV-1. Virology, 190(2), pp. 682-688. (doi: 10.1016/0042-6822(92)90906-6)

McLauchlan, J. and Rixon, F.J. (1992) Characterization of enveloped tegument structures (L particles) produced by alphaherpesviruses: integrity of the tegument does not depend on the presence of capsid or envelope. Journal of General Virology, 73(2), pp. 269-276. (doi: 10.1099/0022-1317-73-2-269)

Rixon, F.J., Addison, C. and McLauchlan, J. (1992) Assembly of enveloped tegument structures (L particles) can occur independently of virion maturation in herpes simplex virus type 1-infected cells. Journal of General Virology, 73(2), pp. 277-284. (doi: 10.1099/0022-1317-73-2-277)

1991

Furlong, J., Conner, J., McLauchlan, J. , Lankinen, H., Galt, C., Marsden, H.S. and Clements, J.B. (1991) The large subunit of herpes simplex virus type 1 ribonucleotide reductase: expression in Escherichia coli and purification. Virology, 182(2), pp. 846-851. (doi: 10.1016/0042-6822(91)90627-N)

Lankinen, H., McLauchlan, J. , Weir, M., Furlong, J., Conner, J., McGarrity, A., Mistry, A., Clements, J.B. and Marsden, H.S. (1991) Purification and characterization of the herpes simplex virus type 1 ribonucleotide reductase small subunit following expression in Escherichia coli. Journal of General Virology, 72(6), pp. 1383-1392. (doi: 10.1099/0022-1317-72-6-1383)

1990

Rixon, F.J. and McLauchlan, J. (1990) Insertion of DNA sequences at a unique restriction enzyme site engineered for vector purposes into the genome of herpes simplex virus type 1. Journal of General Virology, 71(12), pp. 2931-2939. (doi: 10.1099/0022-1317-71-12-2931)

1989

McLauchlan, J. , Simpson, S. and Clements, J.B. (1989) Herpes simplex virus induces a processing factor that stimulates poly(A) site usage. Cell, 59(6), pp. 1093-1105. (doi: 10.1016/0092-8674(89)90765-4)

1988

McLauchlan, J. , Moore, C.L., Simpson, S. and Clements, J.B. (1988) Components required for in vitro cleavage and polyadenylation of eukaryotic mRNA. Nucleic Acids Research, 16(12), pp. 5323-5344. (doi: 10.1093/nar/16.12.5323)

1986

Nikas, I., McLauchlan, J. , Davison, A.J. , Taylor, W.R. and Clements, J.B. (1986) Structural features of ribonucleotide reductase. Proteins: Structure Function and Bioinformatics, 1(4), pp. 376-84. (doi: 10.1002/prot.340010411)

1985

Gaffney, D.F., McLauchlan, J. , Whitton, J.L. and Clements, J.B. (1985) A modular system for the assay of transcription regulatory signals: the sequence TAATGARAT is required for herpes simplex virus immediate early gene activation. Nucleic Acids Research, 13(21), pp. 7847-7863. (doi: 10.1093/nar/13.21.7847)

McLauchlan, J. , Gaffney, D., Whitton, J.L. and Clements, J.B. (1985) The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini. Nucleic Acids Research, 13(4), pp. 1347-1368. (doi: 10.1093/nar/13.4.1347)

1983

McLauchlan, J. and Clements, J.B. (1983) Organization of the Herpes Simplex virus Type 1 transcription unit encoding two early proteins with molecular weights of 140000 and 40000. Journal of General Virology, 64(5), pp. 997-1006. (doi: 10.1099/0022-1317-64-5-997)

McLauchlan, J. and Clements, J.B. (1983) DNA sequence homology between two co-linear loci on the HSV genome which have different transforming abilities. EMBO Journal, 2(11), pp. 1953-61.

1982

McLauchlan, J. and Clements, J.B. (1982) A 3′ co-terminus of two early herpes simplex virus type 1 mRNAs. Nucleic Acids Research, 10(2), pp. 501-512. (doi: 10.1093/nar/10.2.501)

1979

Clements, J.B., McLauchlan, J. and McGeoch, D.J. (1979) Orientation of herpes simplex virus type 1 immediate early mRNA's. Nucleic Acids Research, 7(1), pp. 77-91. (doi: 10.1093/nar/7.1.77)

This list was generated on Mon Apr 22 20:23:47 2024 BST.

Jump to: Articles | Book Sections | Conference or Workshop Item

Number of items: 114.

Articles

Niemi, M. E. K. et al. (2021) Mapping the human genetic architecture of COVID-19. Nature, 600(7889), pp. 472-477. (doi: 10.1038/s41586-021-03767-x) (PMID:34237774) (PMCID:PMC8674144)

Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi: 10.7554/eLife.42463) (PMID:31478835) (PMCID:PMC6721795)

Singer, J. B. et al. (2019) Interpreting viral deep sequencing data with GLUE. Viruses, 11(4), 323. (doi: 10.3390/v11040323) (PMID:30987147) (PMCID:PMC6520954)

Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi: 10.1099/jgv.0.000241) (PMID:26315040)

Abdelrahman, T., Hughes, J. , Main, J., McLauchlan, J. , Thursz, M. and Thomson, E. (2015) Reply. Hepatology, 61(4), p. 1438. (doi: 10.1002/hep.27393) (PMID:25147121) (PMCID:PMC4407921)

Filipe, A. and McLauchlan, J. (2015) Hepatitis C virus and lipid droplets: finding a niche. Trends in Molecular Medicine, 21(1), pp. 34-42. (doi: 10.1016/j.molmed.2014.11.003)

Targett-Adams, P., Boulant, S., Douglas, M. W. and McLauchlan, J. (2010) Lipid metabolism and HCV infection. Viruses, 2(5), pp. 1195-1217. (doi: 10.3390/v2051195) (PMID:21994676) (PMCID:PMC3187597)

McLauchlan, J. (2009) Hepatitis C virus: viral proteins on the move. Biochemical Society Transactions, 37(5), p. 986. (doi: 10.1042/BST0370986) (PMID:19754437)

McLauchlan, J. (1997) The abundance of the herpes simplex virus type 1 UL37 tegument protein in virus particles is closely controlled. Journal of General Virology, 78(1), pp. 189-194.

McLauchlan, J. and Clements, J.B. (1983) DNA sequence homology between two co-linear loci on the HSV genome which have different transforming abilities. EMBO Journal, 2(11), pp. 1953-61.

McLauchlan, J. and Clements, J.B. (1982) A 3′ co-terminus of two early herpes simplex virus type 1 mRNAs. Nucleic Acids Research, 10(2), pp. 501-512. (doi: 10.1093/nar/10.2.501)

Clements, J.B., McLauchlan, J. and McGeoch, D.J. (1979) Orientation of herpes simplex virus type 1 immediate early mRNA's. Nucleic Acids Research, 7(1), pp. 77-91. (doi: 10.1093/nar/7.1.77)

Book Sections

Conference or Workshop Item

This list was generated on Mon Apr 22 20:23:47 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

Enhancing dengue surveillance in the Philippines
British Council
2020 - 2023
UK-Indonesian Consortium to Identify Biomarkers Predictive of Dengue Disease Severity
Medical Research Council
2017 - 2019
Quinquennial Core Funds
Medical Research Council
2016 - 2021
Grant for collection of the real world data on use of direct acting antiviral agents in the treatment of chronic HCV infection in the UK
AbbVie
2016 - 2016
DENV project
Medical Research Council
2016 - 2019
Validation of metabolomics as a technique to identify determinants of treatment response in HCV infection (ISSF Catalyst)
Wellcome Trust
2014 - 2015
Stratified medicine to Optimise the Treatment with Hepatitis C Virus Infection (STOP-HCV) *** Original Agreement Budgets and Costs***
Medical Research Council
2013 - 2018
Establishment of a Resource for Long-Term Study of Hepatitis C Virus Infection in the UK
Medical Research Foundation
2013 - 2016
Virus-host interactions in hepatitis C virus infection
Medical Research Council
2013 - 2016

Research datasets

Jump to: 2022

Number of items: 1.

2022

McLauchlan, J. , Irving, W. and McDonald, S. (2022) Clinical, Biorepository and Research Datasets for HCV Research UK. [Data Collection]

This list was generated on Mon Apr 22 20:16:47 2024 BST.

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Professor John McLauchlan

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