Dr Joe Grove
- Senior Lecturer (Virology)
Publications
2023
Cantoni, D. and Grove, J. (2023) Low hanging fruit for combatting SARS‐CoV‐2? EMBO Reports, 24(4), e56979. (doi: 10.15252/embr.202356979) (PMID:36876512)
2022
Mersmann, S. F., Johns, E., Yong, T., McEwan, W. A., James, L. C., Cohen, E. A.K. and Grove, J. (2022) A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling. Scientific Reports, 12, 17286. (doi: 10.1038/s41598-022-20506-y) (PMID:36241663) (PMCID:PMC9568568)
Cantoni, D. et al. (2022) Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike. EMBO Reports, 23(10), e54322. (doi: 10.15252/embr.202154322) (PMID:35999696) (PMCID:PMC9535765)
Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)
Stejskal, L. et al. (2022) An entropic safety catch controls Hepatitis C virus entry and antibody resistance. eLife, 11, e71854. (doi: 10.7554/eLife.71854) (PMID:35796426) (PMCID:PMC9333995)
2021
Schmidt, N. M. et al. (2021) Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint. Nature Communications, 12, 2814. (doi: 10.1038/s41467-021-22967-7) (PMID:33990561) (PMCID:PMC8121939)
Kalemera, M. D., Capella-Pujol, J., Chumbe, A., Underwood, A., Bull, R. A., Schinkel, J., Sliepen, K. and Grove, J. (2021) Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins. Journal of General Virology, 102(1), 001512. (doi: 10.1099/jgv.0.001512) (PMID:33147126) (PMCID:PMC8116788)
2020
Palor, M. et al. (2020) Cholesterol sensing by CD81 is important for hepatitis C virus entry. Journal of Biological Chemistry, 295(50), pp. 16931-16948. (doi: 10.1074/jbc.RA120.014761) (PMID:32900848) (PMCID:PMC7863897)
Stejskal, L., Lees, W. D., Moss, D. S., Palor, M., Bingham, R. J., Shepherd, A. J. and Grove, J. (2020) Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein. PLoS Computational Biology, 16(2), e1007710. (doi: 10.1371/journal.pcbi.1007710) (PMID:32109245) (PMCID:PMC7065822)
2019
Davies, S. P. et al. (2019) Hepatocytes delete regulatory T cells by enclysis, a CD4+ T cell engulfment process. Cell Reports, 29(6), 1610-1620.e4. (doi: 10.1016/j.celrep.2019.09.068) (PMID:31693899) (PMCID:PMC7057271)
Mazzon, M. et al. (2019) Identification of broad-spectrum antiviral compounds by targeting viral entry. Viruses, 11(2), 176. (doi: 10.3390/v11020176) (PMID:30791609) (PMCID:PMC6410080)
2018
pereira, P. M., Jacobs, C. and Grove, J. (2018) Investigating hepatitis C virus infection using super-resolution microscopy. In: Law, M. (ed.) Hepatitis C Virus Protocols. Series: Methods in molecular biology (1911). Humana Press: New York, NY, pp. 247-261. ISBN 9781493989751 (doi: 10.1007/978-1-4939-8976-8_17)
2017
Grove, J. , Hu, K., Farquhar, M. J., Goodall, M., Walker, L., Jamshad, M., Drummer, H. E., Bill, R. M., Balfe, P. and McKeating, J. A. (2017) A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81. Wellcome Open Research, 2, 82. (doi: 10.12688/wellcomeopenres.12058.1) (PMID:29090272) (PMCID:PMC5657224)
Lythgoe, K. A., Gardner, A., Pybus, O. G. and Grove, J. (2017) Short-sighted virus evolution and a germline hypothesis for chronic viral infections. Trends in Microbiology, 25(5), pp. 336-348. (doi: 10.1016/j.tim.2017.03.003) (PMID:28377208) (PMCID:PMC5405858)
2016
Culley, S., Towers, G. J., Selwood, D. L., Henriques, R. and Grove, J. (2016) Infection counter: automated quantification of in vitro virus replication by fluorescence microscopy. Viruses, 8(7), 201. (doi: 10.3390/v8070201) (PMID:27455304) (PMCID:PMC4974536)
2014
Grove, J. , Metcalf, D. J., Knight, A. E., Wavre-Shapton, S. T., Sun, T., Protonotarios, E. D., Griffin, L. D., Lippincott-Schwartz, J. and Marsh, M. (2014) Flat clathrin lattices: stable features of the plasma membrane. Molecular Biology of the Cell, 25(22), pp. 3581-3594. (doi: 10.1091/mbc.E14-06-1154) (PMID:25165141) (PMCID:PMC4230618)
Grove, J. (2014) Super-resolution microscopy: a virus' eye view of the cell. Viruses, 6(3), pp. 1365-1378. (doi: 10.3390/v6031365) (PMID:24651030) (PMCID:PMC3970155)
2012
Henry, A. G., Hislop, J. N., Grove, J. , Thorn, K., Marsh, M. and von Zastrow, M. (2012) Regulation of endocytic clathrin dynamics by cargo ubiquitination. Developmental Cell, 23(3), pp. 519-532. (doi: 10.1016/j.devcel.2012.08.003) (PMID:22940114) (PMCID:PMC3470869)
2011
Grove, J. and Marsh, M. (2011) The cell biology of receptor-mediated virus entry. Journal of Cell Biology, 195(7), pp. 1071-1082. (doi: 10.1083/jcb.201108131) (PMID:22123832) (PMCID:PMC3246895)
Brimacombe, C. L. et al. (2011) Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. Journal of Virology, 85(1), pp. 596-605. (doi: 10.1128/JVI.01592-10) (PMID:20962076) (PMCID:PMC3014195)
Syder, A. J. et al. (2011) Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors. Journal of Hepatology, 54(1), pp. 48-55. (doi: 10.1016/j.jhep.2010.06.024) (PMID:20932595)
2010
Wagoner, J. et al. (2010) Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology, 51(6), pp. 1912-1921. (doi: 10.1002/hep.23587) (PMID:20512985) (PMCID:PMC2909978)
Articles
Cantoni, D. and Grove, J. (2023) Low hanging fruit for combatting SARS‐CoV‐2? EMBO Reports, 24(4), e56979. (doi: 10.15252/embr.202356979) (PMID:36876512)
Mersmann, S. F., Johns, E., Yong, T., McEwan, W. A., James, L. C., Cohen, E. A.K. and Grove, J. (2022) A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling. Scientific Reports, 12, 17286. (doi: 10.1038/s41598-022-20506-y) (PMID:36241663) (PMCID:PMC9568568)
Cantoni, D. et al. (2022) Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike. EMBO Reports, 23(10), e54322. (doi: 10.15252/embr.202154322) (PMID:35999696) (PMCID:PMC9535765)
Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)
Stejskal, L. et al. (2022) An entropic safety catch controls Hepatitis C virus entry and antibody resistance. eLife, 11, e71854. (doi: 10.7554/eLife.71854) (PMID:35796426) (PMCID:PMC9333995)
Schmidt, N. M. et al. (2021) Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint. Nature Communications, 12, 2814. (doi: 10.1038/s41467-021-22967-7) (PMID:33990561) (PMCID:PMC8121939)
Kalemera, M. D., Capella-Pujol, J., Chumbe, A., Underwood, A., Bull, R. A., Schinkel, J., Sliepen, K. and Grove, J. (2021) Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins. Journal of General Virology, 102(1), 001512. (doi: 10.1099/jgv.0.001512) (PMID:33147126) (PMCID:PMC8116788)
Palor, M. et al. (2020) Cholesterol sensing by CD81 is important for hepatitis C virus entry. Journal of Biological Chemistry, 295(50), pp. 16931-16948. (doi: 10.1074/jbc.RA120.014761) (PMID:32900848) (PMCID:PMC7863897)
Stejskal, L., Lees, W. D., Moss, D. S., Palor, M., Bingham, R. J., Shepherd, A. J. and Grove, J. (2020) Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein. PLoS Computational Biology, 16(2), e1007710. (doi: 10.1371/journal.pcbi.1007710) (PMID:32109245) (PMCID:PMC7065822)
Davies, S. P. et al. (2019) Hepatocytes delete regulatory T cells by enclysis, a CD4+ T cell engulfment process. Cell Reports, 29(6), 1610-1620.e4. (doi: 10.1016/j.celrep.2019.09.068) (PMID:31693899) (PMCID:PMC7057271)
Mazzon, M. et al. (2019) Identification of broad-spectrum antiviral compounds by targeting viral entry. Viruses, 11(2), 176. (doi: 10.3390/v11020176) (PMID:30791609) (PMCID:PMC6410080)
Grove, J. , Hu, K., Farquhar, M. J., Goodall, M., Walker, L., Jamshad, M., Drummer, H. E., Bill, R. M., Balfe, P. and McKeating, J. A. (2017) A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81. Wellcome Open Research, 2, 82. (doi: 10.12688/wellcomeopenres.12058.1) (PMID:29090272) (PMCID:PMC5657224)
Lythgoe, K. A., Gardner, A., Pybus, O. G. and Grove, J. (2017) Short-sighted virus evolution and a germline hypothesis for chronic viral infections. Trends in Microbiology, 25(5), pp. 336-348. (doi: 10.1016/j.tim.2017.03.003) (PMID:28377208) (PMCID:PMC5405858)
Culley, S., Towers, G. J., Selwood, D. L., Henriques, R. and Grove, J. (2016) Infection counter: automated quantification of in vitro virus replication by fluorescence microscopy. Viruses, 8(7), 201. (doi: 10.3390/v8070201) (PMID:27455304) (PMCID:PMC4974536)
Grove, J. , Metcalf, D. J., Knight, A. E., Wavre-Shapton, S. T., Sun, T., Protonotarios, E. D., Griffin, L. D., Lippincott-Schwartz, J. and Marsh, M. (2014) Flat clathrin lattices: stable features of the plasma membrane. Molecular Biology of the Cell, 25(22), pp. 3581-3594. (doi: 10.1091/mbc.E14-06-1154) (PMID:25165141) (PMCID:PMC4230618)
Grove, J. (2014) Super-resolution microscopy: a virus' eye view of the cell. Viruses, 6(3), pp. 1365-1378. (doi: 10.3390/v6031365) (PMID:24651030) (PMCID:PMC3970155)
Henry, A. G., Hislop, J. N., Grove, J. , Thorn, K., Marsh, M. and von Zastrow, M. (2012) Regulation of endocytic clathrin dynamics by cargo ubiquitination. Developmental Cell, 23(3), pp. 519-532. (doi: 10.1016/j.devcel.2012.08.003) (PMID:22940114) (PMCID:PMC3470869)
Grove, J. and Marsh, M. (2011) The cell biology of receptor-mediated virus entry. Journal of Cell Biology, 195(7), pp. 1071-1082. (doi: 10.1083/jcb.201108131) (PMID:22123832) (PMCID:PMC3246895)
Brimacombe, C. L. et al. (2011) Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. Journal of Virology, 85(1), pp. 596-605. (doi: 10.1128/JVI.01592-10) (PMID:20962076) (PMCID:PMC3014195)
Syder, A. J. et al. (2011) Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors. Journal of Hepatology, 54(1), pp. 48-55. (doi: 10.1016/j.jhep.2010.06.024) (PMID:20932595)
Wagoner, J. et al. (2010) Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology, 51(6), pp. 1912-1921. (doi: 10.1002/hep.23587) (PMID:20512985) (PMCID:PMC2909978)
Book Sections
pereira, P. M., Jacobs, C. and Grove, J. (2018) Investigating hepatitis C virus infection using super-resolution microscopy. In: Law, M. (ed.) Hepatitis C Virus Protocols. Series: Methods in molecular biology (1911). Humana Press: New York, NY, pp. 247-261. ISBN 9781493989751 (doi: 10.1007/978-1-4939-8976-8_17)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Investigating the structural basis of membrane fusion by hepatitis C virus
University of Edinburgh
2022 - 2023