Dr Jonathan Wilkes
- Affiliate Researcher (School of Infection & Immunity)
email:
Jonathan.Wilkes@glasgow.ac.uk
RI III, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA
https://orcid.org/0000-0002-0920-6967Publications
2020
Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)
2019
Stortz, J. F., Del Rosario, M., Singer, M., Wilkes, J. M. , Meissner, M. and Das, S. (2019) Formin-2 drives polymerisation of actin filaments enabling segregation of apicoplasts and cytokinesis in Plasmodium falciparum. eLife, 8, e49030. (doi: 10.7554/eLife.49030) (PMID:31322501)
2017
Cuypers, B. et al. (2017) Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum. Genome Biology and Evolution, 9(8), pp. 1990-1997. (doi: 10.1093/gbe/evx102) (PMID:28541535) (PMCID:PMC5566637)
Stortz, J. A. et al. (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS Pathogens, 13(7), e1006477. (doi: 10.1371/journal.ppat.1006477) (PMID:28742144) (PMCID:PMC5542689)
Fernandez-Cortes, F., Serafim, T. D., Wilkes, J. M. , Jones, N. G., Ritchie, R., McCulloch, R. and Mottram, J. C. (2017) RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Scientific Reports, 7, 6156. (doi: 10.1038/s41598-017-06501-8) (PMID:28733613) (PMCID:PMC5522463)
2016
Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)
2015
Baker, N., Hamilton, G., Wilkes, J.M. , Hutchinson, S., Barrett, M.P. and Horn, D. (2015) Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 112(29), pp. 9112-9117. (doi: 10.1073/pnas.1505411112) (PMID:2615048) (PMCID:PMC4517229)
Woo, Y. H. et al. (2015) Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites. eLife, 4, e06974. (doi: 10.7554/eLife.06974) (PMID:26175406) (PMCID:PMC4501334)
2013
Kremer, K. et al. (2013) An overexpression screen of toxoplasma gondii rab-GTPases reveals distinct transport routes to the micronemes. PLoS Pathogens, 9(3), e1003213. (doi: 10.1371/journal.ppat.1003213)
2011
Dobson, R., Stockdale, C., Lapsley, C., Wilkes, J. and McCulloch, R. (2011) Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation. Molecular Microbiology, 81(2), pp. 434-456. (doi: 10.1111/j.1365-2958.2011.07703.x)
2010
Reininger, L., Wilkes, J.M. , Bourgade, H., Miranda-Saavedra, D. and Doerig, C. (2010) An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony. Molecular Microbiology, 79(1), pp. 205-221. (doi: 10.1111/j.1365-2958.2010.07442.x)
2009
Fennell, C., Babbitt, S., Russo, I., Wilkes, J. , Ranford-Cartwright, L.C. , Goldberg, D. and Doerig, C. (2009) PfeIK1, a eukaryotic initiation factor 2[alpha] kinase of the human malaria parasite Plasmodium falciparum , regulates stress-response to amino-acid starvation. Malaria Journal, 8(1), p. 99. (doi: 10.1186/1475-2875-8-99)
Articles
Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)
Stortz, J. F., Del Rosario, M., Singer, M., Wilkes, J. M. , Meissner, M. and Das, S. (2019) Formin-2 drives polymerisation of actin filaments enabling segregation of apicoplasts and cytokinesis in Plasmodium falciparum. eLife, 8, e49030. (doi: 10.7554/eLife.49030) (PMID:31322501)
Cuypers, B. et al. (2017) Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum. Genome Biology and Evolution, 9(8), pp. 1990-1997. (doi: 10.1093/gbe/evx102) (PMID:28541535) (PMCID:PMC5566637)
Stortz, J. A. et al. (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS Pathogens, 13(7), e1006477. (doi: 10.1371/journal.ppat.1006477) (PMID:28742144) (PMCID:PMC5542689)
Fernandez-Cortes, F., Serafim, T. D., Wilkes, J. M. , Jones, N. G., Ritchie, R., McCulloch, R. and Mottram, J. C. (2017) RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Scientific Reports, 7, 6156. (doi: 10.1038/s41598-017-06501-8) (PMID:28733613) (PMCID:PMC5522463)
Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)
Baker, N., Hamilton, G., Wilkes, J.M. , Hutchinson, S., Barrett, M.P. and Horn, D. (2015) Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 112(29), pp. 9112-9117. (doi: 10.1073/pnas.1505411112) (PMID:2615048) (PMCID:PMC4517229)
Woo, Y. H. et al. (2015) Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites. eLife, 4, e06974. (doi: 10.7554/eLife.06974) (PMID:26175406) (PMCID:PMC4501334)
Kremer, K. et al. (2013) An overexpression screen of toxoplasma gondii rab-GTPases reveals distinct transport routes to the micronemes. PLoS Pathogens, 9(3), e1003213. (doi: 10.1371/journal.ppat.1003213)
Dobson, R., Stockdale, C., Lapsley, C., Wilkes, J. and McCulloch, R. (2011) Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation. Molecular Microbiology, 81(2), pp. 434-456. (doi: 10.1111/j.1365-2958.2011.07703.x)
Reininger, L., Wilkes, J.M. , Bourgade, H., Miranda-Saavedra, D. and Doerig, C. (2010) An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony. Molecular Microbiology, 79(1), pp. 205-221. (doi: 10.1111/j.1365-2958.2010.07442.x)
Fennell, C., Babbitt, S., Russo, I., Wilkes, J. , Ranford-Cartwright, L.C. , Goldberg, D. and Doerig, C. (2009) PfeIK1, a eukaryotic initiation factor 2[alpha] kinase of the human malaria parasite Plasmodium falciparum , regulates stress-response to amino-acid starvation. Malaria Journal, 8(1), p. 99. (doi: 10.1186/1475-2875-8-99)