Miss Emma Briggs

  • Affiliate Research fellow (School of Infection & Immunity)

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017
Number of items: 19.

2025

Laidlaw, Ross F., Briggs, Emma M., Matthews, Keith R., Mamlouk, Amir Madany, McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X and Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 (2025) TrAGEDy—trajectory alignment of gene expression dynamics. Bioinformatics, 41(3), btaf073. (doi: 10.1093/bioinformatics/btaf073) (PMID:40065693) (PMCID:PMC11908647)

Agboraw, E. et al. (2025) paraCell: a novel software tool for the interactive analysis and visualization of standard and dual host-parasite single cell RNA-Seq data. Nucleic Acids Research, 53(4), gkaf091. (doi: 10.1093/nar/gkaf091)

Krasilnikova, Marija ORCID logoORCID: https://orcid.org/0000-0002-9140-9746, Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Briggs, Emma, Lapsley, Craig, Hamilton, Graham, Beraldi, Dario, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762 and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2025) Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei. Nature Communications, 16, 751. (doi: 10.1038/s41467-025-56087-3)

2024

Damasceno, Jeziel D. ORCID logoORCID: https://orcid.org/0000-0003-2077-3214, Briggs, Emma M., Krasilnikova, Marija ORCID logoORCID: https://orcid.org/0000-0002-9140-9746, Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Lapsley, Craig and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2024) R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in Leishmania. bioRxiv, (doi: 10.1101/2024.04.29.591643)

2023

Girasol, M. J. et al. (2023) RAD51-mediated R-loop formation acts to repair transcription associated DNA breaks driving antigenic variation in Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America, 120(48), e230930612. (doi: 10.1073/pnas.2309306120) (PMID:37988471) (PMCID:PMC10691351)

Girasol, Mark J., Briggs, Emma, Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Batista, Jose M., Beraldi, Dario, Buchmore, Richard, Lemgruber, Leandro ORCID logoORCID: https://orcid.org/0000-0003-2832-6806 and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2023) Immunoprecipitation of RNA-DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved and novel activities, including in the control of surface antigen expression needed for immune evasion by antigenic variation. Nucleic Acids Research, 51(20), pp. 11123-11141. (doi: 10.1093/nar/gkad836) (PMID:37843098) (PMCID:PMC10639054)

Briggs, Emma M., Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Oldrieve, Guy R., Hu, Jihua, Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 and Matthews, Keith R. (2023) Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single cell transcriptomics. eLife, 12, e86325. (doi: 10.7554/eLife.86325) (PMID:37166108) (PMCID:PMC10212563)

2022

Faria, Joana, Briggs, Emma M., Black, Jennifer A. and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2022) Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome. Current Opinion in Microbiology, 70, 102209. (doi: 10.1016/j.mib.2022.102209) (PMID:36215868)

Quintana, J. F. et al. (2022) Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection. Nature Communications, 13, 5752. (doi: 10.1038/s41467-022-33542-z) (PMID:36180478) (PMCID:PMC9525673)

Kent, Robyn S., Briggs, Emma, Colon, Beatrice L., Alvarez, Catalina, Silva Pereira, Sara and De Niz, Mariana (2022) Paving the way: contributions of big data to apicomplexan and kinetoplastid research. Frontiers in Cellular and Infection Microbiology, 12, 900878. (doi: 10.3389/fcimb.2022.900878) (PMID:35734575) (PMCID:PMC9207352)

2021

Briggs, Emma M., Rojas, Federico, McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X, Matthews, Keith R. and Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 (2021) Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing. Nature Communications, 12, 5268. (doi: 10.1038/s41467-021-25607-2) (PMID:34489460) (PMCID:PMC8421343)

Briggs, Emma M., Warren, Felix S.L., Matthews, Keith R., McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X and Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 (2021) Application of single cell transcriptomics to kinetoplastid research. Parasitology, 148(10), pp. 1223-1236. (doi: 10.1017/S003118202100041X) (PMID:33678213) (PMCID:PMC8311972)

Damasceno, Jeziel D. ORCID logoORCID: https://orcid.org/0000-0003-2077-3214, Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Black, Jennifer, Briggs, Emma and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2021) Read, write, adapt: challenges and opportunities during kinetoplastid genome replication. Trends in Genetics, 37(1), pp. 21-34. (doi: 10.1016/j.tig.2020.09.002) (PMID:32993968) (PMCID:PMC9213392)

2020

Briggs, Emma M., Marques, Catarina ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Reis-Cunha, Joao, Black, Jennifer, Campbell, Samantha, Damasceno, Jeziel ORCID logoORCID: https://orcid.org/0000-0003-2077-3214, Bartholomeu, Daniella, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762 and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2020) Next-generation analysis of trypanosomatid genome stability and instability. In: Michels, Paul A.M., Ginger, Michael L. and Zilberstein, Dan (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in Molecular Biology (2116). Springer, pp. 225-262. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_15)

2019

Briggs, Emma, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762, Lemgruber Soares, Leandro ORCID logoORCID: https://orcid.org/0000-0003-2832-6806, Hamilton, Graham, Lapsley, Craig and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2019) Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation. Nucleic Acids Research, 47(17), pp. 9180-9197. (doi: 10.1093/nar/gkz644) (PMID:31350892) (PMCID:PMC6753483)

2018

Briggs, Emma, Hamilton, Graham, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762, Lapsley, Craig and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2018) Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome. Nucleic Acids Research, 46(22), pp. 11789-11805. (doi: 10.1093/nar/gky928) (PMID:30304482) (PMCID:PMC6294496)

Briggs, Emma, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762, Lemgruber, Leandro ORCID logoORCID: https://orcid.org/0000-0003-2832-6806, Lapsley, Craig and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2018) Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion. PLoS Genetics, 14(12), e1007729. (doi: 10.1371/journal.pgen.1007729) (PMID:30543624) (PMCID:PMC6292569)

Santos da Silva, Marcelo, Hovel-Miner, Galadriel A., Briggs, Emma M., Elias, Maria Carolina and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2018) Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes. PLoS Pathogens, 14(11), e1007321. (doi: 10.1371/journal.ppat.1007321) (PMID:30440029) (PMCID:PMC6237402)

2017

Stortz, J. A. et al. (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS Pathogens, 13(7), e1006477. (doi: 10.1371/journal.ppat.1006477) (PMID:28742144) (PMCID:PMC5542689)

This list was generated on Sun Jun 15 18:33:55 2025 BST.
Jump to: Articles | Book Sections
Number of items: 19.

Articles

Laidlaw, Ross F., Briggs, Emma M., Matthews, Keith R., Mamlouk, Amir Madany, McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X and Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 (2025) TrAGEDy—trajectory alignment of gene expression dynamics. Bioinformatics, 41(3), btaf073. (doi: 10.1093/bioinformatics/btaf073) (PMID:40065693) (PMCID:PMC11908647)

Agboraw, E. et al. (2025) paraCell: a novel software tool for the interactive analysis and visualization of standard and dual host-parasite single cell RNA-Seq data. Nucleic Acids Research, 53(4), gkaf091. (doi: 10.1093/nar/gkaf091)

Krasilnikova, Marija ORCID logoORCID: https://orcid.org/0000-0002-9140-9746, Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Briggs, Emma, Lapsley, Craig, Hamilton, Graham, Beraldi, Dario, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762 and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2025) Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei. Nature Communications, 16, 751. (doi: 10.1038/s41467-025-56087-3)

Damasceno, Jeziel D. ORCID logoORCID: https://orcid.org/0000-0003-2077-3214, Briggs, Emma M., Krasilnikova, Marija ORCID logoORCID: https://orcid.org/0000-0002-9140-9746, Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Lapsley, Craig and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2024) R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in Leishmania. bioRxiv, (doi: 10.1101/2024.04.29.591643)

Girasol, M. J. et al. (2023) RAD51-mediated R-loop formation acts to repair transcription associated DNA breaks driving antigenic variation in Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America, 120(48), e230930612. (doi: 10.1073/pnas.2309306120) (PMID:37988471) (PMCID:PMC10691351)

Girasol, Mark J., Briggs, Emma, Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Batista, Jose M., Beraldi, Dario, Buchmore, Richard, Lemgruber, Leandro ORCID logoORCID: https://orcid.org/0000-0003-2832-6806 and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2023) Immunoprecipitation of RNA-DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved and novel activities, including in the control of surface antigen expression needed for immune evasion by antigenic variation. Nucleic Acids Research, 51(20), pp. 11123-11141. (doi: 10.1093/nar/gkad836) (PMID:37843098) (PMCID:PMC10639054)

Briggs, Emma M., Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Oldrieve, Guy R., Hu, Jihua, Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 and Matthews, Keith R. (2023) Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single cell transcriptomics. eLife, 12, e86325. (doi: 10.7554/eLife.86325) (PMID:37166108) (PMCID:PMC10212563)

Faria, Joana, Briggs, Emma M., Black, Jennifer A. and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2022) Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome. Current Opinion in Microbiology, 70, 102209. (doi: 10.1016/j.mib.2022.102209) (PMID:36215868)

Quintana, J. F. et al. (2022) Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection. Nature Communications, 13, 5752. (doi: 10.1038/s41467-022-33542-z) (PMID:36180478) (PMCID:PMC9525673)

Kent, Robyn S., Briggs, Emma, Colon, Beatrice L., Alvarez, Catalina, Silva Pereira, Sara and De Niz, Mariana (2022) Paving the way: contributions of big data to apicomplexan and kinetoplastid research. Frontiers in Cellular and Infection Microbiology, 12, 900878. (doi: 10.3389/fcimb.2022.900878) (PMID:35734575) (PMCID:PMC9207352)

Briggs, Emma M., Rojas, Federico, McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X, Matthews, Keith R. and Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 (2021) Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing. Nature Communications, 12, 5268. (doi: 10.1038/s41467-021-25607-2) (PMID:34489460) (PMCID:PMC8421343)

Briggs, Emma M., Warren, Felix S.L., Matthews, Keith R., McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X and Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 (2021) Application of single cell transcriptomics to kinetoplastid research. Parasitology, 148(10), pp. 1223-1236. (doi: 10.1017/S003118202100041X) (PMID:33678213) (PMCID:PMC8311972)

Damasceno, Jeziel D. ORCID logoORCID: https://orcid.org/0000-0003-2077-3214, Marques, Catarina A. ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Black, Jennifer, Briggs, Emma and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2021) Read, write, adapt: challenges and opportunities during kinetoplastid genome replication. Trends in Genetics, 37(1), pp. 21-34. (doi: 10.1016/j.tig.2020.09.002) (PMID:32993968) (PMCID:PMC9213392)

Briggs, Emma, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762, Lemgruber Soares, Leandro ORCID logoORCID: https://orcid.org/0000-0003-2832-6806, Hamilton, Graham, Lapsley, Craig and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2019) Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation. Nucleic Acids Research, 47(17), pp. 9180-9197. (doi: 10.1093/nar/gkz644) (PMID:31350892) (PMCID:PMC6753483)

Briggs, Emma, Hamilton, Graham, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762, Lapsley, Craig and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2018) Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome. Nucleic Acids Research, 46(22), pp. 11789-11805. (doi: 10.1093/nar/gky928) (PMID:30304482) (PMCID:PMC6294496)

Briggs, Emma, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762, Lemgruber, Leandro ORCID logoORCID: https://orcid.org/0000-0003-2832-6806, Lapsley, Craig and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2018) Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion. PLoS Genetics, 14(12), e1007729. (doi: 10.1371/journal.pgen.1007729) (PMID:30543624) (PMCID:PMC6292569)

Santos da Silva, Marcelo, Hovel-Miner, Galadriel A., Briggs, Emma M., Elias, Maria Carolina and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2018) Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes. PLoS Pathogens, 14(11), e1007321. (doi: 10.1371/journal.ppat.1007321) (PMID:30440029) (PMCID:PMC6237402)

Stortz, J. A. et al. (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS Pathogens, 13(7), e1006477. (doi: 10.1371/journal.ppat.1006477) (PMID:28742144) (PMCID:PMC5542689)

Book Sections

Briggs, Emma M., Marques, Catarina ORCID logoORCID: https://orcid.org/0000-0003-1324-5448, Reis-Cunha, Joao, Black, Jennifer, Campbell, Samantha, Damasceno, Jeziel ORCID logoORCID: https://orcid.org/0000-0003-2077-3214, Bartholomeu, Daniella, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762 and McCulloch, Richard ORCID logoORCID: https://orcid.org/0000-0001-5739-976X (2020) Next-generation analysis of trypanosomatid genome stability and instability. In: Michels, Paul A.M., Ginger, Michael L. and Zilberstein, Dan (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in Molecular Biology (2116). Springer, pp. 225-262. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_15)

This list was generated on Sun Jun 15 18:33:55 2025 BST.