2023

Briggs, E. M., Marques, C. A. , Oldrieve, G. R., Hu, J., Otto, T. D. and Matthews, K. R. (2023) Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single cell transcriptomics. eLife, (doi: 10.7554/eLife.86325) (Early Online Publication)

2022

Faria, J., Briggs, E. M., Black, J. A. and McCulloch, R. (2022) Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome. Current Opinion in Microbiology, 70, 102209. (doi: 10.1016/j.mib.2022.102209) (PMID:36215868)

Quintana, J. F. et al. (2022) Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection. Nature Communications, 13, 5752. (doi: 10.1038/s41467-022-33542-z) (PMID:36180478) (PMCID:PMC9525673)

Kent, R. S., Briggs, E., Colon, B. L., Alvarez, C., Silva Pereira, S. and De Niz, M. (2022) Paving the way: contributions of big data to apicomplexan and kinetoplastid research. Frontiers in Cellular and Infection Microbiology, 12, 900878. (doi: 10.3389/fcimb.2022.900878) (PMID:35734575) (PMCID:PMC9207352)

2021

Briggs, E. M., Rojas, F., McCulloch, R. , Matthews, K. R. and Otto, T. D. (2021) Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing. Nature Communications, 12, 5268. (doi: 10.1038/s41467-021-25607-2) (PMID:34489460) (PMCID:PMC8421343)

Briggs, E. M., Warren, F. S.L., Matthews, K. R., McCulloch, R. and Otto, T. D. (2021) Application of single cell transcriptomics to kinetoplastid research. Parasitology, 148(10), pp. 1223-1236. (doi: 10.1017/S003118202100041X) (PMID:33678213) (PMCID:PMC8311972)

Damasceno, J. D., Marques, C. A., Black, J., Briggs, E. and McCulloch, R. (2021) Read, write, adapt: challenges and opportunities during kinetoplastid genome replication. Trends in Genetics, 37(1), pp. 21-34. (doi: 10.1016/j.tig.2020.09.002) (PMID:32993968) (PMCID:PMC9213392)

2020

Briggs, E. M., Marques, C. A., Reis-Cunha, J., Black, J., Campbell, S., Damasceno, J., Bartholomeu, D., Crouch, K. and McCulloch, R. (2020) Next-generation analysis of trypanosomatid genome stability and instability. In: Michels, P. A.M., Ginger, M. L. and Zilberstein, D. (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in Molecular Biology (2116). Springer, pp. 225-262. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_15)

2019

Briggs, E., Crouch, K. , Lemgruber Soares, L. , Hamilton, G., Lapsley, C. and McCulloch, R. (2019) Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation. Nucleic Acids Research, 47(17), pp. 9180-9197. (doi: 10.1093/nar/gkz644) (PMID:31350892) (PMCID:PMC6753483)

2018

Briggs, E., Hamilton, G., Crouch, K. , Lapsley, C. and McCulloch, R. (2018) Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome. Nucleic Acids Research, 46(22), pp. 11789-11805. (doi: 10.1093/nar/gky928) (PMID:30304482) (PMCID:PMC6294496)

Briggs, E., Crouch, K. , Lemgruber, L. , Lapsley, C. and McCulloch, R. (2018) Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion. PLoS Genetics, 14(12), e1007729. (doi: 10.1371/journal.pgen.1007729) (PMID:30543624) (PMCID:PMC6292569)

Santos da Silva, M., Hovel-Miner, G. A., Briggs, E. M., Elias, M. C. and McCulloch, R. (2018) Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes. PLoS Pathogens, 14(11), e1007321. (doi: 10.1371/journal.ppat.1007321) (PMID:30440029) (PMCID:PMC6237402)

2017

Stortz, J. A. et al. (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS Pathogens, 13(7), e1006477. (doi: 10.1371/journal.ppat.1006477) (PMID:28742144) (PMCID:PMC5542689)

Articles

Briggs, E. M., Marques, C. A. , Oldrieve, G. R., Hu, J., Otto, T. D. and Matthews, K. R. (2023) Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single cell transcriptomics. eLife, (doi: 10.7554/eLife.86325) (Early Online Publication)

Faria, J., Briggs, E. M., Black, J. A. and McCulloch, R. (2022) Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome. Current Opinion in Microbiology, 70, 102209. (doi: 10.1016/j.mib.2022.102209) (PMID:36215868)

Quintana, J. F. et al. (2022) Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection. Nature Communications, 13, 5752. (doi: 10.1038/s41467-022-33542-z) (PMID:36180478) (PMCID:PMC9525673)

Kent, R. S., Briggs, E., Colon, B. L., Alvarez, C., Silva Pereira, S. and De Niz, M. (2022) Paving the way: contributions of big data to apicomplexan and kinetoplastid research. Frontiers in Cellular and Infection Microbiology, 12, 900878. (doi: 10.3389/fcimb.2022.900878) (PMID:35734575) (PMCID:PMC9207352)

Briggs, E. M., Rojas, F., McCulloch, R. , Matthews, K. R. and Otto, T. D. (2021) Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing. Nature Communications, 12, 5268. (doi: 10.1038/s41467-021-25607-2) (PMID:34489460) (PMCID:PMC8421343)

Briggs, E. M., Warren, F. S.L., Matthews, K. R., McCulloch, R. and Otto, T. D. (2021) Application of single cell transcriptomics to kinetoplastid research. Parasitology, 148(10), pp. 1223-1236. (doi: 10.1017/S003118202100041X) (PMID:33678213) (PMCID:PMC8311972)

Damasceno, J. D., Marques, C. A., Black, J., Briggs, E. and McCulloch, R. (2021) Read, write, adapt: challenges and opportunities during kinetoplastid genome replication. Trends in Genetics, 37(1), pp. 21-34. (doi: 10.1016/j.tig.2020.09.002) (PMID:32993968) (PMCID:PMC9213392)

Briggs, E., Crouch, K. , Lemgruber Soares, L. , Hamilton, G., Lapsley, C. and McCulloch, R. (2019) Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation. Nucleic Acids Research, 47(17), pp. 9180-9197. (doi: 10.1093/nar/gkz644) (PMID:31350892) (PMCID:PMC6753483)

Briggs, E., Hamilton, G., Crouch, K. , Lapsley, C. and McCulloch, R. (2018) Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome. Nucleic Acids Research, 46(22), pp. 11789-11805. (doi: 10.1093/nar/gky928) (PMID:30304482) (PMCID:PMC6294496)

Briggs, E., Crouch, K. , Lemgruber, L. , Lapsley, C. and McCulloch, R. (2018) Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion. PLoS Genetics, 14(12), e1007729. (doi: 10.1371/journal.pgen.1007729) (PMID:30543624) (PMCID:PMC6292569)

Santos da Silva, M., Hovel-Miner, G. A., Briggs, E. M., Elias, M. C. and McCulloch, R. (2018) Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes. PLoS Pathogens, 14(11), e1007321. (doi: 10.1371/journal.ppat.1007321) (PMID:30440029) (PMCID:PMC6237402)

Stortz, J. A. et al. (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS Pathogens, 13(7), e1006477. (doi: 10.1371/journal.ppat.1006477) (PMID:28742144) (PMCID:PMC5542689)

Book Sections

Briggs, E. M., Marques, C. A., Reis-Cunha, J., Black, J., Campbell, S., Damasceno, J., Bartholomeu, D., Crouch, K. and McCulloch, R. (2020) Next-generation analysis of trypanosomatid genome stability and instability. In: Michels, P. A.M., Ginger, M. L. and Zilberstein, D. (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in Molecular Biology (2116). Springer, pp. 225-262. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_15)