Dr Kyle Cunningham
- Affiliate Researcher (School of Infection & Immunity)
Publications
2025
Ntang, Emmaculate Yaah, Cunningham, Kyle T. ORCID: https://orcid.org/0000-0002-2171-0277, Singh, Shashi P.
ORCID: https://orcid.org/0000-0002-6029-8115, Ciancia, Claire, Sanders, Anna, Lilla, Sergio, Mukundan, Ananya, Ghogomu, Stephen M., Hinck, Andrew P. and Maizels, Rick M.
ORCID: https://orcid.org/0000-0003-3216-1944
(2025)
Structural and functional analysis of the TGF-β mimic, TGM-2: an immunomodulatory helminth protein.
Genes and Immunity,
(doi: 10.1038/s41435-025-00372-0)
(Early Online Publication)
Cunningham, K. T. et al. (2025) Molecular engineering of the helminth TGF-β mimetics, TGM1 and TGM4 reveals a novel antagonist of TGF-β signaling in fibroblasts. FASEB Journal, (Accepted for Publication)
White, S. E. et al. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16(1), 1847. (doi: 10.1038/s41467-025-56954-z) (PMID:39984487) (PMCID:PMC11845725)
Singh, S. P. et al. (2025) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, 26(1), pp. 218-244. (doi: 10.1038/s44319-024-00323-2) (PMID:39609640) (PMCID:PMC11723922)
2024
Cunningham, Kyle T. ORCID: https://orcid.org/0000-0002-2171-0277 and Maizels, Rick M.
ORCID: https://orcid.org/0000-0003-3216-1944
(2024)
We are what we eat: macrophages and efferocytosis.
Trends in Parasitology, 40(6),
pp. 446-448.
(doi: 10.1016/j.pt.2024.05.004)
(PMID:38772757)
Kelly, Christopher J., Lindsay, Susan L. ORCID: https://orcid.org/0000-0003-4241-4933, Smith, Rebecca Sherrard, Keh, Siew, Cunningham, Kyle T.
ORCID: https://orcid.org/0000-0002-2171-0277, Thümmler, Katja
ORCID: https://orcid.org/0000-0002-1681-2359, Maizels, Rick M.
ORCID: https://orcid.org/0000-0003-3216-1944, Campbell, John D.M. and Barnett, Susan C.
ORCID: https://orcid.org/0000-0003-1009-0575
(2024)
Development of good manufacturing practice-compatible isolation and culture methods for human olfactory mucosa-derived mesenchymal stromal cells.
International Journal of Molecular Sciences, 25(2),
743.
(doi: 10.3390/ijms25020743)
(PMID:38255817)
2023
Cunningham, Kyle T. ORCID: https://orcid.org/0000-0002-2171-0277 and Mills, Kingston H. G.
(2023)
Modulation of haematopoiesis by protozoal and helminth parasites.
Parasite Immunology, 45(12),
e12975.
(doi: 10.1111/pim.12975)
(PMID:36797216)
(PMCID:PMC10909493)
van Dinther, M. et al. (2023) CD44 acts as a co-receptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic. Proceedings of the National Academy of Sciences of the United States of America, 120(34), e230237012. (doi: 10.1073/pnas.2302370120) (PMID:37590410) (PMCID:PMC10450677)
2022
Mukundan, Ananya, Byeon, Chang-Hyeock, Hinck, Cynthia S., Cunningham, Kyle ORCID: https://orcid.org/0000-0002-2171-0277, Campion, Tiffany, Smyth, Danielle J.
ORCID: https://orcid.org/0000-0001-6080-2679, Maizels, Rick M.
ORCID: https://orcid.org/0000-0003-3216-1944 and Hinck, Andrew P.
(2022)
Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-ß to its receptors, TßRI and TßRII.
Journal of Biological Chemistry, 298(6),
101994.
(doi: 10.1016/j.jbc.2022.101994)
(PMID:35500648)
(PMCID:PMC9163516)
Articles
Ntang, Emmaculate Yaah, Cunningham, Kyle T. ORCID: https://orcid.org/0000-0002-2171-0277, Singh, Shashi P.
ORCID: https://orcid.org/0000-0002-6029-8115, Ciancia, Claire, Sanders, Anna, Lilla, Sergio, Mukundan, Ananya, Ghogomu, Stephen M., Hinck, Andrew P. and Maizels, Rick M.
ORCID: https://orcid.org/0000-0003-3216-1944
(2025)
Structural and functional analysis of the TGF-β mimic, TGM-2: an immunomodulatory helminth protein.
Genes and Immunity,
(doi: 10.1038/s41435-025-00372-0)
(Early Online Publication)
Cunningham, K. T. et al. (2025) Molecular engineering of the helminth TGF-β mimetics, TGM1 and TGM4 reveals a novel antagonist of TGF-β signaling in fibroblasts. FASEB Journal, (Accepted for Publication)
White, S. E. et al. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16(1), 1847. (doi: 10.1038/s41467-025-56954-z) (PMID:39984487) (PMCID:PMC11845725)
Singh, S. P. et al. (2025) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, 26(1), pp. 218-244. (doi: 10.1038/s44319-024-00323-2) (PMID:39609640) (PMCID:PMC11723922)
Cunningham, Kyle T. ORCID: https://orcid.org/0000-0002-2171-0277 and Maizels, Rick M.
ORCID: https://orcid.org/0000-0003-3216-1944
(2024)
We are what we eat: macrophages and efferocytosis.
Trends in Parasitology, 40(6),
pp. 446-448.
(doi: 10.1016/j.pt.2024.05.004)
(PMID:38772757)
Kelly, Christopher J., Lindsay, Susan L. ORCID: https://orcid.org/0000-0003-4241-4933, Smith, Rebecca Sherrard, Keh, Siew, Cunningham, Kyle T.
ORCID: https://orcid.org/0000-0002-2171-0277, Thümmler, Katja
ORCID: https://orcid.org/0000-0002-1681-2359, Maizels, Rick M.
ORCID: https://orcid.org/0000-0003-3216-1944, Campbell, John D.M. and Barnett, Susan C.
ORCID: https://orcid.org/0000-0003-1009-0575
(2024)
Development of good manufacturing practice-compatible isolation and culture methods for human olfactory mucosa-derived mesenchymal stromal cells.
International Journal of Molecular Sciences, 25(2),
743.
(doi: 10.3390/ijms25020743)
(PMID:38255817)
Cunningham, Kyle T. ORCID: https://orcid.org/0000-0002-2171-0277 and Mills, Kingston H. G.
(2023)
Modulation of haematopoiesis by protozoal and helminth parasites.
Parasite Immunology, 45(12),
e12975.
(doi: 10.1111/pim.12975)
(PMID:36797216)
(PMCID:PMC10909493)
van Dinther, M. et al. (2023) CD44 acts as a co-receptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic. Proceedings of the National Academy of Sciences of the United States of America, 120(34), e230237012. (doi: 10.1073/pnas.2302370120) (PMID:37590410) (PMCID:PMC10450677)
Mukundan, Ananya, Byeon, Chang-Hyeock, Hinck, Cynthia S., Cunningham, Kyle ORCID: https://orcid.org/0000-0002-2171-0277, Campion, Tiffany, Smyth, Danielle J.
ORCID: https://orcid.org/0000-0001-6080-2679, Maizels, Rick M.
ORCID: https://orcid.org/0000-0003-3216-1944 and Hinck, Andrew P.
(2022)
Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-ß to its receptors, TßRI and TßRII.
Journal of Biological Chemistry, 298(6),
101994.
(doi: 10.1016/j.jbc.2022.101994)
(PMID:35500648)
(PMCID:PMC9163516)