2025

Sharma, V. et al. (2025) A 1-year weight management program for difficult-to-treat asthma with obesity: a randomized controlled study. Chest, 167(1), pp. 42-53. (doi: 10.1016/j.chest.2024.09.042) (PMID:39427706) (PMCID:PMC11752128)

2024

Sharma, V., Ricketts, H. C., Steffensen, F., Goodfellow, A., Buchan, D. S. and Cowan, D. C. (2024) Accelerometer-derived sleep metrics in mild and difficult-to-treat asthma. Allergy, Asthma and Clinical Immunology, 20, 5. (doi: 10.1186/s13223-024-00874-y) (PMID:38221641) (PMCID:PMC10787977)

2023

Sharma, V., Ricketts, H. C., McCombie, L., Brosnahan, N. , Crawford, L., Slaughter, L., Goodfellow, A., Lean, M. E.J. and Cowan, D. C. (2023) A total diet replacement weight management programme for difficult-to-treat asthma associated with obesity: a randomised controlled feasibility trial. Chest, 163(5), pp. 1026-1037. (doi: 10.1016/j.chest.2023.01.015) (PMID:36649753)

Ricketts, H. C., Buchan, D. S., Steffensen, F., Chaudhuri, R. , Baker, J. S. and Cowan, D. C. (2023) Physical activity levels in asthma: relationship with disease severity, body mass index and novel accelerometer-derived metrics. Journal of Asthma, 60(4), pp. 824-834. (doi: 10.1080/02770903.2022.2102037) (PMID:35876843)

Sharma, V., Ricketts, H. C., Steffensen, F., Goodfellow, A. and Cowan, D. C. (2023) Obesity affects type 2 biomarker levels in asthma. Journal of Asthma, 60(2), pp. 385-392. (doi: 10.1080/02770903.2022.2051548) (PMID:35260034)

2022

Diver, S. et al. (2022) Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation. Allergy, 77(11), pp. 3362-3376. (doi: 10.1111/all.15425) (PMID:35778780)

Ricketts, H. C., Sharma, V., Steffensen, F., Goodfellow, A., Mackay, E., MacDonald, G., Buchan, D. S., Chaudhuri, R. and Cowan, D. C. (2022) A pragmatic randomised controlled trial of tailored pulmonary rehabilitation in participants with difficult-to-control asthma and elevated body mass index. BMC Pulmonary Medicine, 22, 363. (doi: 10.1186/s12890-022-02152-2) (PMID:36153525) (PMCID:PMC9509551)

McDowell, P. J. et al. (2022) Exacerbation profile and risk factors in a type-2–low enriched severe asthma cohort: a clinical trial to assess asthma exacerbation phenotypes. American Journal of Respiratory and Critical Care Medicine, 206(5), pp. 545-553. (doi: 10.1164/rccm.202201-0129OC) (PMID:35549845)

Busby, J. et al. (2022) Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma. European Respiratory Journal, 59, 2100768. (doi: 10.1183/13993003.00768-2021) (PMID:34561291) (PMCID:PMC9202483)

2021

Sharma, V. and Cowan, D. C. (2021) Obesity, inflammation, and severe asthma: an update. Current Allergy and Asthma Reports, 21(12), 46. (doi: 10.1007/s11882-021-01024-9)

Heaney, L. G. et al. (2021) Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial. Lancet Respiratory Medicine, 9(1), pp. 57-68. (doi: 10.1016/s2213-2600(20)30397-0) (PMID:32916135) (PMCID:PMC7783382)

2019

Ricketts, H. C. and Cowan, D. C. (2019) Asthma, obesity and targeted interventions: an update. Current Opinion in Allergy and Clinical Immunology, 19(1), pp. 68-74. (doi: 10.1097/aci.0000000000000494) (PMID:30480592)

2018

Hanratty, C. E. et al. (2018) A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial. Trials, 19, 5. (doi: 10.1186/s13063-017-2384-7) (PMID:29301585) (PMCID:PMC5753571)

2017

Anderson, D., Boyter, A., MacBride-Stewart, S., Cowan, D. and Bucknall, C. (2017) Monitoring medication uptake in difficult asthma – qualitative analysis. International Journal of Population Data Science, 1(1), 328. (doi: 10.23889/ijpds.v1i1.349) (PMCID:PMC9351090)

2016

Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)

Wang, G., Baines, K. J., Juan Fu, J., Wood, L. G., Simpson, J. L., McDonald, V. M., Cowan, D. C. , Robin Taylor, D., Cowan, J. O. and Gibson, P. G. (2016) Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma. European Respiratory Journal, 47(4), pp. 1123-1133. (doi: 10.1183/13993003.01098-2015) (PMID:26699720)

Heaney, L. G. et al. (2016) Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax, 71(2), pp. 187-189. (doi: 10.1136/thoraxjnl-2015-207326) (PMID:26205878) (PMCID:PMC4752622)

2015

Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)

Cowan, D. C. , Robin Taylor, D., Peterson, L. E., Cowan, J. O., Palmay, R., Williamson, A., Hammel, J., Erzurum, S. C., Hazen, S. L. and Comhair, S. (2015) Biomarker-based asthma phenotypes of corticosteroid response. Journal of Allergy and Clinical Immunology, 135(4), 877-883.e1. (doi: 10.1016/j.jaci.2014.10.026) (PMID:25488689) (PMCID:PMC4388771)

2014

Baines, K. J., Simpson, J. L., Wood, L. G., Scott, R. J., Fibbens, N. L., Powell, H., Cowan, D. C. , Robin Taylor, D., Cowan, J. O. and Gibson, P. G. (2014) Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes. Journal of Allergy and Clinical Immunology, 133(4), pp. 997-1007. (doi: 10.1016/j.jaci.2013.12.1091) (PMID:24582314)

Cowan, D. , Smith, A. and Thomson, N. (2014) Drugs that act on the respiratory tract. In: Aronson, J. K. (ed.) Side Effects of Drugs Annual 35. Series: Side Effects of Drugs Annual, 35. Elsevier, pp. 309-326. ISBN 9780444626356 (doi: 10.1016/b978-0-444-62635-6.00016-4)

2012

Hancox, R. J., Cowan, D. C. , Aldridge, R. E., Cowan, J. O., Palmay, R., Williamson, A., Ian Town, G. and Robin Taylor, D. (2012) Asthma phenotypes: consistency of classification using induced sputum. Respirology, 17(3), pp. 461-466. (doi: 10.1111/j.1440-1843.2011.02113.x) (PMID:22142406)

Cowan, D. C. and Livingston, E. (2012) Obstructive sleep apnoea syndrome and weight loss: review. Sleep Disorders, 2012, 163296. (doi: 10.1155/2012/163296) (PMID:23471145) (PMCID:PMC3581237)

2011

Donnelly, J., Cowan, D. C. , Yeoman, D. J., Lucas, S. J. E., Herbison, G. P., Thomas, K. N., Ainslie, P. N. and Taylor, D. R. (2011) Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude. Respiratory Physiology and Neurobiology, 177(3), pp. 213-217. (doi: 10.1016/j.resp.2011.04.008) (PMID:21515414)

2010

Taylor, D. R. and Cowan, D. C. (2010) Assessing airway inflammation. Thorax, 65(12), pp. 1031-1032. (doi: 10.1136/thx.2009.132985) (PMID:20937643)

Cowan, D. C. , Cowan, J. O., Palmay, R., Williamson, A. and Taylor, D. R. (2010) Simvastatin in the treatment of asthma: lack of steroid-sparing effect. Thorax, 65(10), pp. 891-896. (doi: 10.1136/thx.2010.138990) (PMID:20861293)

Cowan, D. C. , Cowan, J. O., Palmay, R., Williamson, A. and Taylor, D. R. (2010) Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax, 65(5), pp. 384-390. (doi: 10.1136/thx.2009.126722) (PMID:19996343)

Cowan, D. C. , Hewitt, R. S., Cowan, J. O., Palmay, R., Williamson, A., Lucas, S. J. E., Murrell, C. J., Thomas, K. N. and Taylor, D. R. (2010) Exercise-induced wheeze: fraction of exhaled nitric oxide-directed management. Respirology, 15(4), pp. 683-690. (doi: 10.1111/j.1440-1843.2010.01740.x) (PMID:20337988)

Articles

Sharma, V. et al. (2025) A 1-year weight management program for difficult-to-treat asthma with obesity: a randomized controlled study. Chest, 167(1), pp. 42-53. (doi: 10.1016/j.chest.2024.09.042) (PMID:39427706) (PMCID:PMC11752128)

Sharma, V., Ricketts, H. C., Steffensen, F., Goodfellow, A., Buchan, D. S. and Cowan, D. C. (2024) Accelerometer-derived sleep metrics in mild and difficult-to-treat asthma. Allergy, Asthma and Clinical Immunology, 20, 5. (doi: 10.1186/s13223-024-00874-y) (PMID:38221641) (PMCID:PMC10787977)

Sharma, V., Ricketts, H. C., McCombie, L., Brosnahan, N. , Crawford, L., Slaughter, L., Goodfellow, A., Lean, M. E.J. and Cowan, D. C. (2023) A total diet replacement weight management programme for difficult-to-treat asthma associated with obesity: a randomised controlled feasibility trial. Chest, 163(5), pp. 1026-1037. (doi: 10.1016/j.chest.2023.01.015) (PMID:36649753)

Ricketts, H. C., Buchan, D. S., Steffensen, F., Chaudhuri, R. , Baker, J. S. and Cowan, D. C. (2023) Physical activity levels in asthma: relationship with disease severity, body mass index and novel accelerometer-derived metrics. Journal of Asthma, 60(4), pp. 824-834. (doi: 10.1080/02770903.2022.2102037) (PMID:35876843)

Sharma, V., Ricketts, H. C., Steffensen, F., Goodfellow, A. and Cowan, D. C. (2023) Obesity affects type 2 biomarker levels in asthma. Journal of Asthma, 60(2), pp. 385-392. (doi: 10.1080/02770903.2022.2051548) (PMID:35260034)

Diver, S. et al. (2022) Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation. Allergy, 77(11), pp. 3362-3376. (doi: 10.1111/all.15425) (PMID:35778780)

Ricketts, H. C., Sharma, V., Steffensen, F., Goodfellow, A., Mackay, E., MacDonald, G., Buchan, D. S., Chaudhuri, R. and Cowan, D. C. (2022) A pragmatic randomised controlled trial of tailored pulmonary rehabilitation in participants with difficult-to-control asthma and elevated body mass index. BMC Pulmonary Medicine, 22, 363. (doi: 10.1186/s12890-022-02152-2) (PMID:36153525) (PMCID:PMC9509551)

McDowell, P. J. et al. (2022) Exacerbation profile and risk factors in a type-2–low enriched severe asthma cohort: a clinical trial to assess asthma exacerbation phenotypes. American Journal of Respiratory and Critical Care Medicine, 206(5), pp. 545-553. (doi: 10.1164/rccm.202201-0129OC) (PMID:35549845)

Busby, J. et al. (2022) Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma. European Respiratory Journal, 59, 2100768. (doi: 10.1183/13993003.00768-2021) (PMID:34561291) (PMCID:PMC9202483)

Sharma, V. and Cowan, D. C. (2021) Obesity, inflammation, and severe asthma: an update. Current Allergy and Asthma Reports, 21(12), 46. (doi: 10.1007/s11882-021-01024-9)

Heaney, L. G. et al. (2021) Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial. Lancet Respiratory Medicine, 9(1), pp. 57-68. (doi: 10.1016/s2213-2600(20)30397-0) (PMID:32916135) (PMCID:PMC7783382)

Ricketts, H. C. and Cowan, D. C. (2019) Asthma, obesity and targeted interventions: an update. Current Opinion in Allergy and Clinical Immunology, 19(1), pp. 68-74. (doi: 10.1097/aci.0000000000000494) (PMID:30480592)

Hanratty, C. E. et al. (2018) A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial. Trials, 19, 5. (doi: 10.1186/s13063-017-2384-7) (PMID:29301585) (PMCID:PMC5753571)

Anderson, D., Boyter, A., MacBride-Stewart, S., Cowan, D. and Bucknall, C. (2017) Monitoring medication uptake in difficult asthma – qualitative analysis. International Journal of Population Data Science, 1(1), 328. (doi: 10.23889/ijpds.v1i1.349) (PMCID:PMC9351090)

Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)

Wang, G., Baines, K. J., Juan Fu, J., Wood, L. G., Simpson, J. L., McDonald, V. M., Cowan, D. C. , Robin Taylor, D., Cowan, J. O. and Gibson, P. G. (2016) Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma. European Respiratory Journal, 47(4), pp. 1123-1133. (doi: 10.1183/13993003.01098-2015) (PMID:26699720)

Heaney, L. G. et al. (2016) Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax, 71(2), pp. 187-189. (doi: 10.1136/thoraxjnl-2015-207326) (PMID:26205878) (PMCID:PMC4752622)

Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)

Cowan, D. C. , Robin Taylor, D., Peterson, L. E., Cowan, J. O., Palmay, R., Williamson, A., Hammel, J., Erzurum, S. C., Hazen, S. L. and Comhair, S. (2015) Biomarker-based asthma phenotypes of corticosteroid response. Journal of Allergy and Clinical Immunology, 135(4), 877-883.e1. (doi: 10.1016/j.jaci.2014.10.026) (PMID:25488689) (PMCID:PMC4388771)

Baines, K. J., Simpson, J. L., Wood, L. G., Scott, R. J., Fibbens, N. L., Powell, H., Cowan, D. C. , Robin Taylor, D., Cowan, J. O. and Gibson, P. G. (2014) Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes. Journal of Allergy and Clinical Immunology, 133(4), pp. 997-1007. (doi: 10.1016/j.jaci.2013.12.1091) (PMID:24582314)

Hancox, R. J., Cowan, D. C. , Aldridge, R. E., Cowan, J. O., Palmay, R., Williamson, A., Ian Town, G. and Robin Taylor, D. (2012) Asthma phenotypes: consistency of classification using induced sputum. Respirology, 17(3), pp. 461-466. (doi: 10.1111/j.1440-1843.2011.02113.x) (PMID:22142406)

Cowan, D. C. and Livingston, E. (2012) Obstructive sleep apnoea syndrome and weight loss: review. Sleep Disorders, 2012, 163296. (doi: 10.1155/2012/163296) (PMID:23471145) (PMCID:PMC3581237)

Donnelly, J., Cowan, D. C. , Yeoman, D. J., Lucas, S. J. E., Herbison, G. P., Thomas, K. N., Ainslie, P. N. and Taylor, D. R. (2011) Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude. Respiratory Physiology and Neurobiology, 177(3), pp. 213-217. (doi: 10.1016/j.resp.2011.04.008) (PMID:21515414)

Taylor, D. R. and Cowan, D. C. (2010) Assessing airway inflammation. Thorax, 65(12), pp. 1031-1032. (doi: 10.1136/thx.2009.132985) (PMID:20937643)

Cowan, D. C. , Cowan, J. O., Palmay, R., Williamson, A. and Taylor, D. R. (2010) Simvastatin in the treatment of asthma: lack of steroid-sparing effect. Thorax, 65(10), pp. 891-896. (doi: 10.1136/thx.2010.138990) (PMID:20861293)

Cowan, D. C. , Cowan, J. O., Palmay, R., Williamson, A. and Taylor, D. R. (2010) Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax, 65(5), pp. 384-390. (doi: 10.1136/thx.2009.126722) (PMID:19996343)

Cowan, D. C. , Hewitt, R. S., Cowan, J. O., Palmay, R., Williamson, A., Lucas, S. J. E., Murrell, C. J., Thomas, K. N. and Taylor, D. R. (2010) Exercise-induced wheeze: fraction of exhaled nitric oxide-directed management. Respirology, 15(4), pp. 683-690. (doi: 10.1111/j.1440-1843.2010.01740.x) (PMID:20337988)

Book Sections

Cowan, D. , Smith, A. and Thomson, N. (2014) Drugs that act on the respiratory tract. In: Aronson, J. K. (ed.) Side Effects of Drugs Annual 35. Series: Side Effects of Drugs Annual, 35. Elsevier, pp. 309-326. ISBN 9780444626356 (doi: 10.1016/b978-0-444-62635-6.00016-4)