Dr Giuditta De Lorenzo
- Affiliate Researcher (School of Infection & Immunity)
Publications
2025
De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Tandavanitj, Rapeepat, Preciado-Llanes, Lorena, Sanchez-Velazquez, Ricardo, Rocha, Raissa Prado, Kim, Young Chan, Reyes-Sandova, Arturo and Patel, Arvind H.
ORCID: https://orcid.org/0000-0003-4600-2047
(2025)
Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models.
Frontiers in Immunology, 16,
1578427.
(doi: 10.3389/fimmu.2025.1578427)
(PMID:40352923)
(PMCID:PMC12062147)
Furnon, W. et al. (2025) Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic. Nature Microbiology, 10, pp. 77-93. (doi: 10.1038/s41564-024-01878-5) (PMID:39753670) (PMCID:PMC11726466)
2024
Tandavanitj, Rapeepat, Setthapramote, Chayanee, De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Sanchez-Velazquez, Ricardo, Clark, Jordan J., Rocchi, Mara, McInnes, Colin, Kohl, Alain
ORCID: https://orcid.org/0000-0002-1523-9458 and Patel, Arvind H.
ORCID: https://orcid.org/0000-0003-4600-2047
(2024)
Virus-like particles of louping ill virus elicit potent neutralizing antibodies targeting multimers of viral envelope protein.
Vaccine, 42(9),
pp. 2429-2437.
(doi: 10.1016/j.vaccine.2024.03.008)
(PMID:38458875)
Furnon, Wilhelm ORCID: https://orcid.org/0000-0002-5588-4232, Cowton, Vanessa, De Lorenzo, Giuditta
ORCID: https://orcid.org/0000-0002-2736-8740, Patel, Arvind
ORCID: https://orcid.org/0000-0003-4600-2047 and Palmarini, Massimo
ORCID: https://orcid.org/0000-0001-7007-4070
(2024)
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants.
Nature Microbiology, 9,
pp. 451-463.
(doi: 10.1038/s41564-023-01588-4)
(PMID:38228858)
(PMCID:PMC10847042)
2023
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Bouhaddou, M. et al. (2023) SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell, 186(21), pp. 4597-4614. (doi: 10.1016/j.cell.2023.08.026) (PMID:37738970) (PMCID:PMC10604369)
Wallace, S. et al. (2023) Multiplexed biosensing of proteins and virions with disposable plasmonic assays. ACS Sensors, 8(9), pp. 3338-3348. (doi: 10.1021/acssensors.2c02238) (PMID:37610841) (PMCID:PMC10521139)
da Silva Sanches, Paulo Ricardo, Sanchez-Velazquez, Ricardo, Nogueira Batista, Mariana, Moreira Carneiro, Bruno, Bittar, Cintia, De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Rahal, Paula, Patel, Arvind H.
ORCID: https://orcid.org/0000-0003-4600-2047 and Maffud Cilli, Eduardo
(2023)
Antiviral evaluation of new synthetic bioconjugates based on GA-Hecate: A new class of antivirals targeting different steps of Zika Virus replication.
Molecules, 28(13),
4884.
(doi: 10.3390/molecules28134884)
(PMID:37446546)
(PMCID:PMC10343505)
Mancini, M. V. et al. (2023) Evaluation of an engineered Zika virus-like particle vaccine candidate in a mosquito-mouse transmission model. mSphere, 8(2), e00564-22. (doi: 10.1128/msphere.00564-22) (PMID:36840596) (PMCID:PMC10117074)
2022
Lista, M. J. et al. (2022) The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. Journal of Virology, 96(23), e0125022. (doi: 10.1128/jvi.01250-22) (PMID:36350154) (PMCID:PMC9749455)
Willett, B. J. et al. (2022) Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7, 1709. (doi: 10.1038/s41564-022-01241-6) (PMID:36114232) (PMCID:PMC9483304)
Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)
Zhou, J. et al. (2022) Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 38(6), 110344. (doi: 10.1016/j.celrep.2022.110344) (PMID:35093235) (PMCID:PMC8768428)
2021
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)
2020
Sanchez Velazquez, R. et al. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. Antiviral Research, 183, 104939. (doi: 10.1016/j.antiviral.2020.104939) (PMID:32980446) (PMCID:PMC7649875)
Banerjee, A. K. et al. (2020) SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cell, (doi: 10.1016/j.cell.2020.10.004) (PMID:33080218) (PMCID:PMC7543886)
López-Camacho, C. et al. (2020) Immunogenicity and efficacy of Zika virus Envelope Domain III in DNA, protein and ChAdOx1 adenoviral-vectored vaccines. Vaccines, 8(2), 307. (doi: 10.3390/vaccines8020307) (PMID:32560145)
2018
López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)
Eichwald, C. et al. (2018) Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles. Journal of Virology, 92(3), e01943-17. (doi: 10.1128/JVI.01943-17) (PMID:29142132) (PMCID:PMC5774888)
2016
Ziberna, F. et al. (2016) Lack of evidence of rotavirus‐dependent molecular mimicry as a trigger of coeliac disease. Clinical and Experimental Immunology, 186(3), pp. 356-363. (doi: 10.1111/cei.12855) (PMID:27548641)
De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Drikic, Marija, Papa, Guido, Eichwald, Catherine, Burrone, Oscar R. and Arnoldi, Francesca
(2016)
An inhibitory motif on the 5'UTR of several rotavirus genome segments affects protein expression and reverse genetics strategies.
PLoS ONE, 11(11),
e0166719.
(doi: 10.1371/journal.pone.0166719)
(PMID:27846320)
(PMCID:PMC5112996)
2014
Arnoldi, Francesca, De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Mano, Miguel, Schraner, Elisabeth M., Wild, Peter, Eichwald, Catherine and Burrone, Oscar R.
(2014)
Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation.
PLoS ONE, 9(4),
e95197.
(doi: 10.1371/journal.pone.0095197)
(PMID:24736649)
(PMCID:PMC3988245)
2012
De Lorenzo, G. ORCID: https://orcid.org/0000-0002-2736-8740, Eichwald, C., Schraner, E.M., Nicolin, V., Bortul, R., Mano, M., Burrone, O.R. and Arnoldi, F.
(2012)
Production of in vivo-biotinylated rotavirus particles.
Journal of General Virology, 93(7),
pp. 1474-1482.
(doi: 10.1099/vir.0.040089-0)
(PMID:22442113)
Articles
De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Tandavanitj, Rapeepat, Preciado-Llanes, Lorena, Sanchez-Velazquez, Ricardo, Rocha, Raissa Prado, Kim, Young Chan, Reyes-Sandova, Arturo and Patel, Arvind H.
ORCID: https://orcid.org/0000-0003-4600-2047
(2025)
Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models.
Frontiers in Immunology, 16,
1578427.
(doi: 10.3389/fimmu.2025.1578427)
(PMID:40352923)
(PMCID:PMC12062147)
Furnon, W. et al. (2025) Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic. Nature Microbiology, 10, pp. 77-93. (doi: 10.1038/s41564-024-01878-5) (PMID:39753670) (PMCID:PMC11726466)
Tandavanitj, Rapeepat, Setthapramote, Chayanee, De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Sanchez-Velazquez, Ricardo, Clark, Jordan J., Rocchi, Mara, McInnes, Colin, Kohl, Alain
ORCID: https://orcid.org/0000-0002-1523-9458 and Patel, Arvind H.
ORCID: https://orcid.org/0000-0003-4600-2047
(2024)
Virus-like particles of louping ill virus elicit potent neutralizing antibodies targeting multimers of viral envelope protein.
Vaccine, 42(9),
pp. 2429-2437.
(doi: 10.1016/j.vaccine.2024.03.008)
(PMID:38458875)
Furnon, Wilhelm ORCID: https://orcid.org/0000-0002-5588-4232, Cowton, Vanessa, De Lorenzo, Giuditta
ORCID: https://orcid.org/0000-0002-2736-8740, Patel, Arvind
ORCID: https://orcid.org/0000-0003-4600-2047 and Palmarini, Massimo
ORCID: https://orcid.org/0000-0001-7007-4070
(2024)
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants.
Nature Microbiology, 9,
pp. 451-463.
(doi: 10.1038/s41564-023-01588-4)
(PMID:38228858)
(PMCID:PMC10847042)
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Bouhaddou, M. et al. (2023) SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell, 186(21), pp. 4597-4614. (doi: 10.1016/j.cell.2023.08.026) (PMID:37738970) (PMCID:PMC10604369)
Wallace, S. et al. (2023) Multiplexed biosensing of proteins and virions with disposable plasmonic assays. ACS Sensors, 8(9), pp. 3338-3348. (doi: 10.1021/acssensors.2c02238) (PMID:37610841) (PMCID:PMC10521139)
da Silva Sanches, Paulo Ricardo, Sanchez-Velazquez, Ricardo, Nogueira Batista, Mariana, Moreira Carneiro, Bruno, Bittar, Cintia, De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Rahal, Paula, Patel, Arvind H.
ORCID: https://orcid.org/0000-0003-4600-2047 and Maffud Cilli, Eduardo
(2023)
Antiviral evaluation of new synthetic bioconjugates based on GA-Hecate: A new class of antivirals targeting different steps of Zika Virus replication.
Molecules, 28(13),
4884.
(doi: 10.3390/molecules28134884)
(PMID:37446546)
(PMCID:PMC10343505)
Mancini, M. V. et al. (2023) Evaluation of an engineered Zika virus-like particle vaccine candidate in a mosquito-mouse transmission model. mSphere, 8(2), e00564-22. (doi: 10.1128/msphere.00564-22) (PMID:36840596) (PMCID:PMC10117074)
Lista, M. J. et al. (2022) The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. Journal of Virology, 96(23), e0125022. (doi: 10.1128/jvi.01250-22) (PMID:36350154) (PMCID:PMC9749455)
Willett, B. J. et al. (2022) Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7, 1709. (doi: 10.1038/s41564-022-01241-6) (PMID:36114232) (PMCID:PMC9483304)
Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)
Zhou, J. et al. (2022) Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 38(6), 110344. (doi: 10.1016/j.celrep.2022.110344) (PMID:35093235) (PMCID:PMC8768428)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)
Sanchez Velazquez, R. et al. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. Antiviral Research, 183, 104939. (doi: 10.1016/j.antiviral.2020.104939) (PMID:32980446) (PMCID:PMC7649875)
Banerjee, A. K. et al. (2020) SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cell, (doi: 10.1016/j.cell.2020.10.004) (PMID:33080218) (PMCID:PMC7543886)
López-Camacho, C. et al. (2020) Immunogenicity and efficacy of Zika virus Envelope Domain III in DNA, protein and ChAdOx1 adenoviral-vectored vaccines. Vaccines, 8(2), 307. (doi: 10.3390/vaccines8020307) (PMID:32560145)
López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)
Eichwald, C. et al. (2018) Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles. Journal of Virology, 92(3), e01943-17. (doi: 10.1128/JVI.01943-17) (PMID:29142132) (PMCID:PMC5774888)
Ziberna, F. et al. (2016) Lack of evidence of rotavirus‐dependent molecular mimicry as a trigger of coeliac disease. Clinical and Experimental Immunology, 186(3), pp. 356-363. (doi: 10.1111/cei.12855) (PMID:27548641)
De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Drikic, Marija, Papa, Guido, Eichwald, Catherine, Burrone, Oscar R. and Arnoldi, Francesca
(2016)
An inhibitory motif on the 5'UTR of several rotavirus genome segments affects protein expression and reverse genetics strategies.
PLoS ONE, 11(11),
e0166719.
(doi: 10.1371/journal.pone.0166719)
(PMID:27846320)
(PMCID:PMC5112996)
Arnoldi, Francesca, De Lorenzo, Giuditta ORCID: https://orcid.org/0000-0002-2736-8740, Mano, Miguel, Schraner, Elisabeth M., Wild, Peter, Eichwald, Catherine and Burrone, Oscar R.
(2014)
Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation.
PLoS ONE, 9(4),
e95197.
(doi: 10.1371/journal.pone.0095197)
(PMID:24736649)
(PMCID:PMC3988245)
De Lorenzo, G. ORCID: https://orcid.org/0000-0002-2736-8740, Eichwald, C., Schraner, E.M., Nicolin, V., Bortul, R., Mano, M., Burrone, O.R. and Arnoldi, F.
(2012)
Production of in vivo-biotinylated rotavirus particles.
Journal of General Virology, 93(7),
pp. 1474-1482.
(doi: 10.1099/vir.0.040089-0)
(PMID:22442113)
Research datasets
2025
De Lorenzo, G. , Rapeepat, T., Lorena, P.-L., Sanchez-Velazquez, R., Prado Rocha, R., Chan Kim, Y., Reyes- Sandoval, A. and Patel, A. (2025) Heterologous prime-boost Zika virus vaccination induces a comprehensive humoral and cellular immunity in mouse models. [Data Collection]
2024
Furnon, W. , Cowton, V. M., De Lorenzo, G. , Orton, R. , Herder, V. , Cantoni, D. , Ilia, G., Correa Mendonca, D. , Kerr, K., Allan, J., Upfold, N. , Meehan, G. R. , Bakshi, S., Das, U. R., Molina Arias, S., McElwee, M., Little, S., Logan, N., Kwok, K. , Smollett, K. , Willett, B. , Da Silva Filipe, A. , Robertson, D. L. , Grove, J. , Patel, A. H. and Palmarini, M. (2024) Phenotypic evolution of SARS-CoV-2 spike throughout the COVID-19 pandemic. [Data Collection]
2023
Meehan, G. , Herder, V. , Allan, J., Huang, X., Kerr, K., Correa Mendonca, D. , Ilia, G., Wright, D. , Nomikou, K., Gu, Q. , Molina Arias, S., Hansmann, F., Hardas, A., Attipa, C., De Lorenzo, G. , Cowton, V., Upfold, N. , Palmalux, N., Brown, J., Barclay, W., Da Silva Filipe, A. , Furnon, W. , Patel, A. and Palmarini, M. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. [Data Collection]