Dr Wanda Niedbala
- Honorary Research Fellow (School of Infection & Immunity)
email:
Wanda.Niedbala@glasgow.ac.uk
RB430 Level B4, Iii - Gbrc, University Place, Glasgow G12 8TA
Publications
2017
Nascimento, D. C. et al. (2017) IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. Nature Communications, 8, 14919. (doi: 10.1038/ncomms14919) (PMID:28374774) (PMCID:PMC5382289)
2015
Besnard, A.-G., Guabiraba Brito, R., Niedbala, W., Palomo, J., Reverchon, F., Shaw, T. N., Couper, K. N., Ryffel, B. and Liew, F. (2015) IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS Pathogens, 11(2), e1004607. (doi: 10.1371/journal.ppat.1004607) (PMID:25659095) (PMCID:PMC4450060)
2014
Barbour, M. et al. (2014) IL-33 attenuates the development of experimental autoimmune uveitis. European Journal of Immunology, 44(11), pp. 3320-3329. (doi: 10.1002/eji.201444671) (PMID:25116404) (PMCID:PMC4449115)
Niedbala, W. et al. (2014) Nitric oxide enhances Th9 cell differentiation and airway inflammation. Nature Communications, 5(4575), (doi: 10.1038/ncomms5575)
2013
Gabriele, L. et al. (2013) Novel allergic asthma model demonstrates ST2-dependent dendritic cell targeting by cypress pollen. Journal of Allergy and Clinical Immunology, 132(3), 686-695.e7. (doi: 10.1016/j.jaci.2013.02.037)
Niedbala, W., Besnard, A.-G., Jiang, H.-R., Alves-Filho, J.C., Fukada, S.Y., Nascimento, D., Mitani, A., Pushparaj, P., Alqahtani, M.H. and Liew, F.Y. (2013) Nitric oxide-induced regulatory T cells inhibit Th17 but not Th1 cell differentiation and function. Journal of Immunology, 191(1), pp. 164-170. (doi: 10.4049/jimmunol.1202580)
2012
Jiang, H.-R. et al. (2012) IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages. European Journal of Immunology, 42(7), pp. 1804-1814. (doi: 10.1002/eji.201141947)
2011
Niedbala, W., Alves-Filho, J. C., Fukada, S. Y., Vieira, S. M., Mitani, A., Sonego, F., Mirchandani, A., Nascimento, D. C., Cunha, F. Q. and Liew, F. Y. (2011) Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proceedings of the National Academy of Sciences of the United States of America, 108(22), pp. 9220-9225. (doi: 10.1073/pnas.1100667108)
2008
Niedbala, W., Cai, B., Wei, X., Patakas, A., Leung, B. P., McInnes, I. and Liew, F. Y. (2008) Interleukin 27 attenuates collagen-induced arthritis. Annals of the Rheumatic Diseases, 67(10), pp. 1474-1479. (doi: 10.1136/ard.2007.083360) (PMID:18199596)
2007
Cai, B., Hueber, A. J., Leung, B. P., Liew, F. Y., McInnes, I. B. , Niedbala, W. and Wei, X.-q. (2007) IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. European Journal of Immunology, 37(11), pp. 3021-3029. (doi: 10.1002/eji.200737810)
Niedbala, W., Cai, B., Liu, H., Pitman, N., Chang, L. and Liew, F. Y. (2007) Nitric oxide induces CD4+CD25+ Foxp3− regulatory T cells from CD4+CD25− T cells via p53, IL-2, and OX40. Proceedings of the National Academy of Sciences of the United States of America, 104(39), pp. 15478-15483. (doi: 10.1073/pnas.0703725104)
2006
Cai, B., Liew, F. and Niedbala, W. (2006) Role of nitric oxide in the regulation of T cell functions. Annals of the Rheumatic Diseases, 65, pp. 37-40. (doi: 10.1136/ard.2006.058446)
2004
Wei, X., Niedbala, W., Xu, D., Luo, Z., Pollock, K. and Brewer, J. (2004) Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection. Immunology Letters, 94, pp. 35-37. (doi: 10.1016/j.imlet.2004.04.001)
2002
Liew, F., Niedbala, W. and Wei, X. (2002) IL-15 induces type 1 and type 2 CD4(+) and CD8(+) T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12/IL-4 simulation in vitro. European Journal of Immunology, 32, pp. 341-347.
Niedbala, W., Wei, X., Campbell, C., Thomson, D., Komai-Koma, M. and Liew, F. (2002) Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor β2 expression via cGMP. Proceedings of the National Academy of Sciences of the United States of America, 99(25), pp. 16186-16191. (doi: 10.1073/pnas.252464599)
2001
Gao, B., Gracie, J., Guan, H., Leung, B., Liew, F., McInnes, I. , Niedbala, W., Orchardson, M., Paterson, G. and Wei, X. (2001) The sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo. Journal of Immunology, 167, pp. 277-282.
Jiang, H., Wei, X., Niedbala, W., Lumsden, L., Liew, F. and Forrester, J. (2001) IL-18 not required for IRBP peptide-induced EAU: Studies in gene-deficient mice. Investigative Ophthalmology and Visual Science, 42, pp. 177-182.
1999
Niedbala, W., Wei, X.-Q., Piedrafita, D., Xu, D. and Liew, F. Y. (1999) Effects of nitric oxide on the induction and differentiation of Th1 cells. European Journal of Immunology, 29(8), pp. 2498-2505. (doi: 10.1002/(SICI)1521-4141(199908)29:08<2498::AID-IMMU2498>3.0.CO;2-M) (PMID:10458764)
1998
Huang, F.-P., Niedbala, W., Wei, X.-Q., Xu, D., Feng, G.-j., Robinson, J. H., Lam, C. and Liew, F. Y. (1998) Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. European Journal of Immunology, 28(12), pp. 4062-4070. (doi: 10.1002/(SICI)1521-4141(199812)28:12<4062::AID-IMMU4062>3.0.CO;2-K) (PMID:9862342)
Niedbala, W.G. and Stott, D.I. (1998) A comparison of three methods for production of human hybridomas secreting autoantibodies. Hybridoma, 17(3), pp. 299-304.
Articles
Nascimento, D. C. et al. (2017) IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. Nature Communications, 8, 14919. (doi: 10.1038/ncomms14919) (PMID:28374774) (PMCID:PMC5382289)
Besnard, A.-G., Guabiraba Brito, R., Niedbala, W., Palomo, J., Reverchon, F., Shaw, T. N., Couper, K. N., Ryffel, B. and Liew, F. (2015) IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS Pathogens, 11(2), e1004607. (doi: 10.1371/journal.ppat.1004607) (PMID:25659095) (PMCID:PMC4450060)
Barbour, M. et al. (2014) IL-33 attenuates the development of experimental autoimmune uveitis. European Journal of Immunology, 44(11), pp. 3320-3329. (doi: 10.1002/eji.201444671) (PMID:25116404) (PMCID:PMC4449115)
Niedbala, W. et al. (2014) Nitric oxide enhances Th9 cell differentiation and airway inflammation. Nature Communications, 5(4575), (doi: 10.1038/ncomms5575)
Gabriele, L. et al. (2013) Novel allergic asthma model demonstrates ST2-dependent dendritic cell targeting by cypress pollen. Journal of Allergy and Clinical Immunology, 132(3), 686-695.e7. (doi: 10.1016/j.jaci.2013.02.037)
Niedbala, W., Besnard, A.-G., Jiang, H.-R., Alves-Filho, J.C., Fukada, S.Y., Nascimento, D., Mitani, A., Pushparaj, P., Alqahtani, M.H. and Liew, F.Y. (2013) Nitric oxide-induced regulatory T cells inhibit Th17 but not Th1 cell differentiation and function. Journal of Immunology, 191(1), pp. 164-170. (doi: 10.4049/jimmunol.1202580)
Jiang, H.-R. et al. (2012) IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages. European Journal of Immunology, 42(7), pp. 1804-1814. (doi: 10.1002/eji.201141947)
Niedbala, W., Alves-Filho, J. C., Fukada, S. Y., Vieira, S. M., Mitani, A., Sonego, F., Mirchandani, A., Nascimento, D. C., Cunha, F. Q. and Liew, F. Y. (2011) Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proceedings of the National Academy of Sciences of the United States of America, 108(22), pp. 9220-9225. (doi: 10.1073/pnas.1100667108)
Niedbala, W., Cai, B., Wei, X., Patakas, A., Leung, B. P., McInnes, I. and Liew, F. Y. (2008) Interleukin 27 attenuates collagen-induced arthritis. Annals of the Rheumatic Diseases, 67(10), pp. 1474-1479. (doi: 10.1136/ard.2007.083360) (PMID:18199596)
Cai, B., Hueber, A. J., Leung, B. P., Liew, F. Y., McInnes, I. B. , Niedbala, W. and Wei, X.-q. (2007) IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. European Journal of Immunology, 37(11), pp. 3021-3029. (doi: 10.1002/eji.200737810)
Niedbala, W., Cai, B., Liu, H., Pitman, N., Chang, L. and Liew, F. Y. (2007) Nitric oxide induces CD4+CD25+ Foxp3− regulatory T cells from CD4+CD25− T cells via p53, IL-2, and OX40. Proceedings of the National Academy of Sciences of the United States of America, 104(39), pp. 15478-15483. (doi: 10.1073/pnas.0703725104)
Cai, B., Liew, F. and Niedbala, W. (2006) Role of nitric oxide in the regulation of T cell functions. Annals of the Rheumatic Diseases, 65, pp. 37-40. (doi: 10.1136/ard.2006.058446)
Wei, X., Niedbala, W., Xu, D., Luo, Z., Pollock, K. and Brewer, J. (2004) Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection. Immunology Letters, 94, pp. 35-37. (doi: 10.1016/j.imlet.2004.04.001)
Liew, F., Niedbala, W. and Wei, X. (2002) IL-15 induces type 1 and type 2 CD4(+) and CD8(+) T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12/IL-4 simulation in vitro. European Journal of Immunology, 32, pp. 341-347.
Niedbala, W., Wei, X., Campbell, C., Thomson, D., Komai-Koma, M. and Liew, F. (2002) Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor β2 expression via cGMP. Proceedings of the National Academy of Sciences of the United States of America, 99(25), pp. 16186-16191. (doi: 10.1073/pnas.252464599)
Gao, B., Gracie, J., Guan, H., Leung, B., Liew, F., McInnes, I. , Niedbala, W., Orchardson, M., Paterson, G. and Wei, X. (2001) The sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo. Journal of Immunology, 167, pp. 277-282.
Jiang, H., Wei, X., Niedbala, W., Lumsden, L., Liew, F. and Forrester, J. (2001) IL-18 not required for IRBP peptide-induced EAU: Studies in gene-deficient mice. Investigative Ophthalmology and Visual Science, 42, pp. 177-182.
Niedbala, W., Wei, X.-Q., Piedrafita, D., Xu, D. and Liew, F. Y. (1999) Effects of nitric oxide on the induction and differentiation of Th1 cells. European Journal of Immunology, 29(8), pp. 2498-2505. (doi: 10.1002/(SICI)1521-4141(199908)29:08<2498::AID-IMMU2498>3.0.CO;2-M) (PMID:10458764)
Huang, F.-P., Niedbala, W., Wei, X.-Q., Xu, D., Feng, G.-j., Robinson, J. H., Lam, C. and Liew, F. Y. (1998) Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. European Journal of Immunology, 28(12), pp. 4062-4070. (doi: 10.1002/(SICI)1521-4141(199812)28:12<4062::AID-IMMU4062>3.0.CO;2-K) (PMID:9862342)
Niedbala, W.G. and Stott, D.I. (1998) A comparison of three methods for production of human hybridomas secreting autoantibodies. Hybridoma, 17(3), pp. 299-304.