Dr Caroline O'Connell
- Building & Technical Manager (Infection & Immunity Professional Services)
telephone:
01413308147
email:
Caroline.Clucas@glasgow.ac.uk
School of Infection & Immunity, Room 5/14 Sir Graeme Davies Building, 120 University Place, G12 8TA
Publications
2021
Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)
Camara, M. et al. (2021) Extravascular dermal trypanosomes in suspected and confirmed cases of gambiense human African trypanosomiasis. Clinical Infectious Diseases, 73(1), pp. 12-20. (doi: 10.1093/cid/ciaa897) (PMID:32638003) (PMCID:PMC8246823)
2019
Kaboré, J. W. et al. (2019) Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population. Infection, Genetics and Evolution, 71, pp. 108-115. (doi: 10.1016/j.meegid.2019.03.021) (PMID:30914286)
Capewell, P. et al. (2019) Resolving the apparent transmission paradox of African sleeping sickness. PLoS Biology, 17(1), e3000105. (doi: 10.1371/journal.pbio.3000105) (PMID:30633739) (PMCID:PMC6345479)
2016
Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi: 10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)
Cooper, Anneli ORCID: https://orcid.org/0000-0002-1159-142X, Capewell, Paul
ORCID: https://orcid.org/0000-0002-8803-5034, Clucas, Caroline
ORCID: https://orcid.org/0000-0001-5592-6810, Veitch, Nicola
ORCID: https://orcid.org/0000-0002-9583-3915, Weir, William
ORCID: https://orcid.org/0000-0001-8648-666X, Thomson, Russell, Raper, Jayne and MacLeod, Annette
ORCID: https://orcid.org/0000-0002-0150-5049
(2016)
A primate APOL1 variant that kills Trypanosoma brucei gambiense.
PLoS Neglected Tropical Diseases, 10(8),
e0004903.
(doi: 10.1371/journal.pntd.0004903)
(PMID:27494254)
(PMCID:PMC4975595)
Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi: 10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)
2015
Capewell, Paul ORCID: https://orcid.org/0000-0002-8803-5034, Cooper, Anneli
ORCID: https://orcid.org/0000-0002-1159-142X, Clucas, Caroline
ORCID: https://orcid.org/0000-0001-5592-6810, Weir, William
ORCID: https://orcid.org/0000-0001-8648-666X and MacLeod, Annette
ORCID: https://orcid.org/0000-0002-0150-5049
(2015)
A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome.
Parasitology, 142(S1),
S108-S119.
(doi: 10.1017/S0031182014000602)
(PMID:25656360)
(PMCID:PMC4413828)
Capewell, Paul ORCID: https://orcid.org/0000-0002-8803-5034, Cooper, Anneli
ORCID: https://orcid.org/0000-0002-1159-142X, Clucas, Caroline
ORCID: https://orcid.org/0000-0001-5592-6810, Weir, William
ORCID: https://orcid.org/0000-0001-8648-666X, Vaikkinen, Heli, Morrison, Liam, Tait, Andy and MacLeod, Annette
ORCID: https://orcid.org/0000-0002-0150-5049
(2015)
Exploiting genetic variation to discover genes involved in important disease phenotypes.
Methods in Molecular Biology, 1201,
pp. 91-107.
(doi: 10.1007/978-1-4939-1438-8_5)
(PMID:25388109)
2014
Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)
Pickrell, W. O. et al. (2014) Human African Trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical disease? PLoS Neglected Tropical Diseases, 8(12), e3349. (doi: 10.1371/journal.pntd.0003349) (PMID:25522322) (PMCID:PMC4270486)
2013
Jackson, Allison J., Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Mamczur, Nicola J., Ferguson, David J. and Meissner, Markus
ORCID: https://orcid.org/0000-0002-4816-5221
(2013)
Toxoplasma gondii Syntaxin 6 is required for vesicular
transport between endosomal-like compartments and
the Golgi Complex.
Traffic, 14(11),
pp. 1166-1181.
(doi: 10.1111/tra.12102)
Capewell, Paul ORCID: https://orcid.org/0000-0002-8803-5034, Clucas, Caroline
ORCID: https://orcid.org/0000-0001-5592-6810, Weir, William
ORCID: https://orcid.org/0000-0001-8648-666X, Veitch, Nicola
ORCID: https://orcid.org/0000-0002-9583-3915 and MacLeod, Annette
ORCID: https://orcid.org/0000-0002-0150-5049
(2013)
Normal human serum lysis of non-human trypanosomes and resistance of T. b. rhodesiense and T. b. gambiense.
In: Magez, Stefan and Radwanska, Magdalena (eds.)
Trypanosomes and Trypanosomiasis.
Springer, pp. 139-160.
ISBN 9783709115558
(doi: 10.1007/978-3-7091-1556-5_6)
Capewell, P. ORCID: https://orcid.org/0000-0002-8803-5034, Clucas, C.
ORCID: https://orcid.org/0000-0001-5592-6810, DeJesus, E., Kieft, R., Hajduk, S., Veitch, N.
ORCID: https://orcid.org/0000-0002-9583-3915, Steketee, P.C., Cooper, A.
ORCID: https://orcid.org/0000-0002-1159-142X, Weir, W.
ORCID: https://orcid.org/0000-0001-8648-666X and MacLeod, A.
ORCID: https://orcid.org/0000-0002-0150-5049
(2013)
The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense.
PLoS Pathogens, 9(10),
e1003686.
(doi: 10.1371/journal.ppat.1003686)
(PMID:24098129)
(PMCID:PMC3789759)
2012
Benz, C., Clucas, C. ORCID: https://orcid.org/0000-0001-5592-6810, Mottram, J.C.
ORCID: https://orcid.org/0000-0001-5574-3766 and Hammarton, T.C.
ORCID: https://orcid.org/0000-0002-0799-6600
(2012)
Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin.
PLoS ONE, 7(1),
e30367.
(doi: 10.1371/journal.pone.0030367)
(PMID:22279588)
(PMCID:PMC3261199)
2010
Segref, Alexandra, Cabello, Juan, Clucas, Caroline, Schnabel, Ralf and Johnstone, Iain L. (2010) Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine. Molecular Biology of the Cell, 21(5), pp. 725-738. (doi: 10.1091/mbc.E09-04-0268)
Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343. (doi: 10.1128/EC.00200-09) (PMID:19966032) (PMCID:PMC2823006)
2009
Monnerat, Séverine, Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Brown, Elaine, Mottram, Jeremy C.
ORCID: https://orcid.org/0000-0001-5574-3766 and Hammarton, Tansy C.
ORCID: https://orcid.org/0000-0002-0799-6600
(2009)
Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen.
BMC Research Notes, 2(46),
(doi: 10.1186/1756-0500-2-46)
2003
Roberts, B, Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810 and Johnstone, IL
(2003)
Loss of SEC-23 in Caenorhabditis elegans causes defects in oogenesis, morphogenesis, and extracellular matrix secretion.
Molecular Biology of the Cell, 14,
pp. 4414-4426.
2002
Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Cabello, J., Bussing, I., Schnabel, R. and Johnstone, I.L.
(2002)
Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele.
EMBO Journal, 21,
pp. 665-674.
2001
Redmond, DL, Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Johnstone, IL and Knox, DP
(2001)
Expression of Haemonchus contortus pepsinogen in Caenorhabditis elegans.
Molecular and Biochemical Parasitology, 112,
pp. 125-131.
Articles
Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)
Camara, M. et al. (2021) Extravascular dermal trypanosomes in suspected and confirmed cases of gambiense human African trypanosomiasis. Clinical Infectious Diseases, 73(1), pp. 12-20. (doi: 10.1093/cid/ciaa897) (PMID:32638003) (PMCID:PMC8246823)
Kaboré, J. W. et al. (2019) Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population. Infection, Genetics and Evolution, 71, pp. 108-115. (doi: 10.1016/j.meegid.2019.03.021) (PMID:30914286)
Capewell, P. et al. (2019) Resolving the apparent transmission paradox of African sleeping sickness. PLoS Biology, 17(1), e3000105. (doi: 10.1371/journal.pbio.3000105) (PMID:30633739) (PMCID:PMC6345479)
Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi: 10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)
Cooper, Anneli ORCID: https://orcid.org/0000-0002-1159-142X, Capewell, Paul
ORCID: https://orcid.org/0000-0002-8803-5034, Clucas, Caroline
ORCID: https://orcid.org/0000-0001-5592-6810, Veitch, Nicola
ORCID: https://orcid.org/0000-0002-9583-3915, Weir, William
ORCID: https://orcid.org/0000-0001-8648-666X, Thomson, Russell, Raper, Jayne and MacLeod, Annette
ORCID: https://orcid.org/0000-0002-0150-5049
(2016)
A primate APOL1 variant that kills Trypanosoma brucei gambiense.
PLoS Neglected Tropical Diseases, 10(8),
e0004903.
(doi: 10.1371/journal.pntd.0004903)
(PMID:27494254)
(PMCID:PMC4975595)
Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi: 10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)
Capewell, Paul ORCID: https://orcid.org/0000-0002-8803-5034, Cooper, Anneli
ORCID: https://orcid.org/0000-0002-1159-142X, Clucas, Caroline
ORCID: https://orcid.org/0000-0001-5592-6810, Weir, William
ORCID: https://orcid.org/0000-0001-8648-666X and MacLeod, Annette
ORCID: https://orcid.org/0000-0002-0150-5049
(2015)
A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome.
Parasitology, 142(S1),
S108-S119.
(doi: 10.1017/S0031182014000602)
(PMID:25656360)
(PMCID:PMC4413828)
Capewell, Paul ORCID: https://orcid.org/0000-0002-8803-5034, Cooper, Anneli
ORCID: https://orcid.org/0000-0002-1159-142X, Clucas, Caroline
ORCID: https://orcid.org/0000-0001-5592-6810, Weir, William
ORCID: https://orcid.org/0000-0001-8648-666X, Vaikkinen, Heli, Morrison, Liam, Tait, Andy and MacLeod, Annette
ORCID: https://orcid.org/0000-0002-0150-5049
(2015)
Exploiting genetic variation to discover genes involved in important disease phenotypes.
Methods in Molecular Biology, 1201,
pp. 91-107.
(doi: 10.1007/978-1-4939-1438-8_5)
(PMID:25388109)
Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)
Pickrell, W. O. et al. (2014) Human African Trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical disease? PLoS Neglected Tropical Diseases, 8(12), e3349. (doi: 10.1371/journal.pntd.0003349) (PMID:25522322) (PMCID:PMC4270486)
Jackson, Allison J., Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Mamczur, Nicola J., Ferguson, David J. and Meissner, Markus
ORCID: https://orcid.org/0000-0002-4816-5221
(2013)
Toxoplasma gondii Syntaxin 6 is required for vesicular
transport between endosomal-like compartments and
the Golgi Complex.
Traffic, 14(11),
pp. 1166-1181.
(doi: 10.1111/tra.12102)
Capewell, P. ORCID: https://orcid.org/0000-0002-8803-5034, Clucas, C.
ORCID: https://orcid.org/0000-0001-5592-6810, DeJesus, E., Kieft, R., Hajduk, S., Veitch, N.
ORCID: https://orcid.org/0000-0002-9583-3915, Steketee, P.C., Cooper, A.
ORCID: https://orcid.org/0000-0002-1159-142X, Weir, W.
ORCID: https://orcid.org/0000-0001-8648-666X and MacLeod, A.
ORCID: https://orcid.org/0000-0002-0150-5049
(2013)
The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense.
PLoS Pathogens, 9(10),
e1003686.
(doi: 10.1371/journal.ppat.1003686)
(PMID:24098129)
(PMCID:PMC3789759)
Benz, C., Clucas, C. ORCID: https://orcid.org/0000-0001-5592-6810, Mottram, J.C.
ORCID: https://orcid.org/0000-0001-5574-3766 and Hammarton, T.C.
ORCID: https://orcid.org/0000-0002-0799-6600
(2012)
Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin.
PLoS ONE, 7(1),
e30367.
(doi: 10.1371/journal.pone.0030367)
(PMID:22279588)
(PMCID:PMC3261199)
Segref, Alexandra, Cabello, Juan, Clucas, Caroline, Schnabel, Ralf and Johnstone, Iain L. (2010) Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine. Molecular Biology of the Cell, 21(5), pp. 725-738. (doi: 10.1091/mbc.E09-04-0268)
Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343. (doi: 10.1128/EC.00200-09) (PMID:19966032) (PMCID:PMC2823006)
Monnerat, Séverine, Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Brown, Elaine, Mottram, Jeremy C.
ORCID: https://orcid.org/0000-0001-5574-3766 and Hammarton, Tansy C.
ORCID: https://orcid.org/0000-0002-0799-6600
(2009)
Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen.
BMC Research Notes, 2(46),
(doi: 10.1186/1756-0500-2-46)
Roberts, B, Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810 and Johnstone, IL
(2003)
Loss of SEC-23 in Caenorhabditis elegans causes defects in oogenesis, morphogenesis, and extracellular matrix secretion.
Molecular Biology of the Cell, 14,
pp. 4414-4426.
Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Cabello, J., Bussing, I., Schnabel, R. and Johnstone, I.L.
(2002)
Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele.
EMBO Journal, 21,
pp. 665-674.
Redmond, DL, Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Johnstone, IL and Knox, DP
(2001)
Expression of Haemonchus contortus pepsinogen in Caenorhabditis elegans.
Molecular and Biochemical Parasitology, 112,
pp. 125-131.
Book Sections
Capewell, Paul ORCID: https://orcid.org/0000-0002-8803-5034, Clucas, Caroline
ORCID: https://orcid.org/0000-0001-5592-6810, Weir, William
ORCID: https://orcid.org/0000-0001-8648-666X, Veitch, Nicola
ORCID: https://orcid.org/0000-0002-9583-3915 and MacLeod, Annette
ORCID: https://orcid.org/0000-0002-0150-5049
(2013)
Normal human serum lysis of non-human trypanosomes and resistance of T. b. rhodesiense and T. b. gambiense.
In: Magez, Stefan and Radwanska, Magdalena (eds.)
Trypanosomes and Trypanosomiasis.
Springer, pp. 139-160.
ISBN 9783709115558
(doi: 10.1007/978-3-7091-1556-5_6)