Dr Hannah Scales
- Imaging Specialist/Lecturer (Immunology & Infection)
telephone:
0141 330 6968
email:
Hannah.Scales@glasgow.ac.uk
RB516 Level B5, Iii - Gbrc, University Place, Glasgow G12 8TA
Publications
2025
Meehan, G. R. et al. (2025) Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation. Discovery Immunology, (doi: 10.1093/discim/kyaf009) (Accepted for Publication)
2024
Camargo da Rosa, Larissa ORCID: https://orcid.org/0000-0002-4849-8835, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Benson, Robert A.
ORCID: https://orcid.org/0000-0003-3687-0481, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915, McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2024)
The effect of abatacept on T cell activation is not long-lived in vivo.
Discovery Immunology, 3(1),
kyad029.
(doi: 10.1093/discim/kyad029)
2022
Audshasai, T. et al. (2022) Streptococcus pneumoniae rapidly translocate from the nasopharynx through the cribriform plate to invade the outer meninges. mBio, 13(4), e0102422. (doi: 10.1128/mbio.01024-22) (PMID:35924840) (PMCID:PMC9426477)
Prendergast, Catriona T., Benson, Robert A. ORCID: https://orcid.org/0000-0003-3687-0481, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Bonilha, Caio S., Cole, John J., McInnes, Iain
ORCID: https://orcid.org/0000-0002-6462-4280, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2022)
Dissecting the molecular control of immune cell accumulation in the inflamed joint.
JCI Insight, 7(7),
e151281.
(doi: 10.1172/jci.insight.151281)
(PMID:35192549)
(PMCID:PMC9057592)
Camargo da Rosa, Larissa ORCID: https://orcid.org/0000-0002-4849-8835, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Makhija, Sangeet, Sutherland, Katie, Benson, Robert A.
ORCID: https://orcid.org/0000-0003-3687-0481, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2022)
Revealing stromal and lymphoid sources of Col3a1-expression during inflammation using a novel reporter mouse.
Discovery Immunology, 1(1),
kyac008.
(doi: 10.1093/discim/kyac008)
Meehan, Gavin R. ORCID: https://orcid.org/0000-0001-9855-6565, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2022)
Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration.
Immunotherapy Advances, 2(1),
ltac020.
(doi: 10.1093/immadv/ltac020)
(PMID:36268500)
(PMCID:PMC9579813)
2021
Bonilha, Caio S., Benson, Robert A. ORCID: https://orcid.org/0000-0003-3687-0481, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2021)
Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
Immunology Letters, 235,
pp. 32-40.
(doi: 10.1016/j.imlet.2021.05.001)
(PMID:34000305)
De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)
2020
Meehan, Gavin R. ORCID: https://orcid.org/0000-0001-9855-6565, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Osii, Rowland, De Niz, Mariana, Lawton, Jennifer C., Marti, Matthias
ORCID: https://orcid.org/0000-0003-1040-9566, Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287, Craig, Alister and Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915
(2020)
Developing a xenograft model of human vasculature in the mouse ear pinna.
Scientific Reports, 10,
2058.
(doi: 10.1038/s41598-020-58650-y)
(PMID:32029768)
(PMCID:PMC7004987)
2019
Hayes, A. J. et al. (2019) Spatiotemporal modeling of the key migratory events during the initiation of adaptive immunity. Frontiers in Immunology, 10, 598. (doi: 10.3389/fimmu.2019.00598) (PMID:31024523) (PMCID:PMC6460458)
2018
Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)
Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)
2017
Stephen, J., Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Benson, R.A.
ORCID: https://orcid.org/0000-0003-3687-0481, Erben, D., Garside, P.
ORCID: https://orcid.org/0000-0001-5944-0287 and Brewer, J.M.
ORCID: https://orcid.org/0000-0001-7933-0915
(2017)
Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity.
npj Vaccines, 2,
1.
(doi: 10.1038/s41541-016-0001-5)
(PMID:29263862)
(PMCID:PMC5604741)
2016
Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Ierna, Michelle, Smith, Karen M., Ross, Kirsty, Meiklejohn, Gordon R., Patterson-Kane, Janet C., McInnes, Iain B., Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915, Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Maffia, Pasquale
ORCID: https://orcid.org/0000-0003-3926-4225
(2016)
Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging.
Rheumatology, 55(3),
pp. 564-572.
(doi: 10.1093/rheumatology/kev361)
(PMID:26475798)
2010
Ierna, Michelle, Kerr, Alison, Scales, Hannah ORCID: https://orcid.org/0000-0002-4247-2802, Berge, Kjetil and Griinari, Mikko
(2010)
Supplementation of diet with krill oil protects against experimental rheumatoid arthritis.
BMC Musculoskeletal Disorders, 11(1),
136.
(doi: 10.1186/1471-2474-11-136)
(PMID:20587038)
(PMCID:PMC2907316)
2009
Ierna, M.X., Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Mueller, C. and Lawrence, C.E.
(2009)
Transmembrane tumor necrosis factor alpha is required for enteropathy and is sufficient to promote parasite expulsion in gastrointestinal helminth infection.
Infection and Immunity, 77(9),
pp. 3879-3885.
(doi: 10.1128/IAI.01461-08)
(PMID:19564380)
(PMCID:PMC2737992)
2008
Michels, Chesney E., Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Saunders, Karin A., McGowan, S., Brombracher, Frank, Alexander, James and Lawrence, Catherine E.
(2008)
Neither interleukin-4 receptor α expression on CD4+ T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis.
Immunology, 128(1pt2),
e385-e394.
(doi: 10.1111/j.1365-2567.2008.02987.x)
(PMID:19191917)
Ierna, M.X., Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Saunders, K.L. and Lawrence, C.E.
(2008)
Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection.
Mucosal Immunology, 1,
pp. 147-155.
(doi: 10.1038/mi.2007.16)
(PMID:19079172)
2007
Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Ierna, M.X. and Lawrence, C.E.
(2007)
The role of IL-4, IL-13 and IL-4Rα in the development of protective and pathological responses to Trichinella spiralis.
Parasite Immunology, 29(2),
pp. 81-91.
(doi: 10.1111/j.1365-3024.2006.00920.x)
(PMID:17241396)
2006
Mann, Jamie F.S., Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Shakir, Eisin, Alexander, James, Carter, Katharine C., Mullen, Alexander B. and Ferro, Valerie A.
(2006)
Oral delivery of tetanus toxoid using vesicles containing bile salts (bilosomes) induces significant systemic and mucosal immunity.
Methods, 38(2),
90 - 95.
(doi: 10.1016/j.ymeth.2005.11.002)
(PMID:16414269)
Ierna, Michelle X., Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Schwarz, Herbert, Bunce, Campbell, McIlgorm, Anne, Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Lawrence, Catherine E.
(2006)
OX40 interactions in gastrointestinal nematode infection.
Immunology, 117(1),
pp. 108-116.
(doi: 10.1111/j.1365-2567.2005.02271.x)
(PMID:16423046)
2005
Boitelle, A., Di Lorenzo, C., Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Devaney, E.
ORCID: https://orcid.org/0000-0002-1935-834X, Kennedy, M.W., Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Lawrence, C.E.
(2005)
Contrasting effects of acute and chronic gastro-intestinal helminth infections on a heterologous immune response in a transgenic adoptive transfer model.
International Journal for Parasitology, 35(7),
pp. 765-775.
(doi: 10.1016/j.ijpara.2005.02.013)
(PMID:15893319)
2004
Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Ierna, MIchelle X., Gutierrez-Ramos, Jose-Carlos, Coyle, Anthony J., Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Lawrence, Catherine E.
(2004)
Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis.
European Journal of Immunology, 34,
pp. 2854-2862.
(doi: 10.1002/eji.200324364)
(PMID:5368302)
2003
Boitelle, Agnès, Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Di Lorenzo, Caterina, Devaney, Eileen
ORCID: https://orcid.org/0000-0002-1935-834X, Kennedy, Malcolm W.
ORCID: https://orcid.org/0000-0002-0970-5264, Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Lawrence, Catherine E.
(2003)
Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system.
Journal of Immunology, 171(1),
pp. 447-454.
(doi: 10.4049/jimmunol.171.1.447)
(PMID:12817029)
Articles
Meehan, G. R. et al. (2025) Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation. Discovery Immunology, (doi: 10.1093/discim/kyaf009) (Accepted for Publication)
Camargo da Rosa, Larissa ORCID: https://orcid.org/0000-0002-4849-8835, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Benson, Robert A.
ORCID: https://orcid.org/0000-0003-3687-0481, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915, McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2024)
The effect of abatacept on T cell activation is not long-lived in vivo.
Discovery Immunology, 3(1),
kyad029.
(doi: 10.1093/discim/kyad029)
Audshasai, T. et al. (2022) Streptococcus pneumoniae rapidly translocate from the nasopharynx through the cribriform plate to invade the outer meninges. mBio, 13(4), e0102422. (doi: 10.1128/mbio.01024-22) (PMID:35924840) (PMCID:PMC9426477)
Prendergast, Catriona T., Benson, Robert A. ORCID: https://orcid.org/0000-0003-3687-0481, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Bonilha, Caio S., Cole, John J., McInnes, Iain
ORCID: https://orcid.org/0000-0002-6462-4280, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2022)
Dissecting the molecular control of immune cell accumulation in the inflamed joint.
JCI Insight, 7(7),
e151281.
(doi: 10.1172/jci.insight.151281)
(PMID:35192549)
(PMCID:PMC9057592)
Camargo da Rosa, Larissa ORCID: https://orcid.org/0000-0002-4849-8835, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Makhija, Sangeet, Sutherland, Katie, Benson, Robert A.
ORCID: https://orcid.org/0000-0003-3687-0481, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2022)
Revealing stromal and lymphoid sources of Col3a1-expression during inflammation using a novel reporter mouse.
Discovery Immunology, 1(1),
kyac008.
(doi: 10.1093/discim/kyac008)
Meehan, Gavin R. ORCID: https://orcid.org/0000-0001-9855-6565, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2022)
Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration.
Immunotherapy Advances, 2(1),
ltac020.
(doi: 10.1093/immadv/ltac020)
(PMID:36268500)
(PMCID:PMC9579813)
Bonilha, Caio S., Benson, Robert A. ORCID: https://orcid.org/0000-0003-3687-0481, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287
(2021)
Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
Immunology Letters, 235,
pp. 32-40.
(doi: 10.1016/j.imlet.2021.05.001)
(PMID:34000305)
De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)
Meehan, Gavin R. ORCID: https://orcid.org/0000-0001-9855-6565, Scales, Hannah E.
ORCID: https://orcid.org/0000-0002-4247-2802, Osii, Rowland, De Niz, Mariana, Lawton, Jennifer C., Marti, Matthias
ORCID: https://orcid.org/0000-0003-1040-9566, Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287, Craig, Alister and Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915
(2020)
Developing a xenograft model of human vasculature in the mouse ear pinna.
Scientific Reports, 10,
2058.
(doi: 10.1038/s41598-020-58650-y)
(PMID:32029768)
(PMCID:PMC7004987)
Hayes, A. J. et al. (2019) Spatiotemporal modeling of the key migratory events during the initiation of adaptive immunity. Frontiers in Immunology, 10, 598. (doi: 10.3389/fimmu.2019.00598) (PMID:31024523) (PMCID:PMC6460458)
Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)
Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)
Stephen, J., Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Benson, R.A.
ORCID: https://orcid.org/0000-0003-3687-0481, Erben, D., Garside, P.
ORCID: https://orcid.org/0000-0001-5944-0287 and Brewer, J.M.
ORCID: https://orcid.org/0000-0001-7933-0915
(2017)
Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity.
npj Vaccines, 2,
1.
(doi: 10.1038/s41541-016-0001-5)
(PMID:29263862)
(PMCID:PMC5604741)
Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Ierna, Michelle, Smith, Karen M., Ross, Kirsty, Meiklejohn, Gordon R., Patterson-Kane, Janet C., McInnes, Iain B., Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915, Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Maffia, Pasquale
ORCID: https://orcid.org/0000-0003-3926-4225
(2016)
Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging.
Rheumatology, 55(3),
pp. 564-572.
(doi: 10.1093/rheumatology/kev361)
(PMID:26475798)
Ierna, Michelle, Kerr, Alison, Scales, Hannah ORCID: https://orcid.org/0000-0002-4247-2802, Berge, Kjetil and Griinari, Mikko
(2010)
Supplementation of diet with krill oil protects against experimental rheumatoid arthritis.
BMC Musculoskeletal Disorders, 11(1),
136.
(doi: 10.1186/1471-2474-11-136)
(PMID:20587038)
(PMCID:PMC2907316)
Ierna, M.X., Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Mueller, C. and Lawrence, C.E.
(2009)
Transmembrane tumor necrosis factor alpha is required for enteropathy and is sufficient to promote parasite expulsion in gastrointestinal helminth infection.
Infection and Immunity, 77(9),
pp. 3879-3885.
(doi: 10.1128/IAI.01461-08)
(PMID:19564380)
(PMCID:PMC2737992)
Michels, Chesney E., Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Saunders, Karin A., McGowan, S., Brombracher, Frank, Alexander, James and Lawrence, Catherine E.
(2008)
Neither interleukin-4 receptor α expression on CD4+ T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis.
Immunology, 128(1pt2),
e385-e394.
(doi: 10.1111/j.1365-2567.2008.02987.x)
(PMID:19191917)
Ierna, M.X., Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Saunders, K.L. and Lawrence, C.E.
(2008)
Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection.
Mucosal Immunology, 1,
pp. 147-155.
(doi: 10.1038/mi.2007.16)
(PMID:19079172)
Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Ierna, M.X. and Lawrence, C.E.
(2007)
The role of IL-4, IL-13 and IL-4Rα in the development of protective and pathological responses to Trichinella spiralis.
Parasite Immunology, 29(2),
pp. 81-91.
(doi: 10.1111/j.1365-3024.2006.00920.x)
(PMID:17241396)
Mann, Jamie F.S., Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Shakir, Eisin, Alexander, James, Carter, Katharine C., Mullen, Alexander B. and Ferro, Valerie A.
(2006)
Oral delivery of tetanus toxoid using vesicles containing bile salts (bilosomes) induces significant systemic and mucosal immunity.
Methods, 38(2),
90 - 95.
(doi: 10.1016/j.ymeth.2005.11.002)
(PMID:16414269)
Ierna, Michelle X., Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Schwarz, Herbert, Bunce, Campbell, McIlgorm, Anne, Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Lawrence, Catherine E.
(2006)
OX40 interactions in gastrointestinal nematode infection.
Immunology, 117(1),
pp. 108-116.
(doi: 10.1111/j.1365-2567.2005.02271.x)
(PMID:16423046)
Boitelle, A., Di Lorenzo, C., Scales, H.E. ORCID: https://orcid.org/0000-0002-4247-2802, Devaney, E.
ORCID: https://orcid.org/0000-0002-1935-834X, Kennedy, M.W., Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Lawrence, C.E.
(2005)
Contrasting effects of acute and chronic gastro-intestinal helminth infections on a heterologous immune response in a transgenic adoptive transfer model.
International Journal for Parasitology, 35(7),
pp. 765-775.
(doi: 10.1016/j.ijpara.2005.02.013)
(PMID:15893319)
Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Ierna, MIchelle X., Gutierrez-Ramos, Jose-Carlos, Coyle, Anthony J., Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Lawrence, Catherine E.
(2004)
Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis.
European Journal of Immunology, 34,
pp. 2854-2862.
(doi: 10.1002/eji.200324364)
(PMID:5368302)
Boitelle, Agnès, Scales, Hannah E. ORCID: https://orcid.org/0000-0002-4247-2802, Di Lorenzo, Caterina, Devaney, Eileen
ORCID: https://orcid.org/0000-0002-1935-834X, Kennedy, Malcolm W.
ORCID: https://orcid.org/0000-0002-0970-5264, Garside, Paul
ORCID: https://orcid.org/0000-0001-5944-0287 and Lawrence, Catherine E.
(2003)
Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system.
Journal of Immunology, 171(1),
pp. 447-454.
(doi: 10.4049/jimmunol.171.1.447)
(PMID:12817029)