Dr Fiona Achcar

  • Bioinformatician / Computational Biologist (Parasitology)

telephone: 5276
email: Fiona.Achcar@glasgow.ac.uk

Gbrc 6.21, 120 University Place, G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-8792-7615

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2021 | 2020 | 2019 | 2018 | 2015 | 2014 | 2013 | 2012 | 2011 | 2009
Number of items: 24.

2025

Venugopal, Kannan ORCID logoORCID: https://orcid.org/0000-0002-1620-5524, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Wolski, Witold E., Nanni, Paolo, Lemgruber Soares, Leandro ORCID logoORCID: https://orcid.org/0000-0003-2832-6806, Wright, Gavin J. and Marti, Matthias ORCID logoORCID: https://orcid.org/0000-0003-1040-9566 (2025) Defining the proteome of sexually committed parasites in Plasmodium falciparum. Molecular and Cellular Proteomics, (doi: 10.1016/j.mcpro.2025.101505) (PMID:41482054) (Accepted for Publication)

2024

Obaldia III, N. et al. (2024) Sterile protection against vivax malaria by repeated blood stage infection in the Aotus monkey model. Life Science Alliance, 7(3), e202302524. (doi: 10.26508/lsa.202302524) (PMID:38158220) (PMCID:PMC10756917)

2023

Abdi, A. I. et al. (2023) Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment. eLife, 12, e85140. (doi: 10.7554/eLife.85140) (PMID:36916164) (PMCID:PMC10059685)

2021

Steketee, Pieter C., Giordani, Federica ORCID logoORCID: https://orcid.org/0000-0001-9964-281X, Vincent, Isabel M. ORCID logoORCID: https://orcid.org/0000-0003-2663-4389, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Dickens, Nicholas J. ORCID logoORCID: https://orcid.org/0000-0003-0492-5855, Morrison, Liam J., MacLeod, Annette ORCID logoORCID: https://orcid.org/0000-0002-0150-5049 and Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)

Meibalan, E. et al. (2021) Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso. Journal of Infectious Diseases, 223(10), pp. 1822-1830. (doi: 10.1093/infdis/jiz680) (PMID:31875909) (PMCID:PMC8161640)

2020

Blackburn, G. et al. (2020) Running on empty: a metabolomics approach to investigating changing energy metabolism during fasted exercise and rest. Metabolites, 10(10), 399. (doi: 10.3390/metabo10100399) (PMID:33050077) (PMCID:PMC7600507)

Zoltner, M. et al. (2020) Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Journal of Biological Chemistry, 295(24), pp. 8331-8347. (doi: 10.1074/jbc.ra120.012355) (PMID:32354742) (PMCID:PMC7294092)

2019

Ngotho, Priscilla, Blancke Soares, Alexandra, Hentzschel, Franziska, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Bertuccini, Lucia and Marti, Matthias ORCID logoORCID: https://orcid.org/0000-0003-1040-9566 (2019) Revisiting gametocyte biology in malaria parasites. FEMS Microbiology Reviews, 43(4), pp. 401-414. (doi: 10.1093/femsre/fuz010) (PMID:31220244) (PMCID:PMC6606849)

Johnston, Katharina, Kim, Dong-Hyun, Kerkhoven, Eduard J., Burchmore, Richard ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 and Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615 (2019) Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC-MS. Bioscience Reports, 39(5), BSR2018160. (doi: 10.1042/BSR20181601) (PMID:31028136) (PMCID:PMC6522824)

2018

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Kovarova, Julie, Pountain, Andrew W. ORCID logoORCID: https://orcid.org/0000-0001-9651-5145, Wildridge, David, Weidt, Stefan, Bringaud, Frédéric, Burchmore, Richard J.S. ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615 and Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2018) Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana. PLoS Pathogens, 14(3), e1006953. (doi: 10.1371/journal.ppat.1006953) (PMID:29554142) (PMCID:PMC5882173)

Rattigan, Kevin M., Pountain, Andrew W. ORCID logoORCID: https://orcid.org/0000-0001-9651-5145, Regnault, Clement, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Vincent, Isabel M. ORCID logoORCID: https://orcid.org/0000-0003-2663-4389, Goodyear, Carl S. ORCID logoORCID: https://orcid.org/0000-0001-5926-5941 and Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2018) Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli. PLoS ONE, 13(3), e0194126. (doi: 10.1371/journal.pone.0194126) (PMID:29538444) (PMCID:PMC5851634)

2015

Kim, Dong-Hyun, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Breitling, Rainer ORCID logoORCID: https://orcid.org/0000-0001-7173-0922, Burgess, Karl E. and Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2015) LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics, 11(6), pp. 1721-1732. (doi: 10.1007/s11306-015-0827-2) (PMID:26491423) (PMCID:PMC4605981)

Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi: 10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi: 10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)

2014

Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Kerkhoven, Eduard J. and Barrett, Michael P ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi: 10.1016/j.mib.2014.06.007)

Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi: 10.1016/B978-0-12-800143-1.00003-8) (PMID:24797926) (PMCID:PMC4773886)

2013

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS Computational Biology, 9(12), e1003371. (doi: 10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:PMC3854711)

Achcar, F. ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Barrett, M.P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID logoORCID: https://orcid.org/0000-0001-7173-0922 (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi: 10.1111/febs.12436) (PMID:23865459) (PMCID:PMC4768353)

Breitling, R. ORCID logoORCID: https://orcid.org/0000-0001-7173-0922, Achcar, F. ORCID logoORCID: https://orcid.org/0000-0001-8792-7615 and Takano, E. (2013) Modeling challenges in the synthetic biology of secondary metabolism. ACS Synthetic Biology, 2(7), pp. 373-378. (doi: 10.1021/sb4000228)

Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID logoORCID: https://orcid.org/0000-0001-7173-0922 (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi: 10.1093/bioinformatics/bts674) (PMID:23162054) (PMCID:PMC3546800)

2012

Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, Bakker, B.M., Barrett, M.P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID logoORCID: https://orcid.org/0000-0001-7173-0922 (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi: 10.1371/journal.pcbi.1002352) (PMID:22379410) (PMCID:PMC3269904)

2011

Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Camadro, Jean-Michel and Mestivier, Denis (2011) A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress. BMC Systems Biology, 5, 51. (doi: 10.1186/1752-0509-5-51) (PMID:26050742) (PMCID:PMC4464606)

2009

Achcar, F. ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Camadro, J.-M. and Mestivier, D. (2009) AutoClass@IJM: a powerful tool for Bayesian classification of heterogeneous data in biology. Nucleic Acids Research, 37(Sup 2), W63-W67. (doi: 10.1093/nar/gkp430) (PMID:19474346) (PMCID:PMC2703914)

This list was generated on Thu Jan 15 09:48:39 2026 GMT.
Jump to: Articles
Number of items: 24.

Articles

Venugopal, Kannan ORCID logoORCID: https://orcid.org/0000-0002-1620-5524, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Wolski, Witold E., Nanni, Paolo, Lemgruber Soares, Leandro ORCID logoORCID: https://orcid.org/0000-0003-2832-6806, Wright, Gavin J. and Marti, Matthias ORCID logoORCID: https://orcid.org/0000-0003-1040-9566 (2025) Defining the proteome of sexually committed parasites in Plasmodium falciparum. Molecular and Cellular Proteomics, (doi: 10.1016/j.mcpro.2025.101505) (PMID:41482054) (Accepted for Publication)

Obaldia III, N. et al. (2024) Sterile protection against vivax malaria by repeated blood stage infection in the Aotus monkey model. Life Science Alliance, 7(3), e202302524. (doi: 10.26508/lsa.202302524) (PMID:38158220) (PMCID:PMC10756917)

Abdi, A. I. et al. (2023) Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment. eLife, 12, e85140. (doi: 10.7554/eLife.85140) (PMID:36916164) (PMCID:PMC10059685)

Steketee, Pieter C., Giordani, Federica ORCID logoORCID: https://orcid.org/0000-0001-9964-281X, Vincent, Isabel M. ORCID logoORCID: https://orcid.org/0000-0003-2663-4389, Crouch, Kathryn ORCID logoORCID: https://orcid.org/0000-0001-9310-4762, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Dickens, Nicholas J. ORCID logoORCID: https://orcid.org/0000-0003-0492-5855, Morrison, Liam J., MacLeod, Annette ORCID logoORCID: https://orcid.org/0000-0002-0150-5049 and Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)

Meibalan, E. et al. (2021) Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso. Journal of Infectious Diseases, 223(10), pp. 1822-1830. (doi: 10.1093/infdis/jiz680) (PMID:31875909) (PMCID:PMC8161640)

Blackburn, G. et al. (2020) Running on empty: a metabolomics approach to investigating changing energy metabolism during fasted exercise and rest. Metabolites, 10(10), 399. (doi: 10.3390/metabo10100399) (PMID:33050077) (PMCID:PMC7600507)

Zoltner, M. et al. (2020) Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Journal of Biological Chemistry, 295(24), pp. 8331-8347. (doi: 10.1074/jbc.ra120.012355) (PMID:32354742) (PMCID:PMC7294092)

Ngotho, Priscilla, Blancke Soares, Alexandra, Hentzschel, Franziska, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Bertuccini, Lucia and Marti, Matthias ORCID logoORCID: https://orcid.org/0000-0003-1040-9566 (2019) Revisiting gametocyte biology in malaria parasites. FEMS Microbiology Reviews, 43(4), pp. 401-414. (doi: 10.1093/femsre/fuz010) (PMID:31220244) (PMCID:PMC6606849)

Johnston, Katharina, Kim, Dong-Hyun, Kerkhoven, Eduard J., Burchmore, Richard ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 and Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615 (2019) Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC-MS. Bioscience Reports, 39(5), BSR2018160. (doi: 10.1042/BSR20181601) (PMID:31028136) (PMCID:PMC6522824)

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Kovarova, Julie, Pountain, Andrew W. ORCID logoORCID: https://orcid.org/0000-0001-9651-5145, Wildridge, David, Weidt, Stefan, Bringaud, Frédéric, Burchmore, Richard J.S. ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615 and Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2018) Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana. PLoS Pathogens, 14(3), e1006953. (doi: 10.1371/journal.ppat.1006953) (PMID:29554142) (PMCID:PMC5882173)

Rattigan, Kevin M., Pountain, Andrew W. ORCID logoORCID: https://orcid.org/0000-0001-9651-5145, Regnault, Clement, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Vincent, Isabel M. ORCID logoORCID: https://orcid.org/0000-0003-2663-4389, Goodyear, Carl S. ORCID logoORCID: https://orcid.org/0000-0001-5926-5941 and Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2018) Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli. PLoS ONE, 13(3), e0194126. (doi: 10.1371/journal.pone.0194126) (PMID:29538444) (PMCID:PMC5851634)

Kim, Dong-Hyun, Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Breitling, Rainer ORCID logoORCID: https://orcid.org/0000-0001-7173-0922, Burgess, Karl E. and Barrett, Michael P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2015) LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics, 11(6), pp. 1721-1732. (doi: 10.1007/s11306-015-0827-2) (PMID:26491423) (PMCID:PMC4605981)

Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi: 10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi: 10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)

Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Kerkhoven, Eduard J. and Barrett, Michael P ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi: 10.1016/j.mib.2014.06.007)

Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi: 10.1016/B978-0-12-800143-1.00003-8) (PMID:24797926) (PMCID:PMC4773886)

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS Computational Biology, 9(12), e1003371. (doi: 10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:PMC3854711)

Achcar, F. ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Barrett, M.P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID logoORCID: https://orcid.org/0000-0001-7173-0922 (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi: 10.1111/febs.12436) (PMID:23865459) (PMCID:PMC4768353)

Breitling, R. ORCID logoORCID: https://orcid.org/0000-0001-7173-0922, Achcar, F. ORCID logoORCID: https://orcid.org/0000-0001-8792-7615 and Takano, E. (2013) Modeling challenges in the synthetic biology of secondary metabolism. ACS Synthetic Biology, 2(7), pp. 373-378. (doi: 10.1021/sb4000228)

Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID logoORCID: https://orcid.org/0000-0001-7173-0922 (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi: 10.1093/bioinformatics/bts674) (PMID:23162054) (PMCID:PMC3546800)

Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, Bakker, B.M., Barrett, M.P. ORCID logoORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID logoORCID: https://orcid.org/0000-0001-7173-0922 (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi: 10.1371/journal.pcbi.1002352) (PMID:22379410) (PMCID:PMC3269904)

Achcar, Fiona ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Camadro, Jean-Michel and Mestivier, Denis (2011) A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress. BMC Systems Biology, 5, 51. (doi: 10.1186/1752-0509-5-51) (PMID:26050742) (PMCID:PMC4464606)

Achcar, F. ORCID logoORCID: https://orcid.org/0000-0001-8792-7615, Camadro, J.-M. and Mestivier, D. (2009) AutoClass@IJM: a powerful tool for Bayesian classification of heterogeneous data in biology. Nucleic Acids Research, 37(Sup 2), W63-W67. (doi: 10.1093/nar/gkp430) (PMID:19474346) (PMCID:PMC2703914)

This list was generated on Thu Jan 15 09:48:39 2026 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • A new drug discovery pipeline for animal African trypanosomiasis.
    GALVmed
    2016 - 2019
     
  • A new drug discovery pipeline for animal African trypanosomiasis
    Biotechnology and Biological Sciences Research Council
    2016 - 2019
     
  • Metabolic subversion in the interaction between leishmania and the macrophage
    Leverhulme Trust
    2015 - 2018
     
  • Mathematical modelling of the interaction between leishmania and the macrophage using omics data (ISSF Fellowships)
    Wellcome Trust
    2015 - 2015