Dr Federica Giordani

  • Research Associate (Parasitology)

telephone: 0141 330 5276
email: Federica.Giordani@glasgow.ac.uk

Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity & Inflammation, MVLS, Room 524, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA

ORCID iDhttps://orcid.org/0000-0001-9964-281X

Biography

Dr. Federica Giordani is a post-doctoral researcher at the Wellcome Trust Centre for Integrative Parasitology (WCIP) at the University of Glasgow. After a Master Degree in Biological Sciences obtained at the University of Parma (Italy) in 2005, she worked at the same institution as a research fellow untill 2007, focusing on assessment of the mutagenic risk of environmental matrices (soil, water) and of new anti-cancer and anti-parasitic compounds. She then moved to the University of Glasgow, where she obtained her PhD in 2011, working on new fluorescence-based diagnostics for trypanosomiasis, supervised by Prof. Michael P. Barrett. As a research associate at the WCIP, Dr. Giordani has been working on several projects on drug discovery for human and animal trypanosomiasis and leishmaniasis, with the final aim of improving the treatment for these neglected tropical diseases.

Research interests

Drug discovery for parasitic diseases (in particular for trypanosomiasis and leishmaniasis) is Dr. Giordani's main research interest. Working together with other academic institutions, non-profit organizations and private industry, she has contributed to several projects on this subject, gathering data on activity, mode of action and mechanism of resistance of new leads, using "omics" techniques and other tools.

Her current project aims at bridging epigenetics, metabolism and cell cycle in pathogenic trypanosomatids, generating data that will potentially be exploited for identifying new drug targets and improving treatment efficacy. Management and control of communicable diseases, as well as their diagnosis, are all related themes of interest. 

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2014
Number of items: 15.

2021

Steketee, P. C., Giordani, F. , Vincent, I. M. , Crouch, K. , Achcar, F. , Dickens, N. J. , Morrison, L. J., MacLeod, A. and Barrett, M. P. (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)

Brooke, D. P. et al. (2021) Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype. RSC Medicinal Chemistry, 12(8), pp. 1391-1401. (doi: 10.1039/D1MD00110H)

2020

Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)

Dickie, E. A., Giordani, F. , Gould, M. K., Maeser, P., Burri, C., Mottram, J. C. , Rao, S. P.S. and Barrett, M. P. (2020) New drugs for human African trypanosomiasis:a twenty first century success story. Tropical Medicine and Infectious Disease, 5(1), 29. (doi: 10.3390/tropicalmed5010029) (PMID:32092897) (PMCID:PMC7157223)

2019

Giordani, F. , Khalaf, A. I., Gillingwater, K., Munday, J. C. , de Koning, H. P. , Suckling, C. J., Barrett, M. P. and Scott, F. J. (2019) Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model. Journal of Medicinal Chemistry, 62(6), pp. 3021-3035. (doi: 10.1021/acs.jmedchem.8b01847) (PMID:30763102)

2018

Begolo, D. et al. (2018) The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathogens, 14(9), e1007315. (doi: 10.1371/journal.ppat.1007315) (PMID:30252911) (PMCID:PMC6173450)

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

2017

Barrett, M. P. and Giordani, F. (2017) Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease. Parasitology, 144(12), pp. 1652-1662. (doi: 10.1017/S003118201600202X) (PMID:27928980)

Scott, F. J. et al. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, pp. 561-572. (doi: 10.1016/j.ejmech.2017.05.039)

2016

Giordani, F. , Morrison, L. J., Rowan, T. G., De Koning, H. P. and Barrett, M. P. (2016) The animal trypanosomiases and their chemotherapy: a review. Parasitology, 143(14), pp. 1862-1889. (doi: 10.1017/S0031182016001268) (PMID:27719692) (PMCID:PMC5142301)

Scott, F. J., Khalaf, A. I., Giordani, F. , Wong, P. E., Duffy, S., Barrett, M. , Avery, V. M. and Suckling, C. J. (2016) An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry, 116, pp. 116-125. (doi: 10.1016/j.ejmech.2016.03.064) (PMID:27060763) (PMCID:PMC4872591)

2014

Giordani, F. , Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P. , Pellacani, C., Poli, P. and Gilbert, I. H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi: 10.1128/AAC.01449-13)

Giordani, F. , Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W. and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi: 10.1128/AAC.02024-13)

Giordani, F. , Mwenechanya, R. and Barrett, M. (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi: 10.1016/B978-0-12-386882-4.00039-6)

Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F. , Barrett, M. P. , Wong, P. E., Barrack, K. L. and Hunter, W. N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi: 10.1021/jm500483b)

This list was generated on Thu Jun 8 12:03:38 2023 BST.
Jump to: Articles | Book Sections
Number of items: 15.

Articles

Steketee, P. C., Giordani, F. , Vincent, I. M. , Crouch, K. , Achcar, F. , Dickens, N. J. , Morrison, L. J., MacLeod, A. and Barrett, M. P. (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)

Brooke, D. P. et al. (2021) Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype. RSC Medicinal Chemistry, 12(8), pp. 1391-1401. (doi: 10.1039/D1MD00110H)

Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)

Dickie, E. A., Giordani, F. , Gould, M. K., Maeser, P., Burri, C., Mottram, J. C. , Rao, S. P.S. and Barrett, M. P. (2020) New drugs for human African trypanosomiasis:a twenty first century success story. Tropical Medicine and Infectious Disease, 5(1), 29. (doi: 10.3390/tropicalmed5010029) (PMID:32092897) (PMCID:PMC7157223)

Giordani, F. , Khalaf, A. I., Gillingwater, K., Munday, J. C. , de Koning, H. P. , Suckling, C. J., Barrett, M. P. and Scott, F. J. (2019) Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model. Journal of Medicinal Chemistry, 62(6), pp. 3021-3035. (doi: 10.1021/acs.jmedchem.8b01847) (PMID:30763102)

Begolo, D. et al. (2018) The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathogens, 14(9), e1007315. (doi: 10.1371/journal.ppat.1007315) (PMID:30252911) (PMCID:PMC6173450)

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Barrett, M. P. and Giordani, F. (2017) Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease. Parasitology, 144(12), pp. 1652-1662. (doi: 10.1017/S003118201600202X) (PMID:27928980)

Scott, F. J. et al. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, pp. 561-572. (doi: 10.1016/j.ejmech.2017.05.039)

Giordani, F. , Morrison, L. J., Rowan, T. G., De Koning, H. P. and Barrett, M. P. (2016) The animal trypanosomiases and their chemotherapy: a review. Parasitology, 143(14), pp. 1862-1889. (doi: 10.1017/S0031182016001268) (PMID:27719692) (PMCID:PMC5142301)

Scott, F. J., Khalaf, A. I., Giordani, F. , Wong, P. E., Duffy, S., Barrett, M. , Avery, V. M. and Suckling, C. J. (2016) An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry, 116, pp. 116-125. (doi: 10.1016/j.ejmech.2016.03.064) (PMID:27060763) (PMCID:PMC4872591)

Giordani, F. , Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P. , Pellacani, C., Poli, P. and Gilbert, I. H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi: 10.1128/AAC.01449-13)

Giordani, F. , Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W. and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi: 10.1128/AAC.02024-13)

Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F. , Barrett, M. P. , Wong, P. E., Barrack, K. L. and Hunter, W. N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi: 10.1021/jm500483b)

Book Sections

Giordani, F. , Mwenechanya, R. and Barrett, M. (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi: 10.1016/B978-0-12-386882-4.00039-6)

This list was generated on Thu Jun 8 12:03:38 2023 BST.