Dr David Mark
- Research Associate (Bacteriology)
Publications
2025
Serrano, E. et al. (2025) Enterohaemorrhagic Escherichia coli AdhE spirosome length correlates with enzymatic directionality and is perturbed by salicylidene acylhydrazides. Open Biology, 15(6), 250041. (doi: 10.1098/rsob.250041) (PMID:40527451) (PMCID:PMC12173503)
McHugh, Rebecca E. ORCID: https://orcid.org/0000-0003-4664-6125, Rooney, Liam M.
ORCID: https://orcid.org/0000-0002-2237-501X, Mark, David R.
ORCID: https://orcid.org/0000-0002-1688-5224, Wale, Kabo R., Clapperton, Megan, McConnell, Gail, Hoskisson, Paul A., Douce, Gillian R.
ORCID: https://orcid.org/0000-0002-6654-7346 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2025)
Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli.
npj Antimicrobials and Resistance, 3(1),
23.
(doi: 10.1038/s44259-025-00094-3)
(PMID:40169888)
(PMCID:PMC11962119)
2024
Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, O'Boyle, Nicky, Wale, Kabo Ronald, Tucker, Samantha K., McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
Aurodox inhibits type III secretion in multiple Gram-negative pathogens.
Open Biology, 14(11),
240240.
(doi: 10.1098/rsob.240240)
(PMID:39591989)
(PMCID:PMC11597412)
Wale, Kabo R., O'Boyle, Nicky, McHugh, Rebecca ORCID: https://orcid.org/0000-0003-4664-6125, Serrano, Ester
ORCID: https://orcid.org/0000-0001-5075-2954, Mark, David
ORCID: https://orcid.org/0000-0002-1688-5224, Douce, Gillian R.
ORCID: https://orcid.org/0000-0002-6654-7346, Connolly, James P.R. and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens.
PLoS Pathogens, 20(10),
e101245.
(doi: 10.1371/journal.ppat.1012451)
(PMID:39405360)
(PMCID:PMC11508082)
Mark, David ORCID: https://orcid.org/0000-0002-1688-5224, Trolan, Mia, Douce, Gillian, Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134 and McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125
(2024)
The enemy within: how pathogen-free are your commercial specific pathogen-free mice?
bioRxiv,
(doi: 10.1101/2024.07.05.602177)
Mark, David ORCID: https://orcid.org/0000-0002-1688-5224, O’Boyle, Nicky, Wale, Kabo R., Tucker, Samantha K., McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens.
bioRxiv,
(doi: 10.1101/2024.04.19.589875)
2022
Feeney, M. A. et al. (2022) ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria. Microbial Genomics, 8(7), 000824. (doi: 10.1099/mgen.0.000824) (PMID:35775972) (PMCID:PMC9455695)
2021
Algora-Gallardo, Lis, Schniete, Jana K., Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, Hunter, Iain S. and Herron, Paul R.
(2021)
Bilateral symmetry of linear streptomycete chromosomes.
Microbial Genomics, 7(11),
000692.
(doi: 10.1099/mgen.0.000692)
(PMID:34779763)
(PMCID:PMC8743542)
Zin, Noraziah M., Ismail, Aishah, Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, Westrop, Gareth, Schniete, Jana K. and Herron, Paul R.
(2021)
Adaptation to endophytic lifestyle through genome reduction by Kitasatospora sp. SUK42.
Frontiers in Bioengineering and Biotechnology, 9,
740722.
(doi: 10.3389/fbioe.2021.740722)
(PMID:34712653)
(PMCID:PMC8545861)
Rauscher, R. et al. (2021) Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity. Proceedings of the National Academy of Sciences of the United States of America, 118(4), e201061211. (doi: 10.1073/pnas.2010612118) (PMID:33468668) (PMCID:PMC7848603)
2020
Prudence, Samuel M.M., Addington, Emily ORCID: https://orcid.org/0009-0005-0462-5627, Castaño-Espriu, Laia, Mark, David R.
ORCID: https://orcid.org/0000-0002-1688-5224, Pintor-Escobar, Linamaría, Russell, Alicia H. and McLean, Thomas C.
(2020)
Advances in actinomycete research: an ActinoBase review of 2019.
Microbiology, 166(8),
pp. 683-694.
(doi: 10.1099/mic.0.000944)
(PMID:32558638)
(PMCID:PMC7641383)
Articles
Serrano, E. et al. (2025) Enterohaemorrhagic Escherichia coli AdhE spirosome length correlates with enzymatic directionality and is perturbed by salicylidene acylhydrazides. Open Biology, 15(6), 250041. (doi: 10.1098/rsob.250041) (PMID:40527451) (PMCID:PMC12173503)
McHugh, Rebecca E. ORCID: https://orcid.org/0000-0003-4664-6125, Rooney, Liam M.
ORCID: https://orcid.org/0000-0002-2237-501X, Mark, David R.
ORCID: https://orcid.org/0000-0002-1688-5224, Wale, Kabo R., Clapperton, Megan, McConnell, Gail, Hoskisson, Paul A., Douce, Gillian R.
ORCID: https://orcid.org/0000-0002-6654-7346 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2025)
Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli.
npj Antimicrobials and Resistance, 3(1),
23.
(doi: 10.1038/s44259-025-00094-3)
(PMID:40169888)
(PMCID:PMC11962119)
Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, O'Boyle, Nicky, Wale, Kabo Ronald, Tucker, Samantha K., McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
Aurodox inhibits type III secretion in multiple Gram-negative pathogens.
Open Biology, 14(11),
240240.
(doi: 10.1098/rsob.240240)
(PMID:39591989)
(PMCID:PMC11597412)
Wale, Kabo R., O'Boyle, Nicky, McHugh, Rebecca ORCID: https://orcid.org/0000-0003-4664-6125, Serrano, Ester
ORCID: https://orcid.org/0000-0001-5075-2954, Mark, David
ORCID: https://orcid.org/0000-0002-1688-5224, Douce, Gillian R.
ORCID: https://orcid.org/0000-0002-6654-7346, Connolly, James P.R. and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens.
PLoS Pathogens, 20(10),
e101245.
(doi: 10.1371/journal.ppat.1012451)
(PMID:39405360)
(PMCID:PMC11508082)
Mark, David ORCID: https://orcid.org/0000-0002-1688-5224, Trolan, Mia, Douce, Gillian, Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134 and McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125
(2024)
The enemy within: how pathogen-free are your commercial specific pathogen-free mice?
bioRxiv,
(doi: 10.1101/2024.07.05.602177)
Mark, David ORCID: https://orcid.org/0000-0002-1688-5224, O’Boyle, Nicky, Wale, Kabo R., Tucker, Samantha K., McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens.
bioRxiv,
(doi: 10.1101/2024.04.19.589875)
Feeney, M. A. et al. (2022) ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria. Microbial Genomics, 8(7), 000824. (doi: 10.1099/mgen.0.000824) (PMID:35775972) (PMCID:PMC9455695)
Algora-Gallardo, Lis, Schniete, Jana K., Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, Hunter, Iain S. and Herron, Paul R.
(2021)
Bilateral symmetry of linear streptomycete chromosomes.
Microbial Genomics, 7(11),
000692.
(doi: 10.1099/mgen.0.000692)
(PMID:34779763)
(PMCID:PMC8743542)
Zin, Noraziah M., Ismail, Aishah, Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, Westrop, Gareth, Schniete, Jana K. and Herron, Paul R.
(2021)
Adaptation to endophytic lifestyle through genome reduction by Kitasatospora sp. SUK42.
Frontiers in Bioengineering and Biotechnology, 9,
740722.
(doi: 10.3389/fbioe.2021.740722)
(PMID:34712653)
(PMCID:PMC8545861)
Rauscher, R. et al. (2021) Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity. Proceedings of the National Academy of Sciences of the United States of America, 118(4), e201061211. (doi: 10.1073/pnas.2010612118) (PMID:33468668) (PMCID:PMC7848603)
Prudence, Samuel M.M., Addington, Emily ORCID: https://orcid.org/0009-0005-0462-5627, Castaño-Espriu, Laia, Mark, David R.
ORCID: https://orcid.org/0000-0002-1688-5224, Pintor-Escobar, Linamaría, Russell, Alicia H. and McLean, Thomas C.
(2020)
Advances in actinomycete research: an ActinoBase review of 2019.
Microbiology, 166(8),
pp. 683-694.
(doi: 10.1099/mic.0.000944)
(PMID:32558638)
(PMCID:PMC7641383)