Dr David Mark
- Research Associate (Bacteriology)
Publications
2025
McHugh, Rebecca E. ORCID: https://orcid.org/0000-0003-4664-6125, Rooney, Liam M.
ORCID: https://orcid.org/0000-0002-2237-501X, Mark, David R.
ORCID: https://orcid.org/0000-0002-1688-5224, Wale, Kabo R., Clapperton, Megan, McConnell, Gail, Hoskisson, Paul A., Douce, Gillian R.
ORCID: https://orcid.org/0000-0002-6654-7346 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2025)
Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli.
npj Antimicrobials and Resistance, 3(1),
23.
(doi: 10.1038/s44259-025-00094-3)
(PMID:40169888)
(PMCID:PMC11962119)
2024
Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, O'Boyle, Nicky, Wale, Kabo Ronald, Tucker, Samantha K., McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
Aurodox inhibits type III secretion in multiple Gram-negative pathogens.
Open Biology, 14(11),
240240.
(doi: 10.1098/rsob.240240)
(PMID:39591989)
(PMCID:PMC11597412)
Wale, Kabo R., O'Boyle, Nicky, McHugh, Rebecca ORCID: https://orcid.org/0000-0003-4664-6125, Serrano, Ester
ORCID: https://orcid.org/0000-0001-5075-2954, Mark, David
ORCID: https://orcid.org/0000-0002-1688-5224, Douce, Gillian R.
ORCID: https://orcid.org/0000-0002-6654-7346, Connolly, James P.R. and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens.
PLoS Pathogens, 20(10),
e101245.
(doi: 10.1371/journal.ppat.1012451)
(PMID:39405360)
(PMCID:PMC11508082)
Mark, David ORCID: https://orcid.org/0000-0002-1688-5224, Trolan, Mia, Douce, Gillian, Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134 and McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125
(2024)
The enemy within: how pathogen-free are your commercial specific pathogen-free mice?
bioRxiv,
(doi: 10.1101/2024.07.05.602177)
Mark, David ORCID: https://orcid.org/0000-0002-1688-5224, O’Boyle, Nicky, Wale, Kabo R., Tucker, Samantha K., McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens.
bioRxiv,
(doi: 10.1101/2024.04.19.589875)
2022
Feeney, M. A. et al. (2022) ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria. Microbial Genomics, 8(7), 000824. (doi: 10.1099/mgen.0.000824) (PMID:35775972) (PMCID:PMC9455695)
2021
Algora-Gallardo, Lis, Schniete, Jana K., Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, Hunter, Iain S. and Herron, Paul R.
(2021)
Bilateral symmetry of linear streptomycete chromosomes.
Microbial Genomics, 7(11),
000692.
(doi: 10.1099/mgen.0.000692)
(PMID:34779763)
(PMCID:PMC8743542)
Zin, Noraziah M., Ismail, Aishah, Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, Westrop, Gareth, Schniete, Jana K. and Herron, Paul R.
(2021)
Adaptation to endophytic lifestyle through genome reduction by Kitasatospora sp. SUK42.
Frontiers in Bioengineering and Biotechnology, 9,
740722.
(doi: 10.3389/fbioe.2021.740722)
(PMID:34712653)
(PMCID:PMC8545861)
Rauscher, R. et al. (2021) Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity. Proceedings of the National Academy of Sciences of the United States of America, 118(4), e201061211. (doi: 10.1073/pnas.2010612118) (PMID:33468668) (PMCID:PMC7848603)
2020
Prudence, Samuel M.M., Addington, Emily ORCID: https://orcid.org/0009-0005-0462-5627, Castaño-Espriu, Laia, Mark, David R.
ORCID: https://orcid.org/0000-0002-1688-5224, Pintor-Escobar, Linamaría, Russell, Alicia H. and McLean, Thomas C.
(2020)
Advances in actinomycete research: an ActinoBase review of 2019.
Microbiology, 166(8),
pp. 683-694.
(doi: 10.1099/mic.0.000944)
(PMID:32558638)
(PMCID:PMC7641383)
Articles
McHugh, Rebecca E. ORCID: https://orcid.org/0000-0003-4664-6125, Rooney, Liam M.
ORCID: https://orcid.org/0000-0002-2237-501X, Mark, David R.
ORCID: https://orcid.org/0000-0002-1688-5224, Wale, Kabo R., Clapperton, Megan, McConnell, Gail, Hoskisson, Paul A., Douce, Gillian R.
ORCID: https://orcid.org/0000-0002-6654-7346 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2025)
Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli.
npj Antimicrobials and Resistance, 3(1),
23.
(doi: 10.1038/s44259-025-00094-3)
(PMID:40169888)
(PMCID:PMC11962119)
Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, O'Boyle, Nicky, Wale, Kabo Ronald, Tucker, Samantha K., McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
Aurodox inhibits type III secretion in multiple Gram-negative pathogens.
Open Biology, 14(11),
240240.
(doi: 10.1098/rsob.240240)
(PMID:39591989)
(PMCID:PMC11597412)
Wale, Kabo R., O'Boyle, Nicky, McHugh, Rebecca ORCID: https://orcid.org/0000-0003-4664-6125, Serrano, Ester
ORCID: https://orcid.org/0000-0001-5075-2954, Mark, David
ORCID: https://orcid.org/0000-0002-1688-5224, Douce, Gillian R.
ORCID: https://orcid.org/0000-0002-6654-7346, Connolly, James P.R. and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens.
PLoS Pathogens, 20(10),
e101245.
(doi: 10.1371/journal.ppat.1012451)
(PMID:39405360)
(PMCID:PMC11508082)
Mark, David ORCID: https://orcid.org/0000-0002-1688-5224, Trolan, Mia, Douce, Gillian, Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134 and McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125
(2024)
The enemy within: how pathogen-free are your commercial specific pathogen-free mice?
bioRxiv,
(doi: 10.1101/2024.07.05.602177)
Mark, David ORCID: https://orcid.org/0000-0002-1688-5224, O’Boyle, Nicky, Wale, Kabo R., Tucker, Samantha K., McHugh, Rebecca E.
ORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J.
ORCID: https://orcid.org/0000-0003-3698-6134
(2024)
Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens.
bioRxiv,
(doi: 10.1101/2024.04.19.589875)
Feeney, M. A. et al. (2022) ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria. Microbial Genomics, 8(7), 000824. (doi: 10.1099/mgen.0.000824) (PMID:35775972) (PMCID:PMC9455695)
Algora-Gallardo, Lis, Schniete, Jana K., Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, Hunter, Iain S. and Herron, Paul R.
(2021)
Bilateral symmetry of linear streptomycete chromosomes.
Microbial Genomics, 7(11),
000692.
(doi: 10.1099/mgen.0.000692)
(PMID:34779763)
(PMCID:PMC8743542)
Zin, Noraziah M., Ismail, Aishah, Mark, David R. ORCID: https://orcid.org/0000-0002-1688-5224, Westrop, Gareth, Schniete, Jana K. and Herron, Paul R.
(2021)
Adaptation to endophytic lifestyle through genome reduction by Kitasatospora sp. SUK42.
Frontiers in Bioengineering and Biotechnology, 9,
740722.
(doi: 10.3389/fbioe.2021.740722)
(PMID:34712653)
(PMCID:PMC8545861)
Rauscher, R. et al. (2021) Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity. Proceedings of the National Academy of Sciences of the United States of America, 118(4), e201061211. (doi: 10.1073/pnas.2010612118) (PMID:33468668) (PMCID:PMC7848603)
Prudence, Samuel M.M., Addington, Emily ORCID: https://orcid.org/0009-0005-0462-5627, Castaño-Espriu, Laia, Mark, David R.
ORCID: https://orcid.org/0000-0002-1688-5224, Pintor-Escobar, Linamaría, Russell, Alicia H. and McLean, Thomas C.
(2020)
Advances in actinomycete research: an ActinoBase review of 2019.
Microbiology, 166(8),
pp. 683-694.
(doi: 10.1099/mic.0.000944)
(PMID:32558638)
(PMCID:PMC7641383)