Dr Claire Donald

  • Lecturer in Microbiology (Virology) (Bacteriology)

telephone: 01413303012
email: Claire.Donald@glasgow.ac.uk

Room B228, Sir Graeme Davies Building, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ

ORCID iDhttps://orcid.org/0000-0002-4370-0707

Biography

Claire Donald graduated with a BSc (Hons) in Cellular Biology from the University of St Andrews. As part of that degree, she completed her final year project in the lab of Prof Rick Randall studying the V protein of Simian virus 5. 

She then went on to complete an MSc in Drug Design and Biomedical Science at Edinburgh Napier University. Her reserach project, characterising the innate immune responses of the Aedes ageypti- derived Aag2 cell line, was carried out in the lab of Prof Alain Kohl (then at the University of Edinburgh). Following the completion of her MSc degree, Claire continued to study mosquito innate antiviral immune responses to arboviral infections within the Kohl lab, graduating with a PhD in Virology from the University of Glasgow in 2015.

Claire's research has focused on the use of Semliki Forest virus and Zika virus as model arboviruses to investigate the antiviral immune responses of both mosquitoes and mammalian in vivo and in vitro systems.   

Research interests

Scientific Research 

Claire's research interests focus on arbovirus: vector and arbovirus: host interactions.  

 

Scholarship Research 

Claire's scholarship research has focused on the use of virtual reality in enhacing learning at the undergraduate level. 

Publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011
Number of items: 29.

2023

McIntyre, K. , Stapleton, G. , Sherry, L. , Donald, C. , Milling, S. , Nibbs, R. , Douce, G. , Latkovskis, I. and McDonnell, N. (2023) ‘I felt as if I was there’ - Can Virtual Reality (VR) Enhance Students’ Learning Experience of Immunology Teaching? 16th Annual University of Glasgow Learning and Teaching Conference, 29 Mar 2023. (Unpublished)

2022

Crawford, C. L. et al. (2022) SARM1 depletion slows axon degeneration in a CNS model of neurotropic viral infection. Frontiers in Molecular Neuroscience, 15, 860410. (doi: 10.3389/fnmol.2022.860410) (PMID:35493328) (PMCID:PMC9043327)

2021

Veitch, N. and Donald, C. (2021) Improving student engagement in the virtual world of disease diagnostics. In: Tasler, N., O'Brien, R. and Spiers, A. (eds.) Being Creative in the Face of Diversity. Series: The #creativeHE Annual 2021., 1. The Creativity for Learning in Higher Education community, pp. 69-71. (doi: 10.25416/NTR.17709860.v1)

Veitch, N. and Donald, C. (2021) Enhancing the student experience with a virtual reality disease diagnostics lab. ALT-ELESIG Scotland Meeting, Online, 26 November 2021.

Schultz, V. et al. (2021) Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: implications for CNS complications. Glia, 69(8), pp. 2023-2036. (doi: 10.1002/glia.24010) (PMID:33942402) (PMCID:PMC9216243)

Donald, C. , Veitch, N. , Edmond, A., Marks, L., Kirkwood, N., Carman, C. , McDonnell, N. and Macpherson, F. (2021) The Impact of Using Virtual Reality Lessons to Teach Online. Evolving Molecular Bioscience Education, 27-28 May 2021.

Gestuveo, R. J., Royle, J., Donald, C. L. , Lamont, D. J., Hutchinson, E. C. , Merits, A., Kohl, A. and Varjak, M. (2021) Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection. Nature Communications, 12, 2766. (doi: 10.1038/s41467-021-22966-8) (PMID:33986255) (PMCID:PMC8119459)

Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)

Schultz, V. et al. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13(1), 91. (doi: 10.3390/v13010091) (PMID:33440758) (PMCID:PMC7827345)

Hyde, K., Sultana, N., Tran, A. C., Bileckaja, N., Donald, C. L. , Kohl, A. , Stanton, R. J. and Strang, B. L. (2021) Limited replication of human cytomegalovirus in a trophoblast cell line. Journal of General Virology, 102(11), 001683. (doi: 10.1099/jgv.0.001683)

2020

Donald, C. L. , Siriyasatien, P. and Kohl, A. (2020) Toxorhynchites species: A review of current knowledge. Insects, 11(11), 747. (doi: 10.3390/insects11110747)

Royle, J. , Ramírez-Santana, C., Akpunarlieva, S., Donald, C. L. , Gestuveo, R. J., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-regulated protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. Viruses, 12(5), 524. (doi: 10.3390/v12050524)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

2019

Lima, M. C. et al. (2019) The transcriptional and protein profile from human infected neuroprogenitor cells is strongly correlated to Zika virus microcephaly cytokines phenotype evidencing a persistent inflammation in the CNS. Frontiers in Immunology, 10, 1928. (doi: 10.3389/fimmu.2019.01928) (PMID:31474994) (PMCID:PMC6707094)

Zhuang, X. et al. (2019) The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication. Nature Communications, 10, (doi: 10.1038/s41467-019-08299-7) (PMID:30670689) (PMCID:PMC6343007)

2018

Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi: 10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)

Hertzog, J. et al. (2018) Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling. European Journal of Immunology, 48(7), pp. 1120-1136. (doi: 10.1002/eji.201847483) (PMID:29572905) (PMCID:PMC6055886)

López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)

Zmurko, J., Vasey, D. B., Donald, C. L. , Armstrong, A. A., McKee, M. L., Kohl, A. and Clayton, R. F. (2018) Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals. Journal of General Virology, 99, pp. 219-229. (doi: 10.1099/jgv.0.000995) (PMID:29239715) (PMCID:PMC5882083)

2017

Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi: 10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)

Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi: 10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)

Cumberworth, S., Clark, J. J., Kohl, A. and Donald, C. L. (2017) Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses. Cellular Microbiology, 19(5), e12737. (doi: 10.1111/cmi.12737) (PMID:28273394) (PMCID:PMC5413821)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

2016

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

2015

Kean, J., Rainey, S., McFarlane, M. , Donald, C. , Schnettler, E., Kohl, A. and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi: 10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

2014

McFarlane, M. et al. (2014) Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8(7), e2994. (doi: 10.1371/journal.pntd.0002994) (PMID:25058001) (PMCID:PMC4109886)

2013

Schnettler, E., Donald, C. L. , Human, S., Watson, M., Siu, R. W. C., McFarlane, M. , Fazakerley, J. K., Kohl, A. and Fragkoudis, R. (2013) Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells. Journal of General Virology, 94(Pt. 7), pp. 1680-1689. (doi: 10.1099/vir.0.053850-0) (PMID:23559478) (PMCID:PMC3709635)

2012

Donald, C. L. , Kohl, A. and Schnettler, E. (2012) New insights into control of arbovirus replication and spread by insect RNA interference pathways. Insects, 3(2), pp. 511-531. (doi: 10.3390/insects3020511)

2011

Siu, R. W.C. et al. (2011) Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAs. Journal of Virology, 85(6), pp. 2907-2917. (doi: 10.1128/JVI.02052-10)

This list was generated on Sat Jun 3 10:11:06 2023 BST.
Jump to: Articles | Book Sections | Conference or Workshop Item
Number of items: 29.

Articles

Crawford, C. L. et al. (2022) SARM1 depletion slows axon degeneration in a CNS model of neurotropic viral infection. Frontiers in Molecular Neuroscience, 15, 860410. (doi: 10.3389/fnmol.2022.860410) (PMID:35493328) (PMCID:PMC9043327)

Schultz, V. et al. (2021) Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: implications for CNS complications. Glia, 69(8), pp. 2023-2036. (doi: 10.1002/glia.24010) (PMID:33942402) (PMCID:PMC9216243)

Gestuveo, R. J., Royle, J., Donald, C. L. , Lamont, D. J., Hutchinson, E. C. , Merits, A., Kohl, A. and Varjak, M. (2021) Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection. Nature Communications, 12, 2766. (doi: 10.1038/s41467-021-22966-8) (PMID:33986255) (PMCID:PMC8119459)

Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)

Schultz, V. et al. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13(1), 91. (doi: 10.3390/v13010091) (PMID:33440758) (PMCID:PMC7827345)

Hyde, K., Sultana, N., Tran, A. C., Bileckaja, N., Donald, C. L. , Kohl, A. , Stanton, R. J. and Strang, B. L. (2021) Limited replication of human cytomegalovirus in a trophoblast cell line. Journal of General Virology, 102(11), 001683. (doi: 10.1099/jgv.0.001683)

Donald, C. L. , Siriyasatien, P. and Kohl, A. (2020) Toxorhynchites species: A review of current knowledge. Insects, 11(11), 747. (doi: 10.3390/insects11110747)

Royle, J. , Ramírez-Santana, C., Akpunarlieva, S., Donald, C. L. , Gestuveo, R. J., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-regulated protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. Viruses, 12(5), 524. (doi: 10.3390/v12050524)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

Lima, M. C. et al. (2019) The transcriptional and protein profile from human infected neuroprogenitor cells is strongly correlated to Zika virus microcephaly cytokines phenotype evidencing a persistent inflammation in the CNS. Frontiers in Immunology, 10, 1928. (doi: 10.3389/fimmu.2019.01928) (PMID:31474994) (PMCID:PMC6707094)

Zhuang, X. et al. (2019) The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication. Nature Communications, 10, (doi: 10.1038/s41467-019-08299-7) (PMID:30670689) (PMCID:PMC6343007)

Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi: 10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)

Hertzog, J. et al. (2018) Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling. European Journal of Immunology, 48(7), pp. 1120-1136. (doi: 10.1002/eji.201847483) (PMID:29572905) (PMCID:PMC6055886)

López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)

Zmurko, J., Vasey, D. B., Donald, C. L. , Armstrong, A. A., McKee, M. L., Kohl, A. and Clayton, R. F. (2018) Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals. Journal of General Virology, 99, pp. 219-229. (doi: 10.1099/jgv.0.000995) (PMID:29239715) (PMCID:PMC5882083)

Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi: 10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)

Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi: 10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)

Cumberworth, S., Clark, J. J., Kohl, A. and Donald, C. L. (2017) Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses. Cellular Microbiology, 19(5), e12737. (doi: 10.1111/cmi.12737) (PMID:28273394) (PMCID:PMC5413821)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Kean, J., Rainey, S., McFarlane, M. , Donald, C. , Schnettler, E., Kohl, A. and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi: 10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

McFarlane, M. et al. (2014) Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8(7), e2994. (doi: 10.1371/journal.pntd.0002994) (PMID:25058001) (PMCID:PMC4109886)

Schnettler, E., Donald, C. L. , Human, S., Watson, M., Siu, R. W. C., McFarlane, M. , Fazakerley, J. K., Kohl, A. and Fragkoudis, R. (2013) Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells. Journal of General Virology, 94(Pt. 7), pp. 1680-1689. (doi: 10.1099/vir.0.053850-0) (PMID:23559478) (PMCID:PMC3709635)

Donald, C. L. , Kohl, A. and Schnettler, E. (2012) New insights into control of arbovirus replication and spread by insect RNA interference pathways. Insects, 3(2), pp. 511-531. (doi: 10.3390/insects3020511)

Siu, R. W.C. et al. (2011) Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAs. Journal of Virology, 85(6), pp. 2907-2917. (doi: 10.1128/JVI.02052-10)

Book Sections

Veitch, N. and Donald, C. (2021) Improving student engagement in the virtual world of disease diagnostics. In: Tasler, N., O'Brien, R. and Spiers, A. (eds.) Being Creative in the Face of Diversity. Series: The #creativeHE Annual 2021., 1. The Creativity for Learning in Higher Education community, pp. 69-71. (doi: 10.25416/NTR.17709860.v1)

Conference or Workshop Item

McIntyre, K. , Stapleton, G. , Sherry, L. , Donald, C. , Milling, S. , Nibbs, R. , Douce, G. , Latkovskis, I. and McDonnell, N. (2023) ‘I felt as if I was there’ - Can Virtual Reality (VR) Enhance Students’ Learning Experience of Immunology Teaching? 16th Annual University of Glasgow Learning and Teaching Conference, 29 Mar 2023. (Unpublished)

Veitch, N. and Donald, C. (2021) Enhancing the student experience with a virtual reality disease diagnostics lab. ALT-ELESIG Scotland Meeting, Online, 26 November 2021.

Donald, C. , Veitch, N. , Edmond, A., Marks, L., Kirkwood, N., Carman, C. , McDonnell, N. and Macpherson, F. (2021) The Impact of Using Virtual Reality Lessons to Teach Online. Evolving Molecular Bioscience Education, 27-28 May 2021.

This list was generated on Sat Jun 3 10:11:06 2023 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating the role of the circadian rhythm in modulating arbovirus infection in mosquitoes.
    The Carnegie Trust for the Universities of Scotland
    2020 - 2021
     

Teaching

Claire is an advisor of studies and is involved in teaching different aspects of infection biology across Levels 1-4, as well as for several post graduate courses including:

Level 1

  • Biology 1A

Level 2  

  • Fundamental Topics in Biology
  • Contemporary Issues in Biology
  • Microbiology and Immunology (Course Co-Ordinator)

Level 3

  • Medical Microbiology
  • Molecular Methods

 Level 4

  • Honours Project Supervision

Post Graduate Teaching

  • Molecular Genetics of Disease
  • Emerging Viruses
  • Diagnostic Technologies and Devices
  • Biotechnology Applications
  • Role of Insects in Food Security
  • Masters Project Supervision

Research datasets

Jump to: 2021 | 2020 | 2018
Number of items: 4.

2021

Gestuveo, R., Royle, J. , Donald, C. , Merits, A., Kohl, A. and Varjak, M. (2021) Analysis of the Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for the establishment of infection. [Data Collection]

2020

Schultz, V. , Cumberworth, S., Gu, N., Johnson, N., Donald, C. , McCanney, G., Barrie, J., Da Silva Filipe, A. , Linington, C. , Willison, H. , Edgar, J., Barnett, S. and Kohl, A. (2020) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. [Data Collection]

Royle, J., Ramírez-Santana, C., Akpunarlieva, S., Donald, C. , Gestuveo, R., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-Regulated Protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. [Data Collection]

2018

Donald, C. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B., Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. [Data Collection]

This list was generated on Sat Jun 3 10:11:08 2023 BST.