I obtained my PhD from the University of Aberdeen and gained postdoctoral experience at the Universities of Geneva and Birmingham. During this time, I developed expertise in functional genomics, molecular biology, bioinformatics, and spatial transcriptomics to unravel the complexities of inflammatory diseases.

My recent research has centred on identifying novel transcriptional regulators that drive synovial fibroblast pathogenicity in Rheumatoid Arthritis, as well as mapping the cellular landscape of inflamed joints in Juvenile Idiopathic Arthritis (JIA). This work integrates cutting-edge single-cell analysis techniques, spatial transcriptomics, and multiplex imaging to discover novel biomarkers and therapeutic targets, which are subsequently validated through a variety of molecular biology approaches.

Currently based at the University of Glasgow, my now research focuses on elucidating the intricate crosstalk between ageing fibroblasts and immune cells, aiming to uncover age-associated mechanisms that contribute to immune-mediated inflammatory diseases (IMIDs) and therapeutic resistance.

Learn more:

• GitHub: Chris Mahony
• ‪Christopher Mahony - ‪Google Scholar
• Mahony Lab: Data Science and Immunology

My research lies at the intersection of bioinformatics and experimental molecular biology. I specialise in applying advanced computational methods—including single-cell analysis and spatial transcriptomics—to dissect the cellular and molecular mechanisms driving inflammatory diseases. Complementing these bioinformatic approaches, I use a range of wet-lab techniques to functionally validate novel biomarkers and therapeutic targets, ensuring robust translational relevance.

Grants and Awards listed are those received whilst working with the University of Glasgow.

• Unravelling the Interplay Between Ageing Fibroblasts and Immune Cells in Rheumatoid Arthritis
  The Kennedy Trust for Rheumatology Research
  2026 - 2028