Dr Chris Illingworth
- Senior Lecturer (Virology)
Publications
2025
Pascall, D. J. et al. (2025) The NOSTRA model: coherent estimation of infection sources in the case of possible nosocomial transmission. PLoS Computational Biology, 21(4), e1012949. (doi: 10.1371/journal.pcbi.1012949) (PMID:40258227) (PMCID:PMC12121921)
Leiser, R. et al. (2025) Insights into the implementation of a whole genome sequencing report form (SRF) to reduce nosocomial SARS-CoV-2 in UK hospitals within an unfolding pandemic: A qualitative process evaluation using normalisation process theory. PLoS ONE, 20(4), e0321534. (doi: 10.1371/journal.pone.0321534) (PMID:40245025) (PMCID:PMC12005541)
Smith, E. et al. (2025) Variable rates of SARS-CoV-2 evolution in chronic infections. PLoS Pathogens, 21(4), e1013109. (doi: 10.1371/journal.ppat.1013109) (PMID:40294077)
Brock, Rebecca C., Goudie, Robert J.B., Peters, Christine, Thaxter, Rachel, Gouliouris, Theodore, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Morris, Andrew Conway, Beggs, Clive B., Butler, Matthew and Keevil, Victoria L.
(2025)
Efficacy of air cleaning units for preventing SARS-CoV-2 and other hospital-acquired infections on medicine for older people wards: a quasi-experimental controlled before-and-after study.
Journal of Hospital Infection, 155,
pp. 1-8.
(doi: 10.1016/j.jhin.2024.09.017)
(PMID:39374708)
2024
Fozard, John A., Thomson, Emma C. ORCID: https://orcid.org/0000-0003-1482-0889 and Illingworth, Christopher J.R.
ORCID: https://orcid.org/0000-0002-0030-2784
(2024)
Epidemiological inference at the threshold of data availability: an influenza A(H1N2)v spillover event in the United Kingdom.
Journal of the Royal Society: Interface, 21(217),
20240168.
(doi: 10.1098/rsif.2024.0168)
(PMID:39109454)
(PMCID:PMC11304334)
Sinclair, Patrick, Zhao, Lei, Beggs, Clive B. and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2024)
The airborne transmission of viruses causes tight transmission bottlenecks.
Nature Communications, 15(1),
3540.
(doi: 10.1038/s41467-024-47923-z)
(PMID:38670957)
(PMCID:PMC11053022)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Guerra-Assuncao, Jose A., Gregg, Samuel, Charles, Oscar, Pang, Juanita, Roy, Sunando, Abdelnabi, Rana, Neyts, Johan and Breuer, Judith
(2024)
Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection.
Virus Evolution,
(doi: 10.1093/ve/veae001)
(Early Online Publication)
2023
Flowers, Paul ORCID: https://orcid.org/0000-0001-6239-5616, Leiser, Ruth, Mapp, Fiona, McLeod, Julie, Stirrup, Oliver, Illingworth, Christopher J.R.
ORCID: https://orcid.org/0000-0002-0030-2784, Blackstone, James and Breuer, Judith
(2023)
A qualitative process evaluation using the behaviour change wheel approach: did a whole genome sequence report form (SRF) used to reduce nosocomial SARS-CoV-2 within UK hospitals operate as anticipated?
British Journal of Health Psychology, 28(4),
pp. 1011-1035.
(doi: 10.1111/bjhp.12666)
(PMID:37128667)
Brevini, T. et al. (2023) FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature, 615(7950), pp. 134-142. (doi: 10.1038/s41586-022-05594-0) (PMID:36470304) (PMCID:PMC9977684)
2022
Stejskal, L. et al. (2022) An entropic safety catch controls Hepatitis C virus entry and antibody resistance. eLife, 11, e71854. (doi: 10.7554/eLife.71854) (PMID:35796426) (PMCID:PMC9333995)
Nickbakhsh, S. et al. (2022) Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports, 12, 11735. (doi: 10.1038/s41598-022-15661-1) (PMID:35853960) (PMCID:PMC9296497)
Kemp, S. A. et al. (2022) Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers. Scientific Reports, 12, 10492. (doi: 10.1038/s41598-022-14411-7) (PMID:35729228) (PMCID:PMC9212198)
Illingworth, C. J.R. et al. (2022) A2B-COVID: a tool for rapidly evaluating potential SARS-CoV-2 transmission events. Molecular Biology and Evolution, 39(3), msac025. (doi: 10.1093/molbev/msac025) (PMID:35106603) (PMCID:PMC8892943)
Aggarwal, D. et al. (2022) Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13, 1012. (doi: 10.1038/s41467-022-28371-z) (PMID:35197443) (PMCID:PMC8866425)
Aggarwal, D. et al. (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13, 751. (doi: 10.1038/s41467-021-27942-w) (PMID:35136068) (PMCID:PMC8826310)
Twohig, K. A. et al. (2022) Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infectious Diseases, 22(1), pp. 35-42. (doi: 10.1016/S1473-3099(21)00475-8) (PMID:34461056) (PMCID:PMC8397301)
2021
Ferris, M. et al. (2021) Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers. eLife, 10, e71131. (doi: 10.7554/elife.71131) (PMID:34783656)
Illingworth, C. J.R. et al. (2021) Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections. eLife, 10, e67308. (doi: 10.7554/eLife.67308)
Hamilton, W. L. et al. (2021) Applying prospective genomic surveillance to support investigation of hospital-onset COVID-19. Lancet Infectious Diseases, 21(7), pp. 916-917. (doi: 10.1016/S1473-3099(21)00251-6) (PMID:33984262) (PMCID:PMC8110208)
Graham, M. S. et al. (2021) Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. Lancet Public Health, 6(5), e335-e345. (doi: 10.1016/S2468-2667(21)00055-4)
Sanjuán, Rafael, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Geoghegan, Jemma L., Iranzo, Jaime, Zwart, Mark P., Ciota, Alexander T., Moratorio, Gonzalo, Gago-Zachert, Selma, Duffy, Siobain and Vijaykrishna, Dhanasekaran
(2021)
Five challenges in the field of viral diversity and evolution.
Frontiers in Virology, 1,
684949.
(doi: 10.3389/fviro.2021.684949)
Kemp, S. A. et al. (2021) SARS-CoV-2 evolution during treatment of chronic infection. Nature, 592(7853), pp. 277-282. (doi: 10.1038/s41586-021-03291-y) (PMID:33545711) (PMCID:PMC7610568)
2020
Lumby, C. K. et al. (2020) Favipiravir and zanamivir cleared infection with influenza B in a severely immunocompromised child. Clinical Infectious Diseases, 71(7), e191-e194. (doi: 10.1093/cid/ciaa023) (PMID:32124919)
Lumby, Casper K., Zhao, Lei, Breuer, Judith and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2020)
A large effective population size for established within-host influenza virus infection.
eLife, 9,
e56915.
(doi: 10.7554/eLife.56915)
(PMID:32773034)
(PMCID:PMC7431133)
Ghafari, Mahan, Lumby, Casper K., Weissman, Daniel B. and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
(2020)
Inferring transmission bottleneck size from viral sequence data using a novel haplotype reconstruction method.
Journal of Virology, 94(13),
e00014-20.
(doi: 10.1128/JVI.00014-20)
(PMID:32295920)
(PMCID:PMC7307158)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Raghwani, Jayna, Serwadda, David, Sewankambo, Nelson K., Robb, Merlin L., Eller, Michael A., Redd, Andrew R., Quinn, Thomas C. and Lythgoe, Katrina A.
(2020)
A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection.
PLoS Pathogens, 16(6),
e1008171.
(doi: 10.1371/journal.ppat.1008171)
(PMID:32492061)
(PMCID:PMC7295245)
2019
Grech, L. et al. (2019) Fitness landscape of the fission yeast genome. Molecular Biology and Evolution, 36(8), pp. 1612-1623. (doi: 10.1093/molbev/msz113) (PMID:31077324) (PMCID:PMC6657727)
Doyle, S. R. et al. (2019) Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus. BMC Genomics, 20, p. 218. (doi: 10.1186/s12864-019-5592-6) (PMID:30876405) (PMCID:PMC6420744)
Kalemera, Mphatso, Mincheva, Dilyana, Grove, Joe and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
(2019)
Building a mechanistic mathematical model of hepatitis C virus entry.
PLoS Computational Biology, 15(3),
e1006905.
(doi: 10.1371/journal.pcbi.1006905)
(PMID:30883541)
(PMCID:PMC6445459)
Zhao, Lei, Abbasi, Ali B. and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
(2019)
Mutational load causes stochastic evolutionary outcomes in acute RNA viral infection.
Virus Evolution, 5(1),
vez008.
(doi: 10.1093/ve/vez008)
(PMID:31024738)
(PMCID:PMC6476161)
Zhao, Lei and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
(2019)
Measurements of intrahost viral diversity require an unbiased diversity metric.
Virus Evolution, 5(1),
vey041.
(doi: 10.1093/ve/vey041)
(PMID:30723551)
(PMCID:PMC6354029)
2018
Lumby, Casper K., Nene, Nuno R. and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
(2018)
A novel framework for inferring parameters of transmission from viral sequence data.
PLoS Genetics, 14(10),
e1007718.
(doi: 10.1371/journal.pgen.1007718)
(PMID:30325921)
(PMCID:PMC6203404)
Nené, Nuno R., Dunham, Alistair S. and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
(2018)
Inferring fitness effects from time-resolved sequence data with a delay-deterministic model.
Genetics, 209(1),
pp. 255-264.
(doi: 10.1534/genetics.118.300790)
(PMID:29500183)
(PMCID:PMC5937181)
Reid, Adam J., Talman, Arthur M., Bennett, Hayley M., Gomes, Ana R., Sanders, Mandy J., Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784, Billker, Oliver, Berriman, Matthew and Lawniczak, Mara K.N.
(2018)
Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites.
eLife, 7,
e33105.
(doi: 10.7554/eLife.33105)
(PMID:29580379)
(PMCID:PMC5871331)
R. Nené, Nuno, Mustonen, Ville and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2018)
Evaluating genetic drift in time-series evolutionary analysis.
Journal of Theoretical Biology, 437,
pp. 51-57.
(doi: 10.1016/j.jtbi.2017.09.021)
(PMID:28958783)
(PMCID:PMC5703635)
2017
Anderson, T. J.C. et al. (2017) Rapid identification of genes controlling virulence and immunity in malaria parasites. PLoS Pathogens, 13(7), e1006447. (doi: 10.1371/journal.ppat.1006447) (PMID:28704525) (PMCID:PMC5507557)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Roy, Sunando, Beale, Mathew A., Tutill, Helena, Williams, Rachel and Breuer, Judith
(2017)
On the effective depth of viral sequence data.
Virus Evolution, 3(2),
vex030.
(doi: 10.1093/ve/vex030)
(PMID:29250429)
(PMCID:PMC5724399)
Sobel Leonard, A. et al. (2017) The effective rate of influenza reassortment is limited during human infection. PLoS Pathogens, 13(2), e1006203. (doi: 10.1371/journal.ppat.1006203) (PMID:28170438) (PMCID:PMC5315410)
2016
Illingworth, C.J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2016)
SAMFIRE: multi-locus variant calling for time-resolved sequence data.
Bioinformatics, 32(14),
pp. 2208-2209.
(doi: 10.1093/bioinformatics/btw205)
(PMID:27153641)
(PMCID:PMC4937198)
Martinez, Julien ORCID: https://orcid.org/0000-0001-8210-2921, Cogni, Rodrigo, Cao, Chuan, Smith, Sophie, Illingworth, Christopher J.R.
ORCID: https://orcid.org/0000-0002-0030-2784 and Jiggins, Francis M.
(2016)
Addicted? Reduced host resistance in populations with defensive symbionts.
Proceedings of the Royal Society of London Series B: Biological Sciences, 283(1833),
20160778.
(doi: 10.1098/rspb.2016.0778)
(PMID:27335421)
(PMCID:PMC4936038)
Shaw, C.D. et al. (2016) In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization. Molecular Microbiology, 99(6), pp. 1134-1148. (doi: 10.1111/mmi.13291) (PMID:26713880) (PMCID:PMC4832254)
Raghwani, Jayna, Pybus, Oliver G. and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2016)
Population genetic modeling of viruses.
In: Weaver, Scott C., Denison, Mark, Roossinck, Marilyn and Vignuzzi, Marco (eds.)
Virus Evolution: Current Research and Future Directions.
Caister Academic Press: Wymondham, pp. 293-327.
ISBN 9781910190234
2015
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2015)
Fitness inference from short-read data: within-host evolution of a reassortant H5N1 influenza virus.
Molecular Biology and Evolution, 32(11),
pp. 3012-3026.
(doi: 10.1093/molbev/msv171)
(PMID:26243288)
(PMCID:PMC4651230)
2014
Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784, Fischer, Andrej and Mustonen, Ville
(2014)
Identifying selection in the within-host evolution of influenza using viral sequence data.
PLoS Computational Biology, 10(7),
e1003755.
(doi: 10.1371/journal.pcbi.1003755)
(PMID:25080215)
(PMCID:PMC4117419)
Fischer, Andrej, Vázquez-García, Ignacio, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2014)
High-definition reconstruction of clonal composition in cancer.
Cell Reports, 7(5),
pp. 1740-1752.
(doi: 10.1016/j.celrep.2014.04.055)
(PMID:24882004)
(PMCID:PMC4062932)
Chintapalli, Sree V., Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Upton, Graham J. G., Sacquin-Mora, Sophie, Reeves, Philip J., Mohammedali, Hani S. and Reynolds, Christopher A.
(2014)
Assessing the effect of dynamics on the closed-loop protein-folding hypothesis.
Journal of the Royal Society: Interface, 11(91),
20130935.
(doi: 10.1098/rsif.2013.0935)
(PMID:24258160)
(PMCID:PMC3869168)
Roy, Aparna, Taddese, Bruck, Vohra, Shabana, Thimmaraju, Phani K., Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Simpson, Lisa M., Mukherjee, Keya, Reynolds, Christopher A. and Chintapalli, Sree V.
(2014)
Identifying subset errors in multiple sequence alignments.
Journal of Biomolecular Structure and Dynamics, 32(3),
pp. 364-371.
(doi: 10.1080/07391102.2013.770371)
(PMID:23527867)
2013
Cubillos, F. A. et al. (2013) High-resolution mapping of complex traits with a four-parent advanced intercross yeast population. Genetics, 195(3), pp. 1141-1155. (doi: 10.1534/genetics.113.155515) (PMID:24037264) (PMCID:PMC3813843)
Lichten, Michael, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parts, Leopold, Bergström, Anders, Liti, Gianni and Mustonen, Ville
(2013)
Inferring genome-wide recombination landscapes from advanced intercross lines: application to yeast crosses.
PLoS ONE, 8(5),
e62266.
(doi: 10.1371/journal.pone.0062266)
(PMID:23658715)
(PMCID:PMC3642125)
Fischer, Andrej, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Campbell, Peter J. and Mustonen, Ville
(2013)
EMu: probabilistic inference of mutational processes and their localization in the cancer genome.
Genome Biology, 14(4),
R39.
(doi: 10.1186/gb-2013-14-4-r39)
(PMID:23628380)
(PMCID:PMC3663107)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2013)
Quantifying selection in evolving populations using time-resolved genetic data.
Journal of Statistical Mechanics: Theory and Experiment, 2013(01),
P01004.
(doi: 10.1088/1742-5468/2013/01/P01004)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2013)
A method to infer positive selection from marker dynamics in an asexual population.
Bioinformatics, 28(6),
pp. 831-837.
(doi: 10.1093/bioinformatics/btr722)
(PMID:22223745)
(PMCID:PMC3307107)
2012
Andino, Raul, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2012)
Components of selection in the evolution of the influenza virus: linkage effects beat inherent selection.
PLoS Pathogens, 8(12),
e1003091.
(doi: 10.1371/journal.ppat.1003091)
(PMID:23300444)
(PMCID:PMC3531508)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Chintipalli, Sree V., Serapian, Stefano A., Miller, Andrew D., Veverka, Vaclav, Carr, Mark D. and Reynolds, Christopher A.
(2012)
The statistical significance of selected sense-antisense peptide interactions.
Journal of Computational Chemistry, 33(16),
pp. 1440-1447.
(doi: 10.1002/jcc.22977)
(PMID:22488506)
Illingworth, C.J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parts, L., Schiffels, S., Liti, G. and Mustonen, V.
(2012)
Quantifying selection acting on a complex trait using allele frequency time series data.
Molecular Biology and Evolution, 29(4),
pp. 1187-1197.
(doi: 10.1093/molbev/msr289)
(PMID:22114362)
(PMCID:PMC3731369)
Domene, Carmen and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2012)
Effects of point mutations in pVHL on the binding of HIF-1α.
Proteins: Structure Function and Bioinformatics, 80(3),
pp. 733-746.
(doi: 10.1002/prot.23230)
(PMID:22105711)
2011
Gray, Eleanor R., Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Coffin, John M. and Stoye, Jonathan P.
(2011)
Binding of more than one Tva800 molecule is required for ASLV-A entry.
Retrovirology, 8(1),
96.
(doi: 10.1186/1742-4690-8-96)
(PMID:22099981)
(PMCID:PMC3267798)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2011)
Distinguishing driver and passenger mutations in an evolutionary history categorized by interference.
Genetics, 189(3),
pp. 989-1000.
(doi: 10.1534/genetics.111.133975)
(PMID:21900272)
(PMCID:PMC3213378)
2010
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Furini, Simone and Domene, Carmen
(2010)
Computational studies on polarization effects and selectivity in K+ channels.
Journal of Chemical Theory and Computation, 6(12),
pp. 3780-3792.
(doi: 10.1021/ct100276c)
Chintapalli, Sree V., Yew, Boon K., Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Upton, Graham J.G., Reeves, Philip J., Parkes, Kevin E. B., Snell, Christopher R. and Reynolds, Christopher A.
(2010)
Closed loop folding units from structural alignments: experimental foldons revisited.
Journal of Computational Chemistry, 31(15),
pp. 2689-2701.
(doi: 10.1002/jcc.21562)
(PMID:20839296)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Scott, Paul D., Parkes, Kevin E. B., Snell, Christopher R., Campbell, Matthew P. and Reynolds, Christopher A.
(2010)
Connectivity and binding-site recognition: applications relevant to drug design.
Journal of Computational Chemistry, 31(15),
pp. 2677-2688.
(doi: 10.1002/jcc.21561)
(PMID:20839295)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Loenarz, Christoph, Schofield, Christopher J. and Domene, Carmen
(2010)
Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1α.
Biochemistry, 49(32),
pp. 6936-6944.
(doi: 10.1021/bi100358t)
(PMID:20695530)
2009
Illingworth, Christopher J. ORCID: https://orcid.org/0000-0002-0030-2784 and Domene, Carmen
(2009)
Many-body effects and simulations of potassium channels.
Proceedings of the Royal Society of London Series A: Mathematical, Physical and Engineering Sciences, 465(2106),
pp. 1701-1716.
(doi: 10.1098/rspa.2009.0014)
2008
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Morris, Garrett M., Parkes, Kevin E. B., Snell, Christopher R. and Reynolds, Christopher A.
(2008)
Assessing the role of polarization in docking.
Journal of Physical Chemistry A, 112(47),
pp. 12157-12163.
(doi: 10.1021/jp710169m)
(PMID:18986122)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parkes, Kevin E. B., Snell, Christopher R., Ferenczy, György G. and Reynolds, Christopher A.
(2008)
Toward a consistent treatment of polarization in model QM/MM calculations.
Journal of Physical Chemistry A, 112(47),
pp. 12151-12156.
(doi: 10.1021/jp710168q)
(PMID:18986123)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parkes, Kevin E., Snell, Christopher R., Mullineaux, Philip M. and Reynolds, Christopher A.
(2008)
Criteria for confirming sequence periodicity identified by Fourier transform analysis: application to GCR2, a candidate plant GPCR?
Biophysical Chemistry, 133(1-3),
pp. 28-35.
(doi: 10.1016/j.bpc.2007.11.004)
(PMID:18086512)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parkes, Kevin E. B., Snell, Christopher R. and Reynolds, Christopher A.
(2008)
Quantitative measurement of protease ligand conformation.
Journal of Computer-Aided Molecular Design, 22(2),
pp. 105-109.
(doi: 10.1007/s10822-008-9173-z)
(PMID:18204905)
Illingworth, C.J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parkes, K.E., Snell, C.R., Marti, S., Moliner, V. and Reynolds, C.A.
(2008)
The effect of MM polarization on the QM/MM transition state stabilization: application to chorismate mutase.
Molecular Physics, 106(12),
pp. 1511-1515.
(doi: 10.1080/00268970802077850)
Illingworth, C.J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Winn, P.J., Ferenczy, G.G. and Reynolds, Christopher
(2008)
Progress in modelling electrostatics and polarization through effective multipoles and induced charges.
Studia Universitatis Babes-Bolyai Chemia, 2,
pp. 21-28.
2007
Vohra, S., Chintapalli, S.V., Illingworth, C.J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Reeves, P.J., Mullineaux, P.M., Clark, H.S.X., Dean, M.K., Upton, G.J.G. and Reynolds, C.A.
(2007)
Computational studies of Family A and Family B GPCRs.
Biochemical Society Transactions, 35(4),
pp. 749-754.
(doi: 10.1042/BST0350749)
(PMID:17635140)
2006
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Gooding, Stuart R., Winn, Peter J., Jones, Garth A., Ferenczy, György G. and Reynolds, Christopher A.
(2006)
Classical polarization in hybrid QM/MM methods.
Journal of Physical Chemistry A, 110(20),
pp. 6487-6497.
(doi: 10.1021/jp046944i)
(PMID:16706406)
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Efficacy of air cleaning units for preventing SARS-CoV-2 and other hospital-acquired infections on medicine for older people wards: a quasi-experimental controlled before-and-after study.
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ORCID: https://orcid.org/0000-0002-0030-2784
(2024)
Epidemiological inference at the threshold of data availability: an influenza A(H1N2)v spillover event in the United Kingdom.
Journal of the Royal Society: Interface, 21(217),
20240168.
(doi: 10.1098/rsif.2024.0168)
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Sinclair, Patrick, Zhao, Lei, Beggs, Clive B. and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
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The airborne transmission of viruses causes tight transmission bottlenecks.
Nature Communications, 15(1),
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Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Guerra-Assuncao, Jose A., Gregg, Samuel, Charles, Oscar, Pang, Juanita, Roy, Sunando, Abdelnabi, Rana, Neyts, Johan and Breuer, Judith
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Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection.
Virus Evolution,
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Flowers, Paul ORCID: https://orcid.org/0000-0001-6239-5616, Leiser, Ruth, Mapp, Fiona, McLeod, Julie, Stirrup, Oliver, Illingworth, Christopher J.R.
ORCID: https://orcid.org/0000-0002-0030-2784, Blackstone, James and Breuer, Judith
(2023)
A qualitative process evaluation using the behaviour change wheel approach: did a whole genome sequence report form (SRF) used to reduce nosocomial SARS-CoV-2 within UK hospitals operate as anticipated?
British Journal of Health Psychology, 28(4),
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Five challenges in the field of viral diversity and evolution.
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Lumby, Casper K., Zhao, Lei, Breuer, Judith and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
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A large effective population size for established within-host influenza virus infection.
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Ghafari, Mahan, Lumby, Casper K., Weissman, Daniel B. and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
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Inferring transmission bottleneck size from viral sequence data using a novel haplotype reconstruction method.
Journal of Virology, 94(13),
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(doi: 10.1128/JVI.00014-20)
(PMID:32295920)
(PMCID:PMC7307158)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Raghwani, Jayna, Serwadda, David, Sewankambo, Nelson K., Robb, Merlin L., Eller, Michael A., Redd, Andrew R., Quinn, Thomas C. and Lythgoe, Katrina A.
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A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection.
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Kalemera, Mphatso, Mincheva, Dilyana, Grove, Joe and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
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Building a mechanistic mathematical model of hepatitis C virus entry.
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(PMID:30883541)
(PMCID:PMC6445459)
Zhao, Lei, Abbasi, Ali B. and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
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Mutational load causes stochastic evolutionary outcomes in acute RNA viral infection.
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vez008.
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(PMID:31024738)
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Zhao, Lei and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
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Measurements of intrahost viral diversity require an unbiased diversity metric.
Virus Evolution, 5(1),
vey041.
(doi: 10.1093/ve/vey041)
(PMID:30723551)
(PMCID:PMC6354029)
Lumby, Casper K., Nene, Nuno R. and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
(2018)
A novel framework for inferring parameters of transmission from viral sequence data.
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(PMID:30325921)
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Nené, Nuno R., Dunham, Alistair S. and Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784
(2018)
Inferring fitness effects from time-resolved sequence data with a delay-deterministic model.
Genetics, 209(1),
pp. 255-264.
(doi: 10.1534/genetics.118.300790)
(PMID:29500183)
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Reid, Adam J., Talman, Arthur M., Bennett, Hayley M., Gomes, Ana R., Sanders, Mandy J., Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784, Billker, Oliver, Berriman, Matthew and Lawniczak, Mara K.N.
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Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites.
eLife, 7,
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R. Nené, Nuno, Mustonen, Ville and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
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Evaluating genetic drift in time-series evolutionary analysis.
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Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Roy, Sunando, Beale, Mathew A., Tutill, Helena, Williams, Rachel and Breuer, Judith
(2017)
On the effective depth of viral sequence data.
Virus Evolution, 3(2),
vex030.
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Illingworth, C.J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2016)
SAMFIRE: multi-locus variant calling for time-resolved sequence data.
Bioinformatics, 32(14),
pp. 2208-2209.
(doi: 10.1093/bioinformatics/btw205)
(PMID:27153641)
(PMCID:PMC4937198)
Martinez, Julien ORCID: https://orcid.org/0000-0001-8210-2921, Cogni, Rodrigo, Cao, Chuan, Smith, Sophie, Illingworth, Christopher J.R.
ORCID: https://orcid.org/0000-0002-0030-2784 and Jiggins, Francis M.
(2016)
Addicted? Reduced host resistance in populations with defensive symbionts.
Proceedings of the Royal Society of London Series B: Biological Sciences, 283(1833),
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(doi: 10.1098/rspb.2016.0778)
(PMID:27335421)
(PMCID:PMC4936038)
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Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2015)
Fitness inference from short-read data: within-host evolution of a reassortant H5N1 influenza virus.
Molecular Biology and Evolution, 32(11),
pp. 3012-3026.
(doi: 10.1093/molbev/msv171)
(PMID:26243288)
(PMCID:PMC4651230)
Illingworth, Christopher J. R. ORCID: https://orcid.org/0000-0002-0030-2784, Fischer, Andrej and Mustonen, Ville
(2014)
Identifying selection in the within-host evolution of influenza using viral sequence data.
PLoS Computational Biology, 10(7),
e1003755.
(doi: 10.1371/journal.pcbi.1003755)
(PMID:25080215)
(PMCID:PMC4117419)
Fischer, Andrej, Vázquez-García, Ignacio, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2014)
High-definition reconstruction of clonal composition in cancer.
Cell Reports, 7(5),
pp. 1740-1752.
(doi: 10.1016/j.celrep.2014.04.055)
(PMID:24882004)
(PMCID:PMC4062932)
Chintapalli, Sree V., Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Upton, Graham J. G., Sacquin-Mora, Sophie, Reeves, Philip J., Mohammedali, Hani S. and Reynolds, Christopher A.
(2014)
Assessing the effect of dynamics on the closed-loop protein-folding hypothesis.
Journal of the Royal Society: Interface, 11(91),
20130935.
(doi: 10.1098/rsif.2013.0935)
(PMID:24258160)
(PMCID:PMC3869168)
Roy, Aparna, Taddese, Bruck, Vohra, Shabana, Thimmaraju, Phani K., Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Simpson, Lisa M., Mukherjee, Keya, Reynolds, Christopher A. and Chintapalli, Sree V.
(2014)
Identifying subset errors in multiple sequence alignments.
Journal of Biomolecular Structure and Dynamics, 32(3),
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(doi: 10.1080/07391102.2013.770371)
(PMID:23527867)
Cubillos, F. A. et al. (2013) High-resolution mapping of complex traits with a four-parent advanced intercross yeast population. Genetics, 195(3), pp. 1141-1155. (doi: 10.1534/genetics.113.155515) (PMID:24037264) (PMCID:PMC3813843)
Lichten, Michael, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parts, Leopold, Bergström, Anders, Liti, Gianni and Mustonen, Ville
(2013)
Inferring genome-wide recombination landscapes from advanced intercross lines: application to yeast crosses.
PLoS ONE, 8(5),
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(PMID:23658715)
(PMCID:PMC3642125)
Fischer, Andrej, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Campbell, Peter J. and Mustonen, Ville
(2013)
EMu: probabilistic inference of mutational processes and their localization in the cancer genome.
Genome Biology, 14(4),
R39.
(doi: 10.1186/gb-2013-14-4-r39)
(PMID:23628380)
(PMCID:PMC3663107)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2013)
Quantifying selection in evolving populations using time-resolved genetic data.
Journal of Statistical Mechanics: Theory and Experiment, 2013(01),
P01004.
(doi: 10.1088/1742-5468/2013/01/P01004)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2013)
A method to infer positive selection from marker dynamics in an asexual population.
Bioinformatics, 28(6),
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(doi: 10.1093/bioinformatics/btr722)
(PMID:22223745)
(PMCID:PMC3307107)
Andino, Raul, Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2012)
Components of selection in the evolution of the influenza virus: linkage effects beat inherent selection.
PLoS Pathogens, 8(12),
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(doi: 10.1371/journal.ppat.1003091)
(PMID:23300444)
(PMCID:PMC3531508)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Chintipalli, Sree V., Serapian, Stefano A., Miller, Andrew D., Veverka, Vaclav, Carr, Mark D. and Reynolds, Christopher A.
(2012)
The statistical significance of selected sense-antisense peptide interactions.
Journal of Computational Chemistry, 33(16),
pp. 1440-1447.
(doi: 10.1002/jcc.22977)
(PMID:22488506)
Illingworth, C.J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parts, L., Schiffels, S., Liti, G. and Mustonen, V.
(2012)
Quantifying selection acting on a complex trait using allele frequency time series data.
Molecular Biology and Evolution, 29(4),
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(doi: 10.1093/molbev/msr289)
(PMID:22114362)
(PMCID:PMC3731369)
Domene, Carmen and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2012)
Effects of point mutations in pVHL on the binding of HIF-1α.
Proteins: Structure Function and Bioinformatics, 80(3),
pp. 733-746.
(doi: 10.1002/prot.23230)
(PMID:22105711)
Gray, Eleanor R., Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Coffin, John M. and Stoye, Jonathan P.
(2011)
Binding of more than one Tva800 molecule is required for ASLV-A entry.
Retrovirology, 8(1),
96.
(doi: 10.1186/1742-4690-8-96)
(PMID:22099981)
(PMCID:PMC3267798)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784 and Mustonen, Ville
(2011)
Distinguishing driver and passenger mutations in an evolutionary history categorized by interference.
Genetics, 189(3),
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(doi: 10.1534/genetics.111.133975)
(PMID:21900272)
(PMCID:PMC3213378)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Furini, Simone and Domene, Carmen
(2010)
Computational studies on polarization effects and selectivity in K+ channels.
Journal of Chemical Theory and Computation, 6(12),
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Chintapalli, Sree V., Yew, Boon K., Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Upton, Graham J.G., Reeves, Philip J., Parkes, Kevin E. B., Snell, Christopher R. and Reynolds, Christopher A.
(2010)
Closed loop folding units from structural alignments: experimental foldons revisited.
Journal of Computational Chemistry, 31(15),
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(PMID:20839296)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Scott, Paul D., Parkes, Kevin E. B., Snell, Christopher R., Campbell, Matthew P. and Reynolds, Christopher A.
(2010)
Connectivity and binding-site recognition: applications relevant to drug design.
Journal of Computational Chemistry, 31(15),
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(doi: 10.1002/jcc.21561)
(PMID:20839295)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Loenarz, Christoph, Schofield, Christopher J. and Domene, Carmen
(2010)
Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1α.
Biochemistry, 49(32),
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(2009)
Many-body effects and simulations of potassium channels.
Proceedings of the Royal Society of London Series A: Mathematical, Physical and Engineering Sciences, 465(2106),
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Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Morris, Garrett M., Parkes, Kevin E. B., Snell, Christopher R. and Reynolds, Christopher A.
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Assessing the role of polarization in docking.
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Toward a consistent treatment of polarization in model QM/MM calculations.
Journal of Physical Chemistry A, 112(47),
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Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Parkes, Kevin E., Snell, Christopher R., Mullineaux, Philip M. and Reynolds, Christopher A.
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Criteria for confirming sequence periodicity identified by Fourier transform analysis: application to GCR2, a candidate plant GPCR?
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Quantitative measurement of protease ligand conformation.
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The effect of MM polarization on the QM/MM transition state stabilization: application to chorismate mutase.
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Progress in modelling electrostatics and polarization through effective multipoles and induced charges.
Studia Universitatis Babes-Bolyai Chemia, 2,
pp. 21-28.
Vohra, S., Chintapalli, S.V., Illingworth, C.J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Reeves, P.J., Mullineaux, P.M., Clark, H.S.X., Dean, M.K., Upton, G.J.G. and Reynolds, C.A.
(2007)
Computational studies of Family A and Family B GPCRs.
Biochemical Society Transactions, 35(4),
pp. 749-754.
(doi: 10.1042/BST0350749)
(PMID:17635140)
Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784, Gooding, Stuart R., Winn, Peter J., Jones, Garth A., Ferenczy, György G. and Reynolds, Christopher A.
(2006)
Classical polarization in hybrid QM/MM methods.
Journal of Physical Chemistry A, 110(20),
pp. 6487-6497.
(doi: 10.1021/jp046944i)
(PMID:16706406)
Book Sections
Raghwani, Jayna, Pybus, Oliver G. and Illingworth, Christopher J.R. ORCID: https://orcid.org/0000-0002-0030-2784
(2016)
Population genetic modeling of viruses.
In: Weaver, Scott C., Denison, Mark, Roossinck, Marilyn and Vignuzzi, Marco (eds.)
Virus Evolution: Current Research and Future Directions.
Caister Academic Press: Wymondham, pp. 293-327.
ISBN 9781910190234
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Economic analysis of real-time viral genomics as a tool for infection prevention and control
Healthcare Infection Society
2024 - 2027
- CVR Preparedness compute capacity
Medical Research Council
2023 - 2024
- Developing interventions to reduce 'missingness' in health care
UK Health Security Agency
2022 - 2023
Research datasets
2024
Stewart, L., Evans, S., Brevini, T., Sampaziotis, F. and Illingworth, C. J.R. (2024) Modelling the potential use of pre-exposure prophylaxis to reduce nosocomial SARS-CoV-2 transmission. [Data Collection]