Dr Catarina De Almeida Marques
- Research Associate (Parasitology)
telephone:
01413301912
email:
Catarina.DeAlmeidaMarques@glasgow.ac.uk
Room 626, Level 6, Wellcome Center for Molecular Parasitology, GBRC, 120 University Place, G12 8TA
Publications
2023
Briggs, E. M., Marques, C. A. , Oldrieve, G. R., Hu, J., Otto, T. D. and Matthews, K. R. (2023) Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single cell transcriptomics. eLife, 12, e86325. (doi: 10.7554/eLife.86325) (PMID:37166108) (PMCID:PMC10212563)
2022
Marques, C. A. , Ridgway, M., Tinti, M., Cassidy, A. and Horn, D. (2022) Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects. Nature Communications, 13, 5326. (doi: 10.1038/s41467-022-33109-y) (PMID:36088375) (PMCID:PMC9464253)
2020
Damasceno, J. D., Marques, C. A. , Beraldi, D., Crouch, K. , Lapsley, C., Obonaga, R., Tosi, L. R.O. and McCulloch, R. (2020) Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication. eLife, 9, e58030. (doi: 10.7554/eLife.58030) (PMID:32897188) (PMCID:PMC7511235)
de Araujo, C. B. et al. (2020) Replication origin location might contribute to genetic variability in Trypanosoma cruzi. BMC Genomics, 21, 414. (doi: 10.1186/s12864-020-06803-8) (PMID:32571205) (PMCID:PMC7310030)
2019
Glover, L., Marques, C. A. , Suska, O. and Horn, D. (2019) Persistent DNA damage foci and DNA replication with a broken chromosome in the African trypanosome. mBio, 10(4), e01252-19. (doi: 10.1128/mbio.01252-19) (PMID:31289179) (PMCID:PMC6747728)
2018
Marques, C. A. and McCulloch, R. (2018) Conservation and variation in strategies for DNA replication of kinetoplastid nuclear genomes. Current Genomics, 19(2), pp. 98-109. (doi: 10.2174/1389202918666170815144627) (PMID:29491738) (PMCID:PMC5814967)
2017
da Silva, M. S., Pavani, R. S., Damasceno, J. D., Marques, C. A. , McCulloch, R. , Tosi, L. R. O. and Elias, M. C. (2017) Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems. Trends in Parasitology, 33(11), pp. 858-874. (doi: 10.1016/j.pt.2017.08.002) (PMID:28844718) (PMCID:PMC5662062)
Devlin, R., Marques, C. A. and McCulloch, R. (2017) Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome? Current Genetics, 63(3), pp. 441-449. (doi: 10.1007/s00294-016-0662-7) (PMID:27822899) (PMCID:PMC5422504)
2016
Marques, C. A. , Tiengwe, C., Lemgruber Soares, L. , Damasceno, J. D., Scott, A., Paape, D. , Marcello, L. and McCulloch, R. (2016) Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. Nucleic Acids Research, 44(10), pp. 4763-4784. (doi: 10.1093/nar/gkw147) (PMID:26951375) (PMCID:PMC4889932)
Devlin, R., Marques, C. A. , Paape, D. , Prorocic, M., Zurita-Leal, A. C., Campbell, S. J., Lapsley, C., Dickens, N. and McCulloch, R. (2016) Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation. eLife, 5, e12765. (doi: 10.7554/eLife.12765) (PMID:27228154) (PMCID:PMC4946898)
2015
Marques, C. A. , Dickens, N. J. , Paape, D. , Campbell, S. J. and McCulloch, R. (2015) Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe. Genome Biology, 16, 230. (doi: 10.1186/s13059-015-0788-9) (PMID:26481451) (PMCID:PMC4612428)
Calderano, S.G., Drosopoulos, W.C., Quaresma, M. M., Marques, C.A. , Kosiyatrakul, S., McCulloch, R. , Schildkraut, C.L. and Elias, M.C. (2015) Single molecule analysis of Trypanosoma brucei DNA replication dynamics. Nucleic Acids Research, 43(5), pp. 2655-2665. (doi: 10.1093/nar/gku1389) (PMID:25690894) (PMCID:PMC4357695)
2014
Machado, C. R. et al. (2014) Nucleotide excision repair in Trypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcription. Molecular Microbiology, 92(4), pp. 756-776. (doi: 10.1111/mmi.12589) (PMID:24661334) (PMCID:PMC4138998)
Tiengwe, C., Marques, C. A. and McCulloch, R. (2014) Nuclear DNA replication initiation in kinetoplastid parasites: new insights into an ancient process. Trends in Parasitology, 30(1), pp. 27-36. (doi: 10.1016/j.pt.2013.10.009)
2009
Vale, N. et al. (2009) Imidazoquines as antimalarial and antipneumocystis agents. Journal of Medicinal Chemistry, 52(23), pp. 7800-7807. (doi: 10.1021/jm900738c) (PMID:19799426) (PMCID:PMC2788672)
Prudêncio, M., Derbyshire, E. T., Marques, C. A. , Krishna, S., Mota, M. M. and Staines, H. M. (2009) Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells. Cellular Microbiology, 11(10), pp. 1492-1501. (doi: 10.1111/j.1462-5822.2009.01342.x) (PMID:19496788) (PMCID:PMC2774480)
Articles
Briggs, E. M., Marques, C. A. , Oldrieve, G. R., Hu, J., Otto, T. D. and Matthews, K. R. (2023) Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single cell transcriptomics. eLife, 12, e86325. (doi: 10.7554/eLife.86325) (PMID:37166108) (PMCID:PMC10212563)
Marques, C. A. , Ridgway, M., Tinti, M., Cassidy, A. and Horn, D. (2022) Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects. Nature Communications, 13, 5326. (doi: 10.1038/s41467-022-33109-y) (PMID:36088375) (PMCID:PMC9464253)
Damasceno, J. D., Marques, C. A. , Beraldi, D., Crouch, K. , Lapsley, C., Obonaga, R., Tosi, L. R.O. and McCulloch, R. (2020) Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication. eLife, 9, e58030. (doi: 10.7554/eLife.58030) (PMID:32897188) (PMCID:PMC7511235)
de Araujo, C. B. et al. (2020) Replication origin location might contribute to genetic variability in Trypanosoma cruzi. BMC Genomics, 21, 414. (doi: 10.1186/s12864-020-06803-8) (PMID:32571205) (PMCID:PMC7310030)
Glover, L., Marques, C. A. , Suska, O. and Horn, D. (2019) Persistent DNA damage foci and DNA replication with a broken chromosome in the African trypanosome. mBio, 10(4), e01252-19. (doi: 10.1128/mbio.01252-19) (PMID:31289179) (PMCID:PMC6747728)
Marques, C. A. and McCulloch, R. (2018) Conservation and variation in strategies for DNA replication of kinetoplastid nuclear genomes. Current Genomics, 19(2), pp. 98-109. (doi: 10.2174/1389202918666170815144627) (PMID:29491738) (PMCID:PMC5814967)
da Silva, M. S., Pavani, R. S., Damasceno, J. D., Marques, C. A. , McCulloch, R. , Tosi, L. R. O. and Elias, M. C. (2017) Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems. Trends in Parasitology, 33(11), pp. 858-874. (doi: 10.1016/j.pt.2017.08.002) (PMID:28844718) (PMCID:PMC5662062)
Devlin, R., Marques, C. A. and McCulloch, R. (2017) Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome? Current Genetics, 63(3), pp. 441-449. (doi: 10.1007/s00294-016-0662-7) (PMID:27822899) (PMCID:PMC5422504)
Marques, C. A. , Tiengwe, C., Lemgruber Soares, L. , Damasceno, J. D., Scott, A., Paape, D. , Marcello, L. and McCulloch, R. (2016) Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. Nucleic Acids Research, 44(10), pp. 4763-4784. (doi: 10.1093/nar/gkw147) (PMID:26951375) (PMCID:PMC4889932)
Devlin, R., Marques, C. A. , Paape, D. , Prorocic, M., Zurita-Leal, A. C., Campbell, S. J., Lapsley, C., Dickens, N. and McCulloch, R. (2016) Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation. eLife, 5, e12765. (doi: 10.7554/eLife.12765) (PMID:27228154) (PMCID:PMC4946898)
Marques, C. A. , Dickens, N. J. , Paape, D. , Campbell, S. J. and McCulloch, R. (2015) Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe. Genome Biology, 16, 230. (doi: 10.1186/s13059-015-0788-9) (PMID:26481451) (PMCID:PMC4612428)
Calderano, S.G., Drosopoulos, W.C., Quaresma, M. M., Marques, C.A. , Kosiyatrakul, S., McCulloch, R. , Schildkraut, C.L. and Elias, M.C. (2015) Single molecule analysis of Trypanosoma brucei DNA replication dynamics. Nucleic Acids Research, 43(5), pp. 2655-2665. (doi: 10.1093/nar/gku1389) (PMID:25690894) (PMCID:PMC4357695)
Machado, C. R. et al. (2014) Nucleotide excision repair in Trypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcription. Molecular Microbiology, 92(4), pp. 756-776. (doi: 10.1111/mmi.12589) (PMID:24661334) (PMCID:PMC4138998)
Tiengwe, C., Marques, C. A. and McCulloch, R. (2014) Nuclear DNA replication initiation in kinetoplastid parasites: new insights into an ancient process. Trends in Parasitology, 30(1), pp. 27-36. (doi: 10.1016/j.pt.2013.10.009)
Vale, N. et al. (2009) Imidazoquines as antimalarial and antipneumocystis agents. Journal of Medicinal Chemistry, 52(23), pp. 7800-7807. (doi: 10.1021/jm900738c) (PMID:19799426) (PMCID:PMC2788672)
Prudêncio, M., Derbyshire, E. T., Marques, C. A. , Krishna, S., Mota, M. M. and Staines, H. M. (2009) Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells. Cellular Microbiology, 11(10), pp. 1492-1501. (doi: 10.1111/j.1462-5822.2009.01342.x) (PMID:19496788) (PMCID:PMC2774480)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- A distinct mode of DNA replication initiation in trypanosomes?
Biotechnology and Biological Sciences Research Council
2021 - 2024