Ms Barbara Stokes

  • Marie Curie Fellowship (Parasitology)

email: Barbara.Stokes@glasgow.ac.uk

Sir Graeme Davies Building, 126 University Place, Glasgow, Glasgow City, Scotland, G12 8TA

Import to contacts

Biography

Dr Barbara Stokes obtained her bachelor's degree from Brown University in Providence, Rhode Island (United States), where she studied Comparative Literature.

After spending two years at the University of Massachusetts in Boston doing a post-baccalaureate program, Dr Stokes began her PhD in the department of Microbiology & Immunology at Columbia University Medical Center in New York.

During the PhD, she studied mechanisms of antimalarial drug resistance in Plasmodium falciparum parasites in the laboratory of Professor David Fidock.

Barbara's PhD work was focused on mechanisms of resistance to the first-line antimalarial therapy artemisinin, as well as on inhibitors of the Plasmodium proteasome, a novel class of antimalarial compounds currently under drug development.

After completing her PhD, she moved to Glasgow from New York at the beginning of 2021 to begin a postdoc in the Marti Lab.

Research interests

Barbara's research in the Marti Lab is primarily focused on studying the development of Plasmodium falciparum parasites within the hematopoietic niche, i.e., the bone marrow and spleen.

The identification of these organs as major reservoirs for both asexual blood-stage parasite replication and the development of transmission-competent gametocyte stages transformed our understanding of parasite biology.

Nonetheless, the complex cellular composition of these organs and their relative inaccessibility means that the development of parasites in this niche has remained an understudied area of Plasmodium biology.

During her post doc, Dr Stokes will apply single cell profiling techniques to study parasite development in the hematopoietic niche in the context of natural human infection using a combination of ex vivo and in vitro approaches.

She is particularly interested in how parasites sense and adapt to the unique environments of the hematopoietic niche, including both host cell-intrinsic and -extrinsic factors, and in how these factors drive differentiation into asexual or sexual stages.

Publications

List by: Type | Date

Jump to: 2023 | 2021 | 2020 | 2019 | 2018
Number of items: 7.

2023

Deni, I. et al. (2023) Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology, 30(5), 470-485.e6. (doi: 10.1016/j.chembiol.2023.03.002) (PMID:36963402) (PMCID:PMC10198959)

2021

Stokes, B. H. et al. (2021) Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. eLife, 10, e66277. (doi: 10.7554/eLife.66277) (PMID:34279219) (PMCID:PMC8321553)

Mok, S. et al. (2021) Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival. Nature Communications, 12, 530. (doi: 10.1038/s41467-020-20805-w) (PMID:33483501) (PMCID:PMC7822823)

2020

Uwimana, A. et al. (2020) Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda. Nature Medicine, 26(10), pp. 1602-1608. (doi: 10.1038/s41591-020-1005-2) (PMID:32747827) (PMCID:PMC7541349)

Gnädig, N. F. et al. (2020) Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13. PLoS Pathogens, 16(4), e1008482. (doi: 10.1371/journal.ppat.1008482) (PMID:32310999) (PMCID:PMC7192513)

2019

Blackman, M. J. et al. (2019) Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS Pathogens, 15(6), e1007722. (doi: 10.1371/journal.ppat.1007722) (PMID:31170268) (PMCID:PMC6553790)

2018

Yoo, E. et al. (2018) Defining the determinants of specificity of Plasmodium proteasome inhibitors. Journal of the American Chemical Society, 140(36), pp. 11424-11437. (doi: 10.1021/jacs.8b06656) (PMID:30107725) (PMCID:PMC6407133)

This list was generated on Thu Jul 18 16:37:37 2024 BST.
Jump to: Articles
Number of items: 7.

Articles

Deni, I. et al. (2023) Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology, 30(5), 470-485.e6. (doi: 10.1016/j.chembiol.2023.03.002) (PMID:36963402) (PMCID:PMC10198959)

Stokes, B. H. et al. (2021) Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. eLife, 10, e66277. (doi: 10.7554/eLife.66277) (PMID:34279219) (PMCID:PMC8321553)

Mok, S. et al. (2021) Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival. Nature Communications, 12, 530. (doi: 10.1038/s41467-020-20805-w) (PMID:33483501) (PMCID:PMC7822823)

Uwimana, A. et al. (2020) Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda. Nature Medicine, 26(10), pp. 1602-1608. (doi: 10.1038/s41591-020-1005-2) (PMID:32747827) (PMCID:PMC7541349)

Gnädig, N. F. et al. (2020) Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13. PLoS Pathogens, 16(4), e1008482. (doi: 10.1371/journal.ppat.1008482) (PMID:32310999) (PMCID:PMC7192513)

Blackman, M. J. et al. (2019) Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS Pathogens, 15(6), e1007722. (doi: 10.1371/journal.ppat.1007722) (PMID:31170268) (PMCID:PMC6553790)

Yoo, E. et al. (2018) Defining the determinants of specificity of Plasmodium proteasome inhibitors. Journal of the American Chemical Society, 140(36), pp. 11424-11437. (doi: 10.1021/jacs.8b06656) (PMID:30107725) (PMCID:PMC6407133)

This list was generated on Thu Jul 18 16:37:37 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Defining molecular determinants of Plasmodium falciparum hematopoietic infection using singlecell profiling and genetics
    European Molecular Biology Organization
    2022 - 2023