School of Health & Wellbeing

Dr Alasdair McIntosh

  • Biostatistician (Robertson Centre for Biostatistics)

Biography

Alasdair's career in statistics began in 1992 when they joined the then Scottish Office Agriculture and Fisheries Department's Economics and Statistics Unit, leading a small team producing government statistics, running government surveys and providing economic and statistical advice on the aggregate Scottish agricultural economy.

A few years later, they moved to the Scottish Office's Central Statistics Unit where they took over the production of the department's flagship publication, "The Scottish Abstract of Statistics", leading a small team reviewing its content and revamping its presentation. Their team also produced government environment, planning and local government staffing statistics.

From there, they moved into further education funding policy, helping to set up the then new Scottish Further Education Funding Council. They developed and ran the funding model which calculated FE college funding from various statistical inputs as well as advising on and developing the policy behind it. They managed contracted researchers working on projects commissioned by the funding council. They also had a role in the abolition of the full-time FE tuition fee in Scotland.

During a career break to raise their three children, Alasdair was secretary and trustee of a small charity, Alfreton's Party in the Park, working with a committee, leading volunteers to organise charitable events including an annual rock festival and fair on the town's park.

After completing a Master's degree in Statistics with Medical Applications at Sheffield, they returned to Scotland to complete a PhD in Statistics in Glasgow, developing Bayesian models of population-level genetic drift, taking their total number of degrees to seven. At the same time they were involved in teaching the programming language R and courses in probability theory.

They became a Research Assistant at the School of Maths and Statistics working on a Bayesian model of air pollution commissioned by the Scottish Government. It used data including information from monitoring sites to produce maps of air pollution and to forecast probabilities of exceeding thresholds for four pollutants at a range of geographic levels of aggregation including a 1-kilometre-square grid. This was developed and documented into a software product that was delivered to the Scottish Government.

Alasdair now works in the Robertson Centre for Biostatistics in the School of Health and Wellbeing working on the design, implementation, monitoring, analysis and publication of clinical trials and other health-related studies and datasets. They worked on the award-winning DiRECT trial of a dietary intervention for type 2 diabetes. They also teach and develop content on a range of courses including Introduction to Clinical Trials as well as supervising student projects on the Masters of Public Health program. They present work at external conferences, winning the "Best Poster" prize at the NIHR Statistics conference in 2026.

 

 

Research interests

Alasdair's interests in recent years have been quite varied and have included:

  • statistical genetics,
  • air pollution modelling and
  • clinical trial design including newer approaches such as adaptive designs, Bayesian methods, platform, basket and umbrella trials.

These interests have led to the use of, and expertise in, a wide range of amalytical methods alongside standard statistical hypothesis testing and generalised linear models such as Poisson and logistic regression:

  • Bayesian hierarchical models,
  • Lasso and other forms of penalised regression,
  • Naive Bayes,
  • Agent-based models,
  • Deep neural networks,
  • Random forests and
  • Extreme gradient boosting.

These methods have been implemented through a range of programming approaches including the development of multithreaded code. They have also been involved in software development. Programming languages used over the years include, but are not limited to:

  • R,
  • C++,
  • Python,
  • Stata,
  • JavaScript,
  • SAS,
  • Java and
  • BASIC.

 

Publications

List by: Type | Date

Jump to: 2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019
Number of items: 18.

2026

Davies, A., Grieve, E. ORCID logoORCID: https://orcid.org/0000-0002-4115-2882, McCombie, L., McIntosh, A., McConnachie, A. ORCID logoORCID: https://orcid.org/0000-0002-7262-7000, Leslie, W.S., Sattar, N. ORCID logoORCID: https://orcid.org/0000-0002-1604-2593, Taylor, R. and Lean, M.E.J. ORCID logoORCID: https://orcid.org/0000-0003-2216-0083 (2026) Cost-effectiveness of the diabetes remission clinical trial (DiRECT)/Counterweight-Plus weight management programme, based on 5-year follow-up. Diabetic Medicine, (doi: 10.1111/dme.70306) (Early Online Publication)

Kamdar, A. et al. (2026) Illness trajectory in the longer term after hospitalisation for COVID-19: a prospective, multicentre cohort study. BMC Infectious Diseases, 26, 344. (doi: 10.1186/s12879-025-12487-w) (PMID:41559637) (PMCID:PMC12903569)

2025

Sykes, R. et al. (2025) Radiological abnormalities persist following covid-19 and correlate with impaired Health-related Quality of Life: a prospective cohort study of hospitalized patients. BMJ Open Respiratory Research, 12(1), e001985. (doi: 10.1136/bmjresp-2023-001985) (PMID:39929549)

2024

Karmacharya, B. et al. (2024) A service evaluation of weight management for glycaemic control and remission of type 2 diabetes using traditional food in Nepal (Ho-DIRECT NEPAL): a single-arm trial. Lancet Regional Health – Southeast Asia, 29, 100465. (doi: 10.1016/j.lansea.2024.100465)

Malamud, M. et al. (2024) Recognition and control of neutrophil extracellular trap formation by MICL. Nature, 633(8029), pp. 442-450. (doi: 10.1038/s41586-024-07820-3) (PMID:39143217)

Curtain, J. P. et al. (2024) Measuring congestion with a non-invasive monitoring device in heart failure and haemodialysis: CONGEST-HF. European Journal of Heart Failure, 26(6), pp. 1383-1392. (doi: 10.1002/ejhf.3290) (PMID:38741283)

Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)

Varian, F. et al. (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14(1), e12337. (doi: 10.1002/pul2.12337) (PMID:38500737) (PMCID:PMC10945040)

2023

Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)

Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19. Open Heart, 10(1), e002192. (doi: 10.1136/openhrt-2022-002192) (PMID:36822817) (PMCID:PMC9950584)

Wu, X. et al. (2023) [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. Nature Medicine, 29(1), pp. 190-202. (doi: 10.1038/s41591-022-02114-5) (PMID:36646800)

2022

Mangion, K. et al. (2022) Multi-system investigation of COVID-19 illness. British Cardiovascular Society Annual Conference, ‘100 years of Cardiology’, Manchester, UK, 06-08 June 2022. A122.1-A122. (doi: 10.1136/heartjnl-2022-BCS.157)

Morrow, A. J. et al. (2022) A multisystem, cardio-renal investigation of post-COVID-19 illness. Nature Medicine, 28(6), pp. 1303-1313. (doi: 10.1038/s41591-022-01837-9) (PMID:35606551) (PMCID:PMC9205780)

2021

Berry, C. et al. (2021) Post-COVID-19 illness trajectory: a multisystem investigation [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1053331/v1)

Sharma, S. et al. (2021) Periodontal therapy and treatment of hypertension – alternative to the pharmacological approach. A systematic review and meta-analysis. Pharmacological Research, 166, 105511. (doi: 10.1016/j.phrs.2021.105511) (PMID:33617973)

Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)

2020

Henderson, Angela ORCID logoORCID: https://orcid.org/0000-0002-6146-3477, McSkimming, Paula, Kinnear, Deborah, McCowan, Colin ORCID logoORCID: https://orcid.org/0000-0002-9466-833X, McIntosh, Alasdair, Allan, Linda and Cooper, Sally-Ann ORCID logoORCID: https://orcid.org/0000-0001-6054-7700 (2020) Changes over a decade in psychotropic prescribing for people with intellectual disabilities: prospective cohort study. BMJ Open, 10(9), e036862. (doi: 10.1136/bmjopen-2020-036862) (PMID:32912946)

2019

McIntosh, Alasdair and Anderson, Craig ORCID logoORCID: https://orcid.org/0000-0003-1554-5727 (2019) Modelling the Risk of Exceeding Air Quality Monitoring Thresholds in Scotland. Project Report. Scottish Government.

This list was generated on Thu Sep 3 21:11:47 2026 BST.
Number of items: 18.

Articles

Davies, A., Grieve, E. ORCID logoORCID: https://orcid.org/0000-0002-4115-2882, McCombie, L., McIntosh, A., McConnachie, A. ORCID logoORCID: https://orcid.org/0000-0002-7262-7000, Leslie, W.S., Sattar, N. ORCID logoORCID: https://orcid.org/0000-0002-1604-2593, Taylor, R. and Lean, M.E.J. ORCID logoORCID: https://orcid.org/0000-0003-2216-0083 (2026) Cost-effectiveness of the diabetes remission clinical trial (DiRECT)/Counterweight-Plus weight management programme, based on 5-year follow-up. Diabetic Medicine, (doi: 10.1111/dme.70306) (Early Online Publication)

Kamdar, A. et al. (2026) Illness trajectory in the longer term after hospitalisation for COVID-19: a prospective, multicentre cohort study. BMC Infectious Diseases, 26, 344. (doi: 10.1186/s12879-025-12487-w) (PMID:41559637) (PMCID:PMC12903569)

Sykes, R. et al. (2025) Radiological abnormalities persist following covid-19 and correlate with impaired Health-related Quality of Life: a prospective cohort study of hospitalized patients. BMJ Open Respiratory Research, 12(1), e001985. (doi: 10.1136/bmjresp-2023-001985) (PMID:39929549)

Karmacharya, B. et al. (2024) A service evaluation of weight management for glycaemic control and remission of type 2 diabetes using traditional food in Nepal (Ho-DIRECT NEPAL): a single-arm trial. Lancet Regional Health – Southeast Asia, 29, 100465. (doi: 10.1016/j.lansea.2024.100465)

Malamud, M. et al. (2024) Recognition and control of neutrophil extracellular trap formation by MICL. Nature, 633(8029), pp. 442-450. (doi: 10.1038/s41586-024-07820-3) (PMID:39143217)

Curtain, J. P. et al. (2024) Measuring congestion with a non-invasive monitoring device in heart failure and haemodialysis: CONGEST-HF. European Journal of Heart Failure, 26(6), pp. 1383-1392. (doi: 10.1002/ejhf.3290) (PMID:38741283)

Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)

Varian, F. et al. (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14(1), e12337. (doi: 10.1002/pul2.12337) (PMID:38500737) (PMCID:PMC10945040)

Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)

Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19. Open Heart, 10(1), e002192. (doi: 10.1136/openhrt-2022-002192) (PMID:36822817) (PMCID:PMC9950584)

Wu, X. et al. (2023) [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. Nature Medicine, 29(1), pp. 190-202. (doi: 10.1038/s41591-022-02114-5) (PMID:36646800)

Morrow, A. J. et al. (2022) A multisystem, cardio-renal investigation of post-COVID-19 illness. Nature Medicine, 28(6), pp. 1303-1313. (doi: 10.1038/s41591-022-01837-9) (PMID:35606551) (PMCID:PMC9205780)

Berry, C. et al. (2021) Post-COVID-19 illness trajectory: a multisystem investigation [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1053331/v1)

Sharma, S. et al. (2021) Periodontal therapy and treatment of hypertension – alternative to the pharmacological approach. A systematic review and meta-analysis. Pharmacological Research, 166, 105511. (doi: 10.1016/j.phrs.2021.105511) (PMID:33617973)

Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)

Henderson, Angela ORCID logoORCID: https://orcid.org/0000-0002-6146-3477, McSkimming, Paula, Kinnear, Deborah, McCowan, Colin ORCID logoORCID: https://orcid.org/0000-0002-9466-833X, McIntosh, Alasdair, Allan, Linda and Cooper, Sally-Ann ORCID logoORCID: https://orcid.org/0000-0001-6054-7700 (2020) Changes over a decade in psychotropic prescribing for people with intellectual disabilities: prospective cohort study. BMJ Open, 10(9), e036862. (doi: 10.1136/bmjopen-2020-036862) (PMID:32912946)

Research Reports or Papers

McIntosh, Alasdair and Anderson, Craig ORCID logoORCID: https://orcid.org/0000-0003-1554-5727 (2019) Modelling the Risk of Exceeding Air Quality Monitoring Thresholds in Scotland. Project Report. Scottish Government.

Conference or Workshop Item

Mangion, K. et al. (2022) Multi-system investigation of COVID-19 illness. British Cardiovascular Society Annual Conference, ‘100 years of Cardiology’, Manchester, UK, 06-08 June 2022. A122.1-A122. (doi: 10.1136/heartjnl-2022-BCS.157)

This list was generated on Thu Sep 3 21:11:47 2026 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • A community-based dietary programme for type 2 diabetes prevention and remission, clinical trial and implementation evaluation in Nepal (Co-DiaPREM-NEPAL)
    National Institute for Health Research
    2025 - 2029
     
  • HoDiRECT- Nepal: a food based intervention for type 2 diabetes remission in hospital patients with type 2 diabetes
    All Saints Educational Trust
    2021 - 2023
     

Supervision

Master's of Public Health Projects

Jiayi Li - Ethnic differences in poor sleep and stroke risk: A UK biobank study (2025)

Aiko Mori - Relationship between sleep and blood-based pathologic biomarkers of Alzheimer's Disease: A cross-sectional and longitudinal study from UK Biobank (2025)

Yifei Dou - Trends in Life Expectancy of HIV Patients Receiving HAART: A systematic review and Meta-Analysis (2024)

Teaching

Teaching (Ongoing)

Introduction to Clinical Trials - All lectures

Introduction to Epidemiology and Statistics (Masters of Public Health MED5652) - Linear statistical regression lecture

Advanced Statistics (Masters of Public Health MED5021) - Multivariable generalised linear statistical regression lecture

BSc (MedSci) Clinical Medicine - Journal Club Facilitator

Previous Teaching (when employed by the School of Mathematics and Statistics)

Introduction to R - Lab Practicals

Statistics 2R: Probability (STATS2002) - Tutorials + Labs

Statistics 2X: Probability II (STATS2005) - Tutorials + Labs

Statistics Project - Drop in programming support