Dr Jennifer Malcolm

  • Lecturer (Dental School)

telephone: 01412119763
email: Jennifer.Malcolm@glasgow.ac.uk

School of Medicine, Dentistry & Nursing, Level 9, L14, Glasgow Dental School, Glasgow, G2 3JZ

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-0020-0283

Biography

I graduated with a 1st Class BSc/Hons in Microbiology from Glasgow Caledonian University, where I first sparked an interest in host-pathogen interactions in health and disease. I pursued this interest during my PhD at the University of Glasgow, School of Medicine, Dentistry and Nursing, where I investigated oral biofilm development in young children coincident with the maturation of salivary immune responses.

After my PhD, I worked as a Post-Doctoral Research Associate at the University of Glasgow, School of Infection and Immunity, where I developed a discovery pipeline for therapeutic targets for periodontal disease. This work has formed the basis of further investigations of cellular mechanisms in oral health and disease. Subsequently, I was the lead post-doctoral researcher on a Versus Arthritis Research grant. In this project, I identified a novel mechanism of breach of immune tolerance related to non-endogenous bacterial citrullination. These data have implications for understanding how oral bacterial infection can drive autoimmune responses.

In 2018, I took up a teaching position at the University of Glasgow Dental School. Here, I am exploring how oral bacteria exploit innate immunity to subvert adaptive immune responses, and how this impacts the maintenance of immune tolerance in the oral mucosa.

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2018 | 2016 | 2015 | 2014 | 2011
Number of items: 20.

2024

Malcolm, J. and Culshaw, S. (2024) Aberrant immunity in the oral cavity—a link with rheumatoid arthritis? Frontiers in Oral Health, 5, 1430886. (doi: 10.3389/froh.2024.1430886) (PMID:38948089)

Lopez‐Oliva, I., Malcolm, J. and Culshaw, S. (2024) Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases. Periodontology 2000, (doi: 10.1111/prd.12530) (Early Online Publication)

2023

Malcolm, J. et al. (2023) C-Terminal Citrullinated Peptide Alters APC-CD4 T Cell Interactions Leading to Breach of Immune Tolerance. Mastering Immunity ProImmune Conference, February 2023.

Malcolm, J. et al. (2023) C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, 102994. (doi: 10.1016/j.jaut.2023.102994) (PMID:36706535)

Makki, Z., Malcolm, J. and Miguel, J. C. (2023) COVID-19 adaptations with virtual microscopy. In: Varsu, Ourania, Rea, Paul M. and Welsh, Michelle (eds.) Biomedical Visualisation. Series: Advances in experimental medicine and biology, vol 1397. Springer: Cham, pp. 173-197. ISBN 9783031171345 (doi: 10.1007/978-3-031-17135-2_10)

2022

Malcolm, J. (2022) Using Microsoft Teams to Support Active Small Group Learning and Teaching of Biomedical Sciences. Early Career Lecturers in Biosciences Workshop: Lessons Learned during the pandemic, exploring how we continue to use good blended teaching practices and innovations, 14 January 2022.

2021

McKerlie, R. A. , Malcolm, J. , Varsou, O. , Kennedy, C. E. , Colgan, L., Harper, V., McAllan, W., Forgie, A., Rea, P. and Bell, A. (2021) A rapid transition to blended learning: the journey of a dental degree programme pivoting online. Journal of Perspectives in Applied Academic Practice, 9(2), pp. 169-180. (doi: 10.14297/jpaap.v9i2.475)

Malcolm, J. and Rea, P. (2021) Using Microsoft Teams to Support Active Small Group Learning and Teaching. 14th Annual University of Glasgow Learning and Teaching Conference: Transforming Teaching and Taking Stock, University of Glasgow, 18th July 2021.

2020

Malcolm, J. (2020) Using Threshold Concepts to Enhance Integration and Application of Science in Healthcare Curricula. Association of Medical Education in Europe Annual Conference 2020, 7-9 September 2020.

2018

Brown, J.L. , Campbell, L., Malcolm, J. , Adrados Planell, A., Butcher, J.P. and Culshaw, S. (2018) Enrichment of innate lymphoid cell populations in gingival tissue. Journal of Dental Research, 97(12), pp. 1399-1405. (doi: 10.1177/0022034518782141) (PMID:29928824)

Simon-Soro, A., Sherriff, A. , Sadique, S., Ramage, G. , Macpherson, L. , Mira, A., Culshaw, S. and Malcolm, J. (2018) Combined analysis of the salivary microbiome and host defence peptides predicts dental disease. Scientific Reports, 8, 1484. (doi: 10.1038/s41598-018-20085-x) (PMID:29367728) (PMCID:PMC5784018)

2016

Ramage, G. , Lappin, D.F., Millhouse, E., Malcolm, J. , Jose, A., Yang, J., Bradshaw, D.J., Pratten, J.R. and Culshaw, S. (2016) The epithelial cell response to health and disease associated oral biofilm models. Journal of Periodontal Research, 52(3), pp. 325-333. (doi: 10.1111/jre.12395) (PMID:27330034) (PMCID:PMC5412879)

Malcolm, J. et al. (2016) Mast cells contribute to Porphyromonas gingivalis–induced bone loss. Journal of Dental Research, 95(6), pp. 704-710. (doi: 10.1177/0022034516634630) (PMID:26933137)

Campbell, L., Millhouse, E., Malcolm, J. and Culshaw, S. (2016) T cells, teeth and tissue destruction - what do T cells do in periodontal disease? Molecular Oral Microbiology, 31(6), pp. 445-456. (doi: 10.1111/omi.12144) (PMID:26505640)

2015

O'Donnell, L. E., Millhouse, E., Sherry, L. , Kean, R., Malcolm, J. , Nile, C. J. , Ramage, G. and Munro, C. (2015) Polymicrobial candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15(7), fov077. (doi: 10.1093/femsyr/fov077) (PMID:26298018)

Malcolm, J. et al. (2015) IL-33 exacerbates periodontal disease through induction of RANKL. Journal of Dental Research, 94(7), pp. 968-975. (doi: 10.1177/0022034515577815) (PMID:25808546)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B. , Garside, P. , McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)

O’Donnell, L. E. et al. (2015) The oral microbiome of denture wearers is influenced by natural dentition. PLoS ONE, 10(9), e0137717. (doi: 10.1371/journal.pone.0137717) (PMID:26368937) (PMCID:PMC4569385)

2014

Malcolm, J. , Sherriff, A. , Lappin, D. F., Ramage, G. , Conway, D. I. , Macpherson, L. M. and Culshaw, S. (2014) Salivary antimicrobial proteins associate with age-related changes in streptococcal composition in dental plaque. Molecular Oral Microbiology, 29(6), pp. 284-293. (doi: 10.1111/omi.12058)

2011

Butcher, J.P., Malcolm, J. , Benson, R.A. , Deng, D.M., Brewer, J.M. , Garside, P. and Culshaw, S. (2011) Effects of streptococcus mutans on dendritic cell activation and function. Journal of Dental Research, 90(10), pp. 1221-1227. (doi: 10.1177/0022034511412970)

This list was generated on Thu Jun 5 20:34:14 2025 BST.
Jump to: Articles | Book Sections | Conference or Workshop Item
Number of items: 20.

Articles

Malcolm, J. and Culshaw, S. (2024) Aberrant immunity in the oral cavity—a link with rheumatoid arthritis? Frontiers in Oral Health, 5, 1430886. (doi: 10.3389/froh.2024.1430886) (PMID:38948089)

Lopez‐Oliva, I., Malcolm, J. and Culshaw, S. (2024) Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases. Periodontology 2000, (doi: 10.1111/prd.12530) (Early Online Publication)

Malcolm, J. et al. (2023) C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, 102994. (doi: 10.1016/j.jaut.2023.102994) (PMID:36706535)

McKerlie, R. A. , Malcolm, J. , Varsou, O. , Kennedy, C. E. , Colgan, L., Harper, V., McAllan, W., Forgie, A., Rea, P. and Bell, A. (2021) A rapid transition to blended learning: the journey of a dental degree programme pivoting online. Journal of Perspectives in Applied Academic Practice, 9(2), pp. 169-180. (doi: 10.14297/jpaap.v9i2.475)

Brown, J.L. , Campbell, L., Malcolm, J. , Adrados Planell, A., Butcher, J.P. and Culshaw, S. (2018) Enrichment of innate lymphoid cell populations in gingival tissue. Journal of Dental Research, 97(12), pp. 1399-1405. (doi: 10.1177/0022034518782141) (PMID:29928824)

Simon-Soro, A., Sherriff, A. , Sadique, S., Ramage, G. , Macpherson, L. , Mira, A., Culshaw, S. and Malcolm, J. (2018) Combined analysis of the salivary microbiome and host defence peptides predicts dental disease. Scientific Reports, 8, 1484. (doi: 10.1038/s41598-018-20085-x) (PMID:29367728) (PMCID:PMC5784018)

Ramage, G. , Lappin, D.F., Millhouse, E., Malcolm, J. , Jose, A., Yang, J., Bradshaw, D.J., Pratten, J.R. and Culshaw, S. (2016) The epithelial cell response to health and disease associated oral biofilm models. Journal of Periodontal Research, 52(3), pp. 325-333. (doi: 10.1111/jre.12395) (PMID:27330034) (PMCID:PMC5412879)

Malcolm, J. et al. (2016) Mast cells contribute to Porphyromonas gingivalis–induced bone loss. Journal of Dental Research, 95(6), pp. 704-710. (doi: 10.1177/0022034516634630) (PMID:26933137)

Campbell, L., Millhouse, E., Malcolm, J. and Culshaw, S. (2016) T cells, teeth and tissue destruction - what do T cells do in periodontal disease? Molecular Oral Microbiology, 31(6), pp. 445-456. (doi: 10.1111/omi.12144) (PMID:26505640)

O'Donnell, L. E., Millhouse, E., Sherry, L. , Kean, R., Malcolm, J. , Nile, C. J. , Ramage, G. and Munro, C. (2015) Polymicrobial candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15(7), fov077. (doi: 10.1093/femsyr/fov077) (PMID:26298018)

Malcolm, J. et al. (2015) IL-33 exacerbates periodontal disease through induction of RANKL. Journal of Dental Research, 94(7), pp. 968-975. (doi: 10.1177/0022034515577815) (PMID:25808546)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B. , Garside, P. , McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)

O’Donnell, L. E. et al. (2015) The oral microbiome of denture wearers is influenced by natural dentition. PLoS ONE, 10(9), e0137717. (doi: 10.1371/journal.pone.0137717) (PMID:26368937) (PMCID:PMC4569385)

Malcolm, J. , Sherriff, A. , Lappin, D. F., Ramage, G. , Conway, D. I. , Macpherson, L. M. and Culshaw, S. (2014) Salivary antimicrobial proteins associate with age-related changes in streptococcal composition in dental plaque. Molecular Oral Microbiology, 29(6), pp. 284-293. (doi: 10.1111/omi.12058)

Butcher, J.P., Malcolm, J. , Benson, R.A. , Deng, D.M., Brewer, J.M. , Garside, P. and Culshaw, S. (2011) Effects of streptococcus mutans on dendritic cell activation and function. Journal of Dental Research, 90(10), pp. 1221-1227. (doi: 10.1177/0022034511412970)

Book Sections

Makki, Z., Malcolm, J. and Miguel, J. C. (2023) COVID-19 adaptations with virtual microscopy. In: Varsu, Ourania, Rea, Paul M. and Welsh, Michelle (eds.) Biomedical Visualisation. Series: Advances in experimental medicine and biology, vol 1397. Springer: Cham, pp. 173-197. ISBN 9783031171345 (doi: 10.1007/978-3-031-17135-2_10)

Conference or Workshop Item

Malcolm, J. et al. (2023) C-Terminal Citrullinated Peptide Alters APC-CD4 T Cell Interactions Leading to Breach of Immune Tolerance. Mastering Immunity ProImmune Conference, February 2023.

Malcolm, J. (2022) Using Microsoft Teams to Support Active Small Group Learning and Teaching of Biomedical Sciences. Early Career Lecturers in Biosciences Workshop: Lessons Learned during the pandemic, exploring how we continue to use good blended teaching practices and innovations, 14 January 2022.

Malcolm, J. and Rea, P. (2021) Using Microsoft Teams to Support Active Small Group Learning and Teaching. 14th Annual University of Glasgow Learning and Teaching Conference: Transforming Teaching and Taking Stock, University of Glasgow, 18th July 2021.

Malcolm, J. (2020) Using Threshold Concepts to Enhance Integration and Application of Science in Healthcare Curricula. Association of Medical Education in Europe Annual Conference 2020, 7-9 September 2020.

This list was generated on Thu Jun 5 20:34:14 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Identifying the immunopathogenic mechanisms and MHCII neoepitopes linking porphyromonas gingivalis infection of dendritic cells with the activation of autoreactive CD4 T cells
    Academy of Medical Sciences
    2025 - 2027
     
  • In vitro investigation of the interplay between stress, oral biofilms and oral epithelial barrier function
    Oral and Dental Research Trust
    2021 - 2022
     

Supervision

  • Piela, Krystyna
    Holding the front line – maintaining barrier integrity in the mouth