Professor Richard Hartley
- Professor of Chemical Biology (Chemistry)
Professor Richard Hartley is a chemical biologist. The Hartley group uses synthetic organic chemistry to unlock the secrets of biology and treat disease. He is an expert in the chemistry that occurs in mitochondria and in redox signalling. His group is the chemical core of multidisiciplinary teams tackling the biggest problems in medicine. Professor Hartley has helped to pin down the cause of reperfusion injury in stroke, transplant and heart attack; to explain why resting metabolic rates vary naturally; to test the free radical theory of aging; and to explain how inflammation is switched off by the mitochondrial metabolite, itaconate. Profesor Hartley was the originator of the ‘Protection Hypothesis’ in behavioural ecology. The impact of his work is clear. Molecular probes developed in his lab are now marketed worldwide by Cayman Chemical and by other companies. These include MitoB and MitoParaquat. A spin out company, Antoxis, arose from his research.
- Molecular Probes
- Reactive oxygen species (ROS)
- Prodrugs and Photoactivatable compounds
- Redox signalling
- Publons:ResearcherID E-3489-2010
- Booty, L. M. et al. (2019) Selective disruption of mitochondrial thiol redox state in cells and in vivo.Cell Chemical Biology, 26(3), 449-461.e8. (doi:10.1016/j.chembiol.2018.12.002)(PMID:30713096)(PMCID:PMC6436940)
- Mills, E. L. et al. (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.Nature, 5556, pp. 113-117. (doi:10.1038/nature25986)(PMID:29590092)
- Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.Free Radical Biology and Medicine, 89, pp. 883-894. (doi:10.1016/j.freeradbiomed.2015.08.021)(PMID:26454075)
- Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Nature, 515(7527), pp. 431-435. (doi:10.1038/nature13909)(PMID:25383517)(PMCID:PMC4255242)
- Chalmers, S., Caldwell, S. T., Quin, C., Prime, T. A., James, A. M., Cairns, A. G., Murphy, M. P., McCarron, J. G.and Hartley, R. C.(2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore.Journal of the American Chemical Society, 134(2), pp. 758-761. (doi:10.1021/ja2077922)(PMID:22239373)(PMCID:PMC3260739)
- Cochemé, H.M. et al. (2011) Measurement of H2O2within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.Cell Metabolism, 13(3), pp. 340-350. (doi:10.1016/j.cmet.2011.02.003)(PMID:21356523)(PMCID:PMC4413513)
Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 515(7527), pp. 431-435. (doi:10.1038/nature13909) (PMID:25383517) (PMCID:PMC4255242)
Salin, K., Auer, S. K., Villasevil, E. M., Anderson, G. J., Cairns, A. G., Mullen, W. , Hartley, R. C. and Metcalfe, N. B. (2017) Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Scientific Reports, 7, 41228. (doi:10.1038/srep41228) (PMID:28117373) (PMCID:PMC5259740)
Cochemé, H.M. et al. (2012) Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nature Protocols, 7(5), pp. 946-958. (doi:10.1038/nprot.2012.035) (PMID:22517261)
Cochemé, H.M. et al. (2011) Measurement of H2O2 within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism, 13(3), pp. 340-350. (doi:10.1016/j.cmet.2011.02.003) (PMID:21356523) (PMCID:PMC4413513)
Chalmers, S., Caldwell, S. T., Quin, C., Prime, T. A., James, A. M., Cairns, A. G., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi:10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)
Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine, 89, pp. 883-894. (doi:10.1016/j.freeradbiomed.2015.08.021) (PMID:26454075)
Cairns, A. G., Senn, H. M. , Murphy, M. P. and Hartley, R. C. (2014) Expanding the palette of phenanthridinium cations. Chemistry: A European Journal, 20(13), pp. 3742-3751. (doi:10.1002/chem.201304241) (PMID:24677631) (PMCID:PMC4164275)
Chouchani, E. T. et al. (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine, 19(6), pp. 753-759. (doi:10.1038/nm.3212) (PMID:23708290) (PMCID:PMC4019998)
- Level-3 Mechanistic Organic Chemistry
- Level-4 Chemical Biology
Professional activities & recognition
- 2019: Journal of the Royal Society Interface
Professional & learned societies
- 2018: Chemistry Biology Interface Division Council Member, Royal Society of Chemistry
- Fellow, Royal Society of Chemistry
- Fellow of the Royal Society of Chemistry
- MA (Cantab), PhD.
- Wellcome Trust Investigator
Current and Recent Grants
- Exploring mitochondrial metabolism in health and disease using targeted biological chemistry. Wellcome Trust (WT110159AIA) £346,109 (RCH share: 100%). May 2016-Apr 2020.
- MitoWild ERC €2,445,129 (RCH share: 5.0%) (2021-2026).
- “Why do fish fail at high temperatures?” NERC NE/R001510/1£523,409 (RCH share: 10.0%). Feb 2018-Jan 2021
- Thiol Modification and Redox Signalling, MRC Discovery Award. £581,581(RCH share:£173k). Mar 2016-Apr 2018
- The Ecology of Metabolic Phenotypes: From Cells to Populations. ERC £1,701,874 (RCH share: 10.0%), (Dates: May 2013 – April 2018).
External Appointments & Positions
- External Examiner of Undergraduate Degrees (Chemistry), University of Aberdeen
- Elected Member of the Chemistry Biology Interface Division Council (RSC)
- Member of Editorial Board of Journal of the Royal Society Interface
- EPSRC College Member.
Other Notable Achievements
- Originator of ‘Protection Hypothesis’ in behavioural ecology in seminal paper: Are Carotenoids a Red Herring in Sexual Display.
- Spin out company (Antoxis, see http://www.antoxis.com/): I provided its starting research basis by invention of its lead compound, ProxisonTM(WO 2004/007475)
- First and currently best probe for quantify hydrogen peroxide in the mitochondria of living organisms (MitoB)