Professor Richard Hartley
- Professor of Chemical Biology (School of Chemistry)
- Dean of Graduate Studies (Science & Engineering College Senior Management)
Professor Richard Hartley is a chemical biologist. The Hartley group uses synthetic organic chemistry to unlock the secrets of biology and treat disease. He is an expert in the chemistry that occurs in mitochondria and in redox signalling. His group is the chemical core of multidisiciplinary teams tackling the biggest problems in medicine. Professor Hartley has helped to pin down the cause of reperfusion injury in stroke, transplant and heart attack; to explain why resting metabolic rates vary naturally; to test the free radical theory of aging; and to explain how inflammation is switched off by the mitochondrial metabolite, itaconate. Profesor Hartley was the originator of the ‘Protection Hypothesis’ in behavioural ecology. The impact of his work is clear. Molecular probes developed in his lab are now marketed worldwide by Cayman Chemical and by other companies. These include MitoB and MitoParaquat. A spin out company, Antoxis, arose from his research.
- Molecular Probes
- Reactive oxygen species (ROS)
- Prodrugs and Photoactivatable compounds
- Redox signalling
- Publons:ResearcherID E-3489-2010
- Booty, L. M. et al. (2019) Selective disruption of mitochondrial thiol redox state in cells and in vivo.Cell Chemical Biology, 26(3), 449-461.e8. (doi:10.1016/j.chembiol.2018.12.002)(PMID:30713096)(PMCID:PMC6436940)
- Mills, E. L. et al. (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.Nature, 5556, pp. 113-117. (doi:10.1038/nature25986)(PMID:29590092)
- Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.Free Radical Biology and Medicine, 89, pp. 883-894. (doi:10.1016/j.freeradbiomed.2015.08.021)(PMID:26454075)
- Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Nature, 515(7527), pp. 431-435. (doi:10.1038/nature13909)(PMID:25383517)(PMCID:PMC4255242)
- Chalmers, S., Caldwell, S. T., Quin, C., Prime, T. A., James, A. M., Cairns, A. G., Murphy, M. P., McCarron, J. G.and Hartley, R. C.(2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore.Journal of the American Chemical Society, 134(2), pp. 758-761. (doi:10.1021/ja2077922)(PMID:22239373)(PMCID:PMC3260739)
- Cochemé, H.M. et al. (2011) Measurement of H2O2within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.Cell Metabolism, 13(3), pp. 340-350. (doi:10.1016/j.cmet.2011.02.003)(PMID:21356523)(PMCID:PMC4413513)
Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 515(7527), pp. 431-435. (doi: 10.1038/nature13909) (PMID:25383517) (PMCID:PMC4255242)
Salin, K. , Auer, S. K. , Villasevil, E. M. , Anderson, G. J. , Cairns, A. G. , Mullen, W. , Hartley, R. C. and Metcalfe, N. B. (2017) Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Scientific Reports, 7, 41228. (doi: 10.1038/srep41228) (PMID:28117373) (PMCID:PMC5259740)
Cochemé, H.M. et al. (2012) Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nature Protocols, 7(5), pp. 946-958. (doi: 10.1038/nprot.2012.035) (PMID:22517261)
Cochemé, H.M. et al. (2011) Measurement of H2O2 within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism, 13(3), pp. 340-350. (doi: 10.1016/j.cmet.2011.02.003) (PMID:21356523) (PMCID:PMC4413513)
Chalmers, S. , Caldwell, S. T. , Quin, C. , Prime, T. A. , James, A. M. , Cairns, A. G. , Murphy, M. P. , McCarron, J. G. and Hartley, R. C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi: 10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)
Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine, 89, pp. 883-894. (doi: 10.1016/j.freeradbiomed.2015.08.021) (PMID:26454075)
Cairns, A. G. , Senn, H. M. , Murphy, M. P. and Hartley, R. C. (2014) Expanding the palette of phenanthridinium cations. Chemistry: A European Journal, 20(13), pp. 3742-3751. (doi: 10.1002/chem.201304241) (PMID:24677631) (PMCID:PMC4164275)
Chouchani, E. T. et al. (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine, 19(6), pp. 753-759. (doi: 10.1038/nm.3212) (PMID:23708290) (PMCID:PMC4019998)
Careers of PhDs from group by year of award
Dr Alistair P. Rutherford - Alistair went on to do a post-doc with Dr (now Prof.) Alan Armstrong at the University of Nottingham and Imperial College London. He has worked as a medicinal chemist in Vertex Pharmaceuticals (Oxford, UK) since 2000.
Dr Cameron S. Gibb - Cameron worked for Oxford Asymmetry before moving to Albany Molecular Research (NY, USA) in 2001, where he was a Group Leader in Chemical Development. Cameron is now Global Active Ingredient Technology Manager at Arysta Life Science.
Dr Graeme D. McAllister - Graeme joined the group of Prof. Richard Taylor in York (UK) and after 2 years, became Experimental Officer of that research team. He continued his career in the Department of Chemistry at York, where he is now a Senior Research Technician and Microanalyst.
Dr Emma J. Guthrie - Emma worked at Air Products from 2001 to 2016. After a brief spell in the Netherlands, she spent four years in the Fuel Cell Energy Solutions group in Walton-on-Thames (UK), before applying her skills to marketing Food and Industrial Cryogenics applications. She was a Business Development Manager in the Hydrogen Energy group (those eco-friendly, hydrogen-powered buses in London are fuelled by Air Products). In 2016, Emma became Group Development Manager at IMCD N.V.
Dr Stuart T. Caldwell - After a short period with Syngenta at Grangemouth (Scotland), Stuart's interest in antioxidants and isotopic labelling brought him back to the Hartley group in June 2002. In 2007 he joined the Cooke group here at the University of Glasgow and then moved to the Bucher group. In January 2011 he rejoined the Hartley group to work on molecular probes and is the senior researcher in that group.
Dr Calum Macleod - Calum spent two years as a research chemist working in combinatorial chemistry at Adolor Corporation (Pennsylvania, USA) and then moved to Argenta Discovery Ltd (Harlow, UK). He is now Associate Director, Medicinal Chemistry, at Pharmaron.
Dr C. Andrew Woodland - Andrew worked as a synthetic organic chemist with BioFocus (Saffron Walden, UK) before moving to the University of Dundee where he is a medicinal chemist.
Dr Mairi Gibson (now Sime) - Mairi worked as a medicinal chemist with GSK (Harlow, UK) and then in May 2010 took up the post of Team Leader at the Beatson Institute for Cancer Research in Glasgow.
Dr Gordon J. McKiernan – After initially continuing in organic chemistry research including at Syngenta in Huddersfield and a spell as a brewer at the Elland brewery near Halifax, Gordon is now working in finance at Ernst and Young in Edinburgh.
Dr Neil Forrest - Neil began as a synthetic chemist at Peakdale Molecular (Chapel-en-le-Frith, UK) rising to the rank of Lead Chemist and combining this with Project Manager and Environmental officer. In 2013 he left Peakdale and returned to Scotland to take up his current post as a Product Owner at GSK, Montrose.
Dr Alison Hay (now Robinson) - Alison worked with Prof. Stuart Schreiber at Harvard University (Cambridge, USA), before taking up a medicinal chemistry in the University of Dundee. After periods at Research and Enterprise at the University of St Andrews and the University of Stirling, Alison returned to Glasgow worked as a Research Developer at the prestigious Glasgow School of Art, and is now a Strategic Research & Knowledge Exchange Manager at the University of Strathclyde.
Dr Christine Roberts (now Stewart-Liddon) - Christine worked in the group of Dr Mark Moloney at the University of Oxford, before joining Fujifilm in Manchester as a Research Chemist. She then moved back to Scotland to Grangemouth with the same company, and now works for Scaled Solutions Ltd in Livingston.
Dr Hanna Petersson (now Tvedten) - Hanna began as a Research Chemist in Synthesis group at Borregaard, Norway, before moving to Stravanger, where she is now Managing Director of Origo Process. Origo Process provide process services to operators and engineering companies mostly within the Oil and Gas Section, but also perform hazard process analysis for the pharmaceutical industry.
Dr Carolyn Austin - Carolyn joined Novartis production chemistry in Grimsby, and now works with the same company in Switzerland. Having spent some years in production, she is now Global Quality Lead CHAD DS Supply at Novartis, which involves technical research development.
Dr Louis Adriaenssens - Louis carried out postdoctoral research with Dr. Filip Teply in the Institute of Organic Chemistry and Biochemistry AS CR in Prague, and then moved to France and worked in Dijon with Profs Denat and Legendre. He then spent time with Prof. Pablo Ballester's co-workers at the Institut Catala de Investigacio Quimica in Taragonna, Spain. In 2015 he took up a Lectureship at the University of Lincoln, UK
Dr Calver Main - Calver was a Research and Development Scientist in Procter and Gamble working at its Brussels Innovation Centre in Belgium, and he then trained as a teacher. He began teaching at Merchiston in Edinburgh and is now Head of Chemistry at the Glasgow Academy.
Dr Ching Ching Chua - Ching is a researcher at Evotec.
Dr Caroline Quin - Caroline works for Procter and Gamble.
Dr Linsey Robertson - After a period in the Specialist Factual Department of BBC Scotland, Linsey worked for the Royal Society of Chemistry based at Edinburgh University. She then returned to the University of Glasgow, taking up the position of the Project Administrator for the Sensors Initiative.
Dr Guilaine Blanc - Guilaine is working with Lonza S.A. as a Chemist Project Leader in Braien L'Alleud.
Dr Adam Haahr - Adam began as a Clearing Analyst at Morgan Stanley and is now Senior Auditor at Audit Scotland.
Dr Stephen McQuaker - Stephen worked at Reckitt Benckiser as a Research and Development Assistant. He then was working as a Senior Process Development Chemist for Frutarom UK on Teeside, developing synthetic routes to manufacture flavour and fragrance chemicals. Before moving to his current position as a Synthetic Chemist for Arcinova in Alnwick, developing synthetic routes and the scale up manufacturing of APIs (mainly for phase I & II clinicals).
Dr Andrew Cairns - Andrew joined the research group of Prof. Fredrik Almqvist in Umea, Sweden, as a post-doctoral fellow. He worked at Yale in the group of Prof. Alanna Schepartz and is now at the University of Aberdeen.
Dr Justyna Gawel - Justyna was a post-doctoral fellow with Prof. Patrick Gunning at the University of Toronto Mississauga. She is now a Clinical Trial Coordinator for KCRI in Kraków.
Dr Maria Shchepinova - Masha is now working with Prof. Ed Tate at Imperial College London, as a post-doctoral fellow.
Dr Helmi Kreinin - Helmi Kreinin is now on the Teach First Programme.
Dr Sean O’Byrne (supervised for last two years of his PhD) – Sean is a Postdoctoral Researcher at University of North Carolina developing kinase inhibitors with the SGC.
Dr Lewis King - Lewis is a PDRA working on a joint project with Dr Lilach Sheiner and my group.
Dr Laura Pala – Laura is a Product Marketing Manager with Biosynth Carbosynth.
- Level-3 Mechanistic Organic Chemistry
- Level-4 Chemical Biology
Professional activities & recognition
- Journal of the Royal Society Interface
Professional & learned societies
- Fellow, Royal Society of Chemistry
- Fellow, Royal Society of Biology
- Chemistry Biology Interface Division Council Member, Royal Society of Chemistry
- Member, American Chemical Society
- Investigator, Wellcome Trust
- External Examiner of Undergraduate Degrees (Chemistry), University of Aberdeen
- College Member, EPSRC
Researcher ID http://www.researcherid.com/rid/E-3489-2010
- Exploring mitochondrial metabolism in health and disease using targeted biological chemistry Wellcome Trust (220257/B/20/Z) £803k (100%)
- Mitochondrial ROS mapping and control with sub-organellar resolution BB/T003804/1 £685k (35%). Jan 2020-Dec 2022.
- MitoWild ERC €2,445,129 (5%) (2021-2026).
- “Why do fish fail at high temperatures?” NERC NE/R001510/1£523,409 (10%). Feb 2018-Jan 2021.
- Exploring mitochondrial metabolism in health and disease using targeted biological chemistry. Wellcome Trust (110158/Z/15/Z) £346,109 (100%). May 2016-Apr 2020.
- Thiol Modification and Redox Signalling, MRC Discovery Award. £581,581 (RCH share: £173k). Mar 2016-Apr 2018
- The Ecology of Metabolic Phenotypes: From Cells to Populations. ERC £1,701,874 (10%), (Dates: May 2013 – April 2018).
- Originator of ‘Protection Hypothesis’ in behavioural ecology in seminal paper: Are Carotenoids a Red Herring in Sexual Display.
- Spin out company (Antoxis, see http://www.antoxis.com/): I provided its starting research basis by invention of its lead compound, ProxisonTM(WO 2004/007475)
- First and currently best probe for quantify hydrogen peroxide in the mitochondria of living organisms (MitoB)