Professor Richard Hartley

  • Professor of Chemical Biology (School of Chemistry)
  • Dean of Graduate Studies (Science & Engineering College Senior Management)

telephone: 01413304398
email: Richard.Hartley@glasgow.ac.uk

C403c C-wing Level 4, Joseph Black Building, University of Glasgow, Glasgow, G12 8qq

ORCID iDhttps://orcid.org/0000-0003-1033-5405

Research interests

Research Interests

Professor Richard Hartley is a chemical biologist. The Hartley group uses synthetic organic chemistry to unlock the secrets of biology and treat disease.  He is an expert in the chemistry that occurs in mitochondria and in redox signalling.  His group is the chemical core of multidisiciplinary teams tackling the biggest problems in medicine. Professor Hartley has helped to pin down the cause of reperfusion injury in stroke, transplant and heart attack; to explain why resting metabolic rates vary naturally; to test the free radical theory of aging; and to explain how inflammation is switched off by the mitochondrial metabolite, itaconate.  Profesor Hartley was the originator of the ‘Protection Hypothesis’ in behavioural ecology. The impact of his work is clear.  Molecular probes developed in his lab are now marketed worldwide by Cayman Chemical and by other companies. These include MitoB and MitoParaquat. A spin out company, Antoxis, arose from his research. 

Research Topics

  • Mitochondria
  • Molecular Probes
  • Reactive oxygen species (ROS)
  • Prodrugs and Photoactivatable compounds
  • Redox signalling

Publication Metrics

Publication Highlights

 

Richard Hartley research group photo May 2013 

Publications

Selected publications

Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 515(7527), pp. 431-435. (doi: 10.1038/nature13909) (PMID:25383517) (PMCID:PMC4255242)

Salin, K. , Auer, S. K. , Villasevil, E. M. , Anderson, G. J. , Cairns, A. G. , Mullen, W. , Hartley, R. C. and Metcalfe, N. B. (2017) Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Scientific Reports, 7, 41228. (doi: 10.1038/srep41228) (PMID:28117373) (PMCID:PMC5259740)

Cochemé, H.M. et al. (2012) Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nature Protocols, 7(5), pp. 946-958. (doi: 10.1038/nprot.2012.035) (PMID:22517261)

Cochemé, H.M. et al. (2011) Measurement of H2O2 within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism, 13(3), pp. 340-350. (doi: 10.1016/j.cmet.2011.02.003) (PMID:21356523) (PMCID:PMC4413513)

Chalmers, S. , Caldwell, S. T. , Quin, C. , Prime, T. A. , James, A. M. , Cairns, A. G. , Murphy, M. P. , McCarron, J. G. and Hartley, R. C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi: 10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)

Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine, 89, pp. 883-894. (doi: 10.1016/j.freeradbiomed.2015.08.021) (PMID:26454075)

Cairns, A. G. , Senn, H. M. , Murphy, M. P. and Hartley, R. C. (2014) Expanding the palette of phenanthridinium cations. Chemistry: A European Journal, 20(13), pp. 3742-3751. (doi: 10.1002/chem.201304241) (PMID:24677631) (PMCID:PMC4164275)

Chouchani, E. T. et al. (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine, 19(6), pp. 753-759. (doi: 10.1038/nm.3212) (PMID:23708290) (PMCID:PMC4019998)

All publications

List by: Type | Date

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Number of items: 82.

2020

Aggarwal, V. K. et al. (2020) Stuart Warren (24 Dec 1938–22 Mar 2020). Organic and Biomolecular Chemistry, (doi: 10.1039/D0OB90121K) (PMID:32936190) (Early Online Publication)

Pala, L. , Senn, H. M. , Caldwell, S. T. , Prime, T. A. , Warrington, S. , Bright, T. P. , Prag, H. A. , Wilson, C. , Murphy, M. and Hartley, R. C. (2020) Enhancing the mitochondrial uptake of phosphonium cations by carboxylic acid incorporation. Frontiers in Chemistry, 8, 783. (doi: 10.3389/fchem.2020.00783)

Beach, T. E. et al. (2020) Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury. Redox Biology, 36, 101640. (doi: 10.1016/j.redox.2020.101640)

Chowdhury, A. R. , Zielonka, J. , Kalyanaraman, B. , Hartley, R. C. , Murphy, M. P. and Avadhani, N. G. (2020) Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: a dose-dependent phenomenon. Redox Biology, 36, 101606. (doi: 10.1016/j.redox.2020.101606)

Prag, H. A. , Kula-Alwar, D. , Pala, L. , Caldwell, S. T. , Beach, T. E. , James, A. M. , Saeb-Parsy, K. , Krieg, T. , Hartley, R. C. and Murphy, M. P. (2020) Selective delivery of dicarboxylates to mitochondria by conjugation to a lipophilic cation via a cleavable linker. Molecular Pharmaceutics, (doi: 10.1021/acs.molpharmaceut.0c00533) (Early Online Publication)

Prag, H. A. et al. (2020) Ester prodrugs of malonate with enhanced intracellular delivery protect against cardiac ischemia-reperfusion injury in vivo. Cardiovascular Drugs and Therapy, (doi: 10.1007/s10557-020-07033-6) (PMID:32648168) (Early Online Publication)

Burger, N. , Logan, A. , Prime, T. A. , Mottahedin, A. , Caldwell, S. T. , Krieg, T. , Hartley, R. C. , James, A. M. and Murphy, M. P. (2020) A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. Free Radical Biology and Medicine, 147, pp. 37-47. (doi: 10.1016/j.freeradbiomed.2019.11.028) (PMID:31811922) (PMCID:PMC6975167)

2019

Tate, M. et al. (2019) The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide, is cardioprotective in the diabetic heart. Cardiovascular Drugs and Therapy, 33, pp. 669-674. (doi: 10.1007/s10557-019-06929-2) (PMID:31654171) (PMCID:PMC6994445)

Martin, J. et al. (2019) Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation. Nature Metabolism, 1(10), pp. 966-974. (doi: 10.1038/s42255-019-0115-y)

Lim, P. J. et al. (2019) Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nature Metabolism, 1, pp. 519-531. (doi: 10.1038/s42255-019-0063-6) (PMID:31276102)

Antonucci, S. et al. (2019) Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. Free Radical Biology and Medicine, 134, pp. 678-687. (doi: 10.1016/j.freeradbiomed.2019.01.034) (PMID:30731114)

Booty, L. M. et al. (2019) Selective disruption of mitochondrial thiol redox state in cells and in vivo. Cell Chemical Biology, 26(3), 449-461.e8. (doi: 10.1016/j.chembiol.2018.12.002) (PMID:30713096) (PMCID:PMC6436940)

Pinho, B. R. , Reis, S. D. , Hartley, R. C. , Murphy, M. P. and Oliveira, J. M.A. (2019) Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Free Radical Biology and Medicine, 130, pp. 318-327. (doi: 10.1016/j.freeradbiomed.2018.10.446) (PMID:30389496) (PMCID:PMC6340810)

Lau, G. Y. , Barts, N. , Hartley, R. C. , Tobler, M. , Richards, J. G. , Murphy, M. P. and Arndt, S. (2019) Detection of changes in mitochondrial hydrogen sulfide (H2S) in vivo in the fish model Poecilia mexicana (Poeciliidae). Biology Open, 8, bio041467. (doi: 10.1242/bio.041467) (PMID:31072908) (PMCID:PMC6550084)

2018

Murphy, M. P. and Hartley, R. C. (2018) Mitochondria as a therapeutic target for common pathologies. Nature Reviews Drug Discovery, 17, pp. 865-886. (doi: 10.1038/nrd.2018.174) (PMID:30393373)

Salin, K. , Villasevil, E. M. , Anderson, G. J. , Auer, S. K. , Selman, C. , Hartley, R. C. , Mullen, W. , Chinopoulos, C. and Metcalfe, N. B. (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Functional Ecology, 32(9), pp. 2149-2157. (doi: 10.1111/1365-2435.13125) (PMID:30333678) (PMCID:PMC6175143)

De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)

Guthrie, S. , Jensen, T. , Hartley, R. C. , Ramaesh, K. and Lockington, D. (2018) Assessing the accuracy of intracameral phenylephrine preparation in cataract surgery. Eye, 32, pp. 1615-1620. (doi: 10.1038/s41433-018-0143-y) (PMID:29907787)

Fazakerley, D. J. et al. (2018) Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), pp. 7315-7328. (doi: 10.1074/jbc.RA117.001254) (PMID:29599292) (PMCID:PMC5950018)

Mills, E. L. et al. (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 5556, pp. 113-117. (doi: 10.1038/nature25986) (PMID:29590092)

Cao, Z. , Mitchell, L. , Hsia, O. , Scarpa, M. , Caldwell, S. T. , Alfred, A. D. , Gennaris, A. , Collet, J.-F. , Hartley, R. C. and Bulleid, N. J. (2018) Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase. Biochemical Journal, 475, pp. 827-838. (doi: 10.1042/BCJ20170929) (PMID:29420254) (PMCID:PMC6488974)

2017

Shchepinova, M. M. et al. (2017) MitoNeoD: a mitochondria-targeted superoxide probe. Cell Chemical Biology, 24(10), 1285-1298.e12. (doi: 10.1016/j.chembiol.2017.08.003) (PMID:28890317) (PMCID:PMC6278870)

Pawellek, A. , Ryder, U. , Tammsalu, T. , King, L. J. , Kreinin, H. , Ly, T. , Hay, R. T. , Hartley, R. and Lamond, A. I. (2017) Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. eLife, 6, e27402. (doi: 10.7554/eLife.27402) (PMID:28884683)

Arndt, S. et al. (2017) Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA. Journal of Biological Chemistry, 292(19), pp. 7761-7773. (doi: 10.1074/jbc.M117.784678) (PMID:28320864) (PMCID:PMC5427258)

Salin, K. , Auer, S. K. , Villasevil, E. M. , Anderson, G. J. , Cairns, A. G. , Mullen, W. , Hartley, R. C. and Metcalfe, N. B. (2017) Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Scientific Reports, 7, 41228. (doi: 10.1038/srep41228) (PMID:28117373) (PMCID:PMC5259740)

2016

Buskiewicz, I. A. et al. (2016) Reactive oxygen species induce virus-independent MAVS-oligomerization in systemic lupus erythematosus. Science Signaling, 9(456), ra115. (doi: 10.1126/scisignal.aaf1933) (PMID:27899525)

McGarry, D. J. , Shchepinova, M. M. , Lillla, S. , Hartley, R. C. and Olson, M. F. (2016) A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids. ACS Chemical Biology, 11(12), pp. 3300-3304. (doi: 10.1021/acschembio.6b00742) (PMID:27792307)

2015

Caldwell, S. T. , Cairns, A. G. , Olson, M. , Chalmers, S. , Sandison, M. , Mullen, W. , McCarron, J. G. and Hartley, R. C. (2015) Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Tetrahedron, 71(51), pp. 9571-9578. (doi: 10.1016/j.tet.2015.10.052) (PMID:26709317) (PMCID:PMC4660056)

Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine, 89, pp. 883-894. (doi: 10.1016/j.freeradbiomed.2015.08.021) (PMID:26454075)

Salin, K. , Auer, S. k. , Rudolf, A. M. , Anderson, G. J. , Cairns, A. G. , Mullen, W. , Hartley, R. C. , Selman, C. and Metcalfe, N. B. (2015) Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo. Biology Letters, 11(9), 20150538. (doi: 10.1098/rsbl.2015.0538) (PMID:26382073)

Cairns, A. G. , McQuaker, S. J. , Murphy, M. P. and Hartley, R. C. (2015) Targeting mitochondria with small molecules: the preparation of MitoB and MitoP as exomarkers of mitochondrial hydrogen peroxide. In: Weissig, V. and Edeas, M. (eds.) Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function. Series: Methods in Molecular Biology, 1265. Springer New York, pp. 25-50. ISBN 9781493922871 (doi:10.1007/978-1-4939-2288-8_3)

2014

Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 515(7527), pp. 431-435. (doi: 10.1038/nature13909) (PMID:25383517) (PMCID:PMC4255242)

Logan, A. , Shabalina, I. G. , Prime, T. A. , Rogatti, S. , Kalinovich, A. V. , Hartley, R. C. , Budd, R. C. , Cannon, B. and Murphy, M. P. (2014) In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell, 13(4), pp. 765-768. (doi: 10.1111/acel.12212) (PMID:24621297) (PMCID:PMC4326952)

Cairns, A. G. , Senn, H. M. , Murphy, M. P. and Hartley, R. C. (2014) Expanding the palette of phenanthridinium cations. Chemistry: A European Journal, 20(13), pp. 3742-3751. (doi: 10.1002/chem.201304241) (PMID:24677631) (PMCID:PMC4164275)

Li Pun, P. B. et al. (2014) A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radical Biology and Medicine, 67, pp. 437-450. (doi: 10.1016/j.freeradbiomed.2013.11.025) (PMID:24316194) (PMCID:PMC3978666)

Logan, A. et al. (2014) Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica et Biophysica Acta: General Subjects, 1840(2), pp. 923-930. (doi: 10.1016/j.bbagen.2013.05.026) (PMID:23726990)

2013

McQuaker, S. J. , Quinlan, C. L. , Caldwell, S. T. , Brand, M. D. and Hartley, R. C. (2013) A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production. ChemBioChem, 14(8), pp. 993-1000. (doi: 10.1002/cbic.201300115) (PMID:23640856) (PMCID:PMC3743171)

Chouchani, E. T. et al. (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine, 19(6), pp. 753-759. (doi: 10.1038/nm.3212) (PMID:23708290) (PMCID:PMC4019998)

Sikora, A. , Zielonka, J. , Adamus, J. , Debski, D. , Dybala-Defratyka, A. , Michalowski, B. , Joseph, J. , Hartley, R.C. , Murphy, M.P. and Kalyanaraman, B. (2013) Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. Chemical Research in Toxicology, 26(6), pp. 856-867. (doi: 10.1021/tx300499c) (PMID:23611338) (PMCID:PMC3700382)

2012

Harvey, A. L. , Young, L. C. , Kornisiuk, E. , Snitcofsky, M. , Colettis, N. , Blanco, C. , Jerusalinsky, D. , Jamieson, A. G. , Hartley, R. C. and Stone, T. W. (2012) A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance. Behavioural Brain Research, 234(2), pp. 184-191. (doi: 10.1016/j.bbr.2012.06.023)

Smith, R.A.J. , Hartley, R.C. , Cochemé, H.M. and Murphy, M.P. (2012) Mitochondrial pharmacology. Trends in Pharmacological Sciences, 33(6), pp. 341-352. (doi: 10.1016/j.tips.2012.03.010) (PMID:22521106)

Cochemé, H.M. et al. (2012) Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nature Protocols, 7(5), pp. 946-958. (doi: 10.1038/nprot.2012.035) (PMID:22517261)

Caldwell, S.T. , McPhail, D.B. , Duthie, G.D. and Hartley, R.C. (2012) Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants. Canadian Journal of Chemistry = Journal canadien de chimie, 90(1), pp. 23-33. (doi: 10.1139/V11-087)

Chalmers, S. , Caldwell, S. T. , Quin, C. , Prime, T. A. , James, A. M. , Cairns, A. G. , Murphy, M. P. , McCarron, J. G. and Hartley, R. C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi: 10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)

Omar, M.H. , Mullen, W. , Stalmach, A. , Auger, C. , Rouanet, J.-M. , Teissedre, P.-L. , Caldwell, S.T. , Hartley, R.C. and Crozier, A. (2012) Absorption, disposition, metabolism, and excretion of [3-14C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)

2011

Smith, R. A.J. , Hartley, R. C. and Murphy, M. P. (2011) Mitochondria-targeted small molecule therapeutics and probes. Antioxidants and Redox Signaling, 15(12), pp. 3021-3038. (doi: 10.1089/ars.2011.3969) (PMID:21395490)

Figlus, M. , Wellaway, N. , Cooper, A.W.J. , Sollis, S.L. and Hartley, R.C. (2011) Synthesis of arrays using low molecular weight MPEG-assisted Mitsunobu reaction. ACS Combinatorial Science, 13(3), pp. 280-285. (doi: 10.1021/co100091n)

Cochemé, H.M. et al. (2011) Measurement of H2O2 within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism, 13(3), pp. 340-350. (doi: 10.1016/j.cmet.2011.02.003) (PMID:21356523) (PMCID:PMC4413513)

Haahr, A. , Rankovic, Z. and Hartley, R. (2011) A one-pot procedure for methylenating carbonyl compounds using the Nysted reagent and titanocene dichloride. Tetrahedron Letters, 52(23), pp. 3020-3022. (doi: 10.1016/j.tetlet.2011.04.017)

2010

Quin, C., Robertson, L., McQuaker, S.J., Price, N.C., Brand, M.D. and Hartley, R.C. (2010) Caged mitochondrial uncouplers that are released in response to hydrogen peroxide. Tetrahedron, 66(13), pp. 2384-2389. (doi: 10.1016/j.tet.2010.01.103) (PMID:20418941) (PMCID:PMC2852674)

Figlus, M., Tarruella, A.C., Messer, A., Sollis, S.L. and Hartley, R.C. (2010) Low molecular weight MPEG-assisted organic synthesis. Chemical Communications, 46(24), pp. 4405-4407. (doi: 10.1039/c0cc00415d)

2009

Quin, C., Trnka, J., Hay, A., Murphy, M.P. and Hartley, R.C. (2009) Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization. Tetrahedron, 65(39), pp. 8154-8160. (doi: 10.1016/j.tet.2009.07.081) (PMID:19888470) (PMCID:PMC2767131)

Robertson, L. and Hartley, R. C. (2009) Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants. Tetrahedron, 65(27), pp. 5284-5292. (doi: 10.1016/j.tet.2009.04.083) (PMID:19693262) (PMCID:PMC2722452)

El Fangour, S. , Marini, M. , Good, J. , McQuaker, S.J. , Shiels, P.G. and Hartley, R.C. (2009) Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi: 10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

2008

Main, C.A. , Rahman, S.S. and Hartley, R.C. (2008) Synthesis of spiroacetals using functionalised titanium carbenoids. Tetrahedron Letters, 49(32), pp. 4771-4774. (doi: 10.1016/j.tetlet.2008.05.094)

Main, C.A. , Petersson, H.M. , Rahman, S.S. and Hartley, R.C. (2008) High throughput synthesis of 2,5-substituted indoles using a titanium carbenoid bearing boronate functionality. Tetrahedron, 64(5), pp. 901-914. (doi: 10.1016/j.tet.2007.08.119)

Mullen, W. , Rouanet, J.-M. , Auger, C. , Teissèdre, P.-L. , Caldwell, S.T. , Hartley, R.C. , Lean, M.E.J. , Edwards, C.A. and Crozier, A. (2008) Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)

2007

Caldwell, S. T. , Quin, C. , Edge, R. and Hartley, R. C. (2007) A dual sensor spin trap for use with EPR spectroscopy. Organic Letters, 9(18), pp. 3499-3502. (doi: 10.1021/ol071285o)

Adriaenssens, L. V. and Hartley, R. C. (2007) beta-amino acids to piperidinones by petasis methylenation and acid-induced cyclization. Journal of Organic Chemistry, 72(26), pp. 10287-10290. (doi: 10.1021/jo7019948)

Austin, C. , Smith, D. and Hartley, R. (2007) Solid-phase synthesis of cyclic imines - potential for radiolabelling. Journal of Labelled Compounds and Radiopharmaceuticals, 50, pp. 502-503. (doi: 10.1002/jlcr.1224)

Farrugia, L. , Hartley, R. , Calver, A. and Rahman, S. (2007) 5-Bromoanthranil. Acta Crystallographica. Section E: Structure Reports Online, 63, O2540-O2541. (doi: 10.1107/S1600536807017278)

Hartley, R. , Li, J. , Main, C. and McKiernan, G. (2007) Titanium carbenoid reagents for converting carbonyl groups into alkenes. Tetrahedron, 63, pp. 4825-4864. (doi: 10.1016/j.tet.2007.03.015)

2006

Adriaenssens, L. , Austin, C. , Gibson, M. , Smith, D. and Hartley, R. (2006) Stereodivergent diversity oriented synthesis of piperidine alkaloids. European Journal of Organic Chemistry, pp. 4998-5001. (doi: 10.1002/ejoc.200600744)

Caldwell, S., Petersson, H., Farrugia, L., Mullen, W., Crozier, A. and Hartley, R. (2006) Isotopic labelling of quercetin 3-glucoside. Tetrahedron, 62, pp. 7257-7265. (doi: 10.1016/j.tet.2006.05.046)

Sklavounou, E. , Hay, A. , Ashraf, N. , Lamb, K. , Brown, E. , Mac Intyre, A. , George, W.D. , Hartley, R.C. and Shiels, P.G. (2006) The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochemical and Biophysical Research Communications, 347, pp. 420-427. (doi: 10.1016/j.bbrc.2006.06.087)

2005

Graf, B., Mullen, W., Caldwell, S., Hartley, R., Duthie, G., Lean, M., Crozier, A. and Edwards, C. (2005) Disposition and metabolism of [2-C-14]quercetin-4 '-glucoside in rats. Drug Metabolism and Disposition, 33, pp. 1036-1043. (doi: 10.1124/dmd.104.002691)

Hay, A. , Burkitt, M. , Jones, C. and Hartley, R. (2005) Development of a new EPR spin trap, DOD-8C (N-[4-dodecyloxy-2-(7'-carboxyhept-1'-yloxy) benzylidene]-N-tert-butylamine N-oxide), for the trapping of lipid radicals at a predetermined depth within biological membranes. Archives of Biochemistry and Biophysics, 435, pp. 336-346. (doi: 10.1016/j.abb.2004.12.030)

2004

Bennett, C. , Caldwell, S. , McPhail, D. , Morrice, P. , Duthie, G. and Hartley, R. (2004) Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorganic and Medicinal Chemistry, 12, pp. 2079-2098. (doi: 10.1016/j.bmc.2004.02.031)

Macleod, C. , Austin, C. , Hamprecht, D. and Hartley, R. (2004) Preparation of quinolines from resin-bound esters using titanium reagents. Tetrahedron Letters, 45, pp. 8879-8882. (doi: 10.1016/j.tetlet.2004.09.170)

Roberts, C. and Hartley, R. (2004) Titanium reagents for the synthesis of 2-substituted benzo[b]thiophenes on the solid phase. Journal of Organic Chemistry, 69, pp. 6145-6148. (doi: 10.1021/jo049344o)

Woodland, C. , Crawley, G. and Hartley, R. (2004) Stereoselectivity in the anionic oxy-Cope rearrangement of acyclic vinyl sulfides. Tetrahedron Letters, 45, pp. 1227-1231. (doi: 10.1016/j.tetlet.2003.11.132)

2003

Gibson, M. , Goodman, J. , Farrugia, L. and Hartley, R. (2003) Controlling neighbouring group participation from thioacetals. Tetrahedron Letters, 44, pp. 2841-2844. (doi: 10.1016/S0040-4039(03)00440-4)

Macleod, C. , McKiernan, G. , Guthrie, E. , Farrugia, L. , Hamprecht, D. , Macritchie, J. and Hartley, R. (2003) Synthesis of 2-substituted benzofurans and Indoles using functionalized titanium benzylidene reagents on solid phase. Journal of Organic Chemistry, 68, pp. 387-401. (doi: 10.1021/jo026384o)

McKiernan, G. and Hartley, R. (2003) Boronate titanium alkylidene reagents for diversity-based synthesis of benzofurans. Organic Letters, 5, pp. 4389-4392. (doi: 10.1021/ol035677g)

McPhail, D. , Hartley, R. , Gardner, P. and Duthie, G. (2003) Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. Journal of Agricultural and Food Chemistry, 51, pp. 1684-1690. (doi: 10.1021/jf025922v)

Mullen, W., Hartley, R. and Crozier, A. (2003) Detection and identification of C-14-labelled flavonol metabolites by high-performance liquid chromatography-radiocounting and tandem mass spectrometry. Journal of Chromatography A, 1007, pp. 21-29. (doi: 10.1016/S0021-9673(03)00882-3)

2002

Hartley, R.C. and McKiernan, G.J. (2002) Titanium reagents for the alkylidenation of carboxylic acid and carbonic acid derivatives. Journal of the Chemical Society: Perkin Transactions 1, pp. 2763-2793. (doi: 10.1039/b009709h)

Macleod, C. , Hartley, R.C. and Hamprecht, D.W. (2002) Novel functionalized titanium(IV) benzylidenes for the traceless solid-phase synthesis of indoles. Organic Letters, 4, pp. 75-78. (doi: 10.1021/ol016924o)

Mullen, W., Graf, B., Caldwell, S., Hartley, R., Duthie, G., Edwards, C., Lean, M. and Crozier, A. (2002) Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-C-14]quercetin-4' glucoside. Journal of Agricultural and Food Chemistry, 50, pp. 6902-6909. (doi: 10.1021/jf020598p)

2001

Rutherford, A.P. , Gibb, C.S. , Hartley, R.C. and Goodman, J.M. (2001) Stereocontrol in a one-pot procedure for anionic oxy-Cope rearrangement followed by intramolecular aldol reaction. Journal of the Chemical Society: Perkin Transactions 1, pp. 1051-1061. (doi: 10.1039/b010138i)

2000

Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)

Hartley, R. C. and Caldwell, S. T. (2000) Novel methods for the synthesis of three-, four-, five-, six- and seven-membered, saturated and partially unsaturated carbocycles. Journal of the Chemical Society: Perkin Transactions 1, 1(4), pp. 477-501. (doi: 10.1039/A804421J)

This list was generated on Wed Sep 23 21:31:46 2020 BST.
Number of items: 82.

Articles

Aggarwal, V. K. et al. (2020) Stuart Warren (24 Dec 1938–22 Mar 2020). Organic and Biomolecular Chemistry, (doi: 10.1039/D0OB90121K) (PMID:32936190) (Early Online Publication)

Pala, L. , Senn, H. M. , Caldwell, S. T. , Prime, T. A. , Warrington, S. , Bright, T. P. , Prag, H. A. , Wilson, C. , Murphy, M. and Hartley, R. C. (2020) Enhancing the mitochondrial uptake of phosphonium cations by carboxylic acid incorporation. Frontiers in Chemistry, 8, 783. (doi: 10.3389/fchem.2020.00783)

Beach, T. E. et al. (2020) Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury. Redox Biology, 36, 101640. (doi: 10.1016/j.redox.2020.101640)

Chowdhury, A. R. , Zielonka, J. , Kalyanaraman, B. , Hartley, R. C. , Murphy, M. P. and Avadhani, N. G. (2020) Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: a dose-dependent phenomenon. Redox Biology, 36, 101606. (doi: 10.1016/j.redox.2020.101606)

Prag, H. A. , Kula-Alwar, D. , Pala, L. , Caldwell, S. T. , Beach, T. E. , James, A. M. , Saeb-Parsy, K. , Krieg, T. , Hartley, R. C. and Murphy, M. P. (2020) Selective delivery of dicarboxylates to mitochondria by conjugation to a lipophilic cation via a cleavable linker. Molecular Pharmaceutics, (doi: 10.1021/acs.molpharmaceut.0c00533) (Early Online Publication)

Prag, H. A. et al. (2020) Ester prodrugs of malonate with enhanced intracellular delivery protect against cardiac ischemia-reperfusion injury in vivo. Cardiovascular Drugs and Therapy, (doi: 10.1007/s10557-020-07033-6) (PMID:32648168) (Early Online Publication)

Burger, N. , Logan, A. , Prime, T. A. , Mottahedin, A. , Caldwell, S. T. , Krieg, T. , Hartley, R. C. , James, A. M. and Murphy, M. P. (2020) A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. Free Radical Biology and Medicine, 147, pp. 37-47. (doi: 10.1016/j.freeradbiomed.2019.11.028) (PMID:31811922) (PMCID:PMC6975167)

Tate, M. et al. (2019) The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide, is cardioprotective in the diabetic heart. Cardiovascular Drugs and Therapy, 33, pp. 669-674. (doi: 10.1007/s10557-019-06929-2) (PMID:31654171) (PMCID:PMC6994445)

Martin, J. et al. (2019) Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation. Nature Metabolism, 1(10), pp. 966-974. (doi: 10.1038/s42255-019-0115-y)

Lim, P. J. et al. (2019) Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nature Metabolism, 1, pp. 519-531. (doi: 10.1038/s42255-019-0063-6) (PMID:31276102)

Antonucci, S. et al. (2019) Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. Free Radical Biology and Medicine, 134, pp. 678-687. (doi: 10.1016/j.freeradbiomed.2019.01.034) (PMID:30731114)

Booty, L. M. et al. (2019) Selective disruption of mitochondrial thiol redox state in cells and in vivo. Cell Chemical Biology, 26(3), 449-461.e8. (doi: 10.1016/j.chembiol.2018.12.002) (PMID:30713096) (PMCID:PMC6436940)

Pinho, B. R. , Reis, S. D. , Hartley, R. C. , Murphy, M. P. and Oliveira, J. M.A. (2019) Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Free Radical Biology and Medicine, 130, pp. 318-327. (doi: 10.1016/j.freeradbiomed.2018.10.446) (PMID:30389496) (PMCID:PMC6340810)

Lau, G. Y. , Barts, N. , Hartley, R. C. , Tobler, M. , Richards, J. G. , Murphy, M. P. and Arndt, S. (2019) Detection of changes in mitochondrial hydrogen sulfide (H2S) in vivo in the fish model Poecilia mexicana (Poeciliidae). Biology Open, 8, bio041467. (doi: 10.1242/bio.041467) (PMID:31072908) (PMCID:PMC6550084)

Murphy, M. P. and Hartley, R. C. (2018) Mitochondria as a therapeutic target for common pathologies. Nature Reviews Drug Discovery, 17, pp. 865-886. (doi: 10.1038/nrd.2018.174) (PMID:30393373)

Salin, K. , Villasevil, E. M. , Anderson, G. J. , Auer, S. K. , Selman, C. , Hartley, R. C. , Mullen, W. , Chinopoulos, C. and Metcalfe, N. B. (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Functional Ecology, 32(9), pp. 2149-2157. (doi: 10.1111/1365-2435.13125) (PMID:30333678) (PMCID:PMC6175143)

De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)

Guthrie, S. , Jensen, T. , Hartley, R. C. , Ramaesh, K. and Lockington, D. (2018) Assessing the accuracy of intracameral phenylephrine preparation in cataract surgery. Eye, 32, pp. 1615-1620. (doi: 10.1038/s41433-018-0143-y) (PMID:29907787)

Fazakerley, D. J. et al. (2018) Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), pp. 7315-7328. (doi: 10.1074/jbc.RA117.001254) (PMID:29599292) (PMCID:PMC5950018)

Mills, E. L. et al. (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 5556, pp. 113-117. (doi: 10.1038/nature25986) (PMID:29590092)

Cao, Z. , Mitchell, L. , Hsia, O. , Scarpa, M. , Caldwell, S. T. , Alfred, A. D. , Gennaris, A. , Collet, J.-F. , Hartley, R. C. and Bulleid, N. J. (2018) Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase. Biochemical Journal, 475, pp. 827-838. (doi: 10.1042/BCJ20170929) (PMID:29420254) (PMCID:PMC6488974)

Shchepinova, M. M. et al. (2017) MitoNeoD: a mitochondria-targeted superoxide probe. Cell Chemical Biology, 24(10), 1285-1298.e12. (doi: 10.1016/j.chembiol.2017.08.003) (PMID:28890317) (PMCID:PMC6278870)

Pawellek, A. , Ryder, U. , Tammsalu, T. , King, L. J. , Kreinin, H. , Ly, T. , Hay, R. T. , Hartley, R. and Lamond, A. I. (2017) Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. eLife, 6, e27402. (doi: 10.7554/eLife.27402) (PMID:28884683)

Arndt, S. et al. (2017) Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA. Journal of Biological Chemistry, 292(19), pp. 7761-7773. (doi: 10.1074/jbc.M117.784678) (PMID:28320864) (PMCID:PMC5427258)

Salin, K. , Auer, S. K. , Villasevil, E. M. , Anderson, G. J. , Cairns, A. G. , Mullen, W. , Hartley, R. C. and Metcalfe, N. B. (2017) Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Scientific Reports, 7, 41228. (doi: 10.1038/srep41228) (PMID:28117373) (PMCID:PMC5259740)

Buskiewicz, I. A. et al. (2016) Reactive oxygen species induce virus-independent MAVS-oligomerization in systemic lupus erythematosus. Science Signaling, 9(456), ra115. (doi: 10.1126/scisignal.aaf1933) (PMID:27899525)

McGarry, D. J. , Shchepinova, M. M. , Lillla, S. , Hartley, R. C. and Olson, M. F. (2016) A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids. ACS Chemical Biology, 11(12), pp. 3300-3304. (doi: 10.1021/acschembio.6b00742) (PMID:27792307)

Caldwell, S. T. , Cairns, A. G. , Olson, M. , Chalmers, S. , Sandison, M. , Mullen, W. , McCarron, J. G. and Hartley, R. C. (2015) Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Tetrahedron, 71(51), pp. 9571-9578. (doi: 10.1016/j.tet.2015.10.052) (PMID:26709317) (PMCID:PMC4660056)

Robb, E. L. et al. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine, 89, pp. 883-894. (doi: 10.1016/j.freeradbiomed.2015.08.021) (PMID:26454075)

Salin, K. , Auer, S. k. , Rudolf, A. M. , Anderson, G. J. , Cairns, A. G. , Mullen, W. , Hartley, R. C. , Selman, C. and Metcalfe, N. B. (2015) Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo. Biology Letters, 11(9), 20150538. (doi: 10.1098/rsbl.2015.0538) (PMID:26382073)

Chouchani, E. T. et al. (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 515(7527), pp. 431-435. (doi: 10.1038/nature13909) (PMID:25383517) (PMCID:PMC4255242)

Logan, A. , Shabalina, I. G. , Prime, T. A. , Rogatti, S. , Kalinovich, A. V. , Hartley, R. C. , Budd, R. C. , Cannon, B. and Murphy, M. P. (2014) In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell, 13(4), pp. 765-768. (doi: 10.1111/acel.12212) (PMID:24621297) (PMCID:PMC4326952)

Cairns, A. G. , Senn, H. M. , Murphy, M. P. and Hartley, R. C. (2014) Expanding the palette of phenanthridinium cations. Chemistry: A European Journal, 20(13), pp. 3742-3751. (doi: 10.1002/chem.201304241) (PMID:24677631) (PMCID:PMC4164275)

Li Pun, P. B. et al. (2014) A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radical Biology and Medicine, 67, pp. 437-450. (doi: 10.1016/j.freeradbiomed.2013.11.025) (PMID:24316194) (PMCID:PMC3978666)

Logan, A. et al. (2014) Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica et Biophysica Acta: General Subjects, 1840(2), pp. 923-930. (doi: 10.1016/j.bbagen.2013.05.026) (PMID:23726990)

McQuaker, S. J. , Quinlan, C. L. , Caldwell, S. T. , Brand, M. D. and Hartley, R. C. (2013) A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production. ChemBioChem, 14(8), pp. 993-1000. (doi: 10.1002/cbic.201300115) (PMID:23640856) (PMCID:PMC3743171)

Chouchani, E. T. et al. (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine, 19(6), pp. 753-759. (doi: 10.1038/nm.3212) (PMID:23708290) (PMCID:PMC4019998)

Sikora, A. , Zielonka, J. , Adamus, J. , Debski, D. , Dybala-Defratyka, A. , Michalowski, B. , Joseph, J. , Hartley, R.C. , Murphy, M.P. and Kalyanaraman, B. (2013) Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. Chemical Research in Toxicology, 26(6), pp. 856-867. (doi: 10.1021/tx300499c) (PMID:23611338) (PMCID:PMC3700382)

Harvey, A. L. , Young, L. C. , Kornisiuk, E. , Snitcofsky, M. , Colettis, N. , Blanco, C. , Jerusalinsky, D. , Jamieson, A. G. , Hartley, R. C. and Stone, T. W. (2012) A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance. Behavioural Brain Research, 234(2), pp. 184-191. (doi: 10.1016/j.bbr.2012.06.023)

Smith, R.A.J. , Hartley, R.C. , Cochemé, H.M. and Murphy, M.P. (2012) Mitochondrial pharmacology. Trends in Pharmacological Sciences, 33(6), pp. 341-352. (doi: 10.1016/j.tips.2012.03.010) (PMID:22521106)

Cochemé, H.M. et al. (2012) Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nature Protocols, 7(5), pp. 946-958. (doi: 10.1038/nprot.2012.035) (PMID:22517261)

Caldwell, S.T. , McPhail, D.B. , Duthie, G.D. and Hartley, R.C. (2012) Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants. Canadian Journal of Chemistry = Journal canadien de chimie, 90(1), pp. 23-33. (doi: 10.1139/V11-087)

Chalmers, S. , Caldwell, S. T. , Quin, C. , Prime, T. A. , James, A. M. , Cairns, A. G. , Murphy, M. P. , McCarron, J. G. and Hartley, R. C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi: 10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)

Omar, M.H. , Mullen, W. , Stalmach, A. , Auger, C. , Rouanet, J.-M. , Teissedre, P.-L. , Caldwell, S.T. , Hartley, R.C. and Crozier, A. (2012) Absorption, disposition, metabolism, and excretion of [3-14C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)

Smith, R. A.J. , Hartley, R. C. and Murphy, M. P. (2011) Mitochondria-targeted small molecule therapeutics and probes. Antioxidants and Redox Signaling, 15(12), pp. 3021-3038. (doi: 10.1089/ars.2011.3969) (PMID:21395490)

Figlus, M. , Wellaway, N. , Cooper, A.W.J. , Sollis, S.L. and Hartley, R.C. (2011) Synthesis of arrays using low molecular weight MPEG-assisted Mitsunobu reaction. ACS Combinatorial Science, 13(3), pp. 280-285. (doi: 10.1021/co100091n)

Cochemé, H.M. et al. (2011) Measurement of H2O2 within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism, 13(3), pp. 340-350. (doi: 10.1016/j.cmet.2011.02.003) (PMID:21356523) (PMCID:PMC4413513)

Haahr, A. , Rankovic, Z. and Hartley, R. (2011) A one-pot procedure for methylenating carbonyl compounds using the Nysted reagent and titanocene dichloride. Tetrahedron Letters, 52(23), pp. 3020-3022. (doi: 10.1016/j.tetlet.2011.04.017)

Quin, C., Robertson, L., McQuaker, S.J., Price, N.C., Brand, M.D. and Hartley, R.C. (2010) Caged mitochondrial uncouplers that are released in response to hydrogen peroxide. Tetrahedron, 66(13), pp. 2384-2389. (doi: 10.1016/j.tet.2010.01.103) (PMID:20418941) (PMCID:PMC2852674)

Figlus, M., Tarruella, A.C., Messer, A., Sollis, S.L. and Hartley, R.C. (2010) Low molecular weight MPEG-assisted organic synthesis. Chemical Communications, 46(24), pp. 4405-4407. (doi: 10.1039/c0cc00415d)

Quin, C., Trnka, J., Hay, A., Murphy, M.P. and Hartley, R.C. (2009) Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization. Tetrahedron, 65(39), pp. 8154-8160. (doi: 10.1016/j.tet.2009.07.081) (PMID:19888470) (PMCID:PMC2767131)

Robertson, L. and Hartley, R. C. (2009) Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants. Tetrahedron, 65(27), pp. 5284-5292. (doi: 10.1016/j.tet.2009.04.083) (PMID:19693262) (PMCID:PMC2722452)

El Fangour, S. , Marini, M. , Good, J. , McQuaker, S.J. , Shiels, P.G. and Hartley, R.C. (2009) Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi: 10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

Main, C.A. , Rahman, S.S. and Hartley, R.C. (2008) Synthesis of spiroacetals using functionalised titanium carbenoids. Tetrahedron Letters, 49(32), pp. 4771-4774. (doi: 10.1016/j.tetlet.2008.05.094)

Main, C.A. , Petersson, H.M. , Rahman, S.S. and Hartley, R.C. (2008) High throughput synthesis of 2,5-substituted indoles using a titanium carbenoid bearing boronate functionality. Tetrahedron, 64(5), pp. 901-914. (doi: 10.1016/j.tet.2007.08.119)

Mullen, W. , Rouanet, J.-M. , Auger, C. , Teissèdre, P.-L. , Caldwell, S.T. , Hartley, R.C. , Lean, M.E.J. , Edwards, C.A. and Crozier, A. (2008) Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)

Caldwell, S. T. , Quin, C. , Edge, R. and Hartley, R. C. (2007) A dual sensor spin trap for use with EPR spectroscopy. Organic Letters, 9(18), pp. 3499-3502. (doi: 10.1021/ol071285o)

Adriaenssens, L. V. and Hartley, R. C. (2007) beta-amino acids to piperidinones by petasis methylenation and acid-induced cyclization. Journal of Organic Chemistry, 72(26), pp. 10287-10290. (doi: 10.1021/jo7019948)

Austin, C. , Smith, D. and Hartley, R. (2007) Solid-phase synthesis of cyclic imines - potential for radiolabelling. Journal of Labelled Compounds and Radiopharmaceuticals, 50, pp. 502-503. (doi: 10.1002/jlcr.1224)

Farrugia, L. , Hartley, R. , Calver, A. and Rahman, S. (2007) 5-Bromoanthranil. Acta Crystallographica. Section E: Structure Reports Online, 63, O2540-O2541. (doi: 10.1107/S1600536807017278)

Hartley, R. , Li, J. , Main, C. and McKiernan, G. (2007) Titanium carbenoid reagents for converting carbonyl groups into alkenes. Tetrahedron, 63, pp. 4825-4864. (doi: 10.1016/j.tet.2007.03.015)

Adriaenssens, L. , Austin, C. , Gibson, M. , Smith, D. and Hartley, R. (2006) Stereodivergent diversity oriented synthesis of piperidine alkaloids. European Journal of Organic Chemistry, pp. 4998-5001. (doi: 10.1002/ejoc.200600744)

Caldwell, S., Petersson, H., Farrugia, L., Mullen, W., Crozier, A. and Hartley, R. (2006) Isotopic labelling of quercetin 3-glucoside. Tetrahedron, 62, pp. 7257-7265. (doi: 10.1016/j.tet.2006.05.046)

Sklavounou, E. , Hay, A. , Ashraf, N. , Lamb, K. , Brown, E. , Mac Intyre, A. , George, W.D. , Hartley, R.C. and Shiels, P.G. (2006) The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochemical and Biophysical Research Communications, 347, pp. 420-427. (doi: 10.1016/j.bbrc.2006.06.087)

Graf, B., Mullen, W., Caldwell, S., Hartley, R., Duthie, G., Lean, M., Crozier, A. and Edwards, C. (2005) Disposition and metabolism of [2-C-14]quercetin-4 '-glucoside in rats. Drug Metabolism and Disposition, 33, pp. 1036-1043. (doi: 10.1124/dmd.104.002691)

Hay, A. , Burkitt, M. , Jones, C. and Hartley, R. (2005) Development of a new EPR spin trap, DOD-8C (N-[4-dodecyloxy-2-(7'-carboxyhept-1'-yloxy) benzylidene]-N-tert-butylamine N-oxide), for the trapping of lipid radicals at a predetermined depth within biological membranes. Archives of Biochemistry and Biophysics, 435, pp. 336-346. (doi: 10.1016/j.abb.2004.12.030)

Bennett, C. , Caldwell, S. , McPhail, D. , Morrice, P. , Duthie, G. and Hartley, R. (2004) Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorganic and Medicinal Chemistry, 12, pp. 2079-2098. (doi: 10.1016/j.bmc.2004.02.031)

Macleod, C. , Austin, C. , Hamprecht, D. and Hartley, R. (2004) Preparation of quinolines from resin-bound esters using titanium reagents. Tetrahedron Letters, 45, pp. 8879-8882. (doi: 10.1016/j.tetlet.2004.09.170)

Roberts, C. and Hartley, R. (2004) Titanium reagents for the synthesis of 2-substituted benzo[b]thiophenes on the solid phase. Journal of Organic Chemistry, 69, pp. 6145-6148. (doi: 10.1021/jo049344o)

Woodland, C. , Crawley, G. and Hartley, R. (2004) Stereoselectivity in the anionic oxy-Cope rearrangement of acyclic vinyl sulfides. Tetrahedron Letters, 45, pp. 1227-1231. (doi: 10.1016/j.tetlet.2003.11.132)

Gibson, M. , Goodman, J. , Farrugia, L. and Hartley, R. (2003) Controlling neighbouring group participation from thioacetals. Tetrahedron Letters, 44, pp. 2841-2844. (doi: 10.1016/S0040-4039(03)00440-4)

Macleod, C. , McKiernan, G. , Guthrie, E. , Farrugia, L. , Hamprecht, D. , Macritchie, J. and Hartley, R. (2003) Synthesis of 2-substituted benzofurans and Indoles using functionalized titanium benzylidene reagents on solid phase. Journal of Organic Chemistry, 68, pp. 387-401. (doi: 10.1021/jo026384o)

McKiernan, G. and Hartley, R. (2003) Boronate titanium alkylidene reagents for diversity-based synthesis of benzofurans. Organic Letters, 5, pp. 4389-4392. (doi: 10.1021/ol035677g)

McPhail, D. , Hartley, R. , Gardner, P. and Duthie, G. (2003) Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. Journal of Agricultural and Food Chemistry, 51, pp. 1684-1690. (doi: 10.1021/jf025922v)

Mullen, W., Hartley, R. and Crozier, A. (2003) Detection and identification of C-14-labelled flavonol metabolites by high-performance liquid chromatography-radiocounting and tandem mass spectrometry. Journal of Chromatography A, 1007, pp. 21-29. (doi: 10.1016/S0021-9673(03)00882-3)

Hartley, R.C. and McKiernan, G.J. (2002) Titanium reagents for the alkylidenation of carboxylic acid and carbonic acid derivatives. Journal of the Chemical Society: Perkin Transactions 1, pp. 2763-2793. (doi: 10.1039/b009709h)

Macleod, C. , Hartley, R.C. and Hamprecht, D.W. (2002) Novel functionalized titanium(IV) benzylidenes for the traceless solid-phase synthesis of indoles. Organic Letters, 4, pp. 75-78. (doi: 10.1021/ol016924o)

Mullen, W., Graf, B., Caldwell, S., Hartley, R., Duthie, G., Edwards, C., Lean, M. and Crozier, A. (2002) Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-C-14]quercetin-4' glucoside. Journal of Agricultural and Food Chemistry, 50, pp. 6902-6909. (doi: 10.1021/jf020598p)

Rutherford, A.P. , Gibb, C.S. , Hartley, R.C. and Goodman, J.M. (2001) Stereocontrol in a one-pot procedure for anionic oxy-Cope rearrangement followed by intramolecular aldol reaction. Journal of the Chemical Society: Perkin Transactions 1, pp. 1051-1061. (doi: 10.1039/b010138i)

Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)

Hartley, R. C. and Caldwell, S. T. (2000) Novel methods for the synthesis of three-, four-, five-, six- and seven-membered, saturated and partially unsaturated carbocycles. Journal of the Chemical Society: Perkin Transactions 1, 1(4), pp. 477-501. (doi: 10.1039/A804421J)

Book Sections

Cairns, A. G. , McQuaker, S. J. , Murphy, M. P. and Hartley, R. C. (2015) Targeting mitochondria with small molecules: the preparation of MitoB and MitoP as exomarkers of mitochondrial hydrogen peroxide. In: Weissig, V. and Edeas, M. (eds.) Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function. Series: Methods in Molecular Biology, 1265. Springer New York, pp. 25-50. ISBN 9781493922871 (doi:10.1007/978-1-4939-2288-8_3)

This list was generated on Wed Sep 23 21:31:46 2020 BST.

Supervision

Careers of PhDs from group by year of award

1999
Dr Alistair P. Rutherford - Alistair went on to do a post-doc with Dr (now Prof.) Alan Armstrong at the University of Nottingham and Imperial College London.  He has worked as a medicinal chemist in Vertex Pharmaceuticals (Oxford, UK) since 2000.

Dr Cameron S. Gibb - Cameron worked for Oxford Asymmetry before moving to Albany Molecular Research (NY, USA) in 2001, where he was a Group Leader in Chemical Development. Cameron is now Global Active Ingredient Technology Manager at Arysta Life Science.
 
2000
Dr Graeme D. McAllister - Graeme joined the group of Prof. Richard Taylor in York (UK) and after 2 years, became Experimental Officer of that research team. He continued his career in the Department of Chemistry at York, where he is now a Senior Research Technician and Microanalyst.

2001
Dr Emma J. Guthrie - Emma worked at Air Products from 2001 to 2016.  After a brief spell in the Netherlands, she spent four years in the Fuel Cell Energy Solutions group in Walton-on-Thames (UK), before applying her skills to marketing Food and Industrial Cryogenics applications.  She was a Business Development Manager in the Hydrogen Energy group (those eco-friendly, hydrogen-powered buses in London are fuelled by Air Products).  In 2016, Emma became Group Development Manager at IMCD N.V.

2002
Dr Stuart T. Caldwell - After a short period with Syngenta at Grangemouth (Scotland), Stuart's interest in antioxidants and isotopic labelling brought him back to the Hartley group in June 2002.  In 2007 he joined the Cooke group here at the University of Glasgow and then moved to the Bucher group.  In January 2011 he rejoined the Hartley group to work on molecular probes and is the senior researcher in that group.

2003
Dr Calum Macleod - Calum spent two years as a research chemist working in combinatorial chemistry at Adolor Corporation (Pennsylvania, USA) and then moved to Argenta Discovery Ltd (Harlow, UK).  He is now Associate Director, Medicinal Chemistry, at Pharmaron.

Dr C. Andrew Woodland  - Andrew worked as a synthetic organic chemist with BioFocus (Saffron Walden, UK) before moving to the University of Dundee where he is a medicinal chemist.

2004
Dr Mairi Gibson (now Sime) - Mairi worked as a medicinal chemist with GSK (Harlow, UK) and then in May 2010 took up the post of Team Leader at the Beatson Institute for Cancer Research in Glasgow.

Dr Gordon J. McKiernan – After initially continuing in organic chemistry research including at Syngenta in Huddersfield and a spell as a brewer at the Elland brewery near Halifax, Gordon is now working in finance at Ernst and Young in Edinburgh.

Dr Neil Forrest - Neil began as a synthetic chemist at Peakdale Molecular (Chapel-en-le-Frith, UK) rising to the rank of Lead Chemist and combining this with Project Manager and Environmental officer.  In 2013 he left Peakdale and returned to Scotland to take up his current post as a Product Owner at GSK, Montrose.   

2005
Dr Alison Hay (now Robinson) - Alison worked with Prof. Stuart Schreiber at Harvard University (Cambridge, USA), before taking up a medicinal chemistry in the University of Dundee.  After periods at Research and Enterprise at the University of St Andrews and the University of Stirling, Alison returned to Glasgow worked as a Research Developer at the prestigious Glasgow School of Art, and is now a Strategic Research & Knowledge Exchange Manager at the University of Strathclyde.

Dr Christine Roberts (now Stewart-Liddon) - Christine worked in the group of Dr Mark Moloney at the University of Oxford, before joining Fujifilm in Manchester as a Research Chemist.  She then moved back to Scotland to Grangemouth with the same company, and now works for Scaled Solutions Ltd in Livingston.

Dr Hanna Petersson (now Tvedten) - Hanna began as a Research Chemist in Synthesis group at Borregaard, Norway, before moving to Stravanger, where she is now Managing Director of Origo Process. Origo Process provide process services to operators and engineering companies mostly within the Oil and Gas Section, but also perform hazard process analysis for the pharmaceutical industry.

2006
Dr Carolyn Austin - Carolyn joined Novartis production chemistry in Grimsby, and now works with the same company in Switzerland.  Having spent some years in production, she is now Global Quality Lead CHAD DS Supply at Novartis, which involves technical research development.

2007
Dr Louis Adriaenssens - Louis carried out postdoctoral research with Dr. Filip Teply in the Institute of Organic Chemistry and Biochemistry AS CR in Prague, and then moved to France and worked in Dijon with Profs Denat and Legendre.  He then spent time with Prof. Pablo Ballester's co-workers at the Institut Catala de Investigacio Quimica in Taragonna, Spain. In 2015 he took up a Lectureship at the University of Lincoln, UK

2008
Dr Calver Main - Calver was a Research and Development Scientist in Procter and Gamble working at its Brussels Innovation Centre in Belgium, and he then trained as a teacher. He began teaching at Merchiston in Edinburgh and is now Head of Chemistry at the Glasgow Academy.

2009
Dr Ching Ching Chua - Ching is a researcher at Evotec.

2010
Dr Caroline Quin - Caroline works for Procter and Gamble.

Dr Linsey Robertson - After a period in the Specialist Factual Department of BBC Scotland, Linsey worked for the Royal Society of Chemistry based at Edinburgh University.  She then returned to the University of Glasgow, taking up the position of the Project Administrator for the Sensors Initiative.  

2011
Dr Guilaine Blanc - Guilaine is working with Lonza S.A. as a Chemist Project Leader in Braien L'Alleud.

2012
Dr Adam Haahr - Adam began as a Clearing Analyst at Morgan Stanley and is now Senior Auditor at Audit Scotland.

2013
Dr Stephen McQuaker - Stephen worked at Reckitt Benckiser as a Research and Development Assistant.  He then   was working as a Senior Process Development Chemist for Frutarom UK on Teeside, developing synthetic routes to manufacture flavour and fragrance chemicals. Before moving to his current position as a Synthetic Chemist for Arcinova in Alnwick, developing synthetic routes and the scale up manufacturing of APIs (mainly for phase I & II clinicals).

2014
Dr Andrew Cairns - Andrew joined the research group of Prof. Fredrik Almqvist in Umea, Sweden, as a post-doctoral fellow.  He worked at Yale in the group of Prof. Alanna Schepartz and is now at the University of Aberdeen.

2015
Dr Justyna Gawel - Justyna was a post-doctoral fellow with Prof. Patrick Gunning at the University of Toronto Mississauga.  She is now a Clinical Trial Coordinator for KCRI in Kraków.

2016
Dr Maria Shchepinova - Masha is now working with Prof. Ed Tate at Imperial College London, as a post-doctoral fellow.

2017
Dr Helmi Kreinin - Helmi Kreinin is now on the Teach First Programme.

Dr Sean O’Byrne (supervised for last two years of his PhD) – Sean is a Postdoctoral Researcher at University of North Carolina developing kinase inhibitors with the SGC.

2018
Dr Lewis King - Lewis is a PDRA working on a joint project with Dr Lilach Sheiner and my group.

2019
Dr Laura Pala – Laura is a Product Marketing Manager with Biosynth Carbosynth.

Teaching

Teaching

  • Level-3 Mechanistic Organic Chemistry
  • Level-4 Chemical Biology

Professional activities & recognition

Editorial boards

  • Journal of the Royal Society Interface

Professional & learned societies

  • Fellow, Royal Society of Chemistry
  • Fellow, Royal Society of Biology
  • Chemistry Biology Interface Division Council Member, Royal Society of Chemistry
  • Member, American Chemical Society
  • Investigator, Wellcome Trust
  • External Examiner of Undergraduate Degrees (Chemistry), University of Aberdeen
  • College Member, EPSRC

Research datasets

Jump to: 2020 | 2019 | 2018
Number of items: 6.

2020

Pala, L., Senn, H. , Caldwell, S. , Prime, T. A., Warrington, S., Bright, T. P., Prag, H., Wilson, C. , Murphy, M. and Hartley, R. (2020) Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation. [Data Collection]

Prag, H. A., Kula-Alwar, D., Pala, L., Caldwell, S. , Beach, T., James, A. M., Saeb-Parsy, K., Krieg, T., Hartley, R. and Murphy, M. (2020) Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker. [Data Collection]

2019

Burger, N., Logan, A., Prime, T. A., Mottahedin, A., Caldwell, S. , Krieg, T., Hartley, R. , James, A. M. and Murphy, M. P. (2019) A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. [Data Collection]

Antonucci, S., Mulvey, J. F., Burger, N., Di Sante, M., Hall, A. R., Hinchy, E. C., Caldwell, S. , Gruszczyk, A. V., Deshwal, S., Hartley, R. , Kaludercic, N., Murphy, M. P., Di Lisa, F. and Kreig, T. (2019) Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. [Data Collection]

2018

Tate, M., De Blasio, M. J., Prakoso, D., Deo, M., Higgins, G. C., Lindblom, R., Kiriazis, H., Baeza-Garza, C. D., Caldwell, S., Hartley, R. , Krieg, T., Murphy, M. P., Coughlan, M. T. and Ritchie, R. H. (2018) The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide is cardioprotective in the diabetic heart. [Data Collection] (Unpublished)

Martin, J. L., Costa, A. S. H., Gruszczyk, A., Beach, T., Allen, F., Prag, H., Hinchy, E. C., Mahbubani, K., Hamed, M., Tronci, L., Nikitopoulou, E., James, A. M., Krieg, T., Robinson, A., Huang, M. H., Caldwell, S. , Logan, A., Pala, L., Hartley, R. , Frezza, C., Saeb-Parsy, K. and Murphy, M. (2018) Succinate accumulation during organ storage drives ischemia-reperfusion injury upon transplantation. [Data Collection]

This list was generated on Thu Sep 24 04:14:02 2020 BST.

Additional information

Researcher ID        http://www.researcherid.com/rid/E-3489-2010

Current Grants

  • Exploring mitochondrial metabolism in health and disease using targeted biological chemistry Wellcome Trust (220257/B/20/Z) £803k (100%)
  • Mitochondrial ROS mapping and control with sub-organellar resolution BB/T003804/1 £685k (35%). Jan 2020-Dec 2022.
  • MitoWild ERC €2,445,129 (5%) (2021-2026).
  • “Why do fish fail at high temperatures?” NERC NE/R001510/1£523,409 (10%). Feb 2018-Jan 2021.

Recent Grants

  • Exploring mitochondrial metabolism in health and disease using targeted biological chemistry. Wellcome Trust (110158/Z/15/Z) £346,109 (100%). May 2016-Apr 2020.
  • Thiol Modification and Redox Signalling, MRC Discovery Award. £581,581 (RCH share: £173k). Mar 2016-Apr 2018
  • The Ecology of Metabolic Phenotypes: From Cells to Populations. ERC £1,701,874 (10%), (Dates: May 2013 – April 2018).

Notable Achievements

  • Originator of ‘Protection Hypothesis’ in behavioural ecology in seminal paper: Are Carotenoids a Red Herring in Sexual Display.
  • Spin out company (Antoxis, see http://www.antoxis.com/): I provided its starting research basis by invention of its lead compound, ProxisonTM(WO 2004/007475)
  • First and currently best probe for quantify hydrogen peroxide in the mitochondria of living organisms (MitoB)