Dr Drew Thomson

  • Lecturer (School of Chemistry)

Biography

I have been a lecturer at Glasgow since 2016. My PhD was in supramolecular organic chemistry with David Leigh (then at Edinburgh). After a short postdoc in Edinburgh with David Dryden I moved to Bristol as a postdoc and later research fellow in the lab of Dek Woolfson.


Research interests

Research in our lab is aimed at designing peptides with defined 3D conformations. We use these peptides to ask questions about biological systems, and to mimic behaviour seen in biology. By designing these molecules from first principles, we learn about the fundamental factors that govern the relationship between atomic connectivity and three-dimensional structure. Work in this area is necessarily multidisciplinary: our lab uses a mix of bioinformatics, computational modelling, peptide and organic synthesis, and biophysical characterisation.


Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012 | 2011 | 2009 | 2008 | 2006
Number of items: 29.

2019

Rhys, G. G., Wood, C. W., Beesley, J. L., Zaccai, N. R., Burton, A. J., Brady, R. L., Thomson, A. R. and Woolfson, D. N. (2019) Navigating the structural landscape of de novo α-helical bundles. Journal of the American Chemical Society, 141(22), pp. 8787-8797. (doi:10.1021/jacs.8b13354) (PMID:31066556)

2018

Rhys, G. G., Wood, C. W., Lang, E. J.M., Mulholland, A. J., Brady, R. L., Thomson, A. R. and Woolfson, D. N. (2018) Maintaining and breaking symmetry in homomeric coiled-coil assemblies. Nature Communications, 9(1), 4132. (doi:10.1038/s41467-018-06391-y) (PMID:30297707) (PMCID:PMC6175849)

Heal, J. W., Bartlett, G. J., Wood, C. W., Thomson, A. R. and Woolfson, D. N. (2018) Applying graph theory to protein structures: an atlas of coiled coils. Bioinformatics, 34(19), pp. 3316-3323. (doi:10.1093/bioinformatics/bty347) (PMID:29722888)

2017

Wood, C. W., Heal, J. W., Thomson, A. R. , Bartlett, G. J., Ibarra, A. A., Brady, R. L., Sessions, R. B. and Woolfson, D. N. (2017) ISAMBARD: an open-source computational environment for biomolecular analysis, modelling and design. Bioinformatics, 33(19), pp. 3043-3050. (doi:10.1093/bioinformatics/btx352) (PMID:28582565) (PMCID:PMC5870769)

Niitsu, A., Heal, J. W., Fauland, K., Thomson, A. R. , Woolfson, D. N. and Thomson, A. (2017) Membrane-spanning α-helical barrels as tractable protein-design targets. Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1726), 20160213. (doi:10.1098/rstb.2016.0213) (PMID:28630153)

Small, L. S.R., Bruning, M., Thomson, A. R. , Boyle, A. L., Davies, R. B., Curmi, P. M.G., Forde, N. R., Linke, H., Woolfson, D. N. and Bromley, E. H.C. (2017) Construction of a chassis for a tripartite protein-based molecular motor. ACS Synthetic Biology, 6(6), pp. 1096-1102. (doi:10.1021/acssynbio.7b00037) (PMID:28221767) (PMCID:PMC5477008)

Mahendran, K. R., Niitsu, A., Kong, L., Thomson, A. R. , Sessions, R. B., Woolfson, D. N. and Bayley, H. (2017) A monodisperse transmembrane α-helical peptide barrel. Nature Chemistry, 9(5), pp. 411-419. (doi:10.1038/NCHEM.2647) (PMID:28430192)

2016

Burton, A. J., Thomson, A. R. , Dawson, W. M., Brady, R. L. and Woolfson, D. N. (2016) Installing hydrolytic activity into a completely de novo protein framework. Nature Chemistry, 8(9), pp. 837-844. (doi:10.1038/nchem.2555) (PMID:27554410)

Thomas, F., Burgess, N. C., Thomson, A. R. and Woolfson, D. N. (2016) Controlling the assembly of coiled-coil peptide nanotubes. Angewandte Chemie (International Edition), 55(3), pp. 987-991. (doi:10.1002/anie.201509304) (PMID:26663438) (PMCID:PMC4744968)

2015

Burgess, N. C., Sharp, T. H., Thomas, F., Wood, C. W., Thomson, A. R. , Zaccai, N. R., Brady, R. L., Serpell, L. C. and Woolfson, D. N. (2015) Modular design of self-assembling peptide-based nanotubes. Journal of the American Chemical Society, 137(33), pp. 10554-10562. (doi:10.1021/jacs.5b03973) (PMID:26219086)

Woolfson, D. N., Bartlett, G. J., Burton, A. J., Heal, J. W., Niitsu, A., Thomson, A. R. and Wood, C. W. (2015) De novo protein design: how do we expand into the universe of possible protein structures? Current Opinion in Structural Biology, 33, pp. 16-26. (doi:10.1016/j.sbi.2015.05.009) (PMID:26093060)

Fletcher, J. M. et al. (2015) A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology. ACS Synthetic Biology, 1(6), pp. 240-250. (doi:10.1021/sb300028q) (PMID:23651206)

Mehrban, N. et al. (2015) Functionalized α-helical peptide hydrogels for neural tissue engineering. ACS Biomaterials Science and Engineering, 1(6), pp. 431-439. (doi:10.1021/acsbiomaterials.5b00051) (PMID:26240838) (PMCID:PMC4517957)

2014

Bishop, P., Rubin, P., Thomson, A. R. , Rocca, D. and Henley, J. M. (2014) The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons. Journal of Biological Chemistry, 289(52), pp. 36140-36149. (doi:10.1074/jbc.M114.557124) (PMID:25326379) (PMCID:PMC4276877)

Wood, C. W., Bruning, M., Ibarra, A. Á., Bartlett, G. J., Thomson, A. R. , Sessions, R. B., Brady, R. L. and Woolfson, D. N. (2014) CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies. Bioinformatics, 30(21), pp. 3029-3035. (doi:10.1093/bioinformatics/btu502) (PMID:25064570) (PMCID:PMC4201159)

Thomson, A. R. , Wood, C. W., Burton, A. J., Bartlett, G. J., Sessions, R. B., Brady, R. L. and Woolfson, D. N. (2014) Computational design of water-soluble α-helical barrels. Science, 346(6208), pp. 485-488. (doi:10.1126/science.1257452) (PMID:25342807)

Mehrban, N., Abelardo, E., Wasmuth, A., Hudson, K. L., Mullen, L. M., Thomson, A. R. , Birchall, M. A. and Woolfson, D. N. (2014) Assessing cellular response to functionalized α-helical peptide hydrogels. Advanced Healthcare Materials, 3(9), pp. 1387-1391. (doi:10.1002/adhm.201400065) (PMID:24659615) (PMCID:PMC4276410)

2012

Sharp, T. H., Bruning, M., Mantell, J., Sessions, R. B., Thomson, A. R. , Zaccai, N. R., Brady, R. L., Verkade, P. and Woolfson, D. N. (2012) Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design. Proceedings of the National Academy of Sciences of the United States of America, 109(33), pp. 13266-13271. (doi:10.1073/pnas.1118622109) (PMID:22847414) (PMCID:PMC3421226)

Woolfson, D. N., Bartlett, G. J., Bruning, M. and Thomson, A. R. (2012) New currency for old rope: from coiled-coil assemblies to α-helical barrels. Current Opinion in Structural Biology, 22(4), pp. 432-441. (doi:10.1016/j.sbi.2012.03.002) (PMID:22445228)

2011

Zaccai, N. R. et al. (2011) A de novo peptide hexamer with a mutable channel. Nature Chemical Biology, 7(12), pp. 935-941. (doi:10.1038/nchembio.692) (PMID:22037471) (PMCID:PMC3223406)

Mahmoud, Z. N., Gunnoo, S. B., Thomson, A. R. , Fletcher, J. M. and Woolfson, D. N. (2011) Bioorthogonal dual functionalization of self-assembling peptide fibers. Biomaterials, 32(15), pp. 3712-3720. (doi:10.1016/j.biomaterials.2010.12.002) (PMID:21353303)

2009

Stephanou, A. S., Roberts, G. A., Cooper, L. P., Clarke, D. J., Thomson, A. R. , MacKay, C. L., Nutley, M., Cooper, A. and Dryden, D. T.F. (2009) Dissection of the DNA mimicry of the bacteriophage T7 Ocr protein using chemical modification. Journal of Molecular Biology, 391(3), pp. 565-576. (doi:10.1016/j.jmb.2009.06.020) (PMID:19523474) (PMCID:PMC2806950)

Armstrong, C. T., Boyle, A. L., Bromley, E. H.C., Mahmoud, Z. N., Smith, L., Thomson, A. R. and Woolfson, D. N. (2009) Rational design of peptide-based building blocks for nanoscience and synthetic biology. Faraday Discussions, 143, pp. 305-317. (doi:10.1039/B901610D) (PMID:20334109)

Leigh, D. A., Lusby, P. J., McBurney, R. T., Morelli, A., Slawin, A. M.Z., Thomson, A. R. and Walker, D. B. (2009) Getting harder: cobalt (III)-template synthesis of catenanes and rotaxanes. Journal of the American Chemical Society, 131(10), pp. 3762-3771. (doi:10.1021/ja809627j) (PMID:19275264)

Bromley, E. H.C., Sessions, R. B., Thomson, A. R. and Woolfson, D. N. (2009) Designed α-helical tectons for constructing multicomponent synthetic biological systems. Journal of the American Chemical Society, 131(3), pp. 928-930. (doi:10.1021/ja804231a) (PMID:19115943)

2008

Leigh, D. A. and Thomson, A. R. (2008) An ammonium/bis-ammonium switchable molecular shuttle. Tetrahedron Letters, 64(36), pp. 8411-8416. (doi:10.1016/j.tet.2008.05.130)

Dryden, D. T.F., Thomson, A. R. and White, J. H. (2008) How much of protein sequence space has been explored by life on Earth? Journal of the Royal Society: Interface, 5(25), pp. 953-956. (doi:10.1098/rsif.2008.0085) (PMID:18426772) (PMCID:PMC2459213)

2006

Leigh, D. A. and Thomson, A. R. (2006) Switchable dual binding mode molecular shuttle. Organic Letters, 8(23), pp. 5377-5379. (doi:10.1021/ol062284j) (PMID:17078722)

Aucagne, V., Leigh, D. A., Lock, J. S. and Thomson, A. R. (2006) Rotaxanes of cyclic peptides. Journal of the American Chemical Society, 128(6), pp. 1784-1785. (doi:10.1021/ja057206q) (PMID:16464065)

This list was generated on Fri Dec 13 07:26:07 2019 GMT.
Jump to: Articles
Number of items: 29.

Articles

Rhys, G. G., Wood, C. W., Beesley, J. L., Zaccai, N. R., Burton, A. J., Brady, R. L., Thomson, A. R. and Woolfson, D. N. (2019) Navigating the structural landscape of de novo α-helical bundles. Journal of the American Chemical Society, 141(22), pp. 8787-8797. (doi:10.1021/jacs.8b13354) (PMID:31066556)

Rhys, G. G., Wood, C. W., Lang, E. J.M., Mulholland, A. J., Brady, R. L., Thomson, A. R. and Woolfson, D. N. (2018) Maintaining and breaking symmetry in homomeric coiled-coil assemblies. Nature Communications, 9(1), 4132. (doi:10.1038/s41467-018-06391-y) (PMID:30297707) (PMCID:PMC6175849)

Heal, J. W., Bartlett, G. J., Wood, C. W., Thomson, A. R. and Woolfson, D. N. (2018) Applying graph theory to protein structures: an atlas of coiled coils. Bioinformatics, 34(19), pp. 3316-3323. (doi:10.1093/bioinformatics/bty347) (PMID:29722888)

Wood, C. W., Heal, J. W., Thomson, A. R. , Bartlett, G. J., Ibarra, A. A., Brady, R. L., Sessions, R. B. and Woolfson, D. N. (2017) ISAMBARD: an open-source computational environment for biomolecular analysis, modelling and design. Bioinformatics, 33(19), pp. 3043-3050. (doi:10.1093/bioinformatics/btx352) (PMID:28582565) (PMCID:PMC5870769)

Niitsu, A., Heal, J. W., Fauland, K., Thomson, A. R. , Woolfson, D. N. and Thomson, A. (2017) Membrane-spanning α-helical barrels as tractable protein-design targets. Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1726), 20160213. (doi:10.1098/rstb.2016.0213) (PMID:28630153)

Small, L. S.R., Bruning, M., Thomson, A. R. , Boyle, A. L., Davies, R. B., Curmi, P. M.G., Forde, N. R., Linke, H., Woolfson, D. N. and Bromley, E. H.C. (2017) Construction of a chassis for a tripartite protein-based molecular motor. ACS Synthetic Biology, 6(6), pp. 1096-1102. (doi:10.1021/acssynbio.7b00037) (PMID:28221767) (PMCID:PMC5477008)

Mahendran, K. R., Niitsu, A., Kong, L., Thomson, A. R. , Sessions, R. B., Woolfson, D. N. and Bayley, H. (2017) A monodisperse transmembrane α-helical peptide barrel. Nature Chemistry, 9(5), pp. 411-419. (doi:10.1038/NCHEM.2647) (PMID:28430192)

Burton, A. J., Thomson, A. R. , Dawson, W. M., Brady, R. L. and Woolfson, D. N. (2016) Installing hydrolytic activity into a completely de novo protein framework. Nature Chemistry, 8(9), pp. 837-844. (doi:10.1038/nchem.2555) (PMID:27554410)

Thomas, F., Burgess, N. C., Thomson, A. R. and Woolfson, D. N. (2016) Controlling the assembly of coiled-coil peptide nanotubes. Angewandte Chemie (International Edition), 55(3), pp. 987-991. (doi:10.1002/anie.201509304) (PMID:26663438) (PMCID:PMC4744968)

Burgess, N. C., Sharp, T. H., Thomas, F., Wood, C. W., Thomson, A. R. , Zaccai, N. R., Brady, R. L., Serpell, L. C. and Woolfson, D. N. (2015) Modular design of self-assembling peptide-based nanotubes. Journal of the American Chemical Society, 137(33), pp. 10554-10562. (doi:10.1021/jacs.5b03973) (PMID:26219086)

Woolfson, D. N., Bartlett, G. J., Burton, A. J., Heal, J. W., Niitsu, A., Thomson, A. R. and Wood, C. W. (2015) De novo protein design: how do we expand into the universe of possible protein structures? Current Opinion in Structural Biology, 33, pp. 16-26. (doi:10.1016/j.sbi.2015.05.009) (PMID:26093060)

Fletcher, J. M. et al. (2015) A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology. ACS Synthetic Biology, 1(6), pp. 240-250. (doi:10.1021/sb300028q) (PMID:23651206)

Mehrban, N. et al. (2015) Functionalized α-helical peptide hydrogels for neural tissue engineering. ACS Biomaterials Science and Engineering, 1(6), pp. 431-439. (doi:10.1021/acsbiomaterials.5b00051) (PMID:26240838) (PMCID:PMC4517957)

Bishop, P., Rubin, P., Thomson, A. R. , Rocca, D. and Henley, J. M. (2014) The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons. Journal of Biological Chemistry, 289(52), pp. 36140-36149. (doi:10.1074/jbc.M114.557124) (PMID:25326379) (PMCID:PMC4276877)

Wood, C. W., Bruning, M., Ibarra, A. Á., Bartlett, G. J., Thomson, A. R. , Sessions, R. B., Brady, R. L. and Woolfson, D. N. (2014) CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies. Bioinformatics, 30(21), pp. 3029-3035. (doi:10.1093/bioinformatics/btu502) (PMID:25064570) (PMCID:PMC4201159)

Thomson, A. R. , Wood, C. W., Burton, A. J., Bartlett, G. J., Sessions, R. B., Brady, R. L. and Woolfson, D. N. (2014) Computational design of water-soluble α-helical barrels. Science, 346(6208), pp. 485-488. (doi:10.1126/science.1257452) (PMID:25342807)

Mehrban, N., Abelardo, E., Wasmuth, A., Hudson, K. L., Mullen, L. M., Thomson, A. R. , Birchall, M. A. and Woolfson, D. N. (2014) Assessing cellular response to functionalized α-helical peptide hydrogels. Advanced Healthcare Materials, 3(9), pp. 1387-1391. (doi:10.1002/adhm.201400065) (PMID:24659615) (PMCID:PMC4276410)

Sharp, T. H., Bruning, M., Mantell, J., Sessions, R. B., Thomson, A. R. , Zaccai, N. R., Brady, R. L., Verkade, P. and Woolfson, D. N. (2012) Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design. Proceedings of the National Academy of Sciences of the United States of America, 109(33), pp. 13266-13271. (doi:10.1073/pnas.1118622109) (PMID:22847414) (PMCID:PMC3421226)

Woolfson, D. N., Bartlett, G. J., Bruning, M. and Thomson, A. R. (2012) New currency for old rope: from coiled-coil assemblies to α-helical barrels. Current Opinion in Structural Biology, 22(4), pp. 432-441. (doi:10.1016/j.sbi.2012.03.002) (PMID:22445228)

Zaccai, N. R. et al. (2011) A de novo peptide hexamer with a mutable channel. Nature Chemical Biology, 7(12), pp. 935-941. (doi:10.1038/nchembio.692) (PMID:22037471) (PMCID:PMC3223406)

Mahmoud, Z. N., Gunnoo, S. B., Thomson, A. R. , Fletcher, J. M. and Woolfson, D. N. (2011) Bioorthogonal dual functionalization of self-assembling peptide fibers. Biomaterials, 32(15), pp. 3712-3720. (doi:10.1016/j.biomaterials.2010.12.002) (PMID:21353303)

Stephanou, A. S., Roberts, G. A., Cooper, L. P., Clarke, D. J., Thomson, A. R. , MacKay, C. L., Nutley, M., Cooper, A. and Dryden, D. T.F. (2009) Dissection of the DNA mimicry of the bacteriophage T7 Ocr protein using chemical modification. Journal of Molecular Biology, 391(3), pp. 565-576. (doi:10.1016/j.jmb.2009.06.020) (PMID:19523474) (PMCID:PMC2806950)

Armstrong, C. T., Boyle, A. L., Bromley, E. H.C., Mahmoud, Z. N., Smith, L., Thomson, A. R. and Woolfson, D. N. (2009) Rational design of peptide-based building blocks for nanoscience and synthetic biology. Faraday Discussions, 143, pp. 305-317. (doi:10.1039/B901610D) (PMID:20334109)

Leigh, D. A., Lusby, P. J., McBurney, R. T., Morelli, A., Slawin, A. M.Z., Thomson, A. R. and Walker, D. B. (2009) Getting harder: cobalt (III)-template synthesis of catenanes and rotaxanes. Journal of the American Chemical Society, 131(10), pp. 3762-3771. (doi:10.1021/ja809627j) (PMID:19275264)

Bromley, E. H.C., Sessions, R. B., Thomson, A. R. and Woolfson, D. N. (2009) Designed α-helical tectons for constructing multicomponent synthetic biological systems. Journal of the American Chemical Society, 131(3), pp. 928-930. (doi:10.1021/ja804231a) (PMID:19115943)

Leigh, D. A. and Thomson, A. R. (2008) An ammonium/bis-ammonium switchable molecular shuttle. Tetrahedron Letters, 64(36), pp. 8411-8416. (doi:10.1016/j.tet.2008.05.130)

Dryden, D. T.F., Thomson, A. R. and White, J. H. (2008) How much of protein sequence space has been explored by life on Earth? Journal of the Royal Society: Interface, 5(25), pp. 953-956. (doi:10.1098/rsif.2008.0085) (PMID:18426772) (PMCID:PMC2459213)

Leigh, D. A. and Thomson, A. R. (2006) Switchable dual binding mode molecular shuttle. Organic Letters, 8(23), pp. 5377-5379. (doi:10.1021/ol062284j) (PMID:17078722)

Aucagne, V., Leigh, D. A., Lock, J. S. and Thomson, A. R. (2006) Rotaxanes of cyclic peptides. Journal of the American Chemical Society, 128(6), pp. 1784-1785. (doi:10.1021/ja057206q) (PMID:16464065)

This list was generated on Fri Dec 13 07:26:07 2019 GMT.

Teaching

Level 1: Organic Chemistry 2

Level 3: Organic Synthesis 1