Professor Andrew Jamieson
- Professor of Chemical Biology (School of Chemistry)
Andrew Jamieson was born in Glasgow and raised in Strathaven, Scotland.
In 2003, he completed a BSc Honours degree (1st Class) in Chemistry with Medicinal Chemistry at the University of Glasgow.
He subsequently studied for a Ph.D. at the University of Glasgow under the supervision of Dr Andrew Sutherland. The aim of his Ph.D. was to investigate a new substrate directed, palladium-catalysed aza-Claisen rearrangement, and utilise this novel reaction for the synthesis of natural products.
In 2007, he took up a postdoctoral research fellowship with Professor William Lubell at the University of Montreal, Canada. During this time he developed a novel synthetic method with which to systematically scan peptides for secondary structure. His research emphasis was determining the bioactive conformation of the growth hormone secretagogue, GHRP-6, as well as the allosteric modulator of the IL-1 receptor, 101.10 (rytvela).
In 2008, he took up a postdoctoral position with Professor Andrew Hamilton FRS at Yale University, USA. While there he worked on the design and synthesis of a novel peptide beta-strand mimetic, before moving with Professor Hamilton in 2009 to the University of Oxford, UK.
He was then appointed as a senior lecturer in Chemical Biology at the University of Glasgow School of Chemistry in July 2016. He currently runs a research group whose work focuses on the synthesis of peptides and peptidomimetics that can be used to probe the biological mechanisms of cancer and Alzheimer’s disease.
Andrew’s main hobbies outside of chemical biology are running, rugby and snowboarding.
A PhD studentship is currently available to work in the group developing a new peptidomimetic. For further details, please follow the link.
Research in the Jamieson Group is focused on the design and synthesis of peptides and peptidomimetics that can be used to probe the biological mechanisms underpinning disease. The information obtained from these studies is then used to inform the development of precision medicines.
We are particularly interested in the selective regulation of ion-channels by conotoxins with potential application in the treatment of severe pain. We are also investigating the structural activation and substrate binding of deubiquitinase (DUB) and histone deacetylase (HDAC) enzymes and developing novel peptide based inhibitors. We are also attempting to determine the structure of toxic amyloid proteins that are proposed to be the underlying cause of Alzheimer’s disease.
- P. J. Watson, C. J. Millard, A. M. Riley, N. S. Robertson, L. C. Wright, H. Y. Godage, S. M. Cowley, A. G. Jamieson, B. V. L. Potter, John W. R. Schwabe, The mechanism of activation of class I HDAC complexes by inositol phosphates. Nat. Commun., 2016, 7, 11262 (DOI: 10.1038/ncomms11262)
- M. J. Burton, S. M. Kapetanaki, R. C. Stratton, A. G. Jamieson, N. W. Davies, J. S. Mitcheson, R. Schmid, P. C. E. Moody, E. L. Raven, N. M. Storey, Heme modulates cardiac KATP channel function., PNAS, 2016, 113, 3785–3790.
- N. Allaway, A. G. Jamieson, Regulation of Protein-Protein Interactions using Stapled Peptides. Rep. Org Chem., 2015, 5, 65 - 74.
- B. Aillard, N. S. Robertson, A. R. Baldwin, S. Robins, A. G. Jamieson, Robust Asymmetric Synthesis of Unnatural Alkenyl Amino Acids for Conformationally Constrained alpha-Helix Peptides. Org. Biomol. Chem., 2014, 12, 8775.
Selected Recent Talks
“Next Generation Histone Deacetylase Inhibitors: Structure-Based Design of Peptide Mimetics” 50th European Symposium on Biological and Organic Chemistry, Gregynog, Newtown, Wales, May 2016
“Peptide Tools for Chemical Biology and Drug Discovery”, Sygnature Discovery, Nottingham, May 2016
“Regulation of HDAC-Corepressor PPIs: Towards Next Generation HDAC inhibitors”, EPSRC Programme Grant on PPIs Launch Event, University of Leeds, May 2016
“Conformationally-Constrained alpha-Helix Peptides: New Tools for Chemical Biology and Drug Discovery”, Defense Science and Technology Laboratory (DSTL), Porton Down, Salisbury, September 2015.
External Appointments & Positions
EPSRC College and Panel Member
Member of the SCI Industry Young Chemists Panel
Member of the RSC Chemical Biology and Bioorganic Group Committee
Member of the L'Agence Nationale de la Recherche (ANR) Grant Review Panel
Level-1 Organic Chemistry