Dr Paul Connelly

  • Honorary Clinical Lecturer (School of Cardiovascular & Metabolic Health)

email: Paul.Connelly@glasgow.ac.uk

Department of Endocrinology & Diabetes, Queen Elizabeth University Hospital, Glasgow, G51 4TF

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-1744-9977

Biography

I studied medicine at the University of Dundee (MBChB) with an intercalated BMSc(hons) in pharmacology. I graduated in 2012 and commenced Academic Training Foundation training in Ninewells Hospital, Dundee and then Glasgow Academic Training Environment Core Medical Training in Glasgow Royal Infirmary. I obtained Membership of the Royal College of Physicians in 2015 and commenced speciality training in Endocrinology and Diabetes, and General Internal Medicine in 2016 in the West of Scotland. I am currently undertaking a PhD funded by the British Heart Foundation Centre for Research Excellence.

Research interests

Research Interests

Sex steroids and vascular health

 

Project Summary

The effect of sex steroids upon vascular function and physiology is a topic of great interest. A deeper understanding of the alterations in vascular pathology and outcomes in transgender people receiving gender-affirming hormone therapy could be fundamental in informing the management of cardiovascular risk in this population and more broadly advance our understanding of the role of sex and gender in vascular health and disease.

 

We will undertake a series of studies to carefully assess vascular phenotypes, structure and function in people utilising gender-affirming hormone therapy, which will help us understand how sex hormones influence vascular health and impact risk of cardiovascular disease.

 

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015
Number of items: 24.

2024

Lim, M. W. S., Lucas-Herald, A. K. , Mason, A., Delles, C. and Connelly, P. J. (2024) Sex differences in the cardiovascular effects of GnRH analogues. Journal of Endocrinology, 261(1), e230309. (doi: 10.1530/JOE-23-0309) (PMID:38265843)

Sani, R. N., Connelly, P. J. , Toft, M., Rowa-Dewar, N., Delles, C. , Gasevic, D. and Karaye, K. M. (2024) Rural-urban difference in the prevalence of hypertension in West Africa: a systematic review and meta-analysis. Journal of Human Hypertension, 38, pp. 352-364. (doi: 10.1038/s41371-022-00688-8) (PMID:35430612) (PMCID:PMC11001577)

2023

Connelly, P. , Osmanska, J., Lee, M. M.Y. , Delles, C. , McEntegart, M. B. and Byrne, J. (2023) A case report of myocardial infarction in a young transgender man with testosterone therapy? raising awareness on healthcare issues in the transgender community and a call for further research. European Heart Journal: Case Reports, 7(12), ytad562. (doi: 10.1093/ehjcr/ytad562) (PMID:38093823) (PMCID:PMC10716680)

Murphy, C. N., Delles, C. , Davies, E. and Connelly, P. J. (2023) Cardiovascular disease in transgender individuals. Atherosclerosis, 384, 117282. (doi: 10.1016/j.atherosclerosis.2023.117282) (PMID:37821271)

Mangion, K. et al. (2023) Post-COVID-19 illness and associations with sex and gender. BMC Cardiovascular Disorders, 23, 389. (doi: 10.1186/s12872-023-03412-7) (PMID:37553628) (PMCID:PMC10408208)

Connelly, P. J. and Delles, C. (2023) Journal of Human Hypertension special issue on sex and gender differences in hypertension. Journal of Human Hypertension, 37(8), pp. 587-588. (doi: 10.1038/s41371-023-00847-5) (PMID:37474602)

Angelov, A., Connelly, P. J. , Delles, C. and Kararigas, G. (2023) Sex-biased and sex hormone-dependent regulation of apolipoprotein A1. Current Opinion in Physiology, 33, 100654. (doi: 10.1016/j.cophys.2023.100654)

Rytz, C. L. et al. (2023) Improving the inclusion of transgender and nonbinary individuals in the planning, completion, and mobilization of cardiovascular research. American Journal of Physiology: Heart and Circulatory Physiology, 324(3), H366-H372. (doi: 10.1152/ajpheart.00494.2022) (PMID:36637972)

Lim, M. W.S., Setjiadi, D., Dobbin, S. J.H., Lang, N. N. , Delles, C. and Connelly, P. J. (2023) Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review. Blood Pressure Monitoring, 28(1), pp. 24-32. (doi: 10.1097/MBP.0000000000000624) (PMID:36281701) (PMCID:PMC9815820)

2022

Connelly, P. J. , Currie, G. and Delles, C. (2022) Sex differences in the prevalence, outcomes and management of hypertension. Current Hypertension Reports, 24(6), pp. 185-192. (doi: 10.1007/s11906-022-01183-8) (PMID:35254589) (PMCID:PMC9239955)

Doherty, D. J., Sykes, R. , Connelly, P. J. and Hood, S. (2022) ST-elevation myocardial infarction due to coronary thrombus in a young patient with diabetic ketoacidosis and a new diagnosis of type-2 diabetes. BMJ Case Reports, 15, e247090. (doi: 10.1136/bcr-2021-247090) (PMID:35236686)

Connelly, P. J. , Casey, H., Montezano, A. C., Touyz, R. M. and Delles, C. (2022) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, 36(2), pp. 120-125. (doi: 10.1038/s41371-021-00576-7) (PMID:34230581) (PMCID:PMC8850193)

2021

Connelly, P. J. and Delles, C. (2021) Cardiovascular disease in transgender people: recent research and emerging evidence. Cardiovascular Research, 117(14), e174-e176. (doi: 10.1093/cvr/cvab288) (PMID:34568899) (PMCID:PMC8683701)

Connelly, P. J. , Azizi, Z., Alipour, P., Delles, C. , Pilote, L. and Raparelli, V. (2021) The importance of gender to understand sex differences in cardiovascular disease. Canadian Journal of Cardiology, 37(5), pp. 699-710. (doi: 10.1016/j.cjca.2021.02.005) (PMID:33592281)

Connelly, P. J. , Clark, A., Touyz, R. M. and Delles, C. (2021) Transgender adults, gender-affirming hormone therapy and blood pressure: a systematic review. Journal of Hypertension, 39(2), pp. 223-230. (doi: 10.1097/HJH.0000000000002632) (PMID:32809982) (PMCID:PMC7810409)

2020

Connelly, P. J. , Jandeleit-Dahm, K. A.M. and Delles, C. (2020) Sex and gender aspects in vascular pathophysiology. Clinical Science, 134(16), pp. 2203-2207. (doi: 10.1042/CS20200876) (PMID:32844996)

2019

Connelly, P. J. , Freel, E. M., Perry, C., Ewan, J., Touyz, R. M. , Currie, G. and Delles, C. (2019) Gender-affirming hormone therapy, vascular health and cardiovascular disease in transgender adults. Hypertension, 74(6), pp. 1266-1274. (doi: 10.1161/HYPERTENSIONAHA.119.13080) (PMID:31656099) (PMCID:PMC6887638)

2018

Collier, A., Connelly, P. J. , Hair, M., Cameron, L., Ghosh, S. and Waugh, N. (2018) Mortality risk remains higher in individuals with type 1 diabetes: a population-based cohort study (the Ayrshire diabetes follow-up cohort [ADOC]). Diabetes, Obesity and Metabolism, 20(8), pp. 1965-1971. (doi: 10.1111/dom.13334) (PMID:29687581)

McCreight, L. J., Stage, T. B., Connelly, P. , Lonergan, M., Nielsen, F., Prehn, C., Adamski, J., Brøsen, K. and Pearson, E. R. (2018) Pharmacokinetics of metformin in patients with gastrointestinal intolerance. Diabetes, Obesity and Metabolism, 20(7), pp. 1593-1601. (doi: 10.1111/dom.13264) (PMID:29457876) (PMCID:PMC6033038)

Bell, S., Soto-Pedre, E., Connelly, P. , Livingstone, S. and Pearson, E. (2018) Clarifying the relationship between metformin, acute kidney injury and lactic acidosis. Nature Reviews Nephrology, 14(1), p. 70. (doi: 10.1038/nrneph.2017.172) (PMID:29234163)

2017

Connelly, P. J. , Lonergan, M., Soto-Pedre, E., Donnelly, L., Zhou, K. and Pearson, E. R. (2017) Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: a GoDarts study. Diabetes, Obesity and Metabolism, 19(11), pp. 1579-1586. (doi: 10.1111/dom.12978) (PMID:28432751) (PMCID:PMC5655780)

Kueh, C. J.L., Connelly, P. , Harte, R., Smith, C. and Boyle, J. G. (2017) The impact of dapagliflozin on HbA1c, systolic blood pressure and weight: a review of dapagliflozin use in a Scottish city. Practical Diabetes, 34(4), pp. 129-130. (doi: 10.1002/pdi.2100)

2016

Connelly, P.J. , Smith, N., Chadwick, R., Exley, A.R., Shneerson, J.M. and Pearson, E.R. (2016) Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance. Diabetic Medicine, 33(3), pp. 371-375. (doi: 10.1111/dme.13037) (PMID:26606753) (PMCID:PMC4832393)

2015

Connelly, P. , McKay, G. and Petrie, J. R. (2015) Metformin in type 1 diabetes. Practical Diabetes, 32(5), 186-187a. (doi: 10.1002/pdi.1954)

This list was generated on Thu Jul 18 12:36:09 2024 BST.
Jump to: Articles
Number of items: 24.

Articles

Lim, M. W. S., Lucas-Herald, A. K. , Mason, A., Delles, C. and Connelly, P. J. (2024) Sex differences in the cardiovascular effects of GnRH analogues. Journal of Endocrinology, 261(1), e230309. (doi: 10.1530/JOE-23-0309) (PMID:38265843)

Sani, R. N., Connelly, P. J. , Toft, M., Rowa-Dewar, N., Delles, C. , Gasevic, D. and Karaye, K. M. (2024) Rural-urban difference in the prevalence of hypertension in West Africa: a systematic review and meta-analysis. Journal of Human Hypertension, 38, pp. 352-364. (doi: 10.1038/s41371-022-00688-8) (PMID:35430612) (PMCID:PMC11001577)

Connelly, P. , Osmanska, J., Lee, M. M.Y. , Delles, C. , McEntegart, M. B. and Byrne, J. (2023) A case report of myocardial infarction in a young transgender man with testosterone therapy? raising awareness on healthcare issues in the transgender community and a call for further research. European Heart Journal: Case Reports, 7(12), ytad562. (doi: 10.1093/ehjcr/ytad562) (PMID:38093823) (PMCID:PMC10716680)

Murphy, C. N., Delles, C. , Davies, E. and Connelly, P. J. (2023) Cardiovascular disease in transgender individuals. Atherosclerosis, 384, 117282. (doi: 10.1016/j.atherosclerosis.2023.117282) (PMID:37821271)

Mangion, K. et al. (2023) Post-COVID-19 illness and associations with sex and gender. BMC Cardiovascular Disorders, 23, 389. (doi: 10.1186/s12872-023-03412-7) (PMID:37553628) (PMCID:PMC10408208)

Connelly, P. J. and Delles, C. (2023) Journal of Human Hypertension special issue on sex and gender differences in hypertension. Journal of Human Hypertension, 37(8), pp. 587-588. (doi: 10.1038/s41371-023-00847-5) (PMID:37474602)

Angelov, A., Connelly, P. J. , Delles, C. and Kararigas, G. (2023) Sex-biased and sex hormone-dependent regulation of apolipoprotein A1. Current Opinion in Physiology, 33, 100654. (doi: 10.1016/j.cophys.2023.100654)

Rytz, C. L. et al. (2023) Improving the inclusion of transgender and nonbinary individuals in the planning, completion, and mobilization of cardiovascular research. American Journal of Physiology: Heart and Circulatory Physiology, 324(3), H366-H372. (doi: 10.1152/ajpheart.00494.2022) (PMID:36637972)

Lim, M. W.S., Setjiadi, D., Dobbin, S. J.H., Lang, N. N. , Delles, C. and Connelly, P. J. (2023) Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review. Blood Pressure Monitoring, 28(1), pp. 24-32. (doi: 10.1097/MBP.0000000000000624) (PMID:36281701) (PMCID:PMC9815820)

Connelly, P. J. , Currie, G. and Delles, C. (2022) Sex differences in the prevalence, outcomes and management of hypertension. Current Hypertension Reports, 24(6), pp. 185-192. (doi: 10.1007/s11906-022-01183-8) (PMID:35254589) (PMCID:PMC9239955)

Doherty, D. J., Sykes, R. , Connelly, P. J. and Hood, S. (2022) ST-elevation myocardial infarction due to coronary thrombus in a young patient with diabetic ketoacidosis and a new diagnosis of type-2 diabetes. BMJ Case Reports, 15, e247090. (doi: 10.1136/bcr-2021-247090) (PMID:35236686)

Connelly, P. J. , Casey, H., Montezano, A. C., Touyz, R. M. and Delles, C. (2022) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, 36(2), pp. 120-125. (doi: 10.1038/s41371-021-00576-7) (PMID:34230581) (PMCID:PMC8850193)

Connelly, P. J. and Delles, C. (2021) Cardiovascular disease in transgender people: recent research and emerging evidence. Cardiovascular Research, 117(14), e174-e176. (doi: 10.1093/cvr/cvab288) (PMID:34568899) (PMCID:PMC8683701)

Connelly, P. J. , Azizi, Z., Alipour, P., Delles, C. , Pilote, L. and Raparelli, V. (2021) The importance of gender to understand sex differences in cardiovascular disease. Canadian Journal of Cardiology, 37(5), pp. 699-710. (doi: 10.1016/j.cjca.2021.02.005) (PMID:33592281)

Connelly, P. J. , Clark, A., Touyz, R. M. and Delles, C. (2021) Transgender adults, gender-affirming hormone therapy and blood pressure: a systematic review. Journal of Hypertension, 39(2), pp. 223-230. (doi: 10.1097/HJH.0000000000002632) (PMID:32809982) (PMCID:PMC7810409)

Connelly, P. J. , Jandeleit-Dahm, K. A.M. and Delles, C. (2020) Sex and gender aspects in vascular pathophysiology. Clinical Science, 134(16), pp. 2203-2207. (doi: 10.1042/CS20200876) (PMID:32844996)

Connelly, P. J. , Freel, E. M., Perry, C., Ewan, J., Touyz, R. M. , Currie, G. and Delles, C. (2019) Gender-affirming hormone therapy, vascular health and cardiovascular disease in transgender adults. Hypertension, 74(6), pp. 1266-1274. (doi: 10.1161/HYPERTENSIONAHA.119.13080) (PMID:31656099) (PMCID:PMC6887638)

Collier, A., Connelly, P. J. , Hair, M., Cameron, L., Ghosh, S. and Waugh, N. (2018) Mortality risk remains higher in individuals with type 1 diabetes: a population-based cohort study (the Ayrshire diabetes follow-up cohort [ADOC]). Diabetes, Obesity and Metabolism, 20(8), pp. 1965-1971. (doi: 10.1111/dom.13334) (PMID:29687581)

McCreight, L. J., Stage, T. B., Connelly, P. , Lonergan, M., Nielsen, F., Prehn, C., Adamski, J., Brøsen, K. and Pearson, E. R. (2018) Pharmacokinetics of metformin in patients with gastrointestinal intolerance. Diabetes, Obesity and Metabolism, 20(7), pp. 1593-1601. (doi: 10.1111/dom.13264) (PMID:29457876) (PMCID:PMC6033038)

Bell, S., Soto-Pedre, E., Connelly, P. , Livingstone, S. and Pearson, E. (2018) Clarifying the relationship between metformin, acute kidney injury and lactic acidosis. Nature Reviews Nephrology, 14(1), p. 70. (doi: 10.1038/nrneph.2017.172) (PMID:29234163)

Connelly, P. J. , Lonergan, M., Soto-Pedre, E., Donnelly, L., Zhou, K. and Pearson, E. R. (2017) Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: a GoDarts study. Diabetes, Obesity and Metabolism, 19(11), pp. 1579-1586. (doi: 10.1111/dom.12978) (PMID:28432751) (PMCID:PMC5655780)

Kueh, C. J.L., Connelly, P. , Harte, R., Smith, C. and Boyle, J. G. (2017) The impact of dapagliflozin on HbA1c, systolic blood pressure and weight: a review of dapagliflozin use in a Scottish city. Practical Diabetes, 34(4), pp. 129-130. (doi: 10.1002/pdi.2100)

Connelly, P.J. , Smith, N., Chadwick, R., Exley, A.R., Shneerson, J.M. and Pearson, E.R. (2016) Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance. Diabetic Medicine, 33(3), pp. 371-375. (doi: 10.1111/dme.13037) (PMID:26606753) (PMCID:PMC4832393)

Connelly, P. , McKay, G. and Petrie, J. R. (2015) Metformin in type 1 diabetes. Practical Diabetes, 32(5), 186-187a. (doi: 10.1002/pdi.1954)

This list was generated on Thu Jul 18 12:36:09 2024 BST.