Dr Angie Sin

  • Research Associate (School of Cardiovascular & Metabolic Health)

telephone: +441413306388
email: Angie.Sin@glasgow.ac.uk

Import to contacts

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2006
Number of items: 22.

2025

Montezano, A. C. et al. (2025) Ang-(1-7) and ET-1 interplay through Mas and ETB receptor interaction defines a novel vasoprotective mechanism. Hypertension, 82(2), pp. 267-281. (doi: 10.1161/HYPERTENSIONAHA.124.22693) (PMID:39633565)

2024

Sin, Y. Y. et al. (2024) Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS Journal, (doi: 10.1111/febs.17359) (PMID:39673076) (Early Online Publication)

Main, Alice, Mary, Sheon ORCID logoORCID: https://orcid.org/0000-0001-9392-3020, Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Wright, Tom A., Ling, Jiayue, Blair, Connor M., Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741, Fuller, Will ORCID logoORCID: https://orcid.org/0000-0002-5883-4433 and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

McNeilly, S. et al. (2024) Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage. EBioMedicine, 107, 105315. (doi: 10.1016/j.ebiom.2024.105315) (PMID:39216230) (PMCID:PMC11402910)

Sin, Y. Y. et al. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598(13), pp. 1591-1604. (doi: 10.1002/1873-3468.14902) (PMID:38724485)

Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546) (PMCID:PMC11026450)

2020

Ngandu Mpoyi, E. et al. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts. Biomaterials, 252, 120090. (doi: 10.1016/j.biomaterials.2020.120090) (PMID:32413593)

2019

Gatseva, Anna ORCID logoORCID: https://orcid.org/0000-0003-1601-5277, Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Brezzo, Gaia and Van Agtmael, Tom ORCID logoORCID: https://orcid.org/0000-0003-4282-449X (2019) Basement membrane collagens and disease mechanisms. Essays in Biochemistry, 63(3), pp. 297-312. (doi: 10.1042/EBC20180071) (PMID:31387942) (PMCID:PMC6744580)

2018

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Ballantyne, Laurel L., Richmond, Christopher R. and Funk, Colin D. (2018) Transplantation of gene-edited hepatocyte-like cells modestly improves survival of arginase-1 deficient mice. Molecular Therapy - Nucleic Acids, 10, pp. 122-130. (doi: 10.1016/j.omtn.2017.11.012)

2017

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Price, Phillipe R., Ballantyne, Laurel L. and Funk, Colin D. (2017) Proof-of-concept gene editing for the murine model of inducible arginase-1 deficiency. Scientific Reports, 7, 2585. (doi: 10.1038/s41598-017-02927-2) (PMID:28566761) (PMCID:PMC5451454)

2016

Ballantyne, Laurel L., Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Al-Dirbashi, Osama Y., Li, Xinzhi, Hurlbut, David J. and Funk, Colin D. (2016) Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency. Molecular Genetics and Metabolism Reports, 9, pp. 54-60. (doi: 10.1016/j.ymgmr.2016.10.003) (PMID:27761413) (PMCID:PMC5065044)

2015

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Baron, Garrett, Schulze, Andreas and Funk, Colin D. (2015) Arginase-1 deficiency. Journal of Molecular Medicine, 93(12), pp. 1287-1296. (doi: 10.1007/s00109-015-1354-3) (PMID:26467175)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266 and Baillie, George ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1). Cell Biochemistry and Function, 33(7), pp. 421-426. (doi: 10.1002/cbf.3147) (PMID:26443497) (PMCID:PMC4973849)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Ballantyne, Laurel L., Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, St. Amand, Tim, Si, Joshua, Goossens, Steven, Haenebalcke, Lieven, Haigh, Jody J., Kyriakopoulou, Lianna, Schulze, Andreas and Funk, Colin D. (2015) Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. PLoS ONE, 10(5), e0125967. (doi: 10.1371/journal.pone.0125967) (PMID:25938595) (PMCID:PMC4418594)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Martin, Tamara P. ORCID logoORCID: https://orcid.org/0000-0002-2509-2613, Wills, Lauren, Currie, Susan and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, 16. (doi: 10.1186/s12964-015-0094-x) (PMID:25889640) (PMCID:PMC4356135)

2013

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Ballantyne, Laurel L., Mukherjee, Kamalika, St. Amand, Tim, Kyriakopoulou, Lianna, Schulze, Andreas and Funk, Colin D. (2013) Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. PLoS ONE, 8(11), e80001. (doi: 10.1371/journal.pone.0080001) (PMID:24224027) (PMCID:PMC3817112)

Berthouze-Duquesnes, M., Lucas, A., Saulière, A., Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Laurent, A.C., Galés, C., Baillie, G. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 and Lezoualc'h, F. (2013) Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling. Cellular Signalling, 25(4), pp. 970-980. (doi: 10.1016/j.cellsig.2012.12.007) (PMID:23266473)

2012

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266 and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2012) Protein kinase D in the hypertrophy pathway. Biochemical Society Transactions, 40(1), pp. 287-289. (doi: 10.1042/BST20110626) (PMID:22260707)

2011

Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Edwards, H.V., Li, X., Day, J.P., Christian, F. ORCID logoORCID: https://orcid.org/0000-0001-8208-5930, Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50(5), pp. 872-883. (doi: 10.1016/j.yjmcc.2011.02.006) (PMID:21334344)

Anthony, D.F., Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519, Houslay, M.D. and Baillie, G.S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2011) β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31(5), pp. 1066-1075. (doi: 10.1128/MCB.00883-10) (PMID:21173159) (PMCID:PMC3067824)

2006

Harris, T P, Gomas, K P, Weir, F, Holyoake, A J, McHugh, P, Wu, M, Sin, Y ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Sin, I L and Sin, F Y T (2006) Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men. International Journal of Andrology, 29(3), pp. 421-433. (doi: 10.1111/j.1365-2605.2005.00633.x) (PMID:16487403)

This list was generated on Sat Jun 14 13:15:00 2025 BST.
Jump to: Articles
Number of items: 22.

Articles

Montezano, A. C. et al. (2025) Ang-(1-7) and ET-1 interplay through Mas and ETB receptor interaction defines a novel vasoprotective mechanism. Hypertension, 82(2), pp. 267-281. (doi: 10.1161/HYPERTENSIONAHA.124.22693) (PMID:39633565)

Sin, Y. Y. et al. (2024) Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS Journal, (doi: 10.1111/febs.17359) (PMID:39673076) (Early Online Publication)

Main, Alice, Mary, Sheon ORCID logoORCID: https://orcid.org/0000-0001-9392-3020, Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Wright, Tom A., Ling, Jiayue, Blair, Connor M., Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741, Fuller, Will ORCID logoORCID: https://orcid.org/0000-0002-5883-4433 and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

McNeilly, S. et al. (2024) Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage. EBioMedicine, 107, 105315. (doi: 10.1016/j.ebiom.2024.105315) (PMID:39216230) (PMCID:PMC11402910)

Sin, Y. Y. et al. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598(13), pp. 1591-1604. (doi: 10.1002/1873-3468.14902) (PMID:38724485)

Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546) (PMCID:PMC11026450)

Ngandu Mpoyi, E. et al. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts. Biomaterials, 252, 120090. (doi: 10.1016/j.biomaterials.2020.120090) (PMID:32413593)

Gatseva, Anna ORCID logoORCID: https://orcid.org/0000-0003-1601-5277, Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Brezzo, Gaia and Van Agtmael, Tom ORCID logoORCID: https://orcid.org/0000-0003-4282-449X (2019) Basement membrane collagens and disease mechanisms. Essays in Biochemistry, 63(3), pp. 297-312. (doi: 10.1042/EBC20180071) (PMID:31387942) (PMCID:PMC6744580)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Ballantyne, Laurel L., Richmond, Christopher R. and Funk, Colin D. (2018) Transplantation of gene-edited hepatocyte-like cells modestly improves survival of arginase-1 deficient mice. Molecular Therapy - Nucleic Acids, 10, pp. 122-130. (doi: 10.1016/j.omtn.2017.11.012)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Price, Phillipe R., Ballantyne, Laurel L. and Funk, Colin D. (2017) Proof-of-concept gene editing for the murine model of inducible arginase-1 deficiency. Scientific Reports, 7, 2585. (doi: 10.1038/s41598-017-02927-2) (PMID:28566761) (PMCID:PMC5451454)

Ballantyne, Laurel L., Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Al-Dirbashi, Osama Y., Li, Xinzhi, Hurlbut, David J. and Funk, Colin D. (2016) Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency. Molecular Genetics and Metabolism Reports, 9, pp. 54-60. (doi: 10.1016/j.ymgmr.2016.10.003) (PMID:27761413) (PMCID:PMC5065044)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Baron, Garrett, Schulze, Andreas and Funk, Colin D. (2015) Arginase-1 deficiency. Journal of Molecular Medicine, 93(12), pp. 1287-1296. (doi: 10.1007/s00109-015-1354-3) (PMID:26467175)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266 and Baillie, George ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1). Cell Biochemistry and Function, 33(7), pp. 421-426. (doi: 10.1002/cbf.3147) (PMID:26443497) (PMCID:PMC4973849)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Ballantyne, Laurel L., Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, St. Amand, Tim, Si, Joshua, Goossens, Steven, Haenebalcke, Lieven, Haigh, Jody J., Kyriakopoulou, Lianna, Schulze, Andreas and Funk, Colin D. (2015) Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. PLoS ONE, 10(5), e0125967. (doi: 10.1371/journal.pone.0125967) (PMID:25938595) (PMCID:PMC4418594)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Martin, Tamara P. ORCID logoORCID: https://orcid.org/0000-0002-2509-2613, Wills, Lauren, Currie, Susan and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, 16. (doi: 10.1186/s12964-015-0094-x) (PMID:25889640) (PMCID:PMC4356135)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Ballantyne, Laurel L., Mukherjee, Kamalika, St. Amand, Tim, Kyriakopoulou, Lianna, Schulze, Andreas and Funk, Colin D. (2013) Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. PLoS ONE, 8(11), e80001. (doi: 10.1371/journal.pone.0080001) (PMID:24224027) (PMCID:PMC3817112)

Berthouze-Duquesnes, M., Lucas, A., Saulière, A., Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Laurent, A.C., Galés, C., Baillie, G. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 and Lezoualc'h, F. (2013) Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling. Cellular Signalling, 25(4), pp. 970-980. (doi: 10.1016/j.cellsig.2012.12.007) (PMID:23266473)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266 and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2012) Protein kinase D in the hypertrophy pathway. Biochemical Society Transactions, 40(1), pp. 287-289. (doi: 10.1042/BST20110626) (PMID:22260707)

Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Edwards, H.V., Li, X., Day, J.P., Christian, F. ORCID logoORCID: https://orcid.org/0000-0001-8208-5930, Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50(5), pp. 872-883. (doi: 10.1016/j.yjmcc.2011.02.006) (PMID:21334344)

Anthony, D.F., Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519, Houslay, M.D. and Baillie, G.S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2011) β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31(5), pp. 1066-1075. (doi: 10.1128/MCB.00883-10) (PMID:21173159) (PMCID:PMC3067824)

Harris, T P, Gomas, K P, Weir, F, Holyoake, A J, McHugh, P, Wu, M, Sin, Y ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Sin, I L and Sin, F Y T (2006) Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men. International Journal of Andrology, 29(3), pp. 421-433. (doi: 10.1111/j.1365-2605.2005.00633.x) (PMID:16487403)

This list was generated on Sat Jun 14 13:15:00 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Developing 3D culture systems for the validation of phosphodiesteras-4 inhibitors
    Medical Research Council
    2024 - 2025