2025

Cooke, S. F. et al. (2025) Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells. Molecular Therapy Oncology, 33(3), 201029. (doi: 10.1016/j.omton.2025.201029) (PMID:40896364) (PMCID:PMC12395054)

2024

Main, Alice, Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020, Sin, Yuan Yan ORCID: https://orcid.org/0000-0001-6537-5266, Wright, Tom A., Ling, Jiayue, Blair, Connor M., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741, Fuller, Will ORCID: https://orcid.org/0000-0002-5883-4433 and Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316 (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

Thongyim, Saruda, Wright, Thomas A., Sattayawat, Pachara, Kaewkod, Thida, Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, Tragoolpua, Yingmanee, Jangsutthivorawat, Siriphorn and Panya, Aussara (2024) Clinacanthus nutans extract lowers periodontal inflammation under high-glucose conditions via inhibiting NF-κB signaling pathway. Frontiers in Pharmacology, 15, 1410419. (doi: 10.3389/fphar.2024.1410419)

Sin, Y. Y. et al. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598(13), pp. 1591-1604. (doi: 10.1002/1873-3468.14902) (PMID:38724485)

Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546) (PMCID:PMC11026450)

2023

Wright, Thomas A., Gemmell, Alistair O., Tejeda, Gonzalo S. ORCID: https://orcid.org/0000-0002-2900-6276, Blair, Connor M. and Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316 (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, 106453. (doi: 10.1016/j.biocel.2023.106453) (PMID:37499270)

Articles

Cooke, S. F. et al. (2025) Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells. Molecular Therapy Oncology, 33(3), 201029. (doi: 10.1016/j.omton.2025.201029) (PMID:40896364) (PMCID:PMC12395054)

Main, Alice, Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020, Sin, Yuan Yan ORCID: https://orcid.org/0000-0001-6537-5266, Wright, Tom A., Ling, Jiayue, Blair, Connor M., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741, Fuller, Will ORCID: https://orcid.org/0000-0002-5883-4433 and Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316 (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

Thongyim, Saruda, Wright, Thomas A., Sattayawat, Pachara, Kaewkod, Thida, Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, Tragoolpua, Yingmanee, Jangsutthivorawat, Siriphorn and Panya, Aussara (2024) Clinacanthus nutans extract lowers periodontal inflammation under high-glucose conditions via inhibiting NF-κB signaling pathway. Frontiers in Pharmacology, 15, 1410419. (doi: 10.3389/fphar.2024.1410419)

Sin, Y. Y. et al. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598(13), pp. 1591-1604. (doi: 10.1002/1873-3468.14902) (PMID:38724485)

Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546) (PMCID:PMC11026450)

Wright, Thomas A., Gemmell, Alistair O., Tejeda, Gonzalo S. ORCID: https://orcid.org/0000-0002-2900-6276, Blair, Connor M. and Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316 (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, 106453. (doi: 10.1016/j.biocel.2023.106453) (PMID:37499270)