Dr Stephan Dreyer
- Honorary Clinical Lecturer (School of Cancer Sciences)
Research interests
Publications
2025
Dreyer, Stephan B., Beer, Philip, Hingorani, Sunil R. and Biankin, Andrew ORCID: https://orcid.org/0000-0002-0362-5597
(2025)
Improving outcomes of patients with pancreatic cancer.
Nature Reviews Clinical Oncology, 22(6),
pp. 439-456.
(doi: 10.1038/s41571-025-01019-9)
(PMID:40329051)
Herbert, Katharine J. ORCID: https://orcid.org/0000-0001-9437-0253, Upstill-Goddard, Rosie, Dreyer, Stephan B., Rebus, Selma, Pilarsky, Christian, Debabrata, Mukhopadhyay, Lord, Christopher J., Biankin, Andrew V.
ORCID: https://orcid.org/0000-0002-0362-5597, Froeling, Fieke E.M.
ORCID: https://orcid.org/0000-0002-8653-8164 and Chang, David K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2025)
Sequential ATR and PARP inhibition overcomes acquired DNA damaging agent resistance in pancreatic ductal adenocarcinoma.
British Journal of Cancer,
(doi: 10.1038/s41416-025-03051-z)
(Early Online Publication)
2024
Boey, A., Bryce, A. ORCID: https://orcid.org/0000-0003-0253-9723, Dickson, E., Coats, M., McKay, C., Jamieson, N.
ORCID: https://orcid.org/0000-0002-9552-4725, Chang, D.
ORCID: https://orcid.org/0000-0002-4821-3078, Holroyd, D. and Dreyer, S.
(2024)
The Impact of Pre-operative Indeterminate Lung Nodules in the Surgical Management of Pancreatic Ductal Adenocarcinoma.
16th World Congress of the International Hepato-Pancreato-Biliary Association, Cape Town, South Africa, 15-18 May 2024.
S148.
(doi: 10.1016/j.hpb.2024.03.269)
Bryce, Adam ORCID: https://orcid.org/0000-0003-0253-9723, Dreyer, Stephan, Dolan, Ross
ORCID: https://orcid.org/0000-0002-5272-5906, Froeling, Fieke
ORCID: https://orcid.org/0000-0002-8653-8164 and Chang, David
ORCID: https://orcid.org/0000-0002-4821-3078
(2024)
Host phenotypic adversity independently predicts progression to resection in neoadjuvantly-treated pancreatic cancer.
42nd Congress of the European Society of Surgical Oncology, Florence, Italy, 25-27 Oct 2023.
(doi: 10.1016/j.ejso.2023.107753)
Dreyer, Stephan, Bryce, Adam ORCID: https://orcid.org/0000-0003-0253-9723, Australian Pancreatic Cancer Genome Initiative, Biankin, Andrew
ORCID: https://orcid.org/0000-0002-0362-5597, Jamieson, Nigel
ORCID: https://orcid.org/0000-0002-9552-4725 and Chang, David
ORCID: https://orcid.org/0000-0002-4821-3078
(2024)
The clinical and molecular landscape of early onset pancreatic cancer.
42nd Congress of the European Society of Surgical Oncology, Florence, Italy, 25-27 Oct 2023.
(doi: 10.1016/j.ejso.2023.107348)
2023
Dreyer, S. B. et al. (2023) The impact of molecular subtyping on pathological staging of pancreatic cancer. Annals of Surgery, 277(2), e396-e405. (doi: 10.1097/SLA.0000000000005050) (PMID:36745763) (PMCID:PMC9831035)
2022
Bryce, Adam S. ORCID: https://orcid.org/0000-0003-0253-9723, Dreyer, Stephan B., Froeling, Fieke E.M.
ORCID: https://orcid.org/0000-0002-8653-8164 and Chang, David K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2022)
Exploring the biology of cancer-associated fibroblasts in pancreatic cancer.
Cancers, 14(21),
5302.
(doi: 10.3390/cancers14215302)
(PMID:36358721)
(PMCID:PMC9659154)
Khan, Khurram S. ORCID: https://orcid.org/0000-0002-8304-5970, Gall, Lewis S., Dreyer, Stephan, McCollum, Catherine, Chuntamongkol, Rongkagorn, Craig, Carol, MacKay, Colin, Macdonald, Andrew and Forshaw, Matthew
(2022)
Stage migration in newly diagnosed oesophagogastric cancer during the first wave of the COVID-19 pandemic.
British Journal of Surgery, 109(8),
pp. 773-774.
(doi: 10.1093/bjs/znac112)
(PMID:35616120)
Dreyer, Stephan B., Upstill-Goddard, Rosie, Legrini, Assya ORCID: https://orcid.org/0000-0001-5377-3048, Biankin, Andrew V.
ORCID: https://orcid.org/0000-0002-0362-5597, Jamieson, Nigel B.
ORCID: https://orcid.org/0000-0002-9552-4725 and Chang, David K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2022)
Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence.
Gastroenterology, 162(1),
320-324.e4.
(doi: 10.1053/j.gastro.2021.09.022)
(PMID:34534536)
(PMCID:PMC8721486)
Dreyer, S., Upstill-Goddard, R., Legrini, A. ORCID: https://orcid.org/0000-0001-5377-3048, Biankin, A.
ORCID: https://orcid.org/0000-0002-0362-5597, Jamieson, N.
ORCID: https://orcid.org/0000-0002-9552-4725 and Chang, D.
ORCID: https://orcid.org/0000-0002-4821-3078
(2022)
Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence.
15th World Congress of the International Hepato-Pancreato-Biliary Association, New York, USA, 30 Mar - 02 Apr 2022.
S44-S45.
(doi: 10.1016/j.hpb.2022.05.086)
2021
Casolino, R. et al. (2021) Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine. Annals of Oncology, 32(2), pp. 183-196. (doi: 10.1016/j.annonc.2020.11.013) (PMID:33248227) (PMCID:PMC7840891)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
2020
Moekotte, A. L. et al. (2020) Histopathologic predictors of survival and recurrence in resected ampullary adenocarcinoma. Annals of Surgery, 272(6), pp. 1086-1093. (doi: 10.1097/SLA.0000000000003177) (PMID:30628913)
Moekotte, A. L. et al. (2020) Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma. European Journal of Surgical Oncology, 46(9), pp. 1717-1726. (doi: 10.1016/j.ejso.2020.04.011) (PMID:32624291)
Dreyer, S. B. et al. (2020) Precision oncology in surgery: patient selection for operable pancreatic cancer. Annals of Surgery, 272(2), pp. 366-376. (doi: 10.1097/SLA.0000000000003143) (PMID:32675551) (PMCID:PMC7373491)
Moekotte, A.L. et al. (2020) Gemcitabine-based adjuvant chemotherapy in subtypes of ampullary adenocarcinoma: international propensity score-matched cohort study. British Journal of Surgery, 107(9), pp. 1171-1182. (doi: 10.1002/bjs.11555) (PMID:32259295)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
Dreyer, S.B., Jamieson, N.B. ORCID: https://orcid.org/0000-0002-9552-4725, Cooke, S.L.
ORCID: https://orcid.org/0000-0002-0955-0346, Valle, J.W., McKay, C.J., Biankin, A.V.
ORCID: https://orcid.org/0000-0002-0362-5597 and Chang, D.K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2020)
PRECISION-Panc: the next generation therapeutic development platform for pancreatic cancer.
Clinical Oncology, 32(1),
pp. 1-4.
(doi: 10.1016/j.clon.2019.07.011)
(PMID:31378449)
Dreyer, S.B., Jamieson, N.B. ORCID: https://orcid.org/0000-0002-9552-4725, Morton, J.P.
ORCID: https://orcid.org/0000-0001-5766-9141, Sansom, O.J.
ORCID: https://orcid.org/0000-0001-9540-3010, Biankin, A.V.
ORCID: https://orcid.org/0000-0002-0362-5597 and Chang, D.K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2020)
Pancreatic cancer: from genome discovery to PRECISION-Panc.
Clinical Oncology, 32(1),
pp. 5-8.
(doi: 10.1016/j.clon.2019.08.007)
(PMID:31522943)
2019
Halbrook, C. J. et al. (2019) Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer. Cell Metabolism, 29(6), 1390-1399.e6. (doi: 10.1016/j.cmet.2019.02.001) (PMID:30827862) (PMCID:PMC6602533)
Dreyer, S. B. et al. (2019) Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling. Chinese Clinical Oncology, 8(2), 16. (doi: 10.21037/cco.2019.04.06) (PMID:31070037)
2018
Dreyer, S.B., Jamieson, N.B. ORCID: https://orcid.org/0000-0002-9552-4725, Upstill-Goddard, R., Bailey, P.J.
ORCID: https://orcid.org/0000-0002-0857-2041, McKay, C.J., Australian Pancreatic Cancer Genome Initiative, Biankin, A.V.
ORCID: https://orcid.org/0000-0002-0362-5597 and Chang, D.K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2018)
Defining the molecular pathology of pancreatic body and tail adenocarcinom.
British Journal of Surgery, 105(2),
e183-e191.
(doi: 10.1002/bjs.10772)
(PMID:29341146)
(PMCID:PMC5817249)
2017
Dreyer, Stephan B., Powell, Arfon G.M.T., McSorley, Stephen T. ORCID: https://orcid.org/0000-0002-5459-8445, Waterston, Ashita, Going, James J., Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906, McMillan, Donald C.
ORCID: https://orcid.org/0000-0003-4260-5334 and Horgan, Paul G.
ORCID: https://orcid.org/0000-0001-5557-7905
(2017)
The pretreatment systemic inflammatory response is an important determinant of poor pathologic response for patients undergoing neoadjuvant therapy for rectal cancer.
Annals of Surgical Oncology, 24(5),
pp. 1295-1303.
(doi: 10.1245/s10434-016-5684-3)
(PMID:27873100)
Dreyer, Stephan B., Chang, David K. ORCID: https://orcid.org/0000-0002-4821-3078, Bailey, Peter
ORCID: https://orcid.org/0000-0002-0857-2041 and Biankin, Andrew V.
ORCID: https://orcid.org/0000-0002-0362-5597
(2017)
Pancreatic cancer genomes: implications for clinical management and therapeutic development.
Clinical Cancer Research, 23(7),
pp. 1638-1646.
(doi: 10.1158/1078-0432.CCR-16-2411)
(PMID:28373362)
Articles
Dreyer, Stephan B., Beer, Philip, Hingorani, Sunil R. and Biankin, Andrew ORCID: https://orcid.org/0000-0002-0362-5597
(2025)
Improving outcomes of patients with pancreatic cancer.
Nature Reviews Clinical Oncology, 22(6),
pp. 439-456.
(doi: 10.1038/s41571-025-01019-9)
(PMID:40329051)
Herbert, Katharine J. ORCID: https://orcid.org/0000-0001-9437-0253, Upstill-Goddard, Rosie, Dreyer, Stephan B., Rebus, Selma, Pilarsky, Christian, Debabrata, Mukhopadhyay, Lord, Christopher J., Biankin, Andrew V.
ORCID: https://orcid.org/0000-0002-0362-5597, Froeling, Fieke E.M.
ORCID: https://orcid.org/0000-0002-8653-8164 and Chang, David K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2025)
Sequential ATR and PARP inhibition overcomes acquired DNA damaging agent resistance in pancreatic ductal adenocarcinoma.
British Journal of Cancer,
(doi: 10.1038/s41416-025-03051-z)
(Early Online Publication)
Dreyer, S. B. et al. (2023) The impact of molecular subtyping on pathological staging of pancreatic cancer. Annals of Surgery, 277(2), e396-e405. (doi: 10.1097/SLA.0000000000005050) (PMID:36745763) (PMCID:PMC9831035)
Bryce, Adam S. ORCID: https://orcid.org/0000-0003-0253-9723, Dreyer, Stephan B., Froeling, Fieke E.M.
ORCID: https://orcid.org/0000-0002-8653-8164 and Chang, David K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2022)
Exploring the biology of cancer-associated fibroblasts in pancreatic cancer.
Cancers, 14(21),
5302.
(doi: 10.3390/cancers14215302)
(PMID:36358721)
(PMCID:PMC9659154)
Khan, Khurram S. ORCID: https://orcid.org/0000-0002-8304-5970, Gall, Lewis S., Dreyer, Stephan, McCollum, Catherine, Chuntamongkol, Rongkagorn, Craig, Carol, MacKay, Colin, Macdonald, Andrew and Forshaw, Matthew
(2022)
Stage migration in newly diagnosed oesophagogastric cancer during the first wave of the COVID-19 pandemic.
British Journal of Surgery, 109(8),
pp. 773-774.
(doi: 10.1093/bjs/znac112)
(PMID:35616120)
Dreyer, Stephan B., Upstill-Goddard, Rosie, Legrini, Assya ORCID: https://orcid.org/0000-0001-5377-3048, Biankin, Andrew V.
ORCID: https://orcid.org/0000-0002-0362-5597, Jamieson, Nigel B.
ORCID: https://orcid.org/0000-0002-9552-4725 and Chang, David K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2022)
Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence.
Gastroenterology, 162(1),
320-324.e4.
(doi: 10.1053/j.gastro.2021.09.022)
(PMID:34534536)
(PMCID:PMC8721486)
Casolino, R. et al. (2021) Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine. Annals of Oncology, 32(2), pp. 183-196. (doi: 10.1016/j.annonc.2020.11.013) (PMID:33248227) (PMCID:PMC7840891)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
Moekotte, A. L. et al. (2020) Histopathologic predictors of survival and recurrence in resected ampullary adenocarcinoma. Annals of Surgery, 272(6), pp. 1086-1093. (doi: 10.1097/SLA.0000000000003177) (PMID:30628913)
Moekotte, A. L. et al. (2020) Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma. European Journal of Surgical Oncology, 46(9), pp. 1717-1726. (doi: 10.1016/j.ejso.2020.04.011) (PMID:32624291)
Dreyer, S. B. et al. (2020) Precision oncology in surgery: patient selection for operable pancreatic cancer. Annals of Surgery, 272(2), pp. 366-376. (doi: 10.1097/SLA.0000000000003143) (PMID:32675551) (PMCID:PMC7373491)
Moekotte, A.L. et al. (2020) Gemcitabine-based adjuvant chemotherapy in subtypes of ampullary adenocarcinoma: international propensity score-matched cohort study. British Journal of Surgery, 107(9), pp. 1171-1182. (doi: 10.1002/bjs.11555) (PMID:32259295)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
Dreyer, S.B., Jamieson, N.B. ORCID: https://orcid.org/0000-0002-9552-4725, Cooke, S.L.
ORCID: https://orcid.org/0000-0002-0955-0346, Valle, J.W., McKay, C.J., Biankin, A.V.
ORCID: https://orcid.org/0000-0002-0362-5597 and Chang, D.K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2020)
PRECISION-Panc: the next generation therapeutic development platform for pancreatic cancer.
Clinical Oncology, 32(1),
pp. 1-4.
(doi: 10.1016/j.clon.2019.07.011)
(PMID:31378449)
Dreyer, S.B., Jamieson, N.B. ORCID: https://orcid.org/0000-0002-9552-4725, Morton, J.P.
ORCID: https://orcid.org/0000-0001-5766-9141, Sansom, O.J.
ORCID: https://orcid.org/0000-0001-9540-3010, Biankin, A.V.
ORCID: https://orcid.org/0000-0002-0362-5597 and Chang, D.K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2020)
Pancreatic cancer: from genome discovery to PRECISION-Panc.
Clinical Oncology, 32(1),
pp. 5-8.
(doi: 10.1016/j.clon.2019.08.007)
(PMID:31522943)
Halbrook, C. J. et al. (2019) Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer. Cell Metabolism, 29(6), 1390-1399.e6. (doi: 10.1016/j.cmet.2019.02.001) (PMID:30827862) (PMCID:PMC6602533)
Dreyer, S. B. et al. (2019) Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling. Chinese Clinical Oncology, 8(2), 16. (doi: 10.21037/cco.2019.04.06) (PMID:31070037)
Dreyer, S.B., Jamieson, N.B. ORCID: https://orcid.org/0000-0002-9552-4725, Upstill-Goddard, R., Bailey, P.J.
ORCID: https://orcid.org/0000-0002-0857-2041, McKay, C.J., Australian Pancreatic Cancer Genome Initiative, Biankin, A.V.
ORCID: https://orcid.org/0000-0002-0362-5597 and Chang, D.K.
ORCID: https://orcid.org/0000-0002-4821-3078
(2018)
Defining the molecular pathology of pancreatic body and tail adenocarcinom.
British Journal of Surgery, 105(2),
e183-e191.
(doi: 10.1002/bjs.10772)
(PMID:29341146)
(PMCID:PMC5817249)
Dreyer, Stephan B., Powell, Arfon G.M.T., McSorley, Stephen T. ORCID: https://orcid.org/0000-0002-5459-8445, Waterston, Ashita, Going, James J., Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906, McMillan, Donald C.
ORCID: https://orcid.org/0000-0003-4260-5334 and Horgan, Paul G.
ORCID: https://orcid.org/0000-0001-5557-7905
(2017)
The pretreatment systemic inflammatory response is an important determinant of poor pathologic response for patients undergoing neoadjuvant therapy for rectal cancer.
Annals of Surgical Oncology, 24(5),
pp. 1295-1303.
(doi: 10.1245/s10434-016-5684-3)
(PMID:27873100)
Dreyer, Stephan B., Chang, David K. ORCID: https://orcid.org/0000-0002-4821-3078, Bailey, Peter
ORCID: https://orcid.org/0000-0002-0857-2041 and Biankin, Andrew V.
ORCID: https://orcid.org/0000-0002-0362-5597
(2017)
Pancreatic cancer genomes: implications for clinical management and therapeutic development.
Clinical Cancer Research, 23(7),
pp. 1638-1646.
(doi: 10.1158/1078-0432.CCR-16-2411)
(PMID:28373362)
Conference or Workshop Item
Boey, A., Bryce, A. ORCID: https://orcid.org/0000-0003-0253-9723, Dickson, E., Coats, M., McKay, C., Jamieson, N.
ORCID: https://orcid.org/0000-0002-9552-4725, Chang, D.
ORCID: https://orcid.org/0000-0002-4821-3078, Holroyd, D. and Dreyer, S.
(2024)
The Impact of Pre-operative Indeterminate Lung Nodules in the Surgical Management of Pancreatic Ductal Adenocarcinoma.
16th World Congress of the International Hepato-Pancreato-Biliary Association, Cape Town, South Africa, 15-18 May 2024.
S148.
(doi: 10.1016/j.hpb.2024.03.269)
Bryce, Adam ORCID: https://orcid.org/0000-0003-0253-9723, Dreyer, Stephan, Dolan, Ross
ORCID: https://orcid.org/0000-0002-5272-5906, Froeling, Fieke
ORCID: https://orcid.org/0000-0002-8653-8164 and Chang, David
ORCID: https://orcid.org/0000-0002-4821-3078
(2024)
Host phenotypic adversity independently predicts progression to resection in neoadjuvantly-treated pancreatic cancer.
42nd Congress of the European Society of Surgical Oncology, Florence, Italy, 25-27 Oct 2023.
(doi: 10.1016/j.ejso.2023.107753)
Dreyer, Stephan, Bryce, Adam ORCID: https://orcid.org/0000-0003-0253-9723, Australian Pancreatic Cancer Genome Initiative, Biankin, Andrew
ORCID: https://orcid.org/0000-0002-0362-5597, Jamieson, Nigel
ORCID: https://orcid.org/0000-0002-9552-4725 and Chang, David
ORCID: https://orcid.org/0000-0002-4821-3078
(2024)
The clinical and molecular landscape of early onset pancreatic cancer.
42nd Congress of the European Society of Surgical Oncology, Florence, Italy, 25-27 Oct 2023.
(doi: 10.1016/j.ejso.2023.107348)
Dreyer, S., Upstill-Goddard, R., Legrini, A. ORCID: https://orcid.org/0000-0001-5377-3048, Biankin, A.
ORCID: https://orcid.org/0000-0002-0362-5597, Jamieson, N.
ORCID: https://orcid.org/0000-0002-9552-4725 and Chang, D.
ORCID: https://orcid.org/0000-0002-4821-3078
(2022)
Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence.
15th World Congress of the International Hepato-Pancreato-Biliary Association, New York, USA, 30 Mar - 02 Apr 2022.
S44-S45.
(doi: 10.1016/j.hpb.2022.05.086)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- The role of cancer associated fibroblast heterogeneity in determining metastatic patterns in pancreatic and oesophageal adenocarcinoma
Office of the Chief Scientific Adviser
2022 - 2024
- The role of tumour microenvironment heterogeneity in determining metastatic patterns in pancreatic and oesophagogastric adenocarcinoma
Rosetrees Trust
2022 - 2024
- The role of tumour microenvironment heterogeneity in determining metastatic patterns in pancreatic and oesophagogastric adenocarcinoma
The Stoneygate Trust
2022 - 2024
- The role of tumour microenvironment heterogeneity in determining metastatic patterns in oesophago-gastric adenocarcinoma
Tenovus Scotland
2021 - 2023
- Characterising the immune landscape of molecular subtypes of pancreatic ductal adenocarcinoma
Cancer Research UK
2020 - 2022