Ms Leonor Patricia Schubert Santana
- Bioinformatician (Therapeutic Science Research)
Publications
2026
Dreyer, S. et al. (2026) Clinical and molecular landscape of surgically resected early onset pancreatic cancer. BJS Open, 113(5), znag032. (doi: 10.1093/bjs/znag032) (PMCID:PMC13151028)
Pea, A. et al. (2026) Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas. Nature Communications, 17(1), 3427. (doi: 10.1038/s41467-026-69762-w) (PMID:41775703) (PMCID:PMC13076896)
Bryce, A. S. et al. (2026) Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinoma. bioRxiv, (doi: 10.64898/2026.02.06.704414)
Lourenço, F. C. et al. (2026) Decay of driver mutations shapes the landscape of intestinal transformation. Nature, 649(8097), pp. 729-738. (doi: 10.1038/s41586-025-09762-w) (PMID:41339549) (PMCID:PMC12804087)
2025
Hosogane, Tsuyoshi, Schubert Santana, Leonor, Eling, Nils, Moch, Holger and Bodenmiller, Bernd (2025) Compressed sensing expands the multiplexity of imaging mass cytometry. Nature Communications, 16(1), 11671. (doi: 10.1038/s41467-025-66629-4) (PMID:41309632) (PMCID:PMC12748953)
Farndale, L. et al. (2025) Self-supervised AI reveals a hidden landscape of prognostic spatial patterns in multiplex immunofluorescence images. bioRxiv, Oct 16. (doi: 10.1101/2025.10.16.682563)
Beutel, A. K. et al. (2025) Mevalonate biosynthesis is a metabolic vulnerability of gemcitabine-resistant pancreatic cancer. bioRxiv, Sep 20. (doi: 10.1101/2025.09.19.675739)
Pea, A. et al. (2025) Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization. Journal of Pathology, 266(4-5), pp. 421-434. (doi: 10.1002/path.6437) (PMID:40371932) (PMCID:PMC12256392)
Hatthakarnkul, P. et al. (2025) The characteristic of epithelial-specific phenotypes and immunosuppressive microenvironment in the context of tumour budding in colorectal cancer. bioRxiv, Mar 7. (doi: 10.1101/2025.03.05.641608)
2024
Pennel, K. et al. (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14(12), 1629. (doi: 10.3390/biom14121629)
Pea, A. et al. (2024) Clonal evolutionary analysis reveals patterns of malignant transformation in pancreatic cancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN). bioRxiv, August 6. (doi: 10.1101/2024.08.02.606217)
Articles
Dreyer, S. et al. (2026) Clinical and molecular landscape of surgically resected early onset pancreatic cancer. BJS Open, 113(5), znag032. (doi: 10.1093/bjs/znag032) (PMCID:PMC13151028)
Pea, A. et al. (2026) Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas. Nature Communications, 17(1), 3427. (doi: 10.1038/s41467-026-69762-w) (PMID:41775703) (PMCID:PMC13076896)
Bryce, A. S. et al. (2026) Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinoma. bioRxiv, (doi: 10.64898/2026.02.06.704414)
Lourenço, F. C. et al. (2026) Decay of driver mutations shapes the landscape of intestinal transformation. Nature, 649(8097), pp. 729-738. (doi: 10.1038/s41586-025-09762-w) (PMID:41339549) (PMCID:PMC12804087)
Hosogane, Tsuyoshi, Schubert Santana, Leonor, Eling, Nils, Moch, Holger and Bodenmiller, Bernd (2025) Compressed sensing expands the multiplexity of imaging mass cytometry. Nature Communications, 16(1), 11671. (doi: 10.1038/s41467-025-66629-4) (PMID:41309632) (PMCID:PMC12748953)
Farndale, L. et al. (2025) Self-supervised AI reveals a hidden landscape of prognostic spatial patterns in multiplex immunofluorescence images. bioRxiv, Oct 16. (doi: 10.1101/2025.10.16.682563)
Beutel, A. K. et al. (2025) Mevalonate biosynthesis is a metabolic vulnerability of gemcitabine-resistant pancreatic cancer. bioRxiv, Sep 20. (doi: 10.1101/2025.09.19.675739)
Pea, A. et al. (2025) Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization. Journal of Pathology, 266(4-5), pp. 421-434. (doi: 10.1002/path.6437) (PMID:40371932) (PMCID:PMC12256392)
Hatthakarnkul, P. et al. (2025) The characteristic of epithelial-specific phenotypes and immunosuppressive microenvironment in the context of tumour budding in colorectal cancer. bioRxiv, Mar 7. (doi: 10.1101/2025.03.05.641608)
Pennel, K. et al. (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14(12), 1629. (doi: 10.3390/biom14121629)
Pea, A. et al. (2024) Clonal evolutionary analysis reveals patterns of malignant transformation in pancreatic cancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN). bioRxiv, August 6. (doi: 10.1101/2024.08.02.606217)