Professor Karen Blyth
- Professor (CRUK Scotland Institute)
telephone:
01413303686
email:
Karen.Blyth@glasgow.ac.uk
Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Henry Wellcome ICM, Bearsden, Glasgow, G61 1BD
https://orcid.org/0000-0002-9304-439XResearch interests
Research groups
- Urological (Prostate/Bladder/Kidney)
- Breast
- Comprehensive Cancer Models
Publications
2026
Elbassioni, A. A. M. et al. (2026) Targeting Runx1 protects against heart failure with preserved ejection fraction. Cardiovascular Research, (Accepted for Publication)
2025
Whyte, D. et al. (2025) Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. EMBO Reports, 26(17), pp. 4248-4282. (doi: 10.1038/s44319-025-00520-7) (PMID:40702342) (PMCID:PMC12420820)
Ahmed, S. F. et al. (2025) Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia. Molecular Therapy, pp. 3624-3643. (doi: 10.1016/j.ymthe.2025.04.042) (PMID:40329529)
Gounis, M. et al. (2025) Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments. Journal of Cell Biology, 224(8), e202405061. (doi: 10.1083/jcb.202405061) (PMID:40488669) (PMCID:PMC12147664)
May, S. et al. (2025) A precision image-guided model of stereotactic ablative radiotherapy for hepatocellular carcinoma. Disease Models and Mechanisms, 18(5), dmm052301. (doi: 10.1242/dmm.052301) (PMID:40241674) (PMCID:PMC12128222)
Hartley, Andrew, Galbraith, Laura C.A., Shaw, Robin, Tibbo, Amy, Veeratterapillay, Rajan, Wilson, Laura, Heer, Rakesh, Blyth, Karen 
ORCID: https://orcid.org/0000-0002-9304-439X, Leung, Hing ORCID: https://orcid.org/0000-0002-3933-3975 and Ahmad, Imran ORCID: https://orcid.org/0000-0002-4404-1926
(2025)
Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos.
British Journal of Cancer, 132(6),
pp. 502-512.
(doi: 10.1038/s41416-025-02944-3)
(PMID:39885328)
Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, 639(8055), pp. 754-764. (doi: 10.1038/s41586-025-08585-z) (PMID:39972137) (PMCID:PMC11922762)
2024
Strathearn, Lauren S., Spender, Lindsay C., Schoenherr, Christina, Mason, Susan, Edwards, Ruaridh, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Inman, Gareth ORCID: https://orcid.org/0000-0002-6264-4253
(2024)
C1orf106 (INAVA) is a SMAD3-dependent TGF-β target gene that promotes clonogenicity and correlates with poor prognosis in breast cancer.
Cells, 13(18),
1530.
(doi: 10.3390/cells13181530)
Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, 43(14), pp. 2878-2907. (doi: 10.1038/s44318-024-00133-1) (PMID:38816652) (PMCID:PMC11251046)
Mardilovich, Katerina, Naylor, Gregory, Julian, Linda, Phinichkusolchit, Narisa, Keeshan, Karen ORCID: https://orcid.org/0000-0001-7266-0890, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Olson, Michael F. ORCID: https://orcid.org/0000-0003-3428-3507
(2024)
Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice.
Disease Models and Mechanisms, 17(5),
dmm050631.
(doi: 10.1242/dmm.050631)
(PMID:38616733)
(PMCID:PMC11139034)
Mahmood, M. et al. (2024) Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nature Cancer, 5(4), pp. 659-672. (doi: 10.1038/s43018-023-00721-w) (PMID:38286828) (PMCID:PMC11056318)
Leung, E. Y.l. et al. (2024) Chemokine CCL21 Induces an Immunotolerant Tumour Microenvironment Leading to Poorer Survival in Ovarian Cancer. ESGO 2024 Congress, Barcelona, Spain, 7-10 March 2024. (doi: 10.1136/ijgc-2024-esgo.985)
Santi, A. et al. (2024) Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. Science Signaling, 17(827), eade0580. (doi: 10.1126/scisignal.ade0580) (PMID:38470957)
2023
Papalazarou, V. et al. (2023) Phenotypic profiling of solute carriers characterises serine transport in cancer. Nature Metabolism, 5, pp. 2148-2168. (doi: 10.1038/s42255-023-00936-2) (PMID:38066114) (PMCID:PMC10730406)
Papalazarou, V. et al. (2023) Phenotypic profiling of solute carriers characterizes serine transport in cancer. Nature Metabolism, 5(12), pp. 2148-2168. (doi: 10.1038/s42255-023-00936-2) (PMID:38066114) (PMCID:PMC10730406)
Martin, T. P. et al. (2023) Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction. Cardiovascular Research, 119(16), 2663–2671-2663–2671. (doi: 10.1093/cvr/cvad107) (PMID:37433039) (PMCID:PMC10730241)
Dzien, P. et al. (2023) Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo. Cancer and Metabolism, 11, 14. (doi: 10.1186/s40170-023-00314-2) (PMID:37679822) (PMCID:PMC10486058)
Bailey, P. et al. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, 5211. (doi: 10.1038/s41467-023-40822-9) (PMID:37626054) (PMCID:PMC10457401)
Suzuki, T. et al. (2023) β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer Immunology Research, 11(8), pp. 1137-1155. (doi: 10.1158/2326-6066.CIR-22-0644) (PMID:37309673) (PMCID:PMC10398359)
Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115) (PMID:36880595) (PMCID:PMC9997661)
Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)
Khan, Adiba S., Campbell, Kirsteen J., Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491 and Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X
(2023)
The RUNX/CBFβ complex in breast cancer: a conundrum of context.
Cells, 12(4),
641.
(doi: 10.3390/cells12040641)
(PMID:36831308)
(PMCID:PMC9953914)
2022
Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)
Falcone, M. et al. (2022) Sensitisation of cancer cells to radiotherapy by serine and glycine starvation. British Journal of Cancer, 127(10), pp. 1773-1786. (doi: 10.1038/s41416-022-01965-6) (PMID:36115879) (PMCID:PMC9643498)
Edwards, S. C. et al. (2022) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220(2), e20211431. (doi: 10.1084/jem.20211431) (PMID:36480166) (PMCID:PMC9732671)
Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29(10), pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3) (PMID:35473984) (PMCID:PMC9525582)
Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4(6), pp. 693-710. (doi: 10.1038/s42255-022-00582-0) (PMID:35760868) (PMCID:PMC9236907)
Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)
Spiliopoulou, P. et al. (2022) Dual G9A/EZH2 inhibition stimulates anti-tumour immune response in ovarian high grade serous carcinoma. Molecular Cancer Therapeutics, 21(4), pp. 522-534. (doi: 10.1158/1535-7163.MCT-21-0743) (PMID:35131874) (PMCID:PMC9377747)
Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14(3), e14764. (doi: 10.15252/emmm.202114764) (PMID:35014179) (PMCID:PMC8899912)
Humpton, Timothy J., Hall, Holly, Kiourtis, Christos ORCID: https://orcid.org/0000-0002-6682-5668, Nixon, Colin, Clark, William, Hedley, Ann, Shaw, Robin, Bird, Thomas G., Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Vousden, Karen H.
(2022)
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl₄.
Cell Death and Differentiation, 29(3),
pp. 514-526.
(doi: 10.1038/s41418-021-00871-3)
(PMID:34628485)
(PMCID:PMC8901761)
Humpton, T. J. et al. (2022) A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo. Science Signaling, 15(720), eabd9099. (doi: 10.1126/scisignal.abd9099) (PMID:35133863) (PMCID:PMC7612476)
2021
Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)
Bock, F. J. et al. (2021) Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death. Nature Communications, 12, 6572. (doi: 10.1038/s41467-021-26613-0) (PMID:34772930) (PMCID:PMC8590049)
McGarry, David J., Armstrong, Garett, Castino, Giovanni, Mason, Susan, Clark, William, Shaw, Robin, McGarry, Lynn, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Olson, Michael F. ORCID: https://orcid.org/0000-0003-3428-3507
(2021)
MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
Cancer Letters, 519,
pp. 226-236.
(doi: 10.1016/j.canlet.2021.07.039)
(PMID:34314753)
Campbell, K. J. et al. (2021) Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death and Differentiation, 28(9), pp. 2589-2600. (doi: 10.1038/s41418-021-00773-4) (PMID:33785871) (PMCID:PMC8408186)
Koessinger, A. L. et al. (2021) Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. bioRxiv, (doi: 10.1101/2021.06.13.448232)
Newman, Alice Clare, Falcone, Mattia ORCID: https://orcid.org/0000-0003-0906-5735, Huerta Uribe, Alejandro ORCID: https://orcid.org/0000-0002-6452-6111, Zhang, Tong, Athineos, Dimitris, Pietzke, Matthias, Vazquez, Alexei ORCID: https://orcid.org/0000-0003-2764-3244, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Maddocks, Oliver David Kenneth ORCID: https://orcid.org/0000-0002-5551-9091
(2021)
Immune regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells.
Molecular Cell, 81(11),
2290-2302.e7.
(doi: 10.1016/j.molcel.2021.03.019)
(PMID:33831358)
Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)
Tajan, M. et al. (2021) Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nature Communications, 12, 366. (doi: 10.1038/s41467-020-20223-y) (PMID:33446657) (PMCID:PMC7809039)
Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)
Humpton, T. J. et al. (2021) Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes and Development, 35(1-2), pp. 117-132. (doi: 10.1101/gad.341875.120) (PMID:33334825) (PMCID:PMC7778261)
2020
Mevel, R. et al. (2020) RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. eLife, 9, e60225. (doi: 10.7554/elife.60225) (PMID:33025905) (PMCID:PMC7644213)
Zhang, Tong, Bauer, Christin, Newman, Alice C., Uribe, Alejandro Huerta, Athineos, Dimitris, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Maddocks, Oliver D.K. ORCID: https://orcid.org/0000-0002-5551-9091
(2020)
Polyamine pathway activity promotes cysteine essentiality in cancer cells.
Nature Metabolism, 2,
pp. 1062-1076.
(doi: 10.1038/s42255-020-0253-2)
(PMID:32747794)
Millar, Rhona, Kilbey, Anna, Remak, Sarah-Jane, Severson, Tesa M., Dhayade, Sandeep, Sandilands, Emma, Foster, Kyla, Bryant, David M. ORCID: https://orcid.org/0000-0003-2721-5012, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Coffelt, Seth B. ORCID: https://orcid.org/0000-0003-2257-2862
(2020)
The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer.
Molecular Oncology, 14(8),
pp. 1868-1880.
(doi: 10.1002/1878-0261.12734)
(PMID:32484599)
(PMCID:PMC7400785)
Dhayade, Sandeep, Pietzke, Matthias, Wiesheu, Robert, Tait-Mulder, Jacqueline, Athineos, Dimitris, Sumpton, David, Coffelt, Seth ORCID: https://orcid.org/0000-0003-2257-2862, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Vazquez, Alexei ORCID: https://orcid.org/0000-0003-2764-3244
(2020)
Impact of formate supplementation on body weight and plasma amino acids.
Nutrients, 12(8),
2181.
(doi: 10.3390/nu12082181)
(PMID:32708052)
(PMCID:PMC7469024)
Rooney, N. et al. (2020) RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome. Cancer Research, 80(11), pp. 2325-2339. (doi: 10.1158/0008-5472.CAN-19-3870) (PMID:32156779)
Oizel, K. et al. (2020) Formate induces a metabolic switch in nucleotide and energy metabolism. Cell Death and Disease, 11(5), 310. (doi: 10.1038/s41419-020-2523-z) (PMID:32366892) (PMCID:PMC7198490)
Campbell, Kirsteen J. and Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X
(2020)
Somatic base editing to model oncogenic drivers in breast cancer.
Lab Animal, 49,
pp. 115-116.
(doi: 10.1038/s41684-020-0510-8)
(PMID:32152514)
Lie-A-Ling, Michael, Mevel, Renaud, Patel, Rahima, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Baena, Esther, Kouskoff, Valerie and Lacaud, Georges
(2020)
RUNX1 dosage in development and cancer.
Molecules and Cells, 43(2),
pp. 126-138.
(doi: 10.14348/molcells.2019.0301)
(PMID:31991535)
(PMCID:PMC7057845)
Sweeney, Kerri, Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491 and Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X
(2020)
Complex interplay between the RUNX transcription factors and Wnt/β-catenin pathway in cancer: a tango in the night.
Molecules and Cells, 43(2),
pp. 188-197.
(doi: 10.14348/molcells.2019.0310)
(PMID:32041394)
(PMCID:PMC7057843)
MacKenzie, D. J. et al. (2020) DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation. iScience, 23(2), 100838. (doi: 10.1016/j.isci.2020.100838) (PMID:32058953) (PMCID:PMC7000804)
Cheung, Eric C., DeNicola, Gina M., Nixon, Colin, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Labuschagne, Christiaan F., Tuveson, David A. and Vousden, Karen
(2020)
Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer.
Cancer Cell, 37(2),
168-182.e4.
(doi: 10.1016/j.ccell.2019.12.012)
(PMID:31983610)
(PMCID:PMC7008247)
Caraffini, V. et al. (2020) Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis. Haematologica, 105(2), pp. 375-386. (doi: 10.3324/haematol.2018.209650) (PMID:31097632) (PMCID:PMC7012480)
Blagih, J. et al. (2020) Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses. Cell Reports, 30(2), 481-496.e6. (doi: 10.1016/j.celrep.2019.12.028) (PMID:31940491) (PMCID:31940491)
Loveridge, C. J. et al. (2020) BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. Oncogene, 39, pp. 1797-1806. (doi: 10.1038/s41388-019-1106-x) (PMID:31740786) (PMCID:PMC7033044)
Ran, R. et al. (2020) A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells. Oncogene, 39, pp. 2624-2637. (doi: 10.1038/s41388-020-1170-2) (PMID:32005976) (PMCID:PMC7082223)
2019
Liko, D. et al. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26(12), pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7) (PMID:30858608) (PMCID:PMC6861133)
Johnson, Síle A., Ormsby, Michael J. ORCID: https://orcid.org/0000-0002-3991-2336, McIntosh, Anne, Tait, Stephen W.G. ORCID: https://orcid.org/0000-0001-7697-132X, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Wall, Daniel M. ORCID: https://orcid.org/0000-0002-0421-1951
(2019)
Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori.
Cancer Gene Therapy, 26(7-8),
pp. 183-194.
(doi: 10.1038/s41417-018-0039-9)
(PMID:30100607)
(PMCID:PMC6760541)
Rudzka, D. A. et al. (2019) Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. Journal of Cell Science, 132(11), jcs224071. (doi: 10.1242/jcs.224071) (PMID:31152052) (PMCID:PMC6589089)
Vande Voorde, Johan ORCID: https://orcid.org/0000-0002-7686-0926, Ackermann, Tobias, Pfetzer, Nadja, Sumpton, David, Mackay, Gillian, Kalna, Gabriela, Nixon, Colin, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Gottlieb, Eyal ORCID: https://orcid.org/0000-0002-9770-0956 and Tardito, Saverio ORCID: https://orcid.org/0000-0002-5294-8683
(2019)
Improving the metabolic fidelity of cancer models with a physiological cell culture medium.
Science Advances, 5(1),
eaau7314.
(doi: 10.1126/sciadv.aau7314)
(PMID:30613774)
(PMCID:PMC6314821)
Hassan, S. et al. (2019) A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences, 20(14), 3428. (doi: 10.3390/ijms20143428) (PMID:31336867) (PMCID:PMC6678499)
2018
Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)
Meiser, J. et al. (2018) Increased formate overflow is a hallmark of oxidative cancer. Nature Communications, 9, 1368. (doi: 10.1038/s41467-018-03777-w) (PMID:29636461) (PMCID:PMC5893600)
Campbell, K. J. et al. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, 19. (doi: 10.1038/s41419-017-0035-2) (PMID:29339815) (PMCID:PMC5833338)
McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)
2017
Dornier, E. et al. (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8, 2255. (doi: 10.1038/s41467-017-02101-2) (PMID:29269878) (PMCID:PMC5740148)
Walton, J. B. et al. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, 16827. (doi: 10.1038/s41598-017-17119-1) (PMID:29203787) (PMCID:PMC5715106)
Loveridge, C. J. et al. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, 13241. (doi: 10.1038/s41598-017-13346-8) (PMID:29038439) (PMCID:PMC5643304)
van Tuyn, J. et al. (2017) Oncogene-expressing senescent melanocytes upregulate MhC class II, a candidate melanoma suppressor function. Journal of Investigative Dermatology, 137(10), pp. 2197-2207. (doi: 10.1016/j.jid.2017.05.030) (PMID:28647344) (PMCID:PMC5613751)
Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi: 10.1038/ncb3596) (PMID:28846096) (PMCID:PMC5624512)
Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)
Riggio, Alessandra I. and Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X
(2017)
The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives.
FEBS Journal, 284(15),
pp. 2345-2362.
(doi: 10.1111/febs.14059)
(PMID:28304148)
Loveridge, C. J. et al. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77(12), pp. 3158-3168. (doi: 10.1158/0008-5472.CAN-16-2565) (PMID:28515147)
Hock, A. K. et al. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, 1837. (doi: 10.1038/s41598-017-01741-0) (PMID:28500323) (PMCID:PMC5431786)
Maddocks, O. D.K. et al. (2017) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature, 544(7650), pp. 372-376. (doi: 10.1038/nature22056) (PMID:28425994)
Holen, Ingunn, Speirs, Valerie, Morrissey, Bethny and Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X
(2017)
In vivo models in breast cancer research: progress, challenges and future directions.
Disease Models and Mechanisms, 10(4),
pp. 359-371.
(doi: 10.1242/dmm.028274)
(PMID:28381598)
(PMCID:PMC5399571)
Rooney, Nicholas, Riggio, Alessandra I., Mendoza-Villanueva, Daniel, Shore, Paul, Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491 and Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X
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(2003)
Long-range effects of retroviral insertion on c-myb: Overexpression may be obscured by silencing during tumor growth in vitro.
Journal of Virology, 77(2),
pp. 1059-1068.
(doi: 10.1128/JVI.77.2.1059-1068.2003)
(PMID:12502821)
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Wotton, Sandy, Stewart, Monica, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Vaillant, Francois, Kilbey, Anna, Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279 and Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491
(2002)
Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma.
Cancer Research, 62(24),
pp. 7181-7185.
(PMID:12499254)
Vaillant, François, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Andrew, Linda, Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279 and Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491
(2002)
Enforced expression of Runx2 perturbs T cell development at a stage coincident with β-selection.
Journal of Immunology, 169(6),
pp. 2866-2874.
(doi: 10.4049/jimmunol.169.6.2866)
Baxter, Euan W., Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491 and Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279
(2001)
Selection for loss of p53 function in T-cell lymphomagenesis is alleviated by Moloney murine leukemia virus infection in myc transgenic mice.
Journal of Virology, 75(20),
pp. 9790-9798.
(doi: 10.1128/JVI.75.20.9790-9798.2001)
(PMID:11559812)
(PMCID:PMC114551)
Blyth, K. ORCID: https://orcid.org/0000-0002-9304-439X, Terry, A., Mackay, N., Vaillant, F., Bell, M., Cameron, E.R. ORCID: https://orcid.org/0000-0001-8311-1491, Neil, J.C. ORCID: https://orcid.org/0000-0003-4447-8279 and Stewart, M
(2001)
Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging.
Oncogene, 20(3),
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(doi: 10.1038/sj.onc.1204090)
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Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Stewart, Monica, Bell, Margaret, James, Clarwyn, Evan, Gerard, Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279 and Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491
(2000)
Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycERTM mice.
Oncogene, 19(6),
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(doi: 10.1038/sj.onc.1203321)
(PMID:10698495)
Cameron, E.R. ORCID: https://orcid.org/0000-0001-8311-1491, Morton, J. ORCID: https://orcid.org/0000-0001-5766-9141, Johnston, C.J., Irvine, J., Bell, M, Onions, D.E., Neil, J.C. ORCID: https://orcid.org/0000-0003-4447-8279, Campbell, M. and Blyth, K. ORCID: https://orcid.org/0000-0002-9304-439X
(2000)
Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene.
Cell Death and Differentiation, 7(1),
pp. 80-88.
(doi: 10.1038/sj.cdd.4400630)
(PMID:10713723)
Vaillant, François, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Terry, Anne, Bell, Margaret, Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491, Neil, James ORCID: https://orcid.org/0000-0003-4447-8279 and Stewart, Monica
(1999)
A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc.
Oncogene, 18(50),
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(1999)
Identification of murine CBF alpha1, a runt domain transcription factor, as a putative Myc collaborator in T cell lymphoma.
Leukemia, 13(S1),
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(PMID:10232373)
Hall, Anthony P., Irvine, Jane, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X, Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491, Onions, David E. and Campbell, Moyra E.M.
(1998)
Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression.
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(1997)
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(1996)
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Book Sections
Rooney, Nicholas, Riggio, Alessandra I., Mendoza-Villanueva, Daniel, Shore, Paul, Cameron, Ewan R. ORCID: https://orcid.org/0000-0001-8311-1491 and Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X
(2017)
Runx genes in breast cancer and the mammary lineage.
In: Groner, Yoram, Ito, Yoshiaki, Liu, Paul, Neil, James C., Speck, Nancy A. and van Wijnen, Andre (eds.)
RUNX Proteins in Development and Cancer.
Series: Advances in experimental medicine and biology, 96 (962).
Springer, pp. 353-368.
ISBN 9789811032318
(doi: 10.1007/978-981-10-3233-2_22)
Conference or Workshop Item
Leung, E. Y.l. et al. (2024) Chemokine CCL21 Induces an Immunotolerant Tumour Microenvironment Leading to Poorer Survival in Ovarian Cancer. ESGO 2024 Congress, Barcelona, Spain, 7-10 March 2024. (doi: 10.1136/ijgc-2024-esgo.985)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Treatment of Cancer-associated Cachexia
Cancer Research UK
2025 - 2026
- Using complex state of the art mouse models of cancer to improve the understanding and treatment of human cancer
Medical Research Council
2022 - 2027
- MRC MGN Director's flexible funding award
Medical Research Council
2022 - 2027
- Regulation of IL-17-producing T cells in Breast Cancer Metastasis
Breast Cancer Now
2019 - 2023
- Evaluation of metabotropic glutamate receptor 3 as a therapeutic target in breast cancer.
Breast Cancer Now
2019 - 2022
- Regulation of IL-17-producing T cells in breast cancer metastasis
Breast Cancer Now
2019 - 2021
- Targeting MCL-1 in breast cancer
Breast Cancer Now
2016 - 2019
- Annexin A8's role in progenitor cell maintenance within the cells of origin of basal-like breast cancers.
Breast Cancer Now
2013 - 2016
- The role of Runx2 in mammary development and breast cancer
Association for International Cancer Research
2008 - 2008
Supervision
- Kadam, Prerna Pradeep
Integrated pharmacological and genetic identification of therapeutic targets for RDEB Squamous Cell Carcinoma