Professor Danny Huang

  • Professor of Cancer Structural Biology (CRUK Scotland Institute)

Research interests

Research groups

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2009 | 2008 | 2007
Number of items: 36.

2025

Huang, Danny ORCID logoORCID: https://orcid.org/0000-0002-6192-259X and Dearlove, Emily (2025) Insights into non-proteinaceous ubiquitination. Biochemical Society Transactions, (Accepted for Publication)

Morgan, Danielle C., McDougall, Laura, Knuhtsen, Astrid, Buetow, Lori, Steven, Craig F., Shepperson, Oscar, Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X, Hulme, Alison N. and Jamieson, Andrew George ORCID logoORCID: https://orcid.org/0000-0003-1726-7353 (2025) Raman active diyne-Girder conformationally constrained p53 stapled peptides bind to MDM2 for visualisation without fluorophores. RSC Chemical Biology, (doi: 10.1039/D4CB00288A) (Early Online Publication)

2024

Vosbein, Pernille, Vergara, Paula Paredes, Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X and Thomson, Andrew R. ORCID logoORCID: https://orcid.org/0000-0002-1066-1369 (2024) An engineered ubiquitin binding coiled coil peptide. Chemical Science, 15(38), pp. 15776-15782. (doi: 10.1039/d4sc04204b) (PMID:39268210)

Bohlen, J. et al. (2024) Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated monocyte activation. Journal of Clinical Investigation, 134(20), e181604. (doi: 10.1172/JCI181604) (PMID:39403923) (PMCID:PMC11475086)

Dearlove, Emily L., Chatrin, Chatrin, Buetow, Lori, Ahmed, Syed F. ORCID logoORCID: https://orcid.org/0000-0003-0689-5549, Schmidt, Tobias, Bushell, Martin ORCID logoORCID: https://orcid.org/0000-0001-9938-2691, Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2024) DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids. eLife, 13, RP98070. (doi: 10.7554/elife.98070) (PMID:39377462)

Vosbein, Pernille, Paredes Vergara, Paula, Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X and Thomson, Drew ORCID logoORCID: https://orcid.org/0000-0002-1066-1369 (2024) AlphaFold ensemble competition screens enable peptide binder design with single-residue sensitivity. ACS Chemical Biology, (doi: 10.1021/acschembio.4c00418) (Early Online Publication)

Vringer, E. et al. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43(6), pp. 904-930. (doi: 10.1038/s44318-024-00044-1) (PMID:38337057) (PMCID:PMC10943237)

2023

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)

Schmidt, T. et al. (2023) eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51(4), pp. 1859-1879. (doi: 10.1093/nar/gkad030) (PMID:36727461) (PMCID:PMC9976904)

Chen, H. et al. (2023) PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Blood Vessels, 141(3), pp. 244-259. (doi: 10.1182/blood.2022016580) (PMID:36206490)

2022

Kowalczyk, Dominika, Nakasone, Mark A., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2022) Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function. Life Science Alliance, 5(12), e202201472. (doi: 10.26508/lsa.202201472) (PMID:35944929) (PMCID:PMC9366199)

Nakasone, Mark A., Majorek, Karolina A., Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Sibbet, Gary J., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2022) Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension. Nature Chemical Biology, 18, pp. 422-431. (doi: 10.1038/s41589-021-00952-x) (PMID:35027744) (PMCID:PMC8964413)

2021

Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Lilla, Sergio, Sibbet, Gary J., Sumpton, David, Zanivan, Sara ORCID logoORCID: https://orcid.org/0000-0002-9880-9099, Hedley, Ann, Clark, William and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2021) E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis. Oncogene, 40(12), pp. 2149-2164. (doi: 10.1038/s41388-021-01684-x) (PMID:33627783) (PMCID:PMC7994203)

Magnussen, Helge M. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2021) Identification of a catalytic active but non-aggregating MDM2 RING domain variant. Journal of Molecular Biology, 433(5), 166807. (doi: 10.1016/j.jmb.2021.166807) (PMID:33450248) (PMCID:PMC7895813)

Humpton, T. J. et al. (2021) Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes and Development, 35(1-2), pp. 117-132. (doi: 10.1101/gad.341875.120) (PMID:33334825) (PMCID:PMC7778261)

2020

Chatrin, Chatrin, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed F., Sumpton, David, Sibbet, Gary J., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2020) Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases. Science Advances, 6(38), eabc0418. (doi: 10.1126/sciadv.abc0418) (PMID:32948590) (PMCID:PMC7500938)

Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Lilla, Sergio, Chatrin, Chatrin, Sibbet, Gary J., Zanivan, Sara ORCID logoORCID: https://orcid.org/0000-0002-9880-9099 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2020) DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. Science Advances, 6(34), eabc0629. (doi: 10.1126/sciadv.abc0629) (PMID:32937373) (PMCID:PMC7442474)

Magnussen, H. M. et al. (2020) Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nature Communications, 11, 2094. (doi: 10.1038/s41467-020-15783-y) (PMID:32350255) (PMCID:PMC7190642)

2019

Gabrielsen, Mads, Buetow, Lori, Kowalczyk, Dominika, Zhang, Wei, Sidhu, Sachdev S. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2019) Identification and characterization of mutations in ubiquitin required for non-covalent dimer formation. Structure, 27(9), 1452-1459.e4. (doi: 10.1016/j.str.2019.06.008) (PMID:31303481) (PMCID:PMC6720194)

Patel, Amrita, Sibbet, Gary J. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2019) Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B~ubiquitin complex. Journal of Biological Chemistry, 294, pp. 1240-1249. (doi: 10.1074/jbc.RA118.006045) (PMID:30523153) (PMCID:PMC6349121)

2018

Buetow, Lori, Gabrielsen, Mads and Huang, Danny ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2018) Single-Turnover RING/U-Box E3-Mediated Lysine Discharge Assays. In: Mayor, Thibault and Kleiger, Gary (eds.) The Ubiquitin Proteasome System. Series: Methods in Molecular Biology (1844). Humana Press, pp. 19-31. ISBN 9781493987054 (doi: 10.1007/978-1-4939-8706-1_2)

Marciano, Gabriele, Da Vela, Stefano, Tria, Giancarlo, Svergun, Dmitri I., Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2018) Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones. Journal of Biological Chemistry, 293(26), pp. 10071-10083. (doi: 10.1074/jbc.RA117.000994) (PMID:29764934) (PMCID:PMC6028955)

2017

Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed Feroj, Sibbet, Gary J., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168, Zhang, Wei, Sidhu, Sachdev S. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2017) A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants. Molecular Cell, 68(2), 456-470.e10. (doi: 10.1016/j.molcel.2017.09.027) (PMID:29053960) (PMCID:PMC5655547)

Nomura, Koji ORCID logoORCID: https://orcid.org/0000-0002-5912-074X, Klejnot, Marta, Kowalczyk, Dominika, Hock, Andreas K., Sibbet, Gary J., Vousden, Karen and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2017) Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nature Structural and Molecular Biology, 24(7), pp. 578-587. (doi: 10.1038/nsmb.3414) (PMID:28553961)

2016

Buetow, Lori and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2016) Structural insights into the catalysis and regulation of E3 ubiquitin ligases. Nature Reviews Molecular Cell Biology, 17(10), pp. 626-642. (doi: 10.1038/nrm.2016.91) (PMID:27485899)

Buetow, Lori, Tria, Giancarlo, Ahmed, Syed Feroj, Hock, Andreas, Dou, Hao, Sibbet, Gary J., Svergun, Dmitri I. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2016) Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation. BMC Biology, 14, 76. (doi: 10.1186/s12915-016-0298-6) (PMID:27609087) (PMCID:PMC5015263)

Marciano, G. and Huang, D.T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2016) Structure of the human histone chaperone FACT Spt16 N-terminal domain. Acta Crystallographica. Section F: Structural Biology Communications, 72(2), pp. 121-128. (doi: 10.1107/s2053230x15024565) (PMID:26841762) (PMCID:PMC4741192)

Nakasone, Mark and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2016) Ubiquitination accomplished: E1 and E2 enzymes were not necessary. Molecular Cell, 62(6), pp. 807-809. (doi: 10.1016/j.molcel.2016.06.001) (PMID:27315555)

2015

Buetow, Lori, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Anthony, Nahoum G., Dou, Hao, Patel, Amrita, Aitkenhead, Hazel, Sibbet, Gary J., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2015) Activation of a primed RING E3-E2–ubiquitin complex by non-covalent ubiquitin. Molecular Cell, 58(2), pp. 297-310. (doi: 10.1016/j.molcel.2015.02.017) (PMID:25801170)

2013

Dou, Hao, Buetow, Lori, Sibbet, G.J., Cameron, K. and Huang, D.T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2013) Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3. Nature Structural and Molecular Biology, 20(8), pp. 982-986. (doi: 10.1038/nsmb.2621)

2012

Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H. and Huang, D.T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2012) Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl. Nature Structural and Molecular Biology, 19(2), pp. 184-192. (doi: 10.1038/nsmb.2231)

Dou, H., Buetow, L., Sibbet, G.J., Cameron, K. and Huang, D.T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2012) BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer. Nature Structural and Molecular Biology, 19(9), pp. 876-883. (doi: 10.1038/nsmb.2379)

2009

Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X, Ayrault, Olivier, Hunt, Harold W., Taherbhoy, Asad M., Duda, David M., Scott, Daniel C., Borg, Laura A., Neale, Geoffrey, Murray, Peter J. and Roussel, Martine F. (2009) E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification. Molecular Cell, 33(4), pp. 483-495. (doi: 10.1016/j.molcel.2009.01.011)

2008

Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X, Zhuang, Min, Ayrault, Olivier and Schulman, Brenda A (2008) Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2. Nature Structural and Molecular Biology, 15(3), pp. 280-287. (doi: 10.1038/nsmb.1387)

2007

Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X, Hunt, Harold W., Zhuang, Min, Ohi, Melanie D., Holton, James M. and Schulman, Brenda A. (2007) Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity. Nature, 445(7126), pp. 394-398. (doi: 10.1038/nature05490)

This list was generated on Sun Jun 15 09:53:45 2025 BST.
Jump to: Articles | Book Sections
Number of items: 36.

Articles

Huang, Danny ORCID logoORCID: https://orcid.org/0000-0002-6192-259X and Dearlove, Emily (2025) Insights into non-proteinaceous ubiquitination. Biochemical Society Transactions, (Accepted for Publication)

Morgan, Danielle C., McDougall, Laura, Knuhtsen, Astrid, Buetow, Lori, Steven, Craig F., Shepperson, Oscar, Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X, Hulme, Alison N. and Jamieson, Andrew George ORCID logoORCID: https://orcid.org/0000-0003-1726-7353 (2025) Raman active diyne-Girder conformationally constrained p53 stapled peptides bind to MDM2 for visualisation without fluorophores. RSC Chemical Biology, (doi: 10.1039/D4CB00288A) (Early Online Publication)

Vosbein, Pernille, Vergara, Paula Paredes, Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X and Thomson, Andrew R. ORCID logoORCID: https://orcid.org/0000-0002-1066-1369 (2024) An engineered ubiquitin binding coiled coil peptide. Chemical Science, 15(38), pp. 15776-15782. (doi: 10.1039/d4sc04204b) (PMID:39268210)

Bohlen, J. et al. (2024) Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated monocyte activation. Journal of Clinical Investigation, 134(20), e181604. (doi: 10.1172/JCI181604) (PMID:39403923) (PMCID:PMC11475086)

Dearlove, Emily L., Chatrin, Chatrin, Buetow, Lori, Ahmed, Syed F. ORCID logoORCID: https://orcid.org/0000-0003-0689-5549, Schmidt, Tobias, Bushell, Martin ORCID logoORCID: https://orcid.org/0000-0001-9938-2691, Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2024) DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids. eLife, 13, RP98070. (doi: 10.7554/elife.98070) (PMID:39377462)

Vosbein, Pernille, Paredes Vergara, Paula, Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X and Thomson, Drew ORCID logoORCID: https://orcid.org/0000-0002-1066-1369 (2024) AlphaFold ensemble competition screens enable peptide binder design with single-residue sensitivity. ACS Chemical Biology, (doi: 10.1021/acschembio.4c00418) (Early Online Publication)

Vringer, E. et al. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43(6), pp. 904-930. (doi: 10.1038/s44318-024-00044-1) (PMID:38337057) (PMCID:PMC10943237)

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)

Schmidt, T. et al. (2023) eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51(4), pp. 1859-1879. (doi: 10.1093/nar/gkad030) (PMID:36727461) (PMCID:PMC9976904)

Chen, H. et al. (2023) PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Blood Vessels, 141(3), pp. 244-259. (doi: 10.1182/blood.2022016580) (PMID:36206490)

Kowalczyk, Dominika, Nakasone, Mark A., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2022) Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function. Life Science Alliance, 5(12), e202201472. (doi: 10.26508/lsa.202201472) (PMID:35944929) (PMCID:PMC9366199)

Nakasone, Mark A., Majorek, Karolina A., Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Sibbet, Gary J., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2022) Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension. Nature Chemical Biology, 18, pp. 422-431. (doi: 10.1038/s41589-021-00952-x) (PMID:35027744) (PMCID:PMC8964413)

Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Lilla, Sergio, Sibbet, Gary J., Sumpton, David, Zanivan, Sara ORCID logoORCID: https://orcid.org/0000-0002-9880-9099, Hedley, Ann, Clark, William and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2021) E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis. Oncogene, 40(12), pp. 2149-2164. (doi: 10.1038/s41388-021-01684-x) (PMID:33627783) (PMCID:PMC7994203)

Magnussen, Helge M. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2021) Identification of a catalytic active but non-aggregating MDM2 RING domain variant. Journal of Molecular Biology, 433(5), 166807. (doi: 10.1016/j.jmb.2021.166807) (PMID:33450248) (PMCID:PMC7895813)

Humpton, T. J. et al. (2021) Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes and Development, 35(1-2), pp. 117-132. (doi: 10.1101/gad.341875.120) (PMID:33334825) (PMCID:PMC7778261)

Chatrin, Chatrin, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed F., Sumpton, David, Sibbet, Gary J., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2020) Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases. Science Advances, 6(38), eabc0418. (doi: 10.1126/sciadv.abc0418) (PMID:32948590) (PMCID:PMC7500938)

Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Lilla, Sergio, Chatrin, Chatrin, Sibbet, Gary J., Zanivan, Sara ORCID logoORCID: https://orcid.org/0000-0002-9880-9099 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2020) DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. Science Advances, 6(34), eabc0629. (doi: 10.1126/sciadv.abc0629) (PMID:32937373) (PMCID:PMC7442474)

Magnussen, H. M. et al. (2020) Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nature Communications, 11, 2094. (doi: 10.1038/s41467-020-15783-y) (PMID:32350255) (PMCID:PMC7190642)

Gabrielsen, Mads, Buetow, Lori, Kowalczyk, Dominika, Zhang, Wei, Sidhu, Sachdev S. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2019) Identification and characterization of mutations in ubiquitin required for non-covalent dimer formation. Structure, 27(9), 1452-1459.e4. (doi: 10.1016/j.str.2019.06.008) (PMID:31303481) (PMCID:PMC6720194)

Patel, Amrita, Sibbet, Gary J. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2019) Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B~ubiquitin complex. Journal of Biological Chemistry, 294, pp. 1240-1249. (doi: 10.1074/jbc.RA118.006045) (PMID:30523153) (PMCID:PMC6349121)

Marciano, Gabriele, Da Vela, Stefano, Tria, Giancarlo, Svergun, Dmitri I., Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2018) Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones. Journal of Biological Chemistry, 293(26), pp. 10071-10083. (doi: 10.1074/jbc.RA117.000994) (PMID:29764934) (PMCID:PMC6028955)

Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed Feroj, Sibbet, Gary J., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168, Zhang, Wei, Sidhu, Sachdev S. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2017) A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants. Molecular Cell, 68(2), 456-470.e10. (doi: 10.1016/j.molcel.2017.09.027) (PMID:29053960) (PMCID:PMC5655547)

Nomura, Koji ORCID logoORCID: https://orcid.org/0000-0002-5912-074X, Klejnot, Marta, Kowalczyk, Dominika, Hock, Andreas K., Sibbet, Gary J., Vousden, Karen and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2017) Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nature Structural and Molecular Biology, 24(7), pp. 578-587. (doi: 10.1038/nsmb.3414) (PMID:28553961)

Buetow, Lori and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2016) Structural insights into the catalysis and regulation of E3 ubiquitin ligases. Nature Reviews Molecular Cell Biology, 17(10), pp. 626-642. (doi: 10.1038/nrm.2016.91) (PMID:27485899)

Buetow, Lori, Tria, Giancarlo, Ahmed, Syed Feroj, Hock, Andreas, Dou, Hao, Sibbet, Gary J., Svergun, Dmitri I. and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2016) Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation. BMC Biology, 14, 76. (doi: 10.1186/s12915-016-0298-6) (PMID:27609087) (PMCID:PMC5015263)

Marciano, G. and Huang, D.T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2016) Structure of the human histone chaperone FACT Spt16 N-terminal domain. Acta Crystallographica. Section F: Structural Biology Communications, 72(2), pp. 121-128. (doi: 10.1107/s2053230x15024565) (PMID:26841762) (PMCID:PMC4741192)

Nakasone, Mark and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2016) Ubiquitination accomplished: E1 and E2 enzymes were not necessary. Molecular Cell, 62(6), pp. 807-809. (doi: 10.1016/j.molcel.2016.06.001) (PMID:27315555)

Buetow, Lori, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Anthony, Nahoum G., Dou, Hao, Patel, Amrita, Aitkenhead, Hazel, Sibbet, Gary J., Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2015) Activation of a primed RING E3-E2–ubiquitin complex by non-covalent ubiquitin. Molecular Cell, 58(2), pp. 297-310. (doi: 10.1016/j.molcel.2015.02.017) (PMID:25801170)

Dou, Hao, Buetow, Lori, Sibbet, G.J., Cameron, K. and Huang, D.T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2013) Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3. Nature Structural and Molecular Biology, 20(8), pp. 982-986. (doi: 10.1038/nsmb.2621)

Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H. and Huang, D.T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2012) Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl. Nature Structural and Molecular Biology, 19(2), pp. 184-192. (doi: 10.1038/nsmb.2231)

Dou, H., Buetow, L., Sibbet, G.J., Cameron, K. and Huang, D.T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2012) BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer. Nature Structural and Molecular Biology, 19(9), pp. 876-883. (doi: 10.1038/nsmb.2379)

Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X, Ayrault, Olivier, Hunt, Harold W., Taherbhoy, Asad M., Duda, David M., Scott, Daniel C., Borg, Laura A., Neale, Geoffrey, Murray, Peter J. and Roussel, Martine F. (2009) E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification. Molecular Cell, 33(4), pp. 483-495. (doi: 10.1016/j.molcel.2009.01.011)

Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X, Zhuang, Min, Ayrault, Olivier and Schulman, Brenda A (2008) Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2. Nature Structural and Molecular Biology, 15(3), pp. 280-287. (doi: 10.1038/nsmb.1387)

Huang, Danny T. ORCID logoORCID: https://orcid.org/0000-0002-6192-259X, Hunt, Harold W., Zhuang, Min, Ohi, Melanie D., Holton, James M. and Schulman, Brenda A. (2007) Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity. Nature, 445(7126), pp. 394-398. (doi: 10.1038/nature05490)

Book Sections

Buetow, Lori, Gabrielsen, Mads and Huang, Danny ORCID logoORCID: https://orcid.org/0000-0002-6192-259X (2018) Single-Turnover RING/U-Box E3-Mediated Lysine Discharge Assays. In: Mayor, Thibault and Kleiger, Gary (eds.) The Ubiquitin Proteasome System. Series: Methods in Molecular Biology (1844). Humana Press, pp. 19-31. ISBN 9781493987054 (doi: 10.1007/978-1-4939-8706-1_2)

This list was generated on Sun Jun 15 09:53:45 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating the role of DTX2 in DNA damage responses using a mouse model
    Cancer Research UK
    2023 - 2023
     
  • CryoEM - SULSA
    Scottish Universities Life Sciences Alliance
    2018 - 2022
     
  • SMIC-SULSA
    Scottish Funding Council
    2018 - 2021
     
  • The Scottish Macromolecular Imaging Centre (SMIC)
    Medical Research Council
    2017 - 2022
     

Research datasets

Jump to: 2017 | 2016 | 2015 | 2013 | 2012
Number of items: 7.

2017

Gabrielsen, M., Buetow, L., Nakasone, M., Ahmed, S., Sibbet, G., Smith, B. , Zhang, W., Sidhu, S. and Huang, D. (2017) A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants. [Data Collection]

Nomura, K. , Klejnot, M., Kowalczyk, D., Hock, A., Sibbet, G., Vousden, K. and Huang, D. (2017) Structure of MDM2-MDMX-UbcH5B-ubiquitin complex. [Data Collection]

2016

Marciano, G. and Huang, D. (2016) Crystal structure of Human Spt16 N-terminal domain. [Data Collection]

2015

Buetow, L., Gabrielsen, M., Anthony, N., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G., Smith, B. and Huang, D. (2015) Activation of a primed RING E3-E2-ubiquitn complex by non-covalent ubiquitin. [Data Collection]

2013

Dou, H., Buetow, L., Sibbet, G., Cameron, K. and Huang, D. (2013) Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex. [Data Collection]

2012

Dou, H., Buetow, L., Sibbet, G., Cameron, K. and Huang, D. (2012) Structure of BIRC7-UbcH5b-Ub complex. [Data Collection]

Dou, H., Buetow, L., Hock, A., Sibbet, G., Vousden, K. and Huang, D. (2012) Structure of native c-Cbl; c-Cbl-ZAP-70 peptide complex; phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex; modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex and phosphoTyr371-c-Cbl-UbcH5B complex. [Data Collection]

This list was generated on Sun Jun 15 03:46:46 2025 BST.