Dissecting variation in host responsiveness to a recombinant vaccine designed to control teladorsagiosis in sheep

Dr Simon Babayan


In sheep, the primary cause of parasitic gastroenteritis in temperate regions is the abomasal roundworm, Teladorsagia circumcincta, which causes poor productivity, diarrhoea and, in some cases, death in lambs. This project builds on the applicants’ recent findings regarding a sub-unit vaccine prototype for control of teladorsagiosis in sheep. In the proposed project a multidisciplinary approach combining longitudinal histological and transcriptomic samples is taken to understand how the vaccine generates immunity at the host/parasite interface, and to define strategies to overcome non-responsiveness in some individuals, with a focus on young lambs.

First published: 5 February 2016

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