Dr Quan Gu
- Research Scientist (Virology)
email:
Quan.Gu@glasgow.ac.uk
RI of Infection, Immun & Inflam, Centre for Virus Research
Biography
Quan Gu is a Research Bioinformatician at the MRC-University of Glasgow Centre for Virus Research. Before his position at Glasgow, he was a postdoctoral research associate in Bioinformatics at Imperial College London.
Research interests
Quan Gu's broad research interests include:
Transcriptomics analysis, Metabolomics analysis and multi-omics analysis;
Machine learning and artificial intelligence.
Publications
2025
Petit, M. et al. (2025) Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors. Nature Communications, 16(1), 4732. (doi: 10.1038/s41467-025-59565-w) (PMID:40399277) (PMCID:PMC12095547)
Faizo, Arwa Ali A, Bellward, Clare, Hernandez-Lopez, Hegel R., Stevenson, Andrew, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734 and Graham, Sheila
ORCID: https://orcid.org/0000-0002-7140-8279
(2025)
The splicing factor kinase, SR protein kinase 1 (SRPK1) is essential for late events in the human papillomavirus life cycle.
PLoS Pathogens, 21(4),
e1012697.
(doi: 10.1371/journal.ppat.1012697)
(PMID:40203066)
(PMCID:PMC12013937)
Chen, Honglin, Charles, Philip D., Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Liberatori, Sabrina, Robertson, David L.
ORCID: https://orcid.org/0000-0001-6338-0221, Palmarini, Massimo
ORCID: https://orcid.org/0000-0001-7007-4070, Wilson, Sam J.
ORCID: https://orcid.org/0000-0002-6065-0895, Mohammed, Shabaz and Castello, Alfredo
ORCID: https://orcid.org/0000-0002-1499-4662
(2025)
Omics analyses uncover host networks defining virus-permissive and -hostile cellular states.
Molecular and Cellular Proteomics,
(doi: 10.1016/j.mcpro.2025.100966)
(In Press)
2024
Ruscica, V. et al. (2024) XRN1 supplies free nucleotides to feed alphavirus replication. bioRxiv, (doi: 10.1101/2024.12.09.625895)
Herder, V. et al. (2024) Correlates of disease severity in bluetongue as a model of acute arbovirus infection. PLoS Pathogens, 20(8), e1012466. (doi: 10.1371/journal.ppat.1012466) (PMID:39150989) (PMCID:PMC11357116)
Herder, V. et al. (2024) A machine learning framework to identify the correlates of disease severity in acute arbovirus infection. bioRxiv, (doi: 10.1101/2024.02.23.581333) (PMID:PPR810635)
2023
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Cao, G. et al. (2023) Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment. EMBO Journal, 42(16), e110757. (doi: 10.15252/embj.2022110757) (PMID:37427448)
Pinto, R. M. et al. (2023) BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. Nature, 619(7969), pp. 338-347. (doi: 10.1038/s41586-023-06261-8) (PMID:37380775)
Hardy, A. et al. (2023) The timing and magnitude of the type I interferon response are correlated with disease tolerance in arbovirus infection. mBio, 14(3), e0010123. (doi: 10.1128/mbio.00101-23) (PMID:37097030) (PMCID:PMC10294695)
2022
Chai, Haiting, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Robertson, David L.
ORCID: https://orcid.org/0000-0001-6338-0221 and Hughes, Joseph
ORCID: https://orcid.org/0000-0003-2556-2563
(2022)
Defining the characteristics of interferon-alpha–stimulated human genes: insight from expression data and machine learning.
GigaScience, 11,
giac103.
(doi: 10.1093/gigascience/giac103)
(PMID:36399061)
(PMCID:PMC9673497)
Chai, Haiting, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Hughes, Joseph
ORCID: https://orcid.org/0000-0003-2556-2563 and Robertson, David L.
ORCID: https://orcid.org/0000-0001-6338-0221
(2022)
In silico prediction of HIV-1-host molecular interactions and their directionality.
PLoS Computational Biology, 18(2),
e1009720.
(doi: 10.1371/journal.pcbi.1009720)
(PMID:35134057)
(PMCID:PMC8856524)
2021
Amat, J. A.R. et al. (2021) Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage. PLoS Pathogens, 17(12), e1010174. (doi: 10.1371/journal.ppat.1010174) (PMID:34919598) (PMCID:PMC8735595)
Herder, V. et al. (2021) Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defences. PLoS Biology, 19(12), e3001065. (doi: 10.1371/journal.pbio.3001065) (PMID:34932557) (PMCID:PMC8765667)
Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622) (PMCID:PMC7612834)
Lau, B. et al. (2021) Human cytomegalovirus RNA2.7 is required for upregulating multiple cellular genes to promote cell motility and viral spread late in lytic infection. Journal of Virology, 95(20), e00698-21. (doi: 10.1128/JVI.00698-21) (PMID:34346763) (PMCID:PMC8475523)
Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)
Baksmeier, C. et al. (2021) Modified recombinant human IgG1-Fc is superior to natural intravenous immunoglobulin at inhibiting immune-mediated demyelination. Immunology, 164(1), pp. 90-105. (doi: 10.1111/imm.13341) (PMID:33880776) (PMCID:PMC8358725)
Gallo, G. et al. (2021) Interactions of viral proteins from pathogenic and low or non-pathogenic orthohantaviruses with human type I interferon signaling. Viruses, 13(1), 140. (doi: 10.3390/v13010140) (PMID:33478127) (PMCID:PMC7835746)
Schultz, V. et al. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13(1), 91. (doi: 10.3390/v13010091) (PMID:33440758) (PMCID:PMC7827345)
2020
Dimitrov, Daniel and Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734
(2020)
BingleSeq: A user-friendly R package for bulk and single-cell RNA-Seq data analysis.
PeerJ, 8,
e10469.
(doi: 10.7717/peerj.10469)
(PMID:33391870)
(PMCID:PMC7761193)
Lau, Betty ORCID: https://orcid.org/0000-0003-1382-9830, Kerr, Karen, Gu, Quan
ORCID: https://orcid.org/0000-0002-1201-6734, Nightingale, Katie, Antrobus, Robin, Suarez, Nicolas M., Stanton, Richard J., Wang, Eddie C., Weekes, Michael P. and Davison, Andrew J.
ORCID: https://orcid.org/0000-0002-4991-9128
(2020)
Human cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory cytokine IL-6 by blocking NF-κB activation.
Frontiers in Cellular and Infection Microbiology, 10,
361.
(doi: 10.3389/fcimb.2020.00361)
(PMID:32793512)
Sook Yuin Ho, J. et al. (2020) Hybrid gene origination creates human-virus chimeric proteins during infection. Cell, 181(7), 1502-1517.e23. (doi: 10.1016/j.cell.2020.05.035) (PMID:32559462) (PMCID:PMC7323901)
2019
McFarlane, S. et al. (2019) The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLoS Pathogens, 15(3), e1007667. (doi: 10.1371/journal.ppat.1007667) (PMID:30901352) (PMCID:PMC6472835)
2018
Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734 and Veselkov, Kirill
(2018)
Bi-clustering of metabolic data using matrix factorization tools.
Methods, 151,
pp. 12-20.
(doi: 10.1016/j.ymeth.2018.02.004)
(PMID:29438828)
(PMCID:PMC6297113)
Selinger, Martin, Wilkie, Gavin S., Tong, Lily, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Schnettler, Esther, Grubhoffer, Libor and Kohl, Alain
ORCID: https://orcid.org/0000-0002-1523-9458
(2018)
Corrigendum: Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection.
Journal of General Virology, 99(8),
pp. 1147-1149.
(doi: 10.1099/jgv.0.001109)
(PMID:30067173)
Chauché, C., Nogales, A., Zhu, H., Goldfarb, D., Shanizza A.I., Ahmad, Gu, Q. ORCID: https://orcid.org/0000-0002-1201-6734, Parrish, C.R., Martínez-Sobrido, L., Marshall, J.F. and Murcia, P.R.
ORCID: https://orcid.org/0000-0002-4352-394X
(2018)
Mammalian adaptation of an avian influenza A virus involves stepwise changes in NS1.
Journal of Virology, 92(5),
e01875-17.
(doi: 10.1128/JVI.01875-17)
(PMID:29237841)
(PMCID:PMC5809720)
2017
Shaw, A. E. et al. (2017) Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses. PLoS Biology, 15(12), e2004086. (doi: 10.1371/journal.pbio.2004086) (PMID:29253856) (PMCID:PMC574750)
Bhome, R. et al. (2017) Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression. Aging, 9(12), pp. 2666-2694. (doi: 10.18632/aging.101355) (PMID:29283887)
Klymenko, T. et al. (2017) RNA-Seq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus 16 infection, including loss of epithelial barrier function. Journal of Virology, 91(24), e01001-17. (doi: 10.1128/JVI.01001-17) (PMID:29021401) (PMCID:PMC5709591)
Selinger, Martin, Wilkie, Gavin S., Tong, Lily, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Schnettler, Esther, Grubhoffer, Libor and Kohl, Alain
ORCID: https://orcid.org/0000-0002-1523-9458
(2017)
Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection.
Journal of General Virology, 98(8),
pp. 2043-2060.
(doi: 10.1099/jgv.0.000853)
(PMID:28786780)
Dumas, M.-E. et al. (2017) Microbial-host co-metabolites are prodromal markers predicting phenotypic heterogeneity in behavior, obesity, and impaired glucose tolerance. Cell Reports, 20(1), pp. 136-148. (doi: 10.1016/j.celrep.2017.06.039) (PMID:28683308)
2016
Dumas, M.-E. et al. (2016) Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series. Genome Medicine, 8, 101. (doi: 10.1186/s13073-016-0352-6) (PMID:27716393) (PMCID:PMC5045612)
Ratinier, Maxime, Shaw, Andrew E., Barry, Gerald, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Di Gialleonardo, Luigina, Janowicz, Anna, Varela, Mariana, Randall, Richard E., Caporale, Marco and Palmarini, Massimo
ORCID: https://orcid.org/0000-0001-7007-4070
(2016)
Bluetongue virus NS4 protein is an interferon antagonist and a determinant of virus virulence.
Journal of Virology, 90(11),
pp. 5427-5439.
(doi: 10.1128/JVI.00422-16)
(PMID:27009961)
(PMCID:PMC4934764)
Orton, R.J. ORCID: https://orcid.org/0000-0002-3389-4325, Gu, Q.
ORCID: https://orcid.org/0000-0002-1201-6734, Hughes, J.
ORCID: https://orcid.org/0000-0003-2556-2563, Maabar, M., Modha, S.
ORCID: https://orcid.org/0000-0002-8440-885X, Vattipally, Sreenu
ORCID: https://orcid.org/0000-0001-6673-4697, Wilkie, G.S. and Davison, A.
ORCID: https://orcid.org/0000-0002-4991-9128
(2016)
Bioinformatics tools for analysing viral genomic data.
Revue scientifique et technique (International Office of Epizootics), 35(1),
pp. 241-285.
(doi: 10.20506/rst.35.1.2432)
(PMID:27217183)
2015
Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Ding, Yong-Sheng and Zhang, Tong-Liang
(2015)
An ensemble classifier based prediction of G-protein-coupled receptor classes in low homology.
Neurocomputing, 154,
pp. 110-118.
(doi: 10.1016/j.neucom.2014.12.013)
Blomström, A.-L. et al. (2015) Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein. BMC Genomics, 16, 324. (doi: 10.1186/s12864-015-1538-9) (PMID:25896169) (PMCID:PMC4404599)
2014
Hudson, Nicholas J., Baker, Michelle L., Hart, Nathan S., Wynne, James W., Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Huang, Zhiyong, Zhang, Guojie, Ingham, Aaron B., Wang, Linfa and Reverter, Antonio
(2014)
Sensory rewiring in an echolocator: genome-wide modification of retinogenic and auditory genes in the bat myotis davidii.
G3: Genes, Genomes, Genetics, 4(10),
pp. 1825-1835.
(doi: 10.1534/g3.114.011262)
(PMID:25096539)
(PMCID:PMC4199690)
2011
Hudson, Nicholas J., Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Nagaraj, Shivashankar H., Ding, Yong-Sheng, Dalrymple, Brian P. and Reverter, Antonio
(2011)
Eukaryotic evolutionary transitions are associated with extreme codon bias in functionally-related proteins.
PLoS ONE, 6(9),
e25457.
(doi: 10.1371/journal.pone.0025457)
(PMID:21966531)
(PMCID:PMC3179510)
Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Nagaraj, Shivashankar H., Hudson, Nicholas J., Dalrymple, Brian P. and Reverter, Antonio
(2011)
Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle.
BMC Genomics, 12,
23.
(doi: 10.1186/1471-2164-12-23)
(PMID:21226902)
(PMCID:PMC3025955)
2010
Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Ding, Yong-Sheng and Zhang, Tong-Liang
(2010)
Prediction of G-protein-coupled receptor classes in low homology using Chou's pseudo amino acid composition with approximate entropy and hydrophobicity patterns.
Protein and Peptide Letters, 17(5),
pp. 559-567.
(doi: 10.2174/092986610791112693)
Shen, Yi-Zhen, Ding, Yong-Sheng, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734 and Chou, Kuo-Chen
(2010)
Identifying the hub proteins from complicated membrane protein network systems.
Medicinal Chemistry, 6(3),
pp. 165-173.
(doi: 10.2174/1573406411006030165)
(PMID:20507268)
Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Ding, Yong-Sheng, Jiang, Xiao-Ying and Zhang, Tong-Liang
(2010)
Prediction of subcellular location apoptosis proteins with ensemble classifier and feature selection.
Amino Acids, 38(4),
pp. 975-983.
(doi: 10.1007/s00726-008-0209-4)
(PMID:19048186)
2009
Ding, Yong-Sheng, Zhang, Tong-Liang, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Zhao, Pei-Ying and Chou, Kuo-Chen
(2009)
Using maximum entropy model to predict protein secondary structure with single sequence.
Protein and Peptide Letters, 16(5),
pp. 552-560.
(doi: 10.2174/092986609788167833)
(PMID:19442235)
2008
Jiang, Xiaoying, Wei, Rong, Zhang, Tongliang and Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734
(2008)
Using the concept of chous pseudo amino acid composition to predict apoptosis proteins subcellular location: an approach by approximate entropy.
Protein and Peptide Letters, 15(4),
pp. 392-396.
Articles
Petit, M. et al. (2025) Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors. Nature Communications, 16(1), 4732. (doi: 10.1038/s41467-025-59565-w) (PMID:40399277) (PMCID:PMC12095547)
Faizo, Arwa Ali A, Bellward, Clare, Hernandez-Lopez, Hegel R., Stevenson, Andrew, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734 and Graham, Sheila
ORCID: https://orcid.org/0000-0002-7140-8279
(2025)
The splicing factor kinase, SR protein kinase 1 (SRPK1) is essential for late events in the human papillomavirus life cycle.
PLoS Pathogens, 21(4),
e1012697.
(doi: 10.1371/journal.ppat.1012697)
(PMID:40203066)
(PMCID:PMC12013937)
Chen, Honglin, Charles, Philip D., Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Liberatori, Sabrina, Robertson, David L.
ORCID: https://orcid.org/0000-0001-6338-0221, Palmarini, Massimo
ORCID: https://orcid.org/0000-0001-7007-4070, Wilson, Sam J.
ORCID: https://orcid.org/0000-0002-6065-0895, Mohammed, Shabaz and Castello, Alfredo
ORCID: https://orcid.org/0000-0002-1499-4662
(2025)
Omics analyses uncover host networks defining virus-permissive and -hostile cellular states.
Molecular and Cellular Proteomics,
(doi: 10.1016/j.mcpro.2025.100966)
(In Press)
Ruscica, V. et al. (2024) XRN1 supplies free nucleotides to feed alphavirus replication. bioRxiv, (doi: 10.1101/2024.12.09.625895)
Herder, V. et al. (2024) Correlates of disease severity in bluetongue as a model of acute arbovirus infection. PLoS Pathogens, 20(8), e1012466. (doi: 10.1371/journal.ppat.1012466) (PMID:39150989) (PMCID:PMC11357116)
Herder, V. et al. (2024) A machine learning framework to identify the correlates of disease severity in acute arbovirus infection. bioRxiv, (doi: 10.1101/2024.02.23.581333) (PMID:PPR810635)
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Cao, G. et al. (2023) Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment. EMBO Journal, 42(16), e110757. (doi: 10.15252/embj.2022110757) (PMID:37427448)
Pinto, R. M. et al. (2023) BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. Nature, 619(7969), pp. 338-347. (doi: 10.1038/s41586-023-06261-8) (PMID:37380775)
Hardy, A. et al. (2023) The timing and magnitude of the type I interferon response are correlated with disease tolerance in arbovirus infection. mBio, 14(3), e0010123. (doi: 10.1128/mbio.00101-23) (PMID:37097030) (PMCID:PMC10294695)
Chai, Haiting, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Robertson, David L.
ORCID: https://orcid.org/0000-0001-6338-0221 and Hughes, Joseph
ORCID: https://orcid.org/0000-0003-2556-2563
(2022)
Defining the characteristics of interferon-alpha–stimulated human genes: insight from expression data and machine learning.
GigaScience, 11,
giac103.
(doi: 10.1093/gigascience/giac103)
(PMID:36399061)
(PMCID:PMC9673497)
Chai, Haiting, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Hughes, Joseph
ORCID: https://orcid.org/0000-0003-2556-2563 and Robertson, David L.
ORCID: https://orcid.org/0000-0001-6338-0221
(2022)
In silico prediction of HIV-1-host molecular interactions and their directionality.
PLoS Computational Biology, 18(2),
e1009720.
(doi: 10.1371/journal.pcbi.1009720)
(PMID:35134057)
(PMCID:PMC8856524)
Amat, J. A.R. et al. (2021) Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage. PLoS Pathogens, 17(12), e1010174. (doi: 10.1371/journal.ppat.1010174) (PMID:34919598) (PMCID:PMC8735595)
Herder, V. et al. (2021) Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defences. PLoS Biology, 19(12), e3001065. (doi: 10.1371/journal.pbio.3001065) (PMID:34932557) (PMCID:PMC8765667)
Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622) (PMCID:PMC7612834)
Lau, B. et al. (2021) Human cytomegalovirus RNA2.7 is required for upregulating multiple cellular genes to promote cell motility and viral spread late in lytic infection. Journal of Virology, 95(20), e00698-21. (doi: 10.1128/JVI.00698-21) (PMID:34346763) (PMCID:PMC8475523)
Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)
Baksmeier, C. et al. (2021) Modified recombinant human IgG1-Fc is superior to natural intravenous immunoglobulin at inhibiting immune-mediated demyelination. Immunology, 164(1), pp. 90-105. (doi: 10.1111/imm.13341) (PMID:33880776) (PMCID:PMC8358725)
Gallo, G. et al. (2021) Interactions of viral proteins from pathogenic and low or non-pathogenic orthohantaviruses with human type I interferon signaling. Viruses, 13(1), 140. (doi: 10.3390/v13010140) (PMID:33478127) (PMCID:PMC7835746)
Schultz, V. et al. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13(1), 91. (doi: 10.3390/v13010091) (PMID:33440758) (PMCID:PMC7827345)
Dimitrov, Daniel and Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734
(2020)
BingleSeq: A user-friendly R package for bulk and single-cell RNA-Seq data analysis.
PeerJ, 8,
e10469.
(doi: 10.7717/peerj.10469)
(PMID:33391870)
(PMCID:PMC7761193)
Lau, Betty ORCID: https://orcid.org/0000-0003-1382-9830, Kerr, Karen, Gu, Quan
ORCID: https://orcid.org/0000-0002-1201-6734, Nightingale, Katie, Antrobus, Robin, Suarez, Nicolas M., Stanton, Richard J., Wang, Eddie C., Weekes, Michael P. and Davison, Andrew J.
ORCID: https://orcid.org/0000-0002-4991-9128
(2020)
Human cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory cytokine IL-6 by blocking NF-κB activation.
Frontiers in Cellular and Infection Microbiology, 10,
361.
(doi: 10.3389/fcimb.2020.00361)
(PMID:32793512)
Sook Yuin Ho, J. et al. (2020) Hybrid gene origination creates human-virus chimeric proteins during infection. Cell, 181(7), 1502-1517.e23. (doi: 10.1016/j.cell.2020.05.035) (PMID:32559462) (PMCID:PMC7323901)
McFarlane, S. et al. (2019) The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLoS Pathogens, 15(3), e1007667. (doi: 10.1371/journal.ppat.1007667) (PMID:30901352) (PMCID:PMC6472835)
Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734 and Veselkov, Kirill
(2018)
Bi-clustering of metabolic data using matrix factorization tools.
Methods, 151,
pp. 12-20.
(doi: 10.1016/j.ymeth.2018.02.004)
(PMID:29438828)
(PMCID:PMC6297113)
Selinger, Martin, Wilkie, Gavin S., Tong, Lily, Gu, Quan ORCID: https://orcid.org/0000-0002-1201-6734, Schnettler, Esther, Grubhoffer, Libor and Kohl, Alain
ORCID: https://orcid.org/0000-0002-1523-9458
(2018)
Corrigendum: Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection.
Journal of General Virology, 99(8),
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Supervision
- Qin, Zhiling
The host and viral factors influencing SARS-CoV2 infection and replication dynamics in culture models and human patient samples
Completed PhD students
2017-2022, H. Chai (with David Robertson and Joseph Hughes)
Machine-learning-based identification of factors that influence molecular virus-host interactions
Completed MSc students
2024 L. Hao
2023 K. Zhang
2021 E. Agboraw
2021 C. Bellward (with Shiela Graham)
2021 R. Moody (with Shiela Graham)
2019 D. Dimitrov
2018 J. Lim
2017 G. Yang
Research datasets
2023
Meehan, G. , Herder, V. , Allan, J., Huang, X., Kerr, K., Correa Mendonca, D. , Ilia, G., Wright, D. , Nomikou, K., Gu, Q. , Molina Arias, S., Hansmann, F., Hardas, A., Attipa, C., De Lorenzo, G. , Cowton, V., Upfold, N. , Palmalux, N., Brown, J., Barclay, W., Da Silva Filipe, A. , Furnon, W. , Patel, A. and Palmarini, M. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. [Data Collection]
2021
Wickenhagen, A., Sugrue, E. , Lytras, S., Kuchi, S., Noerenberg, M. , Turnbull, M. , Loney, C. , Herder, V., Allan, J., Jarmson, I., Cameron Ruiz, N., Varjak, M. , Pinto, R. , Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D., Swingler, S., Greenwood, E. J. D., Crozier, T. W. M., Gu, Q. , Davies, E., Clohisey, S., Wang, B., Trindade Maranhã Costa, F., Santana, M. F., Carlos de Lima Ferreira, L., Murphy, L., Fawkes, A., Meynert, A., Grimes, G., ISARICC investigators, , Da Silva Filho, J. , Marti, M. , Hughes, J. , Stanton, R. J., Wang, E. C. Y., Ho, A. , Davis, I., Jarrett, R. , Castello, A. , Robertson, D. , Semple, M. G., Openshaw, P. J. M., Palmarini, M. , Lehner, P. J., Baillie, K., Rihn, S. and Wilson, S. (2021) A Prenylated dsRNA Sensor Protects Against Severe COVID-19. [Data Collection]
Shaw, A., Rihn, S. , Mollentze, N. , Wickenhagen, A., Stewart, D., Orton, R. , Kuchi, S., Bakshi, S., Collados Rodriguez, M. , Turnbull, M. , Busby, J., Gu, Q. , Smollett, K., Bamford, C., Sugrue, E. , Johnson, P. , Da Silva Filipe, A. , Castello, A. , Streicker, D. , Robertson, D. , Palmarini, M. and Wilson, S. (2021) The 'antiviral state' has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. [Data Collection] (Unpublished)