Dr Lilach Sheiner
- Reader (Parasitology)
Dr Sheiner is an expert in eukaryotic parasite cell biology and have been researching apicomplexan parasites (causing e.g. Toxoplasmosis and malaria) for over 15 years.
Dr Sheiner's research team aims to understand basic mechanisms that underpin parasite survival and virulence, with focus on the role of their unique plastid (apicoplast) and mitochondrion. The team is mainly using T. gondii as a model organism, and recently commenced work with the human malaria parasite, Plasmodium falciparum.
Lilach and her team developed some of the most widely used tools for Toxoplasma cell biology research1 and made substantial contribution to the understanding of plastids2,3,4 and mitochondria5,6 biology
Apicomplexan parasites are single-cell eukaryotes that evolved from free-living algae into global killers. Having acquired a mitochondrion, then a plastid, and then turning parasitic, these cells display a remarkable collection of globally conserved alongside parasite unique cellular structures and functions.
Our team asks how the plastid and mitochondrion are maintained (organelle protein import, sorting and folding, organelle transport) how do they communicate with each other and with other organelles (what is the role of membrane contact sites in parasite metabolism and homeostasis) and do these organelle’s functions contribute to parasite virulence and survival (what is their contribution to cellular redox regulation).
- Jacot D, Meissner M, Sheiner L, Soldati-Favre D and Striepen B. (2014) Genetic Manipulation of T. gondii. Toxoplasma Gondii (Second Edition). Chapter 17; Pages 577–611. (Editors:Kim k, and Weiss L).
- Sheiner L**, Demerly JL, Poulsen N, Beatty W, Lucas O, Behnke MS, White MW, and Striepen B. A Systematic Screen to Discover and Analyze Apicoplast Proteins Identifies a Conserved and Essential Protein Import Factor. PLoS Pathogens. 2011 Dec;7(12):e1002392.
- Sheiner L**, Fellows JD, Ovciarikova J, Brooks CF, Agrawal S, Holmes ZC, Bietz I, Flinner N, Heiny S, Mirus O, Przyborski JM, Striepen B. Toxoplasma gondii Toc75 functions in import of stromal but not peripheral apicoplast proteins. Traffic. 2015 Sep 18. doi: 10.1111/tra.12333.
- Biddau M*, Bouchut A*, Major J*, Saveria T*, Tottey J*, Oka O, van-Lith M, Jennings KE, Ovciarikova J, DeRocher A, Striepen B, Waller RF, Parsons M and Sheiner L^ Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii. PLoS ppathogens. 2018 Feb 22;14(2):e1006836
- Jana Ovciarikova, Leandro Lemgruber, Krista L. Stilge, William J. Sulliva & Lilach Sheiner** Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii Scientific Reports 2017, Feb 16;7:42746. doi: 10.1038/srep42746
- Sheiner L**, Vaidya AB, and McFadden GI. The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp. Curr Opin Microbiol. 2013 Aug;16(4):452-8. doi: 10.1016/j.mib.2013.07.003
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Lost in translation. A study of the divergent mitochondrial translation pathway of the parasite Toxoplasma gondii
2020 - 2024
- How do REDox regulators control Apicoplast functions in the parasites causing TOxoplasmosis and Malaria
Medical Research Council
2019 - 2022
- Transgenic T. gondii as a platform for MeCP2 protein delivery to the CNS
International Rett Syndrome Foundation
2018 - 2020
- P2D award
Medical Research Council
2018 - 2018
- Dissection of the unusual mitochondrial tRNA import translocon of Toxoplasma gondii
Biotechnology and Biological Sciences Research Council
2016 - 2018
- Dance with me? Mechanisms controlling mitochondrion - cell-cycle synchrony in Toxoplasma gondii
The Royal Society of Edinburgh
2015 - 2020
- Identification and analysis of essential proteins involved in Toxoplasma gondii mitochondrial tRNA import (ISSF Fellowship)
2015 - 2015
- Identification and analysis of essential proteins involved in Toxoplasma gondii mitochondrial biogenesis (ISSF Catalyst)
2014 - 2014
Invited International Presentations
- 2018: Rehovot, Israel - Weizmann Institute of Science. Frontiers in Parasitology
- 2017: Caxambu, Brazil - Brazilian Protozoology Society Annual meeting. Invited Speaker and Panel Member for Round Table about Genome Editing in Parasitic Protozoa.
- 2017: Glasgow, Scotland - University of Strathclyde. Invited seminar speaker.
- 2017: Beer-Sheva, Israel - Ben Gurion University. Invited seminar speaker.
- 2016: Montpellier, France - Université de Montpellier. Invited international speaker
- 2016: Canterbury, UK - University of Kent, School of Biosciences seminar series. Invited seminar speaker.
- 2016: Tuebingen, Germany - Max Planck Institute for Developmental Biology and Friedrich Miescher Laboratory International PhD Program annual retreat. Invited Keynote speaker.
- 2016: Cambridge, UK - Cambridge Parasitology Club seminar series. Invited seminar speaker.
- 2015: London, UK - The Francis Crick Institute (NIMR). Invited seminar speaker.
- 2015: Edinburgh,UK - The University of Edinburgh, Institute of Immunology and Infection Seminar series. Invited seminar speaker.
- 2015: Rio de Janeiro, Brazil - Fiocruz, Instituto Oswaldo Cruiz. Invited seminar speaker.
- 2015: Curitiba, Brazil. - Fiocruz Institututo Carlos Chagas. Invited seminar.
- 2015: Birmingham, UK - SGM Annual Conference 2015, “Mitochondria and related organelles in microbial eukaryotes” session. Invited speaker.
- 2015: Ceske Budejovice, Czech Republic. - University of South Bohemia, Institute of parasitology. Invited seminar speaker.
- 2013: Pennsylvania, USA - University of Pennsylvania, School of Veterinary Medicine. Invited lecture.
- 2012: Jerusalem, Israel - Hebrew University of Jerusalem, Faculty of Medicine. Invited lecture.
- 2012: Glasgow, UK - Glasgow Biomedical Research Centre, University of Glasgow. Invited lecture.
- 2011: Tel Aviv, Israel - Tel-Aviv University, Faculty of Medicine. Invited lecture.
- 2018: Independent - https://www.independent.co.uk/life-style/health-and-families/health-news/cat-parasite-treatment-malaria-toxoplasma-gondii-birth-defects-miscarriage-a8228731.html
- 2018: The Scottish Farmer - http://www.thescottishfarmer.co.uk/news/16043972.Toxoplasmosis_disease_breakthrough/
- 2018: The Conversation - https://theconversation.com/finding-the-achilles-heel-of-the-cat-parasite-could-mean-more-effective-treatment-for-toxoplasmosis-and-malaria-92232
Prizes, Awards and Distinctions
- 2016: co-Founder and co-Director, Middle East Biology of Parasitism http://www.middle-eastbop.com/
- 2015: Royal Society of Edinburgh Personal Research Fellowship
- 2013: Athens, Georgia, USA - NIH pathways to independence
- 2013: Glasgow, Scotland - Lord Kelvin Adam Smith (LKAS) Leadership Fellowship
- 2010: Athens, Georgia, USA - Swiss National Fund "recherche debutant" fellowship
- 2009: Athens, Georgia, USA - Swiss National Fund "recherche debutant" fellowship
- 2008: Geneva, Switzerland - MBL Pioneer Scholarship Fund and the Herbert W. Rand Fellowship and Scholarship Fund
- 2003: Bern, Switzerland - EMBO Short Fellowship 2003