Professor Kevin Maloy

Professor Mucosal Immunology (Immunology & Infection)

Publications

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Number of items: 66.

2023

Heuberger, C.E. et al. (2023) MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses. Mucosal Immunology, (doi: 10.1016/j.mucimm.2023.05.001) (PMID:37209960) (In Press)

2022

Forster, S. C. et al. (2022) Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis. Nature Microbiology, 7(4), pp. 590-599. (doi: 10.1038/s41564-022-01094-z) (PMID:35365791) (PMCID:PMC8975739)

Yogev, N. et al. (2022) CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. Cell Reports, 38(13), 110565. (doi: 10.1016/j.celrep.2022.110565) (PMID:35354043)

2021

Heuberger, C., Pott, J. and Maloy, K. J. (2021) Why do intestinal epithelial cells express MHC class II? Immunology, 162(4), pp. 357-367. (doi: 10.1111/imm.13270) (PMID:32966619) (PMCID:PMC7968399)

dos Santos, L. I., Torres, T. A., DIniz, S. Q., Gonçalves, R., Caballero-Flores, G., Núñez, G., Gazzinelli, R. T., Maloy, K. J. and Antonelli, L. R. d. V. (2021) Disrupted iron metabolism and mortality during co-infection with malaria and an intestinal gram-negative extracellular pathogen. Cell Reports, 34(2), 108613. (doi: 10.1016/j.celrep.2020.108613) (PMID:33440153) (PMCID:PMC8655499)

2020

Abeler-Dörner, L. et al. (2020) High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature Immunology, 21(1), pp. 86-100. (doi: 10.1038/s41590-019-0549-0) (PMID:31844327)

Ahern, P. P. and Maloy, K. J. (2020) Understanding immune–microbiota interactions in the intestine. Immunology, 159(1), pp. 4-14. (doi: 10.1111/imm.13150) (PMID:31777071)

2018

Costa, P. A.C., Figueiredo, M. M., Diniz, S. Q., Peixoto, A. P.M.M., Maloy, K. J. , Teixeira-Carvalho, A., Tada, M. S., Pereira, D. B., Gazzinelli, R. T. and Antonelli, L. R.V. (2018) Plasmodium vivax infection impairs regulatory T-Cell suppressive function during acute malaria. Journal of Infectious Diseases, 218(8), pp. 1314-1323. (doi: 10.1093/infdis/jiy296) (PMID:29800313) (PMCID:PMC6129110)

Murphy, A. G. and Maloy, K. J. (2018) Defens-IN! human α-defensin 5 acts as an unwitting double agent to promote Shigella infection. Immunity, 48(6), pp. 1070-1072. (doi: 10.1016/j.immuni.2018.05.015) (PMID:29924970)

Pott, J., Kabat, A. M. and Maloy, K. J. (2018) Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice. Cell Host and Microbe, 23(2), 191-202.e4. (doi: 10.1016/j.chom.2017.12.017) (PMID:29358084)

De Cicco, P., Sanders, T., Cirino, G., Maloy, K. J. and Ianaro, A. (2018) Hydrogen sulfide reduces myeloid-derived suppressor cell-mediated inflammatory response in a model of Helicobacter hepaticus-induced colitis. Frontiers in Immunology, 9, 499. (doi: 10.3389/fimmu.2018.00499) (PMID:29636751) (PMCID:PMC5880908)

Dumitru, C., Kabat, A. M. and Maloy, K. J. (2018) Metabolic adaptations of CD4+ T Cells in inflammatory disease. Frontiers in Immunology, 9, 540. (doi: 10.3389/fimmu.2018.00540) (PMID:29599783) (PMCID:PMC5862799)

Pott, J. and Maloy, K. J. (2018) Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis. Autophagy, 14(8), pp. 1460-1461. (doi: 10.1080/15548627.2018.1450021) (PMID:29799774) (PMCID:PMC6103553)

2017

Lei-Leston, A., Murphy, A. G. and Maloy, K. J. (2017) Epithelial cell inflammasomes in intestinal immunity and inflammation. Frontiers in Immunology, 8, 1168. (doi: 10.3389/fimmu.2017.01168) (PMID:28979266) (PMCID:PMC5611393)

West, N. R. et al. (2017) Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease. Nature Medicine, 23(5), pp. 579-589. (doi: 10.1038/nm.4307) (PMID:28368383) (PMCID:PMC5420447)

Sanders, T. J., Yrlid, U. and Maloy, K. J. (2017) Intestinal mononuclear phagocytes in health and disease. Microbiology Spectrum, 5(1), MCHD0047-2. (doi: 10.1128/microbiolspec.mchd-0047-2016) (PMID:28102120)

2016

Lei, A. and Maloy, K. J. (2016) Colon cancer in the land of NOD: NLRX1 as an intrinsic tumor suppressor. Trends in Immunology, 37(9), pp. 569-570. (doi: 10.1016/j.it.2016.07.004) (PMID:27452288)

Kabat, A. M., Pott, J. and Maloy, K. J. (2016) The mucosal immune system and its regulation by autophagy. Frontiers in Immunology, 7, 240. (doi: 10.3389/fimmu.2016.00240) (PMID:27446072) (PMCID:PMC4916208)

Pott, J., Maloy, K. J. and Izcue, A. (2016) Barrier regulation: tolerance stops at cell death. Nature Immunology, 17, pp. 349-350. (doi: 10.1038/ni.3418) (PMID:27002834)

Kabat, A. M. et al. (2016) The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. eLife, 5, e12444. (doi: 10.7554/elife.12444) (PMID:26910010) (PMCID:PMC4798959)

2015

Harrison, O.J., Srinivasan, N., Pott, J., Schiering, C., Krausgruber, T., Ilott, N.E. and Maloy, K.J. (2015) Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine. Mucosal Immunology, 8, pp. 1226-1236. (doi: 10.1038/mi.2015.13) (PMID:25736457) (PMCID:PMC4368110)

Sellin, M. E., Maslwowski, K. M., Maloy, K. J. and Hardt, W.-D. (2015) Inflammasomes of the intestinal epithelium. Trends in Immunology, 36(8), pp. 442-450. (doi: 10.1016/j.it.2015.06.002) (PMID:26166583)

2014

Kabat, A. M., Srinivasan, N. and Maloy, K. J. (2014) Modulation of immune development and function by intestinal microbiota. Trends in Immunology, 35(11), pp. 507-517. (doi: 10.1016/j.it.2014.07.010) (PMID:25172617) (PMCID:PMC6485503)

Nordlander, S., Pott, J. and Maloy, K.J. (2014) NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen. Mucosal Immunology, 7, pp. 775-785. (doi: 10.1038/mi.2013.95) (PMID:24280936) (PMCID:PMC4020766)

Song-Zhao, G.X., Srinivasan, N., Pott, J., Baban, D., Frankel, G. and Maloy, K.J. (2014) Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen. Mucosal Immunology, 7, pp. 763-774. (doi: 10.1038/mi.2013.94) (PMID:24280937) (PMCID:PMC4048180)

Kole, A. and Maloy, K. J. (2014) Control of intestinal inflammation by interleukin-10. In: Fillatreau, S. and O'Garra, A. (eds.) Interleukin-10 in Health and Disease. Series: Current topics in microbiology and immunology (380). Springer: Heidelberg, pp. 19-38. ISBN 9783662434918 (doi: 10.1007/978-3-662-43492-5_2)

Song-Zhao, G. X. and Maloy, K. J. (2014) Experimental mouse models of T cell-dependent inflammatory bowel disease. In: Waisman, A. and Becher, B. (eds.) T-Helper Cells: Methods and Protocols. Series: Methods in molecular biology (1193). Humana Press: New York, NY, pp. 199-211. ISBN 9781493912117 (doi: 10.1007/978-1-4939-1212-4_18)

2013

Brain, O. et al. (2013) The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release. Immunity, 39(3), pp. 521-536. (doi: 10.1016/j.immuni.2013.08.035) (PMID:24054330)

Kole, A., He, J., Rivollier, A., Silveira, D. D., Kitamura, K., Maloy, K. J. and Kelsall, B. L. (2013) Type I IFNs regulate effector and regulatory T cell accumulation and anti-Inflammatory cytokine production during T cell–mediated colitis. Journal of Immunology, 191(5), pp. 2771-2779. (doi: 10.4049/jimmunol.1301093) (PMID:23913971) (PMCID:PMC3896249)

Maloy, K. J. and Uhlig, H. H. (2013) ILC1 populations join the border patrol. Immunity, 38(4), pp. 630-632. (doi: 10.1016/j.immuni.2013.03.005) (PMID:23601681)

2012

Coccia, M., Harrison, O. J., Schiering, C., Asquith, M. J., Becher, B., Powrie, F. and Maloy, K. J. (2012) IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells. Journal of Experimental Medicine, 209(9), pp. 1595-1609. (doi: 10.1084/jem.20111453) (PMID:22891275) (PMCID:PMC3428945)

Boulard, O., Kirchberger, S., Royston, D. J., Maloy, K. J. and Powrie, F. M. (2012) Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation. Journal of Experimental Medicine, 209(7), pp. 1309-1324. (doi: 10.1084/jem.20120239) (PMID:22734048) (PMCID:PMC3405508)

2011

Harrison, O. J. and Maloy, K. J. (2011) Innate immune activation in intestinal homeostasis. Journal of Innate Immunity, 3(6), pp. 585-593. (doi: 10.1159/000330913) (PMID:21912101) (PMCID:PMC3224517)

Maloy, K. J. and Powrie, F. (2011) Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature, 474(7351), pp. 298-306. (doi: 10.1038/nature10208) (PMID:21677746)

2010

Ahern, P. P., Schiering, C., Buonocore, S., McGeachy, M. J., Cua, D. J., Maloy, K. J. and Powrie, F. (2010) Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity, 33(2), pp. 279-288. (doi: 10.1016/j.immuni.2010.08.010) (PMID:20732640) (PMCID:PMC3078329)

Asquith, M. J., Boulard, O., Powrie, F. and Maloy, K. J. (2010) Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology, 139(2), 519-529.e2. (doi: 10.1053/j.gastro.2010.04.045) (PMID:20433840) (PMCID:PMC3739016)

Buonocore, S., Ahern, P. A., Uhlig, H. H., Ivanov, I. I., Littman, D. R., Maloy, K. J. and Powrie, F. (2010) Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature, 464(7293), pp. 1371-1375. (doi: 10.1038/nature08949) (PMID:20393462) (PMCID:PMC3796764)

Boulard, O., Asquith, M. J., Powrie, F. and Maloy, K. J. (2010) TLR2-independent induction and regulation of chronic intestinal inflammation. European Journal of Immunology, 40(2), pp. 516-524. (doi: 10.1002/eji.200939669) (PMID:19950179) (PMCID:PMC3812679)

2008

Ahern, P. P., Izcue, A., Maloy, K. J. and Powrie, F. (2008) The interleukin-23 axis in intestinal inflammation. Immunological Reviews, 226(1), pp. 147-159. (doi: 10.1111/j.1600-065x.2008.00705.x) (PMID:19161422)

Maloy, K.J. and Kullberg, M.C. (2008) IL-23 and Th17 cytokines in intestinal homeostasis. Mucosal Immunology, 1(5), pp. 339-349. (doi: 10.1038/mi.2008.28) (PMID:19079198)

Maloy, K. J. (2008) The interleukin-23 / interleukin-17 axis in intestinal inflammation. Journal of Internal Medicine, 263(6), pp. 584-590. (doi: 10.1111/j.1365-2796.2008.01950.x) (PMID:18479257)

Izcue, A., Hue, S., Buonocore, S., Arancibia-Cárcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J. and Powrie, F. (2008) Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity, 28(4), pp. 559-570. (doi: 10.1016/j.immuni.2008.02.019) (PMID:18400195) (PMCID:PMC2292821)

2007

Coombes, J. L. and Maloy, K. J. (2007) Control of intestinal homeostasis by regulatory T cells and dendritic cells. Seminars in Immunology, 19(2), pp. 116-126. (doi: 10.1016/j.smim.2007.01.001) (PMID:17320411)

Maloy, K. J. (2007) Induction and regulation of inflammatory bowel disease in immunodeficient mice by distinct CD4+ T-cell subsets. In: Fairchild, P. J. (ed.) Immunological Tolerance: Methods and Protocols. Series: Methods in molecular biology (380). Humana Press: Totowa, N.J., pp. 327-335. ISBN 9781588296528 (doi: 10.1007/978-1-59745-395-0_19)

2006

Hue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F. and Maloy, K. J. (2006) Interleukin-23 drives innate and T cell-mediated intestinal inflammation. Journal of Experimental Medicine, 203(11), pp. 2473-2483. (doi: 10.1084/jem.20061099) (PMID:17030949) (PMCID:PMC2118132)

Kullberg, M. C. et al. (2006) IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. Journal of Experimental Medicine, 203(11), pp. 2485-2494. (doi: 10.1084/jem.20061082) (PMID:17030948) (PMCID:PMC2118119)

Heinzerling, L., Basch, V., Maloy, K. , Johansen, P., Senti, G., Wüthrich, B., Storni, T. and Kündig, T. M. (2006) Critical role for DNA vaccination frequency in induction of antigen-specific cytotoxic responses. Vaccine, 24(9), pp. 1389-1394. (doi: 10.1016/j.vaccine.2005.09.018) (PMID:16225968)

2005

Maloy, K. J. and Powrie, F. (2005) Fueling regulation: IL-2 keeps CD4+ Treg cells fit. Nature Immunology, 6(11), pp. 1071-1072. (doi: 10.1038/ni1105-1071) (PMID:16239920)

Coombes, J. L., Robinson, N. J., Maloy, K. J. , Uhlig, H. H. and Powrie, F. (2005) Regulatory T cells and intestinal homeostasis. Immunological Reviews, 204(1), pp. 184-194. (doi: 10.1111/j.0105-2896.2005.00250.x) (PMID:15790359)

Maloy, K. J. , Antonelli, L. R.V., Lefevre, M. and Powrie, F. (2005) Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells. Immunology Letters, 97(2), pp. 189-192. (doi: 10.1016/j.imlet.2005.01.004) (PMID:15752557)

Johansen, P. et al. (2005) Direct intralymphatic injection of peptide vaccines enhances immunogenicity. European Journal of Immunology, 35(2), pp. 568-574. (doi: 10.1002/eji.200425599) (PMID:15682446)

2003

Powrie, F. and Maloy, K. J. (2003) Regulating the regulators. Science, 299(5609), pp. 1030-1031. (doi: 10.1126/science.1082031) (PMID:12586934)

Maloy, K. J. , Salaun, L., Cahill, R., Dougan, G., Saunders, N. J. and Powrie, F. (2003) CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. Journal of Experimental Medicine, 197(1), pp. 111-119. (doi: 10.1084/jem.20021345) (PMID:12515818) (PMCID:PMC2193798)

2001

Maloy, K. J. and Powrie, F. (2001) Regulatory T cells in the control of immune pathology. Nature Immunology, 2(9), pp. 816-822. (doi: 10.1038/ni0901-816) (PMID:11526392)

Maloy, K. J. , Erdmann, I., Basch, V., Sierro, S., Kramps, T. A., Zinkernagel, R. M., Oehen, S. and Kündig, T. M. (2001) Intralymphatic immunization enhances DNA vaccination. Proceedings of the National Academy of Sciences of the United States of America, 98(6), pp. 3299-3303. (doi: 10.1073/pnas.051630798) (PMID:11248073) (PMCID:PMC30648)

2000

Senn, K. A., McCoy, K. D., Maloy, K. J. , Stark, G., Fröhli, E., Rülicke, T. and Klemenz, R. (2000) T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis. European Journal of Immunology, 30(7), pp. 1929-1938. (doi: 10.1002/1521-4141(200007)30:7<1929::AID-IMMU1929>3.0.CO;2-1) (PMID:10940882)

Maloy, K. J. , Burkhart, C., Junt, T. M., Odermatt, B., Oxenius, A., Piali, L., Zinkernagel, R. M. and Hengartner, H. (2000) CD4(+) T cell subsets during virus infection: protective capacity depends on effector cytokine secretion and on migratory capability. Journal of Experimental Medicine, 191(12), pp. 2159-2170. (doi: 10.1084/jem.191.12.2159) (PMID:10859340) (PMCID:PMC2193195)

Ludewig, B., Maloy, K. J. , López‐Macías, C., Odermatt, B., Hengartner, H. and Zinkernagel, R. M. (2000) Induction of optimal anti-viral neutralizing B cell responses by dendritic cells requires transport and release of virus particles in secondary lymphoid organs. European Journal of Immunology, 30(1), pp. 185-196. (doi: 10.1002/1521-4141(200001)30:1<185::AID-IMMU185>3.0.CO;2-L) (PMID:10602040)

1999

Maloy, K. J. et al. (1999) Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection. Journal of Immunology, 162(5), pp. 2867-2874. (PMID:10072535)

Steinhoff, U., Maloy, K.J. , Burkhart, C., Clark, A.J., Rülicke, T., Hengartner, H. and Zinkernagel, R.M. (1999) Variable immune response against a developmentally regulated self-antigen. Journal of Autoimmunity, 12(1), pp. 27-34. (doi: 10.1006/jaut.1998.0254) (PMID:10028019)

1998

Maloy, K. J. , Odermatt, B., Hengartner, H. and Zinkernagel, R. M. (1998) Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection. Proceedings of the National Academy of Sciences of the United States of America, 95(3), pp. 1160-1165. (doi: 10.1073/pnas.95.3.1160) (PMID:9448302) (PMCID:PMC18706)

1995

O'Hagan, D.T., Jeffery, H., Maloy, K.J. , Mowat, A.M., Rahman, D. and Challacombe, S.J. (1995) Biodegradable microparticles as oral vaccines. Advances in Experimental Medicine and Biology, 371B, pp. 1463-1467. (PMID:7502838)

Maloy, K. J. , Donachie, A. M. and Mowat, A. M. (1995) Induction of Th1 and Th2 CD4+ T cell responses by oral or parenteral immunization with ISCOMS. European Journal of Immunology, 25(10), pp. 2835-2841. (doi: 10.1002/eji.1830251019) (PMID:7589080)

1994

Maloy, K.J. , Donachie, A.M., O'Hagan, D.T. and Mowat, A.M. (1994) Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles. Immunology, 81(4), pp. 661-667. (PMID:7518802)

1993

Mowat, A.M., Maloy, K.J. and Donachie, A.M. (1993) Immune-stimulating complexes as adjuvants for inducing local and systemic immunity after oral immunization with protein antigens. Immunology, 80(4), pp. 527-534. (PMID:7508416) (PMCID:PMC1422256)

1991

Maloy, K.J. , Mowat, A. M., Zamoyska, R. and Crispe, I.N. (1991) Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine. Immunology, 72(4), pp. 555-562. (PMID:2037315) (PMCID:PMC1384377)

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