2024

Harnett, M. M. , Doonan, J. , Tarafdar, A., Pineda, M. , Duncombe-Moore, J., Buitrago, G., Pan, P., Hoskisson, P., Selman, C. and Harnett, W. (2024) The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner. Frontiers in Tropical Diseases, 4, 1334705. (doi: 10.3389/fitd.2023.1334705)

2023

Jaffery, H. et al. (2023) IĸB Protein BCL3 as a controller of osteogenesis and bone health. Arthritis and Rheumatology, 75(12), 2148-2160-2148-2160. (doi: 10.1002/art.42639) (PMID:37410754)

Bhattacharyya, R., Alloush, A., Wilson, C., Doonan, J. , Rooney, B., Walker, C., Maclean, A. and Blyth, M. (2023) Survivorship of high tibial osteotomy in the treatment of osteoarthritis of the knee: a retrospective cohort study with fourteen years’ follow-up. International Orthopaedics, 47(7), pp. 1765-1770. (doi: 10.1007/s00264-023-05802-0) (PMID:37039819)

Farhan-Alanie, O. M., Altell, T., O'Donnell, S., May, P., Doonan, J. , Rowe, P., Jones, B. and Blyth, M. J.G. (2023) No advantage with navigated versus conventional mechanically aligned total knee arthroplasty—10 year results of a randomised controlled trial. Knee Surgery, Sports Traumatology, Arthroscopy, 31(3), pp. 751-759. (doi: 10.1007/s00167-022-07158-1) (PMID:36166095) (PMCID:PMC9957903)

2022

Farhan-Alanie, O. M., Ha, T. T., Doonan, J. , Mahendra, A. and Gupta, S. (2022) Inflammatory prognostic scoring systems are risk factors for surgical site infection following wide local excision of soft tissue sarcoma. European Journal of Orthopaedic Surgery and Traumatology, 32(8), pp. 1591-1599. (doi: 10.1007/s00590-021-03142-6) (PMID:34628535) (PMCID:PMC9587972)

Harnett, M. M. et al. (2022) The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing. Frontiers in Immunology, 13, 953053. (doi: 10.3389/fimmu.2022.953053) (PMID:36105811) (PMCID:PMC9465317)

Banger, M. S., Doonan, J. , Jones, B. G., MacLean, A. D., Rowe, P. J. and Blyth, M. J. G. (2022) Are there functional biomechanical differences in robotic arm-assisted bi-unicompartmental knee arthroplasty compared with conventional total knee arthroplasty? A prospective, randomized controlled trial. Bone and Joint Journal, 104-B(4), pp. 433-443. (doi: 10.1302/0301-620X.104B4.BJJ-2021-0837.R1) (PMID:35360949)

Spence, S., Doonan, J. , Farhan-Alanie, O. M., Chan, C. D., Tong, D., Cho, H. S., Sahu, M. A., Traub, F. and Gupta, S. (2022) Does the modified Glasgow Prognostic Score aid in the management of patients undergoing surgery for a soft-tissue sarcoma? An international multicentre study. Bone and Joint Journal, 104-B(1), pp. 168-176. (doi: 10.1302/0301-620X.104B1.BJJ-2021-0874.R1) (PMID:34969280)

2021

Shields, D. W., Razii, N., Doonan, J. , Mahendra, A. and Gupta, S. (2021) Closed incision negative pressure wound therapy versus conventional dressings following soft-tissue sarcoma excision: a prospective, randomized controlled trial. Bone and Joint Open, 2(12), pp. 1049-1056. (doi: 10.1302/2633-1462.212.BJO-2021-0103.R1) (PMID:34905941) (PMCID:PMC8711667)

Brown, M., Ramasubbu, R., Jenkinson, M., Doonan, J. , Blyth, M. and Jones, B. (2021) Significant differences in rates of aseptic loosening between two variations of a popular total knee arthroplasty design. International Orthopaedics, 45(11), pp. 2859-2867. (doi: 10.1007/s00264-021-05151-w) (PMID:34392378)

Blyth, M. J. G., Banger, M. S., Doonan, J. , Jones, B. G., MacLean, A. D. and Rowe, P. J. (2021) Early outcomes after robotic arm-assisted bi-unicompartmental knee arthroplasty compared with total knee arthroplasty: a prospective, randomized controlled trial. Bone and Joint Journal, 103-B(10), pp. 1561-1570. (doi: 10.1302/0301-620X.103B10.BJJ-2020-1919.R2) (PMID:34587803) (PMCID:PMC9948427)

Clark, A. N., Hounat, A., O'Donnell, S., May, P., Doonan, J. , Rowe, P., Jones, B. G. and Blyth, M. J.G. (2021) Electromagnetic navigated versus conventional total knee arthroplasty—a five-year follow-up of a single-blind randomized control trial. Journal of Arthroplasty, 36(10), pp. 3451-3455. (doi: 10.1016/j.arth.2021.06.007) (PMID:34226082)

Banger, M., Doonan, J. , Rowe, P., Jones, B., MacLean, A. and Blyth, M. J.B. (2021) Robotic arm-assisted versus conventional medial unicompartmental knee arthroplasty: five-year clinical outcomes of a randomized controlled trial. Bone and Joint Journal, 103-B(6), pp. 1088-1095. (doi: 10.1302/0301-620X.103B6.BJJ-2020-1355.R2) (PMID:34058870) (PMCID:PMC8153511)

Lumb, F. E., Doonan, J. , Corbet, M., Pineda, M. A. , Harnett, M. M. and Harnett, W. (2021) Development of Acanthocheilonema viteae in Meriones shawi : Absence of microfilariae and production of active ES‐62. Parasite Immunology, 43(3), e12803. (doi: 10.1111/pim.12803) (PMID:33091157) (PMCID:PMC7988569)

2020

Banger, M. S., Johnston, W. D., Razii, N., Doonan, J. , Rowe, P. J., Jones, B. G., MacLean, A. D. and Blyth, M. J.G. (2020) Robotic arm-assisted bi-unicompartmental knee arthroplasty maintains natural knee joint anatomy compared with total knee arthroplasty: a prospective randomized controlled trial. Bone and Joint Journal, 102-B(11), pp. 1511-1518. (doi: 10.1302/0301-620X.102B11.BJJ-2020-1166.R1) (PMID:33135443) (PMCID:PMC7954184)

Crowe, J. et al. (2020) The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing. PLoS Pathogens, 16(3), e1008391. (doi: 10.1371/journal.ppat.1008391) (PMID:32163524) (PMCID:PMC7108737)

2019

North, S. J., Botchway, K., Doonan, J. , Lumb, F. E., Dell, A., Harnett, W. and Haslam, S. M. (2019) Site-specific glycoproteomic characterization of ES-62: The major secreted product of the parasitic worm Acanthocheilonema viteae. Glycobiology, 29(8), pp. 562-571. (doi: 10.1093/glycob/cwz035) (PMID:31094418) (PMCID:PMC6639541)

Doonan, J. , Tarafdar, A., Pineda, M. A. , Lumb, F. E., Crowe, J., Khan, A. M., Hoskisson, P. A., Harnett, M. M. and Harnett, W. (2019) The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. Nature Communications, 10, 1554. (doi: 10.1038/s41467-019-09361-0) (PMID:30952846) (PMCID:PMC6451002)

2018

Doonan, J. et al. (2018) Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease. Molecules, 23(10), 2669. (doi: 10.3390/molecules23102669) (PMID:30336585) (PMCID:PMC6222842)

Doonan, J. , Lumb, F. E., Pineda, M. A. , Tarafdar, A., Crowe, J., Khan, A. M., Suckling, C. J., Harnett, M. M. and Harnett, W. (2018) Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis. Frontiers in Immunology, 9, 1016. (doi: 10.3389/fimmu.2018.01016) (PMID:29867986) (PMCID:PMC5967578)

2017

Lumb, F. E., Doonan, J., Bell, K. S., Pineda, M. A. , Corbet, M., Suckling, C. J., Harnett, M. M. and Harnett, W. (2017) Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62. Scientific Reports, 7, 1704. (doi: 10.1038/s41598-017-01651-1) (PMID:28490801) (PMCID:PMC5431997)

2016

Janicova, L., Rzepecka, J., Rodgers, D.T., Doonan, J., Bell, K.S., Lumb, F.E., Suckling, C.J., Harnett, M.M. and Harnett, W. (2016) Testing small molecule analogues of theAcanthocheilonema viteaeimmunomodulator ES-62 against clinically relevant allergens. Parasite Immunology, 38(6), pp. 340-351. (doi: 10.1111/pim.12322) (PMID:27059010) (PMCID:PMC4913752)

Articles

Harnett, M. M. , Doonan, J. , Tarafdar, A., Pineda, M. , Duncombe-Moore, J., Buitrago, G., Pan, P., Hoskisson, P., Selman, C. and Harnett, W. (2024) The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner. Frontiers in Tropical Diseases, 4, 1334705. (doi: 10.3389/fitd.2023.1334705)

Jaffery, H. et al. (2023) IĸB Protein BCL3 as a controller of osteogenesis and bone health. Arthritis and Rheumatology, 75(12), 2148-2160-2148-2160. (doi: 10.1002/art.42639) (PMID:37410754)

Bhattacharyya, R., Alloush, A., Wilson, C., Doonan, J. , Rooney, B., Walker, C., Maclean, A. and Blyth, M. (2023) Survivorship of high tibial osteotomy in the treatment of osteoarthritis of the knee: a retrospective cohort study with fourteen years’ follow-up. International Orthopaedics, 47(7), pp. 1765-1770. (doi: 10.1007/s00264-023-05802-0) (PMID:37039819)

Farhan-Alanie, O. M., Altell, T., O'Donnell, S., May, P., Doonan, J. , Rowe, P., Jones, B. and Blyth, M. J.G. (2023) No advantage with navigated versus conventional mechanically aligned total knee arthroplasty—10 year results of a randomised controlled trial. Knee Surgery, Sports Traumatology, Arthroscopy, 31(3), pp. 751-759. (doi: 10.1007/s00167-022-07158-1) (PMID:36166095) (PMCID:PMC9957903)

Farhan-Alanie, O. M., Ha, T. T., Doonan, J. , Mahendra, A. and Gupta, S. (2022) Inflammatory prognostic scoring systems are risk factors for surgical site infection following wide local excision of soft tissue sarcoma. European Journal of Orthopaedic Surgery and Traumatology, 32(8), pp. 1591-1599. (doi: 10.1007/s00590-021-03142-6) (PMID:34628535) (PMCID:PMC9587972)

Harnett, M. M. et al. (2022) The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing. Frontiers in Immunology, 13, 953053. (doi: 10.3389/fimmu.2022.953053) (PMID:36105811) (PMCID:PMC9465317)

Banger, M. S., Doonan, J. , Jones, B. G., MacLean, A. D., Rowe, P. J. and Blyth, M. J. G. (2022) Are there functional biomechanical differences in robotic arm-assisted bi-unicompartmental knee arthroplasty compared with conventional total knee arthroplasty? A prospective, randomized controlled trial. Bone and Joint Journal, 104-B(4), pp. 433-443. (doi: 10.1302/0301-620X.104B4.BJJ-2021-0837.R1) (PMID:35360949)

Spence, S., Doonan, J. , Farhan-Alanie, O. M., Chan, C. D., Tong, D., Cho, H. S., Sahu, M. A., Traub, F. and Gupta, S. (2022) Does the modified Glasgow Prognostic Score aid in the management of patients undergoing surgery for a soft-tissue sarcoma? An international multicentre study. Bone and Joint Journal, 104-B(1), pp. 168-176. (doi: 10.1302/0301-620X.104B1.BJJ-2021-0874.R1) (PMID:34969280)

Shields, D. W., Razii, N., Doonan, J. , Mahendra, A. and Gupta, S. (2021) Closed incision negative pressure wound therapy versus conventional dressings following soft-tissue sarcoma excision: a prospective, randomized controlled trial. Bone and Joint Open, 2(12), pp. 1049-1056. (doi: 10.1302/2633-1462.212.BJO-2021-0103.R1) (PMID:34905941) (PMCID:PMC8711667)

Brown, M., Ramasubbu, R., Jenkinson, M., Doonan, J. , Blyth, M. and Jones, B. (2021) Significant differences in rates of aseptic loosening between two variations of a popular total knee arthroplasty design. International Orthopaedics, 45(11), pp. 2859-2867. (doi: 10.1007/s00264-021-05151-w) (PMID:34392378)

Blyth, M. J. G., Banger, M. S., Doonan, J. , Jones, B. G., MacLean, A. D. and Rowe, P. J. (2021) Early outcomes after robotic arm-assisted bi-unicompartmental knee arthroplasty compared with total knee arthroplasty: a prospective, randomized controlled trial. Bone and Joint Journal, 103-B(10), pp. 1561-1570. (doi: 10.1302/0301-620X.103B10.BJJ-2020-1919.R2) (PMID:34587803) (PMCID:PMC9948427)

Clark, A. N., Hounat, A., O'Donnell, S., May, P., Doonan, J. , Rowe, P., Jones, B. G. and Blyth, M. J.G. (2021) Electromagnetic navigated versus conventional total knee arthroplasty—a five-year follow-up of a single-blind randomized control trial. Journal of Arthroplasty, 36(10), pp. 3451-3455. (doi: 10.1016/j.arth.2021.06.007) (PMID:34226082)

Banger, M., Doonan, J. , Rowe, P., Jones, B., MacLean, A. and Blyth, M. J.B. (2021) Robotic arm-assisted versus conventional medial unicompartmental knee arthroplasty: five-year clinical outcomes of a randomized controlled trial. Bone and Joint Journal, 103-B(6), pp. 1088-1095. (doi: 10.1302/0301-620X.103B6.BJJ-2020-1355.R2) (PMID:34058870) (PMCID:PMC8153511)

Lumb, F. E., Doonan, J. , Corbet, M., Pineda, M. A. , Harnett, M. M. and Harnett, W. (2021) Development of Acanthocheilonema viteae in Meriones shawi : Absence of microfilariae and production of active ES‐62. Parasite Immunology, 43(3), e12803. (doi: 10.1111/pim.12803) (PMID:33091157) (PMCID:PMC7988569)

Banger, M. S., Johnston, W. D., Razii, N., Doonan, J. , Rowe, P. J., Jones, B. G., MacLean, A. D. and Blyth, M. J.G. (2020) Robotic arm-assisted bi-unicompartmental knee arthroplasty maintains natural knee joint anatomy compared with total knee arthroplasty: a prospective randomized controlled trial. Bone and Joint Journal, 102-B(11), pp. 1511-1518. (doi: 10.1302/0301-620X.102B11.BJJ-2020-1166.R1) (PMID:33135443) (PMCID:PMC7954184)

Crowe, J. et al. (2020) The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing. PLoS Pathogens, 16(3), e1008391. (doi: 10.1371/journal.ppat.1008391) (PMID:32163524) (PMCID:PMC7108737)

North, S. J., Botchway, K., Doonan, J. , Lumb, F. E., Dell, A., Harnett, W. and Haslam, S. M. (2019) Site-specific glycoproteomic characterization of ES-62: The major secreted product of the parasitic worm Acanthocheilonema viteae. Glycobiology, 29(8), pp. 562-571. (doi: 10.1093/glycob/cwz035) (PMID:31094418) (PMCID:PMC6639541)

Doonan, J. , Tarafdar, A., Pineda, M. A. , Lumb, F. E., Crowe, J., Khan, A. M., Hoskisson, P. A., Harnett, M. M. and Harnett, W. (2019) The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. Nature Communications, 10, 1554. (doi: 10.1038/s41467-019-09361-0) (PMID:30952846) (PMCID:PMC6451002)

Doonan, J. et al. (2018) Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease. Molecules, 23(10), 2669. (doi: 10.3390/molecules23102669) (PMID:30336585) (PMCID:PMC6222842)

Doonan, J. , Lumb, F. E., Pineda, M. A. , Tarafdar, A., Crowe, J., Khan, A. M., Suckling, C. J., Harnett, M. M. and Harnett, W. (2018) Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis. Frontiers in Immunology, 9, 1016. (doi: 10.3389/fimmu.2018.01016) (PMID:29867986) (PMCID:PMC5967578)

Lumb, F. E., Doonan, J., Bell, K. S., Pineda, M. A. , Corbet, M., Suckling, C. J., Harnett, M. M. and Harnett, W. (2017) Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62. Scientific Reports, 7, 1704. (doi: 10.1038/s41598-017-01651-1) (PMID:28490801) (PMCID:PMC5431997)

Janicova, L., Rzepecka, J., Rodgers, D.T., Doonan, J., Bell, K.S., Lumb, F.E., Suckling, C.J., Harnett, M.M. and Harnett, W. (2016) Testing small molecule analogues of theAcanthocheilonema viteaeimmunomodulator ES-62 against clinically relevant allergens. Parasite Immunology, 38(6), pp. 340-351. (doi: 10.1111/pim.12322) (PMID:27059010) (PMCID:PMC4913752)