Dr Alasdair Fraser
- Honorary Senior Lecturer (School of Infection & Immunity)
email:
Alasdair.Fraser@glasgow.ac.uk
Chemokine Research Group, Level 3 GBRC, 120 University Place, Glasgow G12 8TA
Publications
2018
Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)
Wilson, R. A.M., Evans, T.R. J. , Fraser, A. R. and Nibbs, R. J.B. (2018) Immune checkpoint inhibitors: new strategies to checkmate cancer. Clinical and Experimental Immunology, 191(2), pp. 133-148. (doi: 10.1111/cei.13081) (PMID:29139554)
2016
Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)
2015
Le Brocq, M., Fraser, A. R., Graham, G. J. and Campbell, J. D.M. (2015) CCL19-sorted mature dendritic cells have enhanced lymph node migratory capacity and function. Journal of Inflammation, 12(S1), P2. (doi: 10.1186/1476-9255-12-S1-P2) (PMCID:PMC4416168)
2014
Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)
Le Brocq, M. L., Fraser, A. R., Cotton, G., Woznica, K., McCulloch, C. V., Hewit, K. D., McKimmie, C. S., Nibbs, R. J.B. , Campbell, J. D.M. and Graham, G. J. (2014) Chemokines as novel and versatile reagents for flow cytometry and cell sorting. Journal of Immunology, 192(12), pp. 6120-6130. (doi: 10.4049/jimmunol.1303371) (PMID:24850722)
Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Vaughan, D. , Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)
Hewit, K. D., Fraser, A., Nibbs, R. J.B. and Graham, G. J. (2014) The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding. Journal of Biological Chemistry, 289(18), pp. 12330-12342. (doi: 10.1074/jbc.M113.534545)
2013
Oleinika, K., Nibbs, R.J. , Graham, G.J. and Fraser, A.R. (2013) Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clinical and Experimental Immunology, 171(1), pp. 36-45. (doi: 10.1111/j.1365-2249.2012.04657.x)
2012
Akbar, M., Fraser, A. R., Graham, G. J. , Brewer, J. M. and Grant, M. H. (2012) Acute inflammatory response to cobalt chromium orthopaedic wear debris in a rodent air-pouch model. Journal of the Royal Society: Interface, 9(74), pp. 2109-2119. (doi: 10.1098/rsif.2012.0006)
Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. , McInnes, I. and Kurowska-Stolarska, M. (2012) The role of miR-155 in monocyte migration in Rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, pp. 588-589. (doi: 10.1111/imm.12002)
Elmesmari, A., Gilchrist, D. S., Fraser, A. D., Vaughan, D. , McQueenie, R., Graham, G. , Brewer, J. , McInnes, I. B. and Kurowska-Stolarska, M. (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi: 10.1002/art.37735)
Marr, L.A., Gilham, D.E., Campbell, J.D.M. and Fraser, A.R. (2012) Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies. Clinical and Experimental Immunology, 167(2), pp. 216-225. (doi: 10.1111/j.1365-2249.2011.04517.x)
2011
Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)
Codullo, V. et al. (2011) An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Annals of the Rheumatic Diseases, 70(6), pp. 1115-1121. (doi: 10.1136/ard.2010.137349) (PMID:21285114)
2010
Fraser, A.R., Perry, M.E., Crilly, A., Reilly, J.H., Hueber, A.J. and McInnes, I.B. (2010) Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase. Annals of the Rheumatic Diseases, 69(4), pp. 776-777. (doi: 10.1136/ard.2008.106047) (PMID:20237127)
2009
McKimmie, C. S. et al. (2009) A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration. Blood, 113(18), pp. 4224-4231. (doi: 10.1182/blood-2008-08-174698) (PMID:19202130)
2008
McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)
Xu, D. et al. (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proceedings of the National Academy of Sciences of the United States of America, 105(31), pp. 10913-10918. (doi: 10.1073/pnas.0801898105) (PMID:18667700) (PMCID:PMC2491487)
Grespan, R., Fukada, S. Y., Lemos, H. P., Vieira, S. M., Napimoga, M. H., Teixeira, M. M., Fraser, A. R., Liew, F. Y., McInnes, I. B. and Cunha, F. Q. (2008) CXCR2‐specific chemokines mediate leukotriene B4–dependent recruitment of neutrophils to inflamed joints in mice with antigen‐induced arthritis. Arthritis and Rheumatism, 58(7), pp. 2030-2040. (doi: 10.1002/art.23597) (PMID:18576322)
Fraser, A., Fraser, A., Hughes, R., McCarthy, A., Tilling, K., Davies, D., Rumley, A., Lowe, G., Smith, G. and Ben Shlomo, Y. (2008) Early life growth and hemostatic factors. American Journal of Epidemiology, 168(2), pp. 179-187.
Fraser, A., Fraser, A., Sattar, N.A., Ebrahim, S. and Lawlor, D.A. (2008) Is serum-glutamylatransferase a biomarker of xenobiotics which are conjugated by glutathione? Response. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(4), E29-E29.
2007
Verri, W. A., Cunha, T. M., Ferreira, S. H., Wei, X., Leung, B. P., Fraser, A., McInnes, I. B. , Liew, F. Y. and Cunha, F. Q. (2007) IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production. European Journal of Immunology, 37(12), pp. 3373-3380. (doi: 10.1002/eji.200737488) (PMID:17979156)
2005
Jongbloed, S. L., Lebre, M. C., Fraser, A. R., Gracie, J. A., Sturrock, R. D., Tak, P. P. and McInnes, I. B. (2005) Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Research and Therapy, 8(1), R15. (doi: 10.1186/ar1864) (PMID:16507115) (PMCID:PMC1526567)
Articles
Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)
Wilson, R. A.M., Evans, T.R. J. , Fraser, A. R. and Nibbs, R. J.B. (2018) Immune checkpoint inhibitors: new strategies to checkmate cancer. Clinical and Experimental Immunology, 191(2), pp. 133-148. (doi: 10.1111/cei.13081) (PMID:29139554)
Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)
Le Brocq, M., Fraser, A. R., Graham, G. J. and Campbell, J. D.M. (2015) CCL19-sorted mature dendritic cells have enhanced lymph node migratory capacity and function. Journal of Inflammation, 12(S1), P2. (doi: 10.1186/1476-9255-12-S1-P2) (PMCID:PMC4416168)
Le Brocq, M. L., Fraser, A. R., Cotton, G., Woznica, K., McCulloch, C. V., Hewit, K. D., McKimmie, C. S., Nibbs, R. J.B. , Campbell, J. D.M. and Graham, G. J. (2014) Chemokines as novel and versatile reagents for flow cytometry and cell sorting. Journal of Immunology, 192(12), pp. 6120-6130. (doi: 10.4049/jimmunol.1303371) (PMID:24850722)
Hewit, K. D., Fraser, A., Nibbs, R. J.B. and Graham, G. J. (2014) The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding. Journal of Biological Chemistry, 289(18), pp. 12330-12342. (doi: 10.1074/jbc.M113.534545)
Oleinika, K., Nibbs, R.J. , Graham, G.J. and Fraser, A.R. (2013) Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clinical and Experimental Immunology, 171(1), pp. 36-45. (doi: 10.1111/j.1365-2249.2012.04657.x)
Akbar, M., Fraser, A. R., Graham, G. J. , Brewer, J. M. and Grant, M. H. (2012) Acute inflammatory response to cobalt chromium orthopaedic wear debris in a rodent air-pouch model. Journal of the Royal Society: Interface, 9(74), pp. 2109-2119. (doi: 10.1098/rsif.2012.0006)
Marr, L.A., Gilham, D.E., Campbell, J.D.M. and Fraser, A.R. (2012) Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies. Clinical and Experimental Immunology, 167(2), pp. 216-225. (doi: 10.1111/j.1365-2249.2011.04517.x)
Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)
Codullo, V. et al. (2011) An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Annals of the Rheumatic Diseases, 70(6), pp. 1115-1121. (doi: 10.1136/ard.2010.137349) (PMID:21285114)
Fraser, A.R., Perry, M.E., Crilly, A., Reilly, J.H., Hueber, A.J. and McInnes, I.B. (2010) Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase. Annals of the Rheumatic Diseases, 69(4), pp. 776-777. (doi: 10.1136/ard.2008.106047) (PMID:20237127)
McKimmie, C. S. et al. (2009) A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration. Blood, 113(18), pp. 4224-4231. (doi: 10.1182/blood-2008-08-174698) (PMID:19202130)
McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)
Xu, D. et al. (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proceedings of the National Academy of Sciences of the United States of America, 105(31), pp. 10913-10918. (doi: 10.1073/pnas.0801898105) (PMID:18667700) (PMCID:PMC2491487)
Grespan, R., Fukada, S. Y., Lemos, H. P., Vieira, S. M., Napimoga, M. H., Teixeira, M. M., Fraser, A. R., Liew, F. Y., McInnes, I. B. and Cunha, F. Q. (2008) CXCR2‐specific chemokines mediate leukotriene B4–dependent recruitment of neutrophils to inflamed joints in mice with antigen‐induced arthritis. Arthritis and Rheumatism, 58(7), pp. 2030-2040. (doi: 10.1002/art.23597) (PMID:18576322)
Fraser, A., Fraser, A., Hughes, R., McCarthy, A., Tilling, K., Davies, D., Rumley, A., Lowe, G., Smith, G. and Ben Shlomo, Y. (2008) Early life growth and hemostatic factors. American Journal of Epidemiology, 168(2), pp. 179-187.
Fraser, A., Fraser, A., Sattar, N.A., Ebrahim, S. and Lawlor, D.A. (2008) Is serum-glutamylatransferase a biomarker of xenobiotics which are conjugated by glutathione? Response. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(4), E29-E29.
Verri, W. A., Cunha, T. M., Ferreira, S. H., Wei, X., Leung, B. P., Fraser, A., McInnes, I. B. , Liew, F. Y. and Cunha, F. Q. (2007) IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production. European Journal of Immunology, 37(12), pp. 3373-3380. (doi: 10.1002/eji.200737488) (PMID:17979156)
Jongbloed, S. L., Lebre, M. C., Fraser, A. R., Gracie, J. A., Sturrock, R. D., Tak, P. P. and McInnes, I. B. (2005) Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Research and Therapy, 8(1), R15. (doi: 10.1186/ar1864) (PMID:16507115) (PMCID:PMC1526567)
Conference or Workshop Item
Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)
Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Vaughan, D. , Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)
Conference Proceedings
Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. , McInnes, I. and Kurowska-Stolarska, M. (2012) The role of miR-155 in monocyte migration in Rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, pp. 588-589. (doi: 10.1111/imm.12002)
Elmesmari, A., Gilchrist, D. S., Fraser, A. D., Vaughan, D. , McQueenie, R., Graham, G. , Brewer, J. , McInnes, I. B. and Kurowska-Stolarska, M. (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi: 10.1002/art.37735)