2023

Khaleva, E. et al. (2023) Definitions of non-response and response to biological therapy for severe asthma: a systematic review. ERJ Open Research, 9(3), 00444-2022. (doi: 10.1183/23120541.00444-2022) (PMID:37143849) (PMCID:PMC10152254)

Khaleva, E. et al. (2023) Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA). European Respiratory Journal, 61(4), 2200606. (doi: 10.1183/13993003.00606-2022) (PMID:36229046) (PMCID:PMC10069873)

Ricketts, H. C., Buchan, D. S., Steffensen, F., Chaudhuri, R. , Baker, J. S. and Cowan, D. C. (2023) Physical activity levels in asthma: relationship with disease severity, body mass index and novel accelerometer-derived metrics. Journal of Asthma, 60(4), pp. 824-834. (doi: 10.1080/02770903.2022.2102037) (PMID:35876843)

Mansur, A. H. et al. (2023) Biologic therapy practices in severe asthma; outcomes from the UK Severe Asthma Registry and survey of specialist opinion. Clinical and Experimental Allergy, 53(2), pp. 173-185. (doi: 10.1111/cea.14222) (PMID:36057784)

2022

Diver, S. et al. (2022) Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation. Allergy, 77(11), pp. 3362-3376. (doi: 10.1111/all.15425) (PMID:35778780)

Yang, F. et al. (2022) Corticosteroid responsiveness following mepolizumab in severe eosinophilic asthma—a randomized, placebo-controlled crossover trial (MAPLE). Journal of Allergy and Clinical Immunology: In Practice, 10(11), 2925-2934.e12. (doi: 10.1016/j.jaip.2022.06.050) (PMID:35863669)

Khalfaoui, L. et al. (2022) Airway remodelling rather than cellular infiltration characterises both type2 cytokine biomarker‐high and ‐low severe asthma. Allergy, 77(10), pp. 2974-2986. (doi: 10.1111/all.15376) (PMID:35579040)

Pilette, C. et al. (2022) REALITI-A study: real-world oral corticosteroid-sparing effect of mepolizumab in severe asthma. Journal of Allergy and Clinical Immunology: In Practice, 10(10), pp. 2646-2656. (doi: 10.1016/j.jaip.2022.05.042) (PMID:35753668)

Ricketts, H. C., Sharma, V., Steffensen, F., Goodfellow, A., Mackay, E., MacDonald, G., Buchan, D. S., Chaudhuri, R. and Cowan, D. C. (2022) A pragmatic randomised controlled trial of tailored pulmonary rehabilitation in participants with difficult-to-control asthma and elevated body mass index. BMC Pulmonary Medicine, 22, 363. (doi: 10.1186/s12890-022-02152-2) (PMID:36153525) (PMCID:PMC9509551)

McDowell, P. J. et al. (2022) Exacerbation profile and risk factors in a type-2–low enriched severe asthma cohort: a clinical trial to assess asthma exacerbation phenotypes. American Journal of Respiratory and Critical Care Medicine, 206(5), pp. 545-553. (doi: 10.1164/rccm.202201-0129OC) (PMID:35549845)

Cotton, S. et al. (2022) Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS). Trials, 23, 307. (doi: 10.1186/s13063-022-06226-8) (PMID:35422024) (PMCID:PMC9009490)

Busby, J. et al. (2022) Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma. European Respiratory Journal, 59, 2100768. (doi: 10.1183/13993003.00768-2021) (PMID:34561291) (PMCID:PMC9202483)

2021

Jackson, D. J., Butler, C., Chaudhuri, R. , Pink, K., Niven, R., Prigmore, S., Renwick, C. and Calvert, J. (2021) Recommendations following a modified UK-Delphi consensus study on best practice for referral and management of severe asthma. BMJ Open Respiratory Research, 8, e001057. (doi: 10.1136/bmjresp-2021-001057) (PMID:34583985) (PMCID:PMC8479936)

Heaney, L. G. et al. (2021) Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial. Lancet Respiratory Medicine, 9(1), pp. 57-68. (doi: 10.1016/s2213-2600(20)30397-0) (PMID:32916135) (PMCID:PMC7783382)

2018

Devereux, G. et al. (2018) Effect of theophylline as adjunct to inhaled corticosteroids on exacerbations in patients with COPD: a randomized clinical trial. JAMA: Journal of the American Medical Association, 320(15), pp. 1548-1559. (doi: 10.1001/jama.2018.14432) (PMID:30326124) (PMCID:PMC6233797)

Yang, J. F. et al. (2018) Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations. npj Primary Care Respiratory Medicine, 28, 35. (doi: 10.1038/s41533-018-0103-9) (PMID:30232329) (PMCID:PMC6145932)

Russell, R. J. et al. (2018) Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial. Lancet Respiratory Medicine, 6(7), pp. 499-510. (doi: 10.1016/S2213-2600(18)30201-7) (PMID:29793857)

Price, D.B. et al. (2018) Use of 'Low-Dose' Theophylline to Reduce Exacerbations of COPD: a Pragmatic Multicentre Randomised Placebo Controlled Trial. ATS 2018 International Conference, San Diego, CA, USA, 18-23 May 2018.

Chernyavsky, I. L. et al. (2018) In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss. European Respiratory Journal, 51(5), 1701680. (doi: 10.1183/13993003.01680-2017) (PMID:29700102)

Hanratty, C. E. et al. (2018) A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial. Trials, 19, 5. (doi: 10.1186/s13063-017-2384-7) (PMID:29301585) (PMCID:PMC5753571)

2016

Johnston, S. L. et al. (2016) Azithromycin for acute exacerbations of asthma : The AZALEA randomized clinical trial. JAMA Internal Medicine, 176(11), pp. 1630-1637. (doi: 10.1001/jamainternmed.2016.5664)

Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)

Morrison, D. , Wyke, S. , Saunderson, K., McConnachie, A. , Agur, K., Chaudhuri, R. , Thomas, M., Thomson, N.C., Yardley, L. and Mair, F.S. (2016) Findings from a pilot randomised trial of an asthma internet self-management intervention (RAISIN). BMJ Open, 6(5), e009254. (doi: 10.1136/bmjopen-2015-009254) (PMID:27173807) (PMCID:PMC4874112)

2015

Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)

Morrison, D. , Mair, F. S. , Chaudhuri, R. , McGee-Lennon, M., Thomas, M., Thomson, N. C., Yardley, L. and Wyke, S. (2015) Details of development of the resource for adults with asthma in the RAISIN (randomized trial of an asthma internet self-management intervention) study. BMC Medical Informatics and Decision Making, 15, 57. (doi: 10.1186/s12911-015-0177-z)

Thomson, N. C., McSharry, C. and Chaudhuri, R. (2015) Response. CHEST Journal, 148(1), e33-e34. (doi: 10.1378/chest.15-0890) (PMID:26149566)

Devereux, G. et al. (2015) Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial. Trials, 16, 267. (doi: 10.1186/s13063-015-0782-2) (PMID:26058585) (PMCID:PMC4465017)

Thomson, N. C., Chaudhuri, R. , Spears, M., Haughney, J. and McSharry, C. (2015) Serum periostin in smokers and never smokers with asthma. Respiratory Medicine, 109(6), pp. 708-715. (doi: 10.1016/j.rmed.2015.03.009) (PMID:PMID:25869)

McSharry, C., Vesper, S., Wymer, L., Howieson, S., Chaudhuri, R. , Wright, G. R. and Thomson, N.C. (2015) Decreased FEV1% in asthmatic adults in Scottish homes with high environmental relative moldiness index values. Clinical and Experimental Allergy, 45(5), pp. 902-907. (doi: 10.1111/cea.12482) (PMID:25580663)

Thomson, N. C., Charron, C. E., Chaudhuri, R. , Spears, M., Ito, K. and McSharry, C. (2015) Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma. Pulmonary Pharmacology and Therapeutics, 31, pp. 1-8. (doi: 10.1016/j.pupt.2015.01.001) (PMID:25595138)

Thomson, N. C., Chaudhuri, R. , Spears, M., Messow, C.-M. , MacNee, W., Connell, M., Murchison, J. T., Sproule, M. and McSharry, C. (2015) Poor symptom control is associated with reduced CT scan segmental airway lumen area in smokers with asthma. Chest, 147(3), p. 735. (doi: 10.1378/chest.14-1119) (PMID:25356950)

2014

McSharry, C., Spears, M., Chaudhuri, R. , Cameron, E. J., Husi, H. and Thomson, N. C. (2014) Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients. Journal of Allergy and Clinical Immunology, 134(5), pp. 1068-1075. (doi: 10.1016/j.jaci.2014.08.022) (PMID:25262463)

Chaudhuri, R. et al. (2014) Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma. European Respiratory Journal, 44(4), pp. 895-904. (doi: 10.1183/09031936.00047014)

Thomson, N.C. et al. (2014) Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69(4), pp. 527-536. (doi: 10.1111/all.12376)

Chaudhuri, R. , Norris, V., Kelly, K., Zhu, C.-Q., Ambery, C., Lafferty, J., Cameron, E. and Thomson, N.C. (2014) Effects of a FLAP inhibitor, GSK2190915, in asthmatics with high sputum neutrophils. Pulmonary Pharmacology and Therapeutics, 27(1), pp. 62-69. (doi: 10.1016/j.pupt.2013.11.007)

Morrison, D. , Wyke, S. , Thomson, N. C., McConnachie, A. , Agur, K., Saunderson, K., Chaudhuri, R. and Mair, F. S. (2014) A randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial. Trials, 15, p. 185. (doi: 10.1186/1745-6215-15-185) (PMID:24884722)

Newby, C., Heaney, L. G., Menzies-Gow, A., Niven, R. M., Mansur, A., Bucknall, C., Chaudhuri, R. , Thompson, J., Burton, P. and Brightling, C. (2014) Statistical cluster analysis of the British thoracic society severe refractory asthma registry: clinical outcomes and phenotype stability. PLoS ONE, 9(7), e102987. (doi: 10.1371/journal.pone.0102987) (PMID:25058007) (PMCID:PMC4109965)

2013

Cameron, E.J. et al. (2013) Randomised controlled trial of azithromycin in smokers with asthma. European Respiratory Journal, 42(5), pp. 1412-1415. (doi: 10.1183/09031936.00093913)

Thomson, N.C., Chaudhuri, R. , Messow, C.M. , Spears, M., MacNee, W., Connell, M., Murchison, J.T., Sproule, M. and McSharry, C. (2013) Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma. Respiratory Medicine, 107(10), pp. 1501-1508. (doi: 10.1016/j.rmed.2013.07.017)

Thomson, N.C., Chaudhuri, R. , Heaney, L., Bucknall, C., Niven, R.M., Brightling, C.E., Menzies-Gow, A., Mansur, A.H. and McSharry, C. (2013) Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma. Journal of Allergy and Clinical Immunology, 131(4), pp. 1008-1016. (doi: 10.1016/j.jaci.2012.12.1574)

Gibeon, D. et al. (2013) Obesity-associated severe asthma represents a distinct clinical phenotype: analysis of the British thoracic society difficult asthma registry patient cohort according to BMI. Chest, 143(2), pp. 406-14.

Albarbarawi, O., Barton, A., Miller, D., McSharry, C., Chaudhuri, R. , Thomson, N. C., Palmer, C. N.A., Devereux, G. and Huang, J. T.-J. (2013) Characterization and validation of an isotope-dilution LC–MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum. Bioanalysis, 5(16), pp. 1991-2001. (doi: 10.4155/BIO.13.164)

Spears, M., McSharry, C., Chaudhuri, R. , Weir, C.J., de Wet, C. and Thomson, N.C. (2013) Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines—an exploratory study. PLoS ONE, 8(8), e71460. (doi: 10.1371/journal.pone.0071460) (PMID:23951170) (PMCID:PMC3739804)

2012

Komai-Koma, M. et al. (2012) Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67(9), pp. 1118-1126. (doi: 10.1111/j.1398-9995.2012.02859.x) (PMID:22702477) (PMCID:PMC3660789)

Huang, J.T.-J. et al. (2012) Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax, 67(6), pp. 502-508. (doi: 10.1136/thoraxjnl-2011-200279)

Chaudhuri, R. et al. (2012) Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. Journal of Allergy and Clinical Immunology, 129(3), 665-663.e8. (doi: 10.1016/j.jaci.2011.12.996)

Thomson, N.C., Bicknell, S. and Chaudhuri, R. (2012) Bronchial thermoplasty for severe asthma. Current Opinion in Allergy and Clinical Immunology, 12(3), pp. 241-248. (doi: 10.1097/ACI.0b013e32835335ca)

Thomson, N.C. and Chaudhuri, R. (2012) Omalizumab: clinical use for the management of asthma. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 6, pp. 27-40. (doi: 10.4137/CCRPM.S7793)

Wan, Y.I. et al. (2012) Genome-wide association study to identify genetic determinants of severe asthma. Thorax, 67(9), pp. 762-768. (doi: 10.1136/thoraxjnl-2011-201262)

2011

Braganza, G. et al. (2011) Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial. BMC Pulmonary Medicine, 11(16), (doi: 10.1186/1471-2466-11-16)

Spears, M. et al. (2011) Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clinical and Experimental Allergy, 41(5), pp. 665-672. (doi: 10.1111/j.1365-2222.2010.03692.x)

Spears, M., Weir, C.J., Smith, A.D., McSharry, C., Chaudhuri, R., Johnson, M., Cameron, E. and Thomson, N.C. (2011) Bronchial nitric oxide flux (J′aw) is sensitive to oral corticosteroids in smokers with asthma. Respiratory Medicine, 105(12), pp. 1823-1830. (doi: 10.1016/j.rmed.2011.06.014)

Thomson, N.C., Chaudhuri, R. and Spears, M. (2011) Emerging therapies for severe asthma. BMC Medicine, 9(1), p. 102. (doi: 10.1186/1741-7015-9-102)

2010

Spears, M., Cameron, E., Chaudhuri, R. and Thomson, N.C. (2010) Challenges of treating asthma in people who smoke. Expert Review of Clinical Immunology, 6(2), pp. 257-268. (doi: 10.1586/ECI.09.85)

2009

Wright, G.R. et al. (2009) Effect of improved home ventilation on asthma control and house dust mite allergen levels. Allergy, 64(11), pp. 1671-1680. (doi: 10.1111/j.1398-9995.2009.02098.x)

Murphy, C., Blyth, K., Chaudhuri, R., Lafferty, J., Hothersall, E., Steedman, T., McSharry, C., Dargie, H. and Thomson, N. (2009) Assessment of the Presence of Occult Myocardial Infarction in Chronic Obstructive Pulmonary Disease Using Contrast-Enhanced Cardiac Magnetic Resonance Imaging. Respiration, 78(3), pp. 263-269.

Spears, M. et al. (2009) Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. European Respiratory Journal, 33(5), pp. 1010-1017. (doi: 10.1183/09031936.00158208)

Spears, M. et al. (2009) Bronchodilatory Effect of the PPAR-gamma Agonist Rosiglitazone in Smokers With Asthma. Clinical Pharmacology and Therapeutics, 86(1), pp. 49-53. (doi: 10.1038/clpt.2009.41)

Thomson, N. and Chaudhuri, R. (2009) Asthma in smokers: challenges and opportunities. Current Opinion in Pulmonary Medicine, 15(1), pp. 39-45.

2008

Chaudhuri, R., McSharry, C., McCoard, A., Livingston, E., Hothersall, E., Spears, M., Lafferty, J. and Thomson, N. (2008) Role of symptoms and lung function in determining asthma control in smokers with asthma. Allergy, 63(1), pp. 132-135.

Hothersall, E. et al. (2008) Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax, 63(12), pp. 1070-1075. (doi: 10.1136/thx.2008.100198)

2006

Chaudhuri, R., Livingston, E., McMahon, A. D., Lafferty, J., Fraser, I., Spears, M., McSharry, C. P. and Thomson, N. C. (2006) Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. American Journal of Respiratory and Critical Care Medicine, 174(2), pp. 127-133. (doi: 10.1164/rccm.200510-1589OC)

2004

Thomson, N. C. and Chaudhuri, R. (2004) Why is eosinophilic bronchitis not asthma? American Journal of Respiratory and Critical Care Medicine, 170(1), pp. 4-5. (doi: 10.1164/rccm.2404005)

2003

Chaudhuri, R. , Livingston, E., McMahon, A. D., Thomson, L., Borland, W. and Thomson, N. C. (2003) Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. American Journal of Respiratory and Critical Care Medicine, 168(11), pp. 1308-1311. (doi: 10.1164/rccm.200304-503OC)

Articles

Khaleva, E. et al. (2023) Definitions of non-response and response to biological therapy for severe asthma: a systematic review. ERJ Open Research, 9(3), 00444-2022. (doi: 10.1183/23120541.00444-2022) (PMID:37143849) (PMCID:PMC10152254)

Khaleva, E. et al. (2023) Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA). European Respiratory Journal, 61(4), 2200606. (doi: 10.1183/13993003.00606-2022) (PMID:36229046) (PMCID:PMC10069873)

Ricketts, H. C., Buchan, D. S., Steffensen, F., Chaudhuri, R. , Baker, J. S. and Cowan, D. C. (2023) Physical activity levels in asthma: relationship with disease severity, body mass index and novel accelerometer-derived metrics. Journal of Asthma, 60(4), pp. 824-834. (doi: 10.1080/02770903.2022.2102037) (PMID:35876843)

Mansur, A. H. et al. (2023) Biologic therapy practices in severe asthma; outcomes from the UK Severe Asthma Registry and survey of specialist opinion. Clinical and Experimental Allergy, 53(2), pp. 173-185. (doi: 10.1111/cea.14222) (PMID:36057784)

Diver, S. et al. (2022) Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation. Allergy, 77(11), pp. 3362-3376. (doi: 10.1111/all.15425) (PMID:35778780)

Yang, F. et al. (2022) Corticosteroid responsiveness following mepolizumab in severe eosinophilic asthma—a randomized, placebo-controlled crossover trial (MAPLE). Journal of Allergy and Clinical Immunology: In Practice, 10(11), 2925-2934.e12. (doi: 10.1016/j.jaip.2022.06.050) (PMID:35863669)

Khalfaoui, L. et al. (2022) Airway remodelling rather than cellular infiltration characterises both type2 cytokine biomarker‐high and ‐low severe asthma. Allergy, 77(10), pp. 2974-2986. (doi: 10.1111/all.15376) (PMID:35579040)

Pilette, C. et al. (2022) REALITI-A study: real-world oral corticosteroid-sparing effect of mepolizumab in severe asthma. Journal of Allergy and Clinical Immunology: In Practice, 10(10), pp. 2646-2656. (doi: 10.1016/j.jaip.2022.05.042) (PMID:35753668)

Ricketts, H. C., Sharma, V., Steffensen, F., Goodfellow, A., Mackay, E., MacDonald, G., Buchan, D. S., Chaudhuri, R. and Cowan, D. C. (2022) A pragmatic randomised controlled trial of tailored pulmonary rehabilitation in participants with difficult-to-control asthma and elevated body mass index. BMC Pulmonary Medicine, 22, 363. (doi: 10.1186/s12890-022-02152-2) (PMID:36153525) (PMCID:PMC9509551)

McDowell, P. J. et al. (2022) Exacerbation profile and risk factors in a type-2–low enriched severe asthma cohort: a clinical trial to assess asthma exacerbation phenotypes. American Journal of Respiratory and Critical Care Medicine, 206(5), pp. 545-553. (doi: 10.1164/rccm.202201-0129OC) (PMID:35549845)

Cotton, S. et al. (2022) Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS). Trials, 23, 307. (doi: 10.1186/s13063-022-06226-8) (PMID:35422024) (PMCID:PMC9009490)

Busby, J. et al. (2022) Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma. European Respiratory Journal, 59, 2100768. (doi: 10.1183/13993003.00768-2021) (PMID:34561291) (PMCID:PMC9202483)

Jackson, D. J., Butler, C., Chaudhuri, R. , Pink, K., Niven, R., Prigmore, S., Renwick, C. and Calvert, J. (2021) Recommendations following a modified UK-Delphi consensus study on best practice for referral and management of severe asthma. BMJ Open Respiratory Research, 8, e001057. (doi: 10.1136/bmjresp-2021-001057) (PMID:34583985) (PMCID:PMC8479936)

Heaney, L. G. et al. (2021) Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial. Lancet Respiratory Medicine, 9(1), pp. 57-68. (doi: 10.1016/s2213-2600(20)30397-0) (PMID:32916135) (PMCID:PMC7783382)

Devereux, G. et al. (2018) Effect of theophylline as adjunct to inhaled corticosteroids on exacerbations in patients with COPD: a randomized clinical trial. JAMA: Journal of the American Medical Association, 320(15), pp. 1548-1559. (doi: 10.1001/jama.2018.14432) (PMID:30326124) (PMCID:PMC6233797)

Yang, J. F. et al. (2018) Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations. npj Primary Care Respiratory Medicine, 28, 35. (doi: 10.1038/s41533-018-0103-9) (PMID:30232329) (PMCID:PMC6145932)

Russell, R. J. et al. (2018) Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial. Lancet Respiratory Medicine, 6(7), pp. 499-510. (doi: 10.1016/S2213-2600(18)30201-7) (PMID:29793857)

Chernyavsky, I. L. et al. (2018) In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss. European Respiratory Journal, 51(5), 1701680. (doi: 10.1183/13993003.01680-2017) (PMID:29700102)

Hanratty, C. E. et al. (2018) A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial. Trials, 19, 5. (doi: 10.1186/s13063-017-2384-7) (PMID:29301585) (PMCID:PMC5753571)

Johnston, S. L. et al. (2016) Azithromycin for acute exacerbations of asthma : The AZALEA randomized clinical trial. JAMA Internal Medicine, 176(11), pp. 1630-1637. (doi: 10.1001/jamainternmed.2016.5664)

Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)

Morrison, D. , Wyke, S. , Saunderson, K., McConnachie, A. , Agur, K., Chaudhuri, R. , Thomas, M., Thomson, N.C., Yardley, L. and Mair, F.S. (2016) Findings from a pilot randomised trial of an asthma internet self-management intervention (RAISIN). BMJ Open, 6(5), e009254. (doi: 10.1136/bmjopen-2015-009254) (PMID:27173807) (PMCID:PMC4874112)

Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)

Morrison, D. , Mair, F. S. , Chaudhuri, R. , McGee-Lennon, M., Thomas, M., Thomson, N. C., Yardley, L. and Wyke, S. (2015) Details of development of the resource for adults with asthma in the RAISIN (randomized trial of an asthma internet self-management intervention) study. BMC Medical Informatics and Decision Making, 15, 57. (doi: 10.1186/s12911-015-0177-z)

Thomson, N. C., McSharry, C. and Chaudhuri, R. (2015) Response. CHEST Journal, 148(1), e33-e34. (doi: 10.1378/chest.15-0890) (PMID:26149566)

Devereux, G. et al. (2015) Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial. Trials, 16, 267. (doi: 10.1186/s13063-015-0782-2) (PMID:26058585) (PMCID:PMC4465017)

Thomson, N. C., Chaudhuri, R. , Spears, M., Haughney, J. and McSharry, C. (2015) Serum periostin in smokers and never smokers with asthma. Respiratory Medicine, 109(6), pp. 708-715. (doi: 10.1016/j.rmed.2015.03.009) (PMID:PMID:25869)

McSharry, C., Vesper, S., Wymer, L., Howieson, S., Chaudhuri, R. , Wright, G. R. and Thomson, N.C. (2015) Decreased FEV1% in asthmatic adults in Scottish homes with high environmental relative moldiness index values. Clinical and Experimental Allergy, 45(5), pp. 902-907. (doi: 10.1111/cea.12482) (PMID:25580663)

Thomson, N. C., Charron, C. E., Chaudhuri, R. , Spears, M., Ito, K. and McSharry, C. (2015) Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma. Pulmonary Pharmacology and Therapeutics, 31, pp. 1-8. (doi: 10.1016/j.pupt.2015.01.001) (PMID:25595138)

Thomson, N. C., Chaudhuri, R. , Spears, M., Messow, C.-M. , MacNee, W., Connell, M., Murchison, J. T., Sproule, M. and McSharry, C. (2015) Poor symptom control is associated with reduced CT scan segmental airway lumen area in smokers with asthma. Chest, 147(3), p. 735. (doi: 10.1378/chest.14-1119) (PMID:25356950)

McSharry, C., Spears, M., Chaudhuri, R. , Cameron, E. J., Husi, H. and Thomson, N. C. (2014) Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients. Journal of Allergy and Clinical Immunology, 134(5), pp. 1068-1075. (doi: 10.1016/j.jaci.2014.08.022) (PMID:25262463)

Chaudhuri, R. et al. (2014) Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma. European Respiratory Journal, 44(4), pp. 895-904. (doi: 10.1183/09031936.00047014)

Thomson, N.C. et al. (2014) Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69(4), pp. 527-536. (doi: 10.1111/all.12376)

Chaudhuri, R. , Norris, V., Kelly, K., Zhu, C.-Q., Ambery, C., Lafferty, J., Cameron, E. and Thomson, N.C. (2014) Effects of a FLAP inhibitor, GSK2190915, in asthmatics with high sputum neutrophils. Pulmonary Pharmacology and Therapeutics, 27(1), pp. 62-69. (doi: 10.1016/j.pupt.2013.11.007)

Morrison, D. , Wyke, S. , Thomson, N. C., McConnachie, A. , Agur, K., Saunderson, K., Chaudhuri, R. and Mair, F. S. (2014) A randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial. Trials, 15, p. 185. (doi: 10.1186/1745-6215-15-185) (PMID:24884722)

Newby, C., Heaney, L. G., Menzies-Gow, A., Niven, R. M., Mansur, A., Bucknall, C., Chaudhuri, R. , Thompson, J., Burton, P. and Brightling, C. (2014) Statistical cluster analysis of the British thoracic society severe refractory asthma registry: clinical outcomes and phenotype stability. PLoS ONE, 9(7), e102987. (doi: 10.1371/journal.pone.0102987) (PMID:25058007) (PMCID:PMC4109965)

Cameron, E.J. et al. (2013) Randomised controlled trial of azithromycin in smokers with asthma. European Respiratory Journal, 42(5), pp. 1412-1415. (doi: 10.1183/09031936.00093913)

Thomson, N.C., Chaudhuri, R. , Messow, C.M. , Spears, M., MacNee, W., Connell, M., Murchison, J.T., Sproule, M. and McSharry, C. (2013) Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma. Respiratory Medicine, 107(10), pp. 1501-1508. (doi: 10.1016/j.rmed.2013.07.017)

Thomson, N.C., Chaudhuri, R. , Heaney, L., Bucknall, C., Niven, R.M., Brightling, C.E., Menzies-Gow, A., Mansur, A.H. and McSharry, C. (2013) Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma. Journal of Allergy and Clinical Immunology, 131(4), pp. 1008-1016. (doi: 10.1016/j.jaci.2012.12.1574)

Gibeon, D. et al. (2013) Obesity-associated severe asthma represents a distinct clinical phenotype: analysis of the British thoracic society difficult asthma registry patient cohort according to BMI. Chest, 143(2), pp. 406-14.

Albarbarawi, O., Barton, A., Miller, D., McSharry, C., Chaudhuri, R. , Thomson, N. C., Palmer, C. N.A., Devereux, G. and Huang, J. T.-J. (2013) Characterization and validation of an isotope-dilution LC–MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum. Bioanalysis, 5(16), pp. 1991-2001. (doi: 10.4155/BIO.13.164)

Spears, M., McSharry, C., Chaudhuri, R. , Weir, C.J., de Wet, C. and Thomson, N.C. (2013) Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines—an exploratory study. PLoS ONE, 8(8), e71460. (doi: 10.1371/journal.pone.0071460) (PMID:23951170) (PMCID:PMC3739804)

Komai-Koma, M. et al. (2012) Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67(9), pp. 1118-1126. (doi: 10.1111/j.1398-9995.2012.02859.x) (PMID:22702477) (PMCID:PMC3660789)

Huang, J.T.-J. et al. (2012) Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax, 67(6), pp. 502-508. (doi: 10.1136/thoraxjnl-2011-200279)

Chaudhuri, R. et al. (2012) Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. Journal of Allergy and Clinical Immunology, 129(3), 665-663.e8. (doi: 10.1016/j.jaci.2011.12.996)

Thomson, N.C., Bicknell, S. and Chaudhuri, R. (2012) Bronchial thermoplasty for severe asthma. Current Opinion in Allergy and Clinical Immunology, 12(3), pp. 241-248. (doi: 10.1097/ACI.0b013e32835335ca)

Thomson, N.C. and Chaudhuri, R. (2012) Omalizumab: clinical use for the management of asthma. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 6, pp. 27-40. (doi: 10.4137/CCRPM.S7793)

Wan, Y.I. et al. (2012) Genome-wide association study to identify genetic determinants of severe asthma. Thorax, 67(9), pp. 762-768. (doi: 10.1136/thoraxjnl-2011-201262)

Braganza, G. et al. (2011) Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial. BMC Pulmonary Medicine, 11(16), (doi: 10.1186/1471-2466-11-16)

Spears, M. et al. (2011) Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clinical and Experimental Allergy, 41(5), pp. 665-672. (doi: 10.1111/j.1365-2222.2010.03692.x)

Spears, M., Weir, C.J., Smith, A.D., McSharry, C., Chaudhuri, R., Johnson, M., Cameron, E. and Thomson, N.C. (2011) Bronchial nitric oxide flux (J′aw) is sensitive to oral corticosteroids in smokers with asthma. Respiratory Medicine, 105(12), pp. 1823-1830. (doi: 10.1016/j.rmed.2011.06.014)

Thomson, N.C., Chaudhuri, R. and Spears, M. (2011) Emerging therapies for severe asthma. BMC Medicine, 9(1), p. 102. (doi: 10.1186/1741-7015-9-102)

Spears, M., Cameron, E., Chaudhuri, R. and Thomson, N.C. (2010) Challenges of treating asthma in people who smoke. Expert Review of Clinical Immunology, 6(2), pp. 257-268. (doi: 10.1586/ECI.09.85)

Wright, G.R. et al. (2009) Effect of improved home ventilation on asthma control and house dust mite allergen levels. Allergy, 64(11), pp. 1671-1680. (doi: 10.1111/j.1398-9995.2009.02098.x)

Murphy, C., Blyth, K., Chaudhuri, R., Lafferty, J., Hothersall, E., Steedman, T., McSharry, C., Dargie, H. and Thomson, N. (2009) Assessment of the Presence of Occult Myocardial Infarction in Chronic Obstructive Pulmonary Disease Using Contrast-Enhanced Cardiac Magnetic Resonance Imaging. Respiration, 78(3), pp. 263-269.

Spears, M. et al. (2009) Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. European Respiratory Journal, 33(5), pp. 1010-1017. (doi: 10.1183/09031936.00158208)

Spears, M. et al. (2009) Bronchodilatory Effect of the PPAR-gamma Agonist Rosiglitazone in Smokers With Asthma. Clinical Pharmacology and Therapeutics, 86(1), pp. 49-53. (doi: 10.1038/clpt.2009.41)

Thomson, N. and Chaudhuri, R. (2009) Asthma in smokers: challenges and opportunities. Current Opinion in Pulmonary Medicine, 15(1), pp. 39-45.

Chaudhuri, R., McSharry, C., McCoard, A., Livingston, E., Hothersall, E., Spears, M., Lafferty, J. and Thomson, N. (2008) Role of symptoms and lung function in determining asthma control in smokers with asthma. Allergy, 63(1), pp. 132-135.

Hothersall, E. et al. (2008) Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax, 63(12), pp. 1070-1075. (doi: 10.1136/thx.2008.100198)

Chaudhuri, R., Livingston, E., McMahon, A. D., Lafferty, J., Fraser, I., Spears, M., McSharry, C. P. and Thomson, N. C. (2006) Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. American Journal of Respiratory and Critical Care Medicine, 174(2), pp. 127-133. (doi: 10.1164/rccm.200510-1589OC)

Thomson, N. C. and Chaudhuri, R. (2004) Why is eosinophilic bronchitis not asthma? American Journal of Respiratory and Critical Care Medicine, 170(1), pp. 4-5. (doi: 10.1164/rccm.2404005)

Chaudhuri, R. , Livingston, E., McMahon, A. D., Thomson, L., Borland, W. and Thomson, N. C. (2003) Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. American Journal of Respiratory and Critical Care Medicine, 168(11), pp. 1308-1311. (doi: 10.1164/rccm.200304-503OC)

Conference or Workshop Item

Price, D.B. et al. (2018) Use of 'Low-Dose' Theophylline to Reduce Exacerbations of COPD: a Pragmatic Multicentre Randomised Placebo Controlled Trial. ATS 2018 International Conference, San Diego, CA, USA, 18-23 May 2018.