Dr Edward Hutchinson

  • Research Fellow (Centre for Virus Research)

Biography

I started working on the molecular biology of influenza viruses as a graduate student with Paul Digard at the University of Cambridge. In 2009 I moved to the University of Oxford to work on influenza with Ervin Fodor, as a postdoctoral researcher at the Sir William Dunn School of Pathology and a Junior Research Fellow at Worcester College (2010-2014), and in 2016 I moved to become a Research Fellow at the MRC-University of Glasgow Centre for Virus Research.

Research interests

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Research Interests

I am interested in the proteins influenza viruses use to infect a host cell. My work aims to identify which viral and host proteins are important in establishing influenza infections, what they do, and how their functions are altered by chemical modifications. 

These are very basic aspects of influenza virus molecular biology. However, our understanding of them is surprisingly incomplete, in large part because influenza viruses are not as simple as they appear. To replicate, a virus must take control of highly complex cellular processes, recruiting and redirecting numerous components of the host cell to cause, for example, the assembly of virions (virus particles) and the subversion of the host’s immune responses. It is extremely challenging to describe this complexity in enough detail to identify the molecular mechanisms which are required for the virus to replicate. 

To tackle this my group uses mass spectrometry, which can characterise the complex assemblies of proteins enlisted by a virus during an infection. We use these data to inform hypotheses about the molecular biology of influenza infections, which we explore using a range of molecular virology methods. Details about specific projects can be found on the Hutchinson group page.

Further information

Pages at ORCID, Google Scholar, ResearchGate, Publons and LinkedIn.

Publications

Selected publications

Sook Yuin Ho, J. et al. (2020) Hybrid gene origination creates human-virus chimeric proteins during infection. Cell, 181(7), 1502-1517.e23. (doi: 10.1016/j.cell.2020.05.035) (PMID:32559462) (PMCID:PMC7323901)

Hawksworth, A., Jayachander, M., Hester, S., Mohammed, S. and Hutchinson, E. (2020) Proteomics as a tool for live attenuated influenza vaccine characterisation. Vaccine, 38(4), pp. 868-877. (doi: 10.1016/j.vaccine.2019.10.082) (PMID:31708181)

Hutchinson, E. C. , Charles, P. D., Hester, S. S., Thomas, B., Trudgian, D., Martínez-Alonso, M. and Fodor, E. (2014) Conserved and host-specific features of influenza virion architecture. Nature Communications, 5, p. 4816. (doi: 10.1038/ncomms5816) (PMID:25226414) (PMCID:PMC4167602)

All publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 26.

2020

Sook Yuin Ho, J. et al. (2020) Hybrid gene origination creates human-virus chimeric proteins during infection. Cell, 181(7), 1502-1517.e23. (doi: 10.1016/j.cell.2020.05.035) (PMID:32559462) (PMCID:PMC7323901)

Hawksworth, A., Jayachander, M., Hester, S., Mohammed, S. and Hutchinson, E. (2020) Proteomics as a tool for live attenuated influenza vaccine characterisation. Vaccine, 38(4), pp. 868-877. (doi: 10.1016/j.vaccine.2019.10.082) (PMID:31708181)

2019

Hirst, J. C. and Hutchinson, E. C. (2019) Single-particle measurements of filamentous influenza virions reveal damage induced by freezing. Journal of General Virology, 100(12), pp. 1631-1640. (doi: 10.1099/jgv.0.001330) (PMID:31553305) (PMCID:PMC6904231)

Charman, M. et al. (2019) Constitutive TRIM22 expression within the respiratory tract identifies tissue-specific and cell-type dependent intrinsic immune barriers to influenza A virus infection. bioRxiv, (doi: 10.1101/679159) (Early Online Publication)

Burke, A., Hirst, J. C. and Hutchinson, E. C. (2019) Altering the Size Distribution of Influenza Virion Populations [Poster]. Microbiology Society Annual Conference, Belfast, UK, 8-11 Apr 2019. (doi:10.1099/acmi.ac2019.po0122)

Hirst, J. C., Burke, A. and Hutchinson, E. C. (2019) Single-particle Measurements Reveal Damage to Filamentous Influenza Virions During Laboratory Handling [Poster]. Microbiology Society Annual Conference, Belfast, UK, 8-11 Apr 2019. (doi:10.1099/acmi.ac2019.po0292)

Lakdawala, S., Nair, N. and Hutchinson, E. (2019) Educational material about influenza viruses. Viruses, 11(3), 231. (doi: 10.3390/v11030231) (PMID:30866478) (PMCID:PMC6466267)

2018

Bottermann, M. et al. (2018) TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination. Proceedings of the National Academy of Sciences of the United States of America, 115(41), pp. 10440-10445. (doi: 10.1073/pnas.1806314115) (PMID:30209217) (PMCID:PMC6187179)

Hutchinson, E. C. (2018) Influenza virus. Trends in Microbiology, 26(9), pp. 809-810. (doi: 10.1016/j.tim.2018.05.013) (PMID:29909041)

Hutchinson, E. C. and Stegmann, M. (2018) Purification and proteomics of influenza virions. In: Yamauchi, Y. (ed.) Influenza Virus. Series: Methods in molecular biology (1836). Humana Press: New York, NY, pp. 89-120. ISBN 9781493986774 (doi:10.1007/978-1-4939-8678-1_5)

Hutchinson, E. C. and Yamauchi, Y. (2018) Understanding influenza. In: Yamauchi, Y. (ed.) Influenza Virus. Series: Methods in molecular biology (1836). Humana Press: New York, NY, pp. 1-21. ISBN 9781493986774 (doi:10.1007/978-1-4939-8678-1_1)

2016

Dadonaite, B., Vijayakrishnan, S. , Fodor, E., Bhella, D. and Hutchinson, E. C. (2016) Filamentous influenza viruses. Journal of General Virology, 97(8), pp. 1755-1764. (doi: 10.1099/jgv.0.000535) (PMID:27365089)

van Wilgenburg, B. et al. (2016) MAIT cells are activated during human viral infections. Nature Communications, 7, 11653. (doi: 10.1038/ncomms11653) (PMID:27337592) (PMCID:PMC4931007)

2015

Hutchinson, E. C. , Charles, P. D., Hester, S. S., Thomas, B., Trudgian, D., Martínez-Alonso, M. and Fodor, E. (2015) Erratum: Conserved and host-specific features of influenza virion architecture. Nature Communications, 6, p. 6446. (doi: 10.1038/ncomms7446)

Turrell, L., Hutchinson, E. C. , Vreede, F. T. and Fodor, E. (2015) Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation. Journal of Virology, 89(2), pp. 1452-1455. (doi: 10.1128/JVI.02332-14) (PMID:25355893) (PMCID:PMC4300657)

2014

York, A., Hutchinson, E. C. and Fodor, E. (2014) Interactome analysis of the influenza a virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication. Journal of Virology, 88(22), pp. 13284-13299. (doi: 10.1128/JVI.01813-14) (PMID:25187537) (PMCID:PMC4249064)

Hutchinson, E. C. , Charles, P. D., Hester, S. S., Thomas, B., Trudgian, D., Martínez-Alonso, M. and Fodor, E. (2014) Conserved and host-specific features of influenza virion architecture. Nature Communications, 5, p. 4816. (doi: 10.1038/ncomms5816) (PMID:25226414) (PMCID:PMC4167602)

2013

Hutchinson, E. C. and Fodor, E. (2013) Transport of the influenza virus genome from nucleus to nucleus. Viruses, 5(10), pp. 2424-2446. (doi: 10.3390/v5102424) (PMID:24104053) (PMCID:PMC3814596)

2012

Hutchinson, E.C. and Fodor, E. (2012) Nuclear import of the influenza A virus transcriptional machinery. Vaccine, 30(51), pp. 7353-7358. (doi: 10.1016/j.vaccine.2012.04.085) (PMID:22652398)

Hutchinson, E. C. , Denham, E. M., Thomas, B., Trudgian, D. C., Hester, S. S., Ridlova, G., York, A., Turrell, L. and Fodor, E. (2012) Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry. PLoS Pathogens, 8(11), e1002993. (doi: 10.1371/journal.ppat.1002993) (PMID:23144613) (PMCID:PMC3493474)

Wise, H. M. et al. (2012) Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain. PLoS Pathogens, 8(11), e1002998. (doi: 10.1371/journal.ppat.1002998) (PMID:23133386) (PMCID:23133386)

2011

Hutchinson, E.C. , Orr, O.E., Man Liu, S., Engelhardt, O.G. and Fodor, E. (2011) Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5. Journal of General Virology, 92(8), pp. 1859-1869. (doi: 10.1099/vir.0.032813-0) (PMID:21562121)

2010

Hutchinson, E.C. , von Kirchbach, J.C., Gog, J.R. and Digard, P. (2010) Genome packaging in influenza A virus. Journal of General Virology, 91(2), pp. 313-328. (doi: 10.1099/vir.0.017608-0) (PMID:19955561)

2009

Hutchinson, E. C. , Wise, H. M., Kudryavtseva, K., Curran, M. D. and Digard, P. (2009) Characterisation of influenza A viruses with mutations in segment 5 packaging signals. Vaccine, 27(45), pp. 6270-6275. (doi: 10.1016/j.vaccine.2009.05.053) (PMID:19840659) (PMCID:19840659)

Noton, S.L., Simpson-Holley, M., Medcalf, E., Wise, H.M., Hutchinson, E.C. , McCauley, J.W. and Digard, P. (2009) Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virions. Journal of Virology, 83(2), pp. 562-571. (doi: 10.1128/JVI.01424-08) (PMID:18987140) (PMCID:PMC2612366)

2008

Hutchinson, E.C. , Curran, M.D., Read, E.K., Gog, J.R. and Digard, P. (2008) Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus. Journal of Virology, 82(23), pp. 11869-11879. (doi: 10.1128/JVI.01634-08) (PMID:18815307) (PMCID:PMC2583641)

This list was generated on Mon Jan 18 21:50:00 2021 GMT.
Jump to: Articles | Book Sections | Conference or Workshop Item
Number of items: 26.

Articles

Sook Yuin Ho, J. et al. (2020) Hybrid gene origination creates human-virus chimeric proteins during infection. Cell, 181(7), 1502-1517.e23. (doi: 10.1016/j.cell.2020.05.035) (PMID:32559462) (PMCID:PMC7323901)

Hawksworth, A., Jayachander, M., Hester, S., Mohammed, S. and Hutchinson, E. (2020) Proteomics as a tool for live attenuated influenza vaccine characterisation. Vaccine, 38(4), pp. 868-877. (doi: 10.1016/j.vaccine.2019.10.082) (PMID:31708181)

Hirst, J. C. and Hutchinson, E. C. (2019) Single-particle measurements of filamentous influenza virions reveal damage induced by freezing. Journal of General Virology, 100(12), pp. 1631-1640. (doi: 10.1099/jgv.0.001330) (PMID:31553305) (PMCID:PMC6904231)

Charman, M. et al. (2019) Constitutive TRIM22 expression within the respiratory tract identifies tissue-specific and cell-type dependent intrinsic immune barriers to influenza A virus infection. bioRxiv, (doi: 10.1101/679159) (Early Online Publication)

Lakdawala, S., Nair, N. and Hutchinson, E. (2019) Educational material about influenza viruses. Viruses, 11(3), 231. (doi: 10.3390/v11030231) (PMID:30866478) (PMCID:PMC6466267)

Bottermann, M. et al. (2018) TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination. Proceedings of the National Academy of Sciences of the United States of America, 115(41), pp. 10440-10445. (doi: 10.1073/pnas.1806314115) (PMID:30209217) (PMCID:PMC6187179)

Hutchinson, E. C. (2018) Influenza virus. Trends in Microbiology, 26(9), pp. 809-810. (doi: 10.1016/j.tim.2018.05.013) (PMID:29909041)

Dadonaite, B., Vijayakrishnan, S. , Fodor, E., Bhella, D. and Hutchinson, E. C. (2016) Filamentous influenza viruses. Journal of General Virology, 97(8), pp. 1755-1764. (doi: 10.1099/jgv.0.000535) (PMID:27365089)

van Wilgenburg, B. et al. (2016) MAIT cells are activated during human viral infections. Nature Communications, 7, 11653. (doi: 10.1038/ncomms11653) (PMID:27337592) (PMCID:PMC4931007)

Hutchinson, E. C. , Charles, P. D., Hester, S. S., Thomas, B., Trudgian, D., Martínez-Alonso, M. and Fodor, E. (2015) Erratum: Conserved and host-specific features of influenza virion architecture. Nature Communications, 6, p. 6446. (doi: 10.1038/ncomms7446)

Turrell, L., Hutchinson, E. C. , Vreede, F. T. and Fodor, E. (2015) Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation. Journal of Virology, 89(2), pp. 1452-1455. (doi: 10.1128/JVI.02332-14) (PMID:25355893) (PMCID:PMC4300657)

York, A., Hutchinson, E. C. and Fodor, E. (2014) Interactome analysis of the influenza a virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication. Journal of Virology, 88(22), pp. 13284-13299. (doi: 10.1128/JVI.01813-14) (PMID:25187537) (PMCID:PMC4249064)

Hutchinson, E. C. , Charles, P. D., Hester, S. S., Thomas, B., Trudgian, D., Martínez-Alonso, M. and Fodor, E. (2014) Conserved and host-specific features of influenza virion architecture. Nature Communications, 5, p. 4816. (doi: 10.1038/ncomms5816) (PMID:25226414) (PMCID:PMC4167602)

Hutchinson, E. C. and Fodor, E. (2013) Transport of the influenza virus genome from nucleus to nucleus. Viruses, 5(10), pp. 2424-2446. (doi: 10.3390/v5102424) (PMID:24104053) (PMCID:PMC3814596)

Hutchinson, E.C. and Fodor, E. (2012) Nuclear import of the influenza A virus transcriptional machinery. Vaccine, 30(51), pp. 7353-7358. (doi: 10.1016/j.vaccine.2012.04.085) (PMID:22652398)

Hutchinson, E. C. , Denham, E. M., Thomas, B., Trudgian, D. C., Hester, S. S., Ridlova, G., York, A., Turrell, L. and Fodor, E. (2012) Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry. PLoS Pathogens, 8(11), e1002993. (doi: 10.1371/journal.ppat.1002993) (PMID:23144613) (PMCID:PMC3493474)

Wise, H. M. et al. (2012) Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain. PLoS Pathogens, 8(11), e1002998. (doi: 10.1371/journal.ppat.1002998) (PMID:23133386) (PMCID:23133386)

Hutchinson, E.C. , Orr, O.E., Man Liu, S., Engelhardt, O.G. and Fodor, E. (2011) Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5. Journal of General Virology, 92(8), pp. 1859-1869. (doi: 10.1099/vir.0.032813-0) (PMID:21562121)

Hutchinson, E.C. , von Kirchbach, J.C., Gog, J.R. and Digard, P. (2010) Genome packaging in influenza A virus. Journal of General Virology, 91(2), pp. 313-328. (doi: 10.1099/vir.0.017608-0) (PMID:19955561)

Hutchinson, E. C. , Wise, H. M., Kudryavtseva, K., Curran, M. D. and Digard, P. (2009) Characterisation of influenza A viruses with mutations in segment 5 packaging signals. Vaccine, 27(45), pp. 6270-6275. (doi: 10.1016/j.vaccine.2009.05.053) (PMID:19840659) (PMCID:19840659)

Noton, S.L., Simpson-Holley, M., Medcalf, E., Wise, H.M., Hutchinson, E.C. , McCauley, J.W. and Digard, P. (2009) Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virions. Journal of Virology, 83(2), pp. 562-571. (doi: 10.1128/JVI.01424-08) (PMID:18987140) (PMCID:PMC2612366)

Hutchinson, E.C. , Curran, M.D., Read, E.K., Gog, J.R. and Digard, P. (2008) Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus. Journal of Virology, 82(23), pp. 11869-11879. (doi: 10.1128/JVI.01634-08) (PMID:18815307) (PMCID:PMC2583641)

Book Sections

Hutchinson, E. C. and Stegmann, M. (2018) Purification and proteomics of influenza virions. In: Yamauchi, Y. (ed.) Influenza Virus. Series: Methods in molecular biology (1836). Humana Press: New York, NY, pp. 89-120. ISBN 9781493986774 (doi:10.1007/978-1-4939-8678-1_5)

Hutchinson, E. C. and Yamauchi, Y. (2018) Understanding influenza. In: Yamauchi, Y. (ed.) Influenza Virus. Series: Methods in molecular biology (1836). Humana Press: New York, NY, pp. 1-21. ISBN 9781493986774 (doi:10.1007/978-1-4939-8678-1_1)

Conference or Workshop Item

Burke, A., Hirst, J. C. and Hutchinson, E. C. (2019) Altering the Size Distribution of Influenza Virion Populations [Poster]. Microbiology Society Annual Conference, Belfast, UK, 8-11 Apr 2019. (doi:10.1099/acmi.ac2019.po0122)

Hirst, J. C., Burke, A. and Hutchinson, E. C. (2019) Single-particle Measurements Reveal Damage to Filamentous Influenza Virions During Laboratory Handling [Poster]. Microbiology Society Annual Conference, Belfast, UK, 8-11 Apr 2019. (doi:10.1099/acmi.ac2019.po0292)

This list was generated on Mon Jan 18 21:50:00 2021 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Functional investigations of the influenza virus proteome
    Medical Research Council
    2016 - 2021
     
  • Quinquennial Core Funds
    Medical Research Council
    2016 - 2021
     

Research datasets

Jump to: 2019 | 2018
Number of items: 2.

2019

Hirst, J. and Hutchinson, E. (2019) Single-particle measurements of filamentous influenza virions reveal damage induced by freezing. [Data Collection]

2018

Hawksworth, A., Jayachander, M., Hester, S., Mohammed, S. and Hutchinson, E. (2018) Proteomics as a tool for Live Attenuated Influenza Vaccine characterisation. [Data Collection] (Unpublished)

This list was generated on Mon Jan 18 21:49:02 2021 GMT.

Additional information

Prizes, awards & distinctions

  • 2008: Biosciences Federation (New Researcher Science Communication Award)
  • 2007: Society for General Microbiology (Young Microbiologist of the Year)

Research fellowships

  • 2016 - 2021: MRC Career Development Award
  • 2010 - 2014: Junior Research Fellowship, Worcester College Oxford

Professional & learned societies

  • 2015: Board Member, European Scientific Working Group on Influenza
  • 2019: Virus Division, Microbiology Society

Ed Hutchinson Dec 2017

 

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