Dr Daniel Wall
- Reader (Bacteriology)
- Associate (School of Life Sciences)
Bacterial pathogens can cause either acute or persistent infections. Their capacity to cause these distinct types of diseases depends on their ability to influence or control the environment they find themselves in once they infect a host organism. Within intestinal epithelial cells or circulating immune cells some bacterial pathogens can establish a niche for survival and replication. Despite attempts by host cells these pathogens survive by undermining host pathways that normally remove and respond to intracellular microbes. As a last resort host cells induce cell suicide, removing themselves and the perceived threat from the body. Some bacterial pathogens we now know can also disrupt this process, keeping infected cells alive for prolonged periods facilitating replication of the bacteria intracellularly. The consequences for the host organism can be profound with persistent periods of inflammation, especially when immune cells such as macrophages and dendritic cells are involved.
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Systemic spread of gut bacterial metabolites and the role in host health
2021 - 2024
- Molecular mechanisms enabling DCs to control CD4 T cell priming.
2020 - 2023
- Elucidating the role of bacterial microcompartments in the pathogenesis of Crohns disease associated adherent-invasive Escherichia coli
2018 - 2019
- Propionic acid use in agriculture and food production is driving evolution of novel Escherichia coli pathotypes
2016 - 2019
- Protein antibiotics for the treatment of Pseudomonas aeruginosa lung infection
2016 - 2019
- Development of novel cancer targeting bacterial strains as delivery vehicles for anti-tumour genes
2014 - 2015
- Survival and dissemination of enteric pathogens through exploitation and inhibition of programmed cell death pathways in circulating immune cells.
2013 - 2016
- Deciphering and harnessing the activation of caspase-3 during infection by Salmonella typhimurium
2010 - 2010
- Controlled induction of apoptotic enzymes by Salmonella typhimurium drives infection and inflammation
2010 - 2011
Invited International Presentations
- 2011: Tenovus Scotland - Sir Robert MacLellan Award
- 2011: University of Strathclyde, UK - "Exploitation of apoptosis by Salmonella Typhimurium"
- 2007: Washington D.C., USA - Experimental Biology Annual General Meeting - Identification of the Salmonella typhimurium SipA functional domain required for intestinal inflammation.
- 2005: Long Island, NY, USA - Cold Spring Harbor Laboratory Microbial Pathogenesis & Host Response meeting. Cold Spring Harbor Laboratory - The S. typhimurium effector protein SipA possesses two discrete functional domains for invasion and inflammation
Prizes, Awards and Distinctions
- 2010: Society for General Microbiology - President's Award
- 2010: University of Massachusetts, USA - Visiting Academic, University of Massachusetts Medical School, Molecular Genetics and Microbiology Department. Funded by the Society for General Microbiology, UK President's Fund.