Dr Benjamin Brennan

  • Sir Henry Dale Fellow (Centre for Virus Research)

Biography

Work in my lab is funded by a Wellcome Trust/Royal Society Sir Henry Dale Fellowship and focuses on how tick-borne viruses interact with their arthropod vector to facilitate transmission. In particular we study viruses belonging to the Banyangvirus and Phlebovirus genera of the Phenuiviridae family.

Recent work has involved the development of a reverse genetics system for the newly discovered Huaiyangshan banyangvirus (severe fever with thrombocytopenia syndrome virus; SFTSV), as well as studies on Heartland (HRTV) and Uukuniemi (UUKV) viruses.

 

In particular, my research focuses on:

- Examining the interaction of tick transmitted viruses with their arthropod vector.

- Developing tools and techniques to study the replication of tick-borne viruses in vitro in tick cell lines and in vivo in ticks.

- Investigating the roles of the viral proteins during infection of both mammalian and arthropod cells.

- Exploring the molecular determinants of virus tropism.

- Developing attenuated viruses for use as potential live-attenuated vaccines or vector control agents.

 

I am also a former member of the laboratory of the late Prof Richard M Elliott (Bunyavirus Group), please contact me via email for requests for reagents/viruses regarding older publications.


Research interests

MRC, University of Glasgow and CVR logos 

Former Member of the Bunyavirus Group at CVR.

Research interests: tick-borne viruses, arthropods, bunyaviruses, reverse genetics, vaccinology.


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • What makes phleboviruses tick? Examining the molecular interactions of tick-borne phleboviruses with their arthropod vector
    Wellcome Trust
    2018 - 2023
     
  • Vaccines and molecular tools for the control of the emerging bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV)
    Biotechnology and Biological Sciences Research Council
    2018 - 2021
     

Professional activities & recognition

Prizes, awards & distinctions

  • 2017: Support Sir Henry Dale Fellowship (Lord Kelvin Adam Smith Leadership Fellow Funding)

Research fellowships

  • 2018: Wellcome Trust/Royal Society Sir Henry Dale Fellowship

Editorial boards

  • 2015: Journal of General Virology

Research datasets

Jump to: 2019
Number of items: 1.

2019

Rezelj, V. V., Mottram, T., Hughes, J., Elliott, R. M., Kohl, A. and Brennan, B. (2019) M segment-based minigenomes and virus-like particle assays as an approach to assess the potential of tick-borne Phlebovirus genome reassortment. [Data Collection]

This list was generated on Sat Sep 21 16:30:35 2019 BST.

Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2011
Number of items: 22.

2019

Choi, Y. et al. (2019) Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis. Nature Microbiology, 4(3), pp. 429-437. (doi:10.1038/s41564-018-0329-x) (PMID:30617349) (PMCID:PMC6548314)

Rezelj, V. V., Mottram, T. J., Hughes, J. , Elliott, R. M., Kohl, A. and Brennan, B. (2019) M segment-based minigenomes and virus-like particle assays as an approach to assess the potential of tick-borne Phlebovirus genome reassortment. Journal of Virology, 93(6), e02068-18. (doi:10.1128/JVI.02068-18) (PMID:30567991) (PMCID:PMC6401446)

2018

Allen, E. R. et al. (2018) A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley fever virus. Cell Reports, 25(13), 3750-3758.e4. (doi:10.1016/j.celrep.2018.12.001) (PMID:30590046) (PMCID:PMC6315105)

Franzke, K. et al. (2018) Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells. Journal of General Virology, 99, pp. 1739-1745. (doi:10.1099/jgv.0.001173) (PMID:30394867)

Dunlop, J. I. et al. (2018) Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas. PLoS Neglected Tropical Diseases, 12(10), e0006884. (doi:10.1371/journal.pntd.0006884) (PMID:30372452) (PMCID:PMC6245839)

Feng, J. et al. (2018) Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20. Journal of Virology, 92(13), e02140-17. (doi:10.1128/JVI.02140-17) (PMID:29695422) (PMCID:PMC6002717)

2017

Barski, M., Brennan, B. , Miller, O. K., Potter, J. A., Vijayakrishnan, S. , Bhella, D. , Naismith, J. H., Elliott, R. M. and Schwarz-Linek, U. (2017) Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments. eLife, 6, e29236. (doi:10.7554/elife.29236) (PMID:28915104) (PMCID:PMC5601994)

Brennan, B. , Rezelj, V. V. and Elliott, R. M. (2017) Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated the generation of NSs-deletant viruses. Journal of Virology, 91(16), e00743-17. (doi:10.1128/JVI.00743-17) (PMID:28592543) (PMCID:PMC5533932)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi:10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

Dietrich, I. et al. (2017) RNA interference restricts rift valley fever virus in multiple insect systems. mSphere, 2(3), 00090-17. (doi:10.1128/mSphere.00090-17) (PMID:28497117) (PMCID:PMC5415632)

Rezelj, V. V., Li, P. , Chaudhary, V., Elliott, R. M., Jin, D.-Y. and Brennan, B. (2017) Differential antagonism of human innate immune responses by tick-borne Phlebovirus nonstructural proteins. mSphere, 2(3), e00234-17. (doi:10.1128/mSphere.00234-17) (PMID:28680969) (PMCID:PMC5489658)

Drake, M. J., Brennan, B. , Briley, K., Bart, S. M., Sherman, E., Szemiel, A. M., Minutillo, M., Bushman, F. D. and Bates, P. (2017) A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry. PLoS Pathogens, 13(4), e1006316. (doi:10.1371/journal.ppat.1006316) (PMID:28388693) (PMCID:PMC5397019)

Mottram, T. J., Li, P. , Dietrich, I., Shi, X. , Brennan, B. , Varjak, M. and Kohl, A. (2017) Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. PLoS Neglected Tropical Diseases, 11(12), e0006155. (doi:10.1371/journal.pntd.0006155) (PMID:29267287) (PMCID:PMC5764413)

2016

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi:10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Shi, X. , Botting, C. H., Li, P. , Niglas, M., Brennan, B. , Shirran, S. L., Szemiel, A. M. and Elliott, R. M. (2016) Bunyamwera orthobunyavirus glycoprotein precursor Is processed by cellular signal peptidase and signal peptide peptidase. Proceedings of the National Academy of Sciences of the United States of America, 113(31), pp. 8825-8830. (doi:10.1073/pnas.1603364113) (PMID:27439867) (PMCID:PMC4978261)

Halldorsson, S., Behrens, A.-J., Harlos, K., Huiskonen, J. T., Elliott, R. M., Crispin, M., Brennan, B. and Bowden, T. A. (2016) Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion. Proceedings of the National Academy of Sciences of the United States of America, 113(26), pp. 7145-7159. (doi:10.1073/pnas.1603827113) (PMID:27325770) (PMCID:PMC4932967)

2015

Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi:10.1099/jgv.0.000241) (PMID:26315040)

2014

Elliott, R. M. and Brennan, B. (2014) Emerging phleboviruses. Current Opinion in Virology, 5, pp. 50-57. (doi:10.1016/j.coviro.2014.01.011)

Brennan, B. , Li, P. , Zhang, S., Li, A., Liang, M., Li, D. and Elliott, R. M. (2014) Reverse genetics system for severe fever with thrombocytopenia syndrome virus. Journal of Virology, 89(6), pp. 3026-3037. (doi:10.1128/JVI.03432-14) (PMID:25552716)

Brennan, B. , Welch, S. R. and Elliott, R. M. (2014) The consequences of reconfiguring the ambisense S genome segment of Rift Valley fever virus on viral replication in mammalian and mosquito cells and for genome packaging. PLoS Pathogens, 10(2), e1003922. (doi:10.1371/journal.ppat.1003922)

2011

Brennan, B. , Li, P. and Elliott, R. M. (2011) Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase. Journal of General Virology, 92(12), pp. 2906-2913. (doi:10.1099/vir.0.036749-0) (PMID:21900422)

Brennan, B. , Welch, S. R., McLees, A. and Elliott, R. M. (2011) Creation of a recombinant Rift Valley fever virus with a two-segmented genome. Journal of Virology, 85(19), pp. 10310-10318. (doi:10.1128/JVI.05252-11) (PMID:21795328) (PMCID:PMC3196426)

This list was generated on Sat Sep 21 16:30:34 2019 BST.
Jump to: Articles
Number of items: 22.

Articles

Choi, Y. et al. (2019) Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis. Nature Microbiology, 4(3), pp. 429-437. (doi:10.1038/s41564-018-0329-x) (PMID:30617349) (PMCID:PMC6548314)

Rezelj, V. V., Mottram, T. J., Hughes, J. , Elliott, R. M., Kohl, A. and Brennan, B. (2019) M segment-based minigenomes and virus-like particle assays as an approach to assess the potential of tick-borne Phlebovirus genome reassortment. Journal of Virology, 93(6), e02068-18. (doi:10.1128/JVI.02068-18) (PMID:30567991) (PMCID:PMC6401446)

Allen, E. R. et al. (2018) A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley fever virus. Cell Reports, 25(13), 3750-3758.e4. (doi:10.1016/j.celrep.2018.12.001) (PMID:30590046) (PMCID:PMC6315105)

Franzke, K. et al. (2018) Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells. Journal of General Virology, 99, pp. 1739-1745. (doi:10.1099/jgv.0.001173) (PMID:30394867)

Dunlop, J. I. et al. (2018) Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas. PLoS Neglected Tropical Diseases, 12(10), e0006884. (doi:10.1371/journal.pntd.0006884) (PMID:30372452) (PMCID:PMC6245839)

Feng, J. et al. (2018) Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20. Journal of Virology, 92(13), e02140-17. (doi:10.1128/JVI.02140-17) (PMID:29695422) (PMCID:PMC6002717)

Barski, M., Brennan, B. , Miller, O. K., Potter, J. A., Vijayakrishnan, S. , Bhella, D. , Naismith, J. H., Elliott, R. M. and Schwarz-Linek, U. (2017) Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments. eLife, 6, e29236. (doi:10.7554/elife.29236) (PMID:28915104) (PMCID:PMC5601994)

Brennan, B. , Rezelj, V. V. and Elliott, R. M. (2017) Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated the generation of NSs-deletant viruses. Journal of Virology, 91(16), e00743-17. (doi:10.1128/JVI.00743-17) (PMID:28592543) (PMCID:PMC5533932)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi:10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

Dietrich, I. et al. (2017) RNA interference restricts rift valley fever virus in multiple insect systems. mSphere, 2(3), 00090-17. (doi:10.1128/mSphere.00090-17) (PMID:28497117) (PMCID:PMC5415632)

Rezelj, V. V., Li, P. , Chaudhary, V., Elliott, R. M., Jin, D.-Y. and Brennan, B. (2017) Differential antagonism of human innate immune responses by tick-borne Phlebovirus nonstructural proteins. mSphere, 2(3), e00234-17. (doi:10.1128/mSphere.00234-17) (PMID:28680969) (PMCID:PMC5489658)

Drake, M. J., Brennan, B. , Briley, K., Bart, S. M., Sherman, E., Szemiel, A. M., Minutillo, M., Bushman, F. D. and Bates, P. (2017) A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry. PLoS Pathogens, 13(4), e1006316. (doi:10.1371/journal.ppat.1006316) (PMID:28388693) (PMCID:PMC5397019)

Mottram, T. J., Li, P. , Dietrich, I., Shi, X. , Brennan, B. , Varjak, M. and Kohl, A. (2017) Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. PLoS Neglected Tropical Diseases, 11(12), e0006155. (doi:10.1371/journal.pntd.0006155) (PMID:29267287) (PMCID:PMC5764413)

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi:10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Shi, X. , Botting, C. H., Li, P. , Niglas, M., Brennan, B. , Shirran, S. L., Szemiel, A. M. and Elliott, R. M. (2016) Bunyamwera orthobunyavirus glycoprotein precursor Is processed by cellular signal peptidase and signal peptide peptidase. Proceedings of the National Academy of Sciences of the United States of America, 113(31), pp. 8825-8830. (doi:10.1073/pnas.1603364113) (PMID:27439867) (PMCID:PMC4978261)

Halldorsson, S., Behrens, A.-J., Harlos, K., Huiskonen, J. T., Elliott, R. M., Crispin, M., Brennan, B. and Bowden, T. A. (2016) Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion. Proceedings of the National Academy of Sciences of the United States of America, 113(26), pp. 7145-7159. (doi:10.1073/pnas.1603827113) (PMID:27325770) (PMCID:PMC4932967)

Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi:10.1099/jgv.0.000241) (PMID:26315040)

Elliott, R. M. and Brennan, B. (2014) Emerging phleboviruses. Current Opinion in Virology, 5, pp. 50-57. (doi:10.1016/j.coviro.2014.01.011)

Brennan, B. , Li, P. , Zhang, S., Li, A., Liang, M., Li, D. and Elliott, R. M. (2014) Reverse genetics system for severe fever with thrombocytopenia syndrome virus. Journal of Virology, 89(6), pp. 3026-3037. (doi:10.1128/JVI.03432-14) (PMID:25552716)

Brennan, B. , Welch, S. R. and Elliott, R. M. (2014) The consequences of reconfiguring the ambisense S genome segment of Rift Valley fever virus on viral replication in mammalian and mosquito cells and for genome packaging. PLoS Pathogens, 10(2), e1003922. (doi:10.1371/journal.ppat.1003922)

Brennan, B. , Li, P. and Elliott, R. M. (2011) Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase. Journal of General Virology, 92(12), pp. 2906-2913. (doi:10.1099/vir.0.036749-0) (PMID:21900422)

Brennan, B. , Welch, S. R., McLees, A. and Elliott, R. M. (2011) Creation of a recombinant Rift Valley fever virus with a two-segmented genome. Journal of Virology, 85(19), pp. 10310-10318. (doi:10.1128/JVI.05252-11) (PMID:21795328) (PMCID:PMC3196426)

This list was generated on Sat Sep 21 16:30:34 2019 BST.


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