Dr Antonia Ho

  • Clinical Senior Lecturer/Consultant in Infectious Diseases (Centre for Virus Research)

Research interests

CVR logo    Virus image CVR Supporting COVID-19 Research Response

My research focuses on the clinical epidemiology of influenza and other respiratory viral infections in UK and sub-Saharan Africa. This has included SARS-CoV-2 since February 2020.

Acute respiratory infections (ARI) are the commonest cause of illness in all ages, and are also a leading cause of mortality worldwide. The advent of molecular diagnostic tests has led to the growing recognition that respiratory viruses cause a substantial proportion of ARI.

My research aims to:

-          Characterise the burden of respiratory viral infections

-          Define risk factors for severe disease

-          Explore viral-bacterial interactions

-          Improve the diagnosis of respiratory viral infections, using next-generation sequencing techniques and evaluating low-cost point-of-care assays

-          design and evaluate optimum preventative strategies to reduce the burden of ARI

 

Clinical role: I work as an infectious disease and general (internal) consultant at the Queen Elizabeth University Hospital in Glasgow, and University Hospital Monklands in Airdrie.

Teaching: I supervise PhD students, and teach on the Glasgow Diploma of Tropical Medicine and Hygiene (DTMH), BSc Immunology, and MSc in Critical Care.

Committees:

  1. British HIV Association Vaccine Guidelines Committee
  2. Scotland Infection Lead, NIHR Urgent Public Health Group
  3. Department of Health and Social Care Scientific Advisory Group on COVID-19 testing

 

Research programmes:

-          Respiratory infections

-          Viral genomics & bioinformatics

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2017 | 2016 | 2014 | 2013 | 2012 | 2011 | 2010
Number of items: 23.

2020

Cevik, M., Tate, M., Lloyd, O., Maraolo, A. E., Schafers, J. and Ho, A. (2020) SARS-CoV-2, SARS-CoV-1 and MERS-CoV viral load dynamics, duration of viral shedding and infectiousness – a systematic review and meta-analysis. Lancet Microbe, (Accepted for Publication)

Knight, S. R. et al. (2020) Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. British Medical Journal, 2020, 370. (doi: 10.1136/bmj.m3339) (PMID:32907855)

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, (doi: 10.1093/cvr/cvaa209) (PMID:32702087) (Early Online Publication)

Nickbakhsh, S. , Ho, A. , Marques, D. F.P., McMenamin, J., Gunson, R. N. and Murcia, P. R. (2020) Epidemiology of seasonal coronaviruses: establishing the context for the emergence of coronavirus disease 2019. Journal of Infectious Diseases, 222(1), pp. 17-25. (doi: 10.1093/infdis/jiaa185) (PMID:32296837) (PMCID:PMC7184404)

Cevik, M., Bamford, C. and Ho, A. (2020) COVID-19 Pandemic – a focused review for clinicians. Clinical Microbiology and Infection, 26(7), pp. 842-847. (doi: 10.1016/j.cmi.2020.04.023) (PMID:32344166) (PMCID:PMC7182753)

Harrison, E. M. et al. (2020) Ethnicity and outcomes from COVID-19: the ISARIC CCP-UK prospective observational cohort study of hospitalised patients. SSRN Electronic Journal, (doi: 10.2139/ssrn.3618215) (Submitted)

Akhvlediani, T. et al. (2020) Global outbreak research: harmony not hegemony. Lancet Infectious Diseases, (doi: 10.1016/S1473-3099(20)30440-0) (PMCID:PMC7266570) (In Press)

Docherty, A. B. et al. (2020) Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. British Medical Journal, 369, m1985. (doi: 10.1136/bmj.m1985) (PMID:32444460)

2019

Ho, A. et al. (2019) Impact of maternal HIV infection and placental malaria on the transplacental transfer of influenza antibodies in mother-infant pairs in Malawi. Open Forum Infectious Diseases, 6(10), ofz383. (doi: 10.1093/ofid/ofz383) (PMID:31660347) (PMCID:PMC6785697)

Aston, S. J. et al. (2019) Etiology and risk factors for mortality in an adult community-acquired pneumonia cohort in Malawi. American Journal of Respiratory and Critical Care Medicine, 200(3), pp. 359-369. (doi: 10.1164/rccm.201807-1333OC) (PMID:30625278) (PMCID:PMC6680311)

Sabroe, I., Ho, A. and Dockrell, D. H. (2019) Human rhinovirus inhibits macrophage phagocytosis of bacteria in chronic obstructive pulmonary disease: More than a common cold. American Journal of Respiratory and Critical Care Medicine, 199(12), pp. 1451-1452. (doi: 10.1164/rccm.201812-2283ED) (PMID:30571921) (PMCID:PMC6580668)

2018

Ho, A. et al. (2018) Impact of human immunodeficiency virus on the burden and severity of influenza illness in Malawian adults: a prospective cohort and parallel case-control study. Clinical Infectious Diseases, 66(6), pp. 865-876. (doi: 10.1093/cid/cix903)

Ho, A. et al. (2018) Epidemiology of severe acute respiratory illness and risk factors for influenza infection and clinical severity among adults in Malawi, 2011–2013. American Journal of Tropical Medicine and Hygiene, 99(3), pp. 772-779. (doi: 10.4269/ajtmh.17-0905) (PMID:30039785)

2017

Jary, H. R., Aston, S., Ho, A. , Giorgi, E., Kalata, N., Nyirenda, M., Mallewa, J., Peterson, I., Gordon, S. B. and Mortimer, K. (2017) Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study. Wellcome Open Research, 2, p. 103. (doi: 10.12688/wellcomeopenres.12621.1) (PMID:29387802) (PMCID:PMC5730861)

2016

Ghebrehewet, S., MacPherson, P. and Ho, A. (2016) Influenza. BMJ, 355, i6258. (doi: 10.1136/bmj.i6258) (PMID:27927672) (PMCID:PMC5141587)

Peterson, I. et al. (2016) Respiratory virus–associated severe acute respiratory illness and viral clustering in Malawian children in a setting with a high prevalence of HIV infection, malaria, and malnutrition. Journal of Infectious Diseases, 214(11), pp. 1700-1711. (doi: 10.1093/infdis/jiw426) (PMID:27630199) (PMCID:PMC5341080)

Geretti, A. M. et al. (2016) British HIV Association guidelines on the use of vaccines in HIV-positive adults 2015. HIV Medicine, 17, s2-s81. (doi: 10.1111/hiv.12424) (PMID:27568789)

2014

Ho, A. (2014) Viral pneumonia in adults and older children in sub-Saharan Africa — epidemiology, aetiology, diagnosis and management. Pneumonia, 5(S1), pp. 18-29. (doi: 10.15172/pneu.2014.5/446)

2013

Duncan, C. J. A., Barr, D. A., Ho, A. , Sharp, E., Semple, L. and Seaton, R. A. (2013) Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditis. Journal of Antimicrobial Chemotherapy, 68(7), pp. 1650-1654. (doi: 10.1093/jac/dkt046) (PMID:23475647) (PMCID:PMC3682687)

2012

Ho, A. (2012) HIV seroconversion. In: Dancer, S. J. and Seaton, R. A. (eds.) Problem Solving in Infection. Clinical Publishing: Oxford, pp. 197-200. ISBN 9781904392835

2011

Ho, A. and Fox, R. (2011) Tailoring response-based treatment for hepatitis C. Viral Hepatitis in Practice, 3(1), pp. 1-5.

2010

Ho, A. , Shankland, G.S. and Seaton, R.A. (2010) Penicillium marneffei infection presenting as an immune reconstitution inflammatory syndrome in an HIV patient. International Journal of STD and AIDS, 21(11), pp. 780-782. (doi: 10.1258/ijsa.2010.010164) (PMID:21187363)

Ho, A. , Fox, R., Seaton, R.A., MacConnachie, A., Peters, E., Mackintosh, C.L., Todd, W.T.A., Kennedy, N., Dundas, S. and Gunson, R. (2010) Hospitalised adult patients with suspected 2009 H1N1 infection at regional infectious diseases units in Scotland – most had alternative final diagnoses. Journal of Infection, 60(1), pp. 83-85. (doi: 10.1016/j.jinf.2009.11.001) (PMID:19896500)

This list was generated on Tue Oct 20 02:40:36 2020 BST.
Number of items: 23.

Articles

Cevik, M., Tate, M., Lloyd, O., Maraolo, A. E., Schafers, J. and Ho, A. (2020) SARS-CoV-2, SARS-CoV-1 and MERS-CoV viral load dynamics, duration of viral shedding and infectiousness – a systematic review and meta-analysis. Lancet Microbe, (Accepted for Publication)

Knight, S. R. et al. (2020) Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. British Medical Journal, 2020, 370. (doi: 10.1136/bmj.m3339) (PMID:32907855)

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, (doi: 10.1093/cvr/cvaa209) (PMID:32702087) (Early Online Publication)

Nickbakhsh, S. , Ho, A. , Marques, D. F.P., McMenamin, J., Gunson, R. N. and Murcia, P. R. (2020) Epidemiology of seasonal coronaviruses: establishing the context for the emergence of coronavirus disease 2019. Journal of Infectious Diseases, 222(1), pp. 17-25. (doi: 10.1093/infdis/jiaa185) (PMID:32296837) (PMCID:PMC7184404)

Cevik, M., Bamford, C. and Ho, A. (2020) COVID-19 Pandemic – a focused review for clinicians. Clinical Microbiology and Infection, 26(7), pp. 842-847. (doi: 10.1016/j.cmi.2020.04.023) (PMID:32344166) (PMCID:PMC7182753)

Harrison, E. M. et al. (2020) Ethnicity and outcomes from COVID-19: the ISARIC CCP-UK prospective observational cohort study of hospitalised patients. SSRN Electronic Journal, (doi: 10.2139/ssrn.3618215) (Submitted)

Akhvlediani, T. et al. (2020) Global outbreak research: harmony not hegemony. Lancet Infectious Diseases, (doi: 10.1016/S1473-3099(20)30440-0) (PMCID:PMC7266570) (In Press)

Docherty, A. B. et al. (2020) Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. British Medical Journal, 369, m1985. (doi: 10.1136/bmj.m1985) (PMID:32444460)

Ho, A. et al. (2019) Impact of maternal HIV infection and placental malaria on the transplacental transfer of influenza antibodies in mother-infant pairs in Malawi. Open Forum Infectious Diseases, 6(10), ofz383. (doi: 10.1093/ofid/ofz383) (PMID:31660347) (PMCID:PMC6785697)

Aston, S. J. et al. (2019) Etiology and risk factors for mortality in an adult community-acquired pneumonia cohort in Malawi. American Journal of Respiratory and Critical Care Medicine, 200(3), pp. 359-369. (doi: 10.1164/rccm.201807-1333OC) (PMID:30625278) (PMCID:PMC6680311)

Sabroe, I., Ho, A. and Dockrell, D. H. (2019) Human rhinovirus inhibits macrophage phagocytosis of bacteria in chronic obstructive pulmonary disease: More than a common cold. American Journal of Respiratory and Critical Care Medicine, 199(12), pp. 1451-1452. (doi: 10.1164/rccm.201812-2283ED) (PMID:30571921) (PMCID:PMC6580668)

Ho, A. et al. (2018) Impact of human immunodeficiency virus on the burden and severity of influenza illness in Malawian adults: a prospective cohort and parallel case-control study. Clinical Infectious Diseases, 66(6), pp. 865-876. (doi: 10.1093/cid/cix903)

Ho, A. et al. (2018) Epidemiology of severe acute respiratory illness and risk factors for influenza infection and clinical severity among adults in Malawi, 2011–2013. American Journal of Tropical Medicine and Hygiene, 99(3), pp. 772-779. (doi: 10.4269/ajtmh.17-0905) (PMID:30039785)

Jary, H. R., Aston, S., Ho, A. , Giorgi, E., Kalata, N., Nyirenda, M., Mallewa, J., Peterson, I., Gordon, S. B. and Mortimer, K. (2017) Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study. Wellcome Open Research, 2, p. 103. (doi: 10.12688/wellcomeopenres.12621.1) (PMID:29387802) (PMCID:PMC5730861)

Ghebrehewet, S., MacPherson, P. and Ho, A. (2016) Influenza. BMJ, 355, i6258. (doi: 10.1136/bmj.i6258) (PMID:27927672) (PMCID:PMC5141587)

Peterson, I. et al. (2016) Respiratory virus–associated severe acute respiratory illness and viral clustering in Malawian children in a setting with a high prevalence of HIV infection, malaria, and malnutrition. Journal of Infectious Diseases, 214(11), pp. 1700-1711. (doi: 10.1093/infdis/jiw426) (PMID:27630199) (PMCID:PMC5341080)

Geretti, A. M. et al. (2016) British HIV Association guidelines on the use of vaccines in HIV-positive adults 2015. HIV Medicine, 17, s2-s81. (doi: 10.1111/hiv.12424) (PMID:27568789)

Ho, A. (2014) Viral pneumonia in adults and older children in sub-Saharan Africa — epidemiology, aetiology, diagnosis and management. Pneumonia, 5(S1), pp. 18-29. (doi: 10.15172/pneu.2014.5/446)

Duncan, C. J. A., Barr, D. A., Ho, A. , Sharp, E., Semple, L. and Seaton, R. A. (2013) Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditis. Journal of Antimicrobial Chemotherapy, 68(7), pp. 1650-1654. (doi: 10.1093/jac/dkt046) (PMID:23475647) (PMCID:PMC3682687)

Ho, A. and Fox, R. (2011) Tailoring response-based treatment for hepatitis C. Viral Hepatitis in Practice, 3(1), pp. 1-5.

Ho, A. , Shankland, G.S. and Seaton, R.A. (2010) Penicillium marneffei infection presenting as an immune reconstitution inflammatory syndrome in an HIV patient. International Journal of STD and AIDS, 21(11), pp. 780-782. (doi: 10.1258/ijsa.2010.010164) (PMID:21187363)

Ho, A. , Fox, R., Seaton, R.A., MacConnachie, A., Peters, E., Mackintosh, C.L., Todd, W.T.A., Kennedy, N., Dundas, S. and Gunson, R. (2010) Hospitalised adult patients with suspected 2009 H1N1 infection at regional infectious diseases units in Scotland – most had alternative final diagnoses. Journal of Infection, 60(1), pp. 83-85. (doi: 10.1016/j.jinf.2009.11.001) (PMID:19896500)

Book Sections

Ho, A. (2012) HIV seroconversion. In: Dancer, S. J. and Seaton, R. A. (eds.) Problem Solving in Infection. Clinical Publishing: Oxford, pp. 197-200. ISBN 9781904392835

This list was generated on Tue Oct 20 02:40:36 2020 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • ISARIC - Coronavirus Clinical Characterisation Consortium
    Medical Research Council
    2020 - 2021
     

Visit the Ho Group webpage

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