Dr Lyn Ferguson

  • Clinical Lecturer in Chemical Pathology and Metabolic Medicine (Institute of Cardiovascular & Medical Sciences)
  • Honorary Clinical Lecturer (School of Medicine, Dentistry & Nursing)

telephone: 0141 3303076
email: Lyn.Ferguson@glasgow.ac.uk

Room 213, Institute of Cardiovascular & Medical Sciences, BHF GCRC, University of Glasgow, 126 University place, Glasgow, G12 8TA

ORCID iDhttps://orcid.org/0000-0002-6136-8349

Biography

Lyn Ferguson trained in medicine at the University of Glasgow (MBChB Hons. 2010), with an intercalated BSc (MedSci) (first class Hons.) in Anatomy (2008).  She undertook academic foundation and core medical training in the West of Scotland and obtained membership of the Royal College of Physicians and Surgeons of Glasgow (MRCP(Glasg)) in 2013, before commencing specialty training in Chemical Pathology and Metabolic Medicine in 2014. In 2016, she became a Diplomate member of the Royal College of Pathogists (DipRCPath).

From August 2016 to August 2019 she undertook a Clinical Research Fellowship, funded by the BHF Centre of Excellence at the University of Glasgow, and was co-investigator of the Immune Metabolic Associations in Psoriatic Arthritis (IMAPA) study. She was awarded her PhD in 2020, entitled 'Cardiometabolic comorbidities in psoriatic disease and modulation by phosphodiesterase (PDE) 4 inhibition'.

Currently she is a Clinical Lecturer in the Institute of Cardiovascular and Medical Sciences and is an Honorary Specialist Registrar in Clinical Biochemistry and Metabolic Medicine in the Queen Elizabeth University Hospital.

Google Scholar

Research interests

1 - Clinical Studies - IMAPA Study

Psoriasis and psoriatic arthritis are chronic inflammatory diseases of the skin and joints, which are also associated with increased risk of type 2 diabetes and cardiovascular disease. Obesity is a frequent comorbidity in psoriatic disease and is increasingly implicated in its pathogenesis, disease severity, and response to treatment. The medication apremilast, a phosphodiesterase (PDE)4 inhibitor, has been shown to improve psoriatic disease, as well as being associated with weight loss.  The Immune Metabolic Associations in Psoriatic Arthritis (IMAPA) study aimed to evaluate the effects of PDE4 inhibition on metabolic, vascular, and immune status in psoriatic disease.

2 - Epidemiological studies - UK Biobank

In collaboration with colleagues from the Institute of Health and Wellbeing, research focuses on the causes, prevention, and management of diabetes, obesity, heart disease, and chronic rheumatic diseases using the UK Biobank. This is a prospective, population cohort study of 500,000 participants designed to determine lifestyle, environmental and genetic factors that predispose to adult chronic diseases.

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2015 | 2013 | 2011
Number of items: 24.

2021

Petermann-Rocha, F., Ferguson, L. D. , Gray, S. R. , Rodríguez-Gómez, I., Sattar, N. , Siebert, S. , Ho, F. K., Pell, J. P. and Celis-Morales, C. (2021) Association of sarcopenia with incident osteoporosis: a prospective study of 168,682 UK biobank participants. Journal of Cachexia, Sarcopenia and Muscle, 12(5), pp. 1179-1188. (doi: 10.1002/jcsm.12757) (PMID:34264024) (PMCID:PMC8517357)

Ferguson, L. et al. (2021) Effect of the phosphodiesterase 4 inhibitor apremilast on cardiometabolic outcomes in psoriatic disease – results of the IMAPA study. Rheumatology, (doi: 10.1093/rheumatology/keab474) (PMID:34097014) (Early Online Publication)

Ferguson, L. D. , Linge, J., Leinhard, O. D., Woodward, R., Hall Barrientos, P., Roditi, G., Radjenovic, A. , McInnes, I. B. , Siebert, S. and Sattar, N. (2021) Psoriatic arthritis is associated with adverse body composition predictive of greater coronary heart disease and type 2 diabetes propensity – a cross-sectional study. Rheumatology, 60(4), pp. 1858-1862. (doi: 10.1093/rheumatology/keaa604) (PMID:33147607)

Ferguson, L. D. , Sattar, N. and McInnes, I. B. (2021) Managing cardiovascular risk in patients with rheumatic disease. Medical Clinics of North America, 105(2), pp. 247-262. (doi: 10.1016/j.mcna.2020.09.010) (PMID:33589100)

Anderson, J. J. et al. (2021) Ethnic differences in prevalence of actionable HbA1c levels in UK Biobank: implications for screening. BMJ Open Diabetes Research and Care, 9(1), e002176. (doi: 10.1136/bmjdrc-2021-002176) (PMID:34353880) (PMCID:PMC8344314)

2020

Ho, F. K. et al. (2020) Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. BMJ Open, 10, e040402. (doi: 10.1136/bmjopen-2020-040402) (PMID:33444201) (PMCID:PMC7678347)

Welsh, P. et al. (2020) Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction and estimating benefits from novel interventions. European Journal of Preventive Cardiology, (doi: 10.1093/eurjpc/zwaa063) (PMID:33624048) (Early Online Publication)

Hayes, S. et al. (2020) Association between walking pace and stroke incidence: findings from the UK Biobank prospective cohort study. Stroke, 51(5), pp. 1388-1395. (doi: 10.1161/STROKEAHA.119.028064) (PMID:32299326)

Welsh, C. et al. (2020) Association of injury related hospital admissions with commuting by bicycle in the UK: prospective population based study. British Medical Journal, 368, m336. (doi: 10.1136/bmj.m336) (PMID:32161038) (PMCID:PMC7190046)

Welsh, C. et al. (2020) Glycated hemoglobin, prediabetes and the links to cardiovascular disease: data from UK Biobank. Diabetes Care, 43(2), pp. 440-445. (doi: 10.2337/dc19-1683) (PMID:31852727)

2019

Ferguson, L. D. , Brown, R., Celis-Morales, C. , Welsh, P. , Lyall, D. M. , Pell, J. P. , McInnes, I. B. , Siebert, S. and Sattar, N. (2019) Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank. Rheumatology, 58(12), pp. 2137-2142. (doi: 10.1093/rheumatology/kez192) (PMID:31131407) (PMCID:PMC6880847)

Sillars, A. et al. (2019) Association of fitness and grip-strength with heart failure: findings from the UK Biobank population-based study. Mayo Clinic Proceedings, 94(11), pp. 2230-2240. (doi: 10.1016/j.mayocp.2019.04.041) (PMID:31685151)

Muilwijk, M. et al. (2019) Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study. BMJ Open Diabetes Research and Care, 7(1), e000765. (doi: 10.1136/bmjdrc-2019-000765) (PMID:31908795) (PMCID:PMC6936483)

Welsh, C. et al. (2019) Comparison of conventional lipoprotein tests and apolipoproteins in the prediction of cardiovascular disease: data from UK Biobank. Circulation, 140(7), pp. 542-552. (doi: 10.1161/CIRCULATIONAHA.119.041149) (PMID:31216866) (PMCID:PMC6693929)

Budu-Aggrey, A. et al. (2019) Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. PLoS Medicine, 16(1), e1002739. (doi: 10.1371/journal.pmed.1002739) (PMID:30703100) (PMCID:PMC6354959)

Ferguson, L. D. , Siebert, S. , McInnes, I. B. and Sattar, N. (2019) Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions. Nature Reviews Rheumatology, 15, pp. 461-474. (doi: 10.1038/s41584-019-0256-0) (PMID:31292564)

2018

Ferguson, L.D. , Ntuk, U.E., Celis-Morales, C. , Mackay, D.F. , Pell, J.P. , Gill, J.M.R. and Sattar, N. (2018) Men across a range of ethnicities have a higher prevalence of diabetes: findings from a cross-sectional study of 500000 UK Biobank participants. Diabetic Medicine, 35(2), pp. 270-276. (doi: 10.1111/dme.13551) (PMID:29171078)

2017

Ferguson, L. D. and Sattar, N. (2017) Impact of obesity on cardiovascular disease. In: Sbraccia, P. and Finer, N. (eds.) Obesity: Pathogenesis, Diagnosis, and Treatment. Series: Endocrinology (4). Springer International Publishing, pp. 1-21. ISBN 9783319476858 (doi: 10.1007/978-3-319-47685-8_25-1)

2015

Ferguson, L. and Sattar, N. (2015) Endothelial function measures: not for clinical prime time? International Journal of Clinical Practice, 69(6), pp. 624-625. (doi: 10.1111/ijcp.12642) (PMID:26010940)

Ferguson, L.D. and Logue, J. (2015) Has IMPROVE-IT improved cardiovascular outcome? Journal of the Royal College of Physicians of Edinburgh, 45(3), pp. 215-217. (PMID:26517102)

2013

Ferguson, L. D. , McKay, G. and Fisher, M. (2013) Bendroflumethiazide. Practical Diabetes, 30(8), 340-341a. (doi: 10.1002/pdi.1808)

Ferguson, L.D. and Sattar, N. (2013) Reducing cardiovascular disease risk in type 2 diabetes: is the focus on glycaemia warranted? Diabetes, Obesity and Metabolism, 15(5), pp. 387-391. (doi: 10.1111/dom.12018)

2011

Ferguson, L.D. , Paterson, T., Ramsay, F., Arrol, K., Dabernig, J., Shaw-Dunn, J. and Morley, S. (2011) Applied anatomy of the latissimus dorsi free flap for refinement in one-stage facial reanimation. Journal of Plastic, Reconstructive and Aesthetic Surgery, 64(11), pp. 1417-1423. (doi: 10.1016/j.bjps.2011.06.013)

Higgins, P., Ferguson, L. D. and Walters, M. R. (2011) Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach. Expert Review of Cardiovascular Therapy, 9(4), pp. 399-401. (doi: 10.1586/erc.11.29) (PMID:21517722)

This list was generated on Sun Dec 5 12:46:28 2021 GMT.
Number of items: 24.

Articles

Petermann-Rocha, F., Ferguson, L. D. , Gray, S. R. , Rodríguez-Gómez, I., Sattar, N. , Siebert, S. , Ho, F. K., Pell, J. P. and Celis-Morales, C. (2021) Association of sarcopenia with incident osteoporosis: a prospective study of 168,682 UK biobank participants. Journal of Cachexia, Sarcopenia and Muscle, 12(5), pp. 1179-1188. (doi: 10.1002/jcsm.12757) (PMID:34264024) (PMCID:PMC8517357)

Ferguson, L. et al. (2021) Effect of the phosphodiesterase 4 inhibitor apremilast on cardiometabolic outcomes in psoriatic disease – results of the IMAPA study. Rheumatology, (doi: 10.1093/rheumatology/keab474) (PMID:34097014) (Early Online Publication)

Ferguson, L. D. , Linge, J., Leinhard, O. D., Woodward, R., Hall Barrientos, P., Roditi, G., Radjenovic, A. , McInnes, I. B. , Siebert, S. and Sattar, N. (2021) Psoriatic arthritis is associated with adverse body composition predictive of greater coronary heart disease and type 2 diabetes propensity – a cross-sectional study. Rheumatology, 60(4), pp. 1858-1862. (doi: 10.1093/rheumatology/keaa604) (PMID:33147607)

Ferguson, L. D. , Sattar, N. and McInnes, I. B. (2021) Managing cardiovascular risk in patients with rheumatic disease. Medical Clinics of North America, 105(2), pp. 247-262. (doi: 10.1016/j.mcna.2020.09.010) (PMID:33589100)

Anderson, J. J. et al. (2021) Ethnic differences in prevalence of actionable HbA1c levels in UK Biobank: implications for screening. BMJ Open Diabetes Research and Care, 9(1), e002176. (doi: 10.1136/bmjdrc-2021-002176) (PMID:34353880) (PMCID:PMC8344314)

Ho, F. K. et al. (2020) Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. BMJ Open, 10, e040402. (doi: 10.1136/bmjopen-2020-040402) (PMID:33444201) (PMCID:PMC7678347)

Welsh, P. et al. (2020) Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction and estimating benefits from novel interventions. European Journal of Preventive Cardiology, (doi: 10.1093/eurjpc/zwaa063) (PMID:33624048) (Early Online Publication)

Hayes, S. et al. (2020) Association between walking pace and stroke incidence: findings from the UK Biobank prospective cohort study. Stroke, 51(5), pp. 1388-1395. (doi: 10.1161/STROKEAHA.119.028064) (PMID:32299326)

Welsh, C. et al. (2020) Association of injury related hospital admissions with commuting by bicycle in the UK: prospective population based study. British Medical Journal, 368, m336. (doi: 10.1136/bmj.m336) (PMID:32161038) (PMCID:PMC7190046)

Welsh, C. et al. (2020) Glycated hemoglobin, prediabetes and the links to cardiovascular disease: data from UK Biobank. Diabetes Care, 43(2), pp. 440-445. (doi: 10.2337/dc19-1683) (PMID:31852727)

Ferguson, L. D. , Brown, R., Celis-Morales, C. , Welsh, P. , Lyall, D. M. , Pell, J. P. , McInnes, I. B. , Siebert, S. and Sattar, N. (2019) Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank. Rheumatology, 58(12), pp. 2137-2142. (doi: 10.1093/rheumatology/kez192) (PMID:31131407) (PMCID:PMC6880847)

Sillars, A. et al. (2019) Association of fitness and grip-strength with heart failure: findings from the UK Biobank population-based study. Mayo Clinic Proceedings, 94(11), pp. 2230-2240. (doi: 10.1016/j.mayocp.2019.04.041) (PMID:31685151)

Muilwijk, M. et al. (2019) Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study. BMJ Open Diabetes Research and Care, 7(1), e000765. (doi: 10.1136/bmjdrc-2019-000765) (PMID:31908795) (PMCID:PMC6936483)

Welsh, C. et al. (2019) Comparison of conventional lipoprotein tests and apolipoproteins in the prediction of cardiovascular disease: data from UK Biobank. Circulation, 140(7), pp. 542-552. (doi: 10.1161/CIRCULATIONAHA.119.041149) (PMID:31216866) (PMCID:PMC6693929)

Budu-Aggrey, A. et al. (2019) Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. PLoS Medicine, 16(1), e1002739. (doi: 10.1371/journal.pmed.1002739) (PMID:30703100) (PMCID:PMC6354959)

Ferguson, L. D. , Siebert, S. , McInnes, I. B. and Sattar, N. (2019) Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions. Nature Reviews Rheumatology, 15, pp. 461-474. (doi: 10.1038/s41584-019-0256-0) (PMID:31292564)

Ferguson, L.D. , Ntuk, U.E., Celis-Morales, C. , Mackay, D.F. , Pell, J.P. , Gill, J.M.R. and Sattar, N. (2018) Men across a range of ethnicities have a higher prevalence of diabetes: findings from a cross-sectional study of 500000 UK Biobank participants. Diabetic Medicine, 35(2), pp. 270-276. (doi: 10.1111/dme.13551) (PMID:29171078)

Ferguson, L. and Sattar, N. (2015) Endothelial function measures: not for clinical prime time? International Journal of Clinical Practice, 69(6), pp. 624-625. (doi: 10.1111/ijcp.12642) (PMID:26010940)

Ferguson, L.D. and Logue, J. (2015) Has IMPROVE-IT improved cardiovascular outcome? Journal of the Royal College of Physicians of Edinburgh, 45(3), pp. 215-217. (PMID:26517102)

Ferguson, L. D. , McKay, G. and Fisher, M. (2013) Bendroflumethiazide. Practical Diabetes, 30(8), 340-341a. (doi: 10.1002/pdi.1808)

Ferguson, L.D. and Sattar, N. (2013) Reducing cardiovascular disease risk in type 2 diabetes: is the focus on glycaemia warranted? Diabetes, Obesity and Metabolism, 15(5), pp. 387-391. (doi: 10.1111/dom.12018)

Ferguson, L.D. , Paterson, T., Ramsay, F., Arrol, K., Dabernig, J., Shaw-Dunn, J. and Morley, S. (2011) Applied anatomy of the latissimus dorsi free flap for refinement in one-stage facial reanimation. Journal of Plastic, Reconstructive and Aesthetic Surgery, 64(11), pp. 1417-1423. (doi: 10.1016/j.bjps.2011.06.013)

Higgins, P., Ferguson, L. D. and Walters, M. R. (2011) Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach. Expert Review of Cardiovascular Therapy, 9(4), pp. 399-401. (doi: 10.1586/erc.11.29) (PMID:21517722)

Book Sections

Ferguson, L. D. and Sattar, N. (2017) Impact of obesity on cardiovascular disease. In: Sbraccia, P. and Finer, N. (eds.) Obesity: Pathogenesis, Diagnosis, and Treatment. Series: Endocrinology (4). Springer International Publishing, pp. 1-21. ISBN 9783319476858 (doi: 10.1007/978-3-319-47685-8_25-1)

This list was generated on Sun Dec 5 12:46:28 2021 GMT.

Teaching

Lyn Ferguson lectures on the MBChB year 2 curriculum.

Additional information

Prizes, Awards and Distinctions

  • 2017: Diabetes UK Professional Conference - Diabetes UK Type 2 Diabetes Research Award
  • 2015: Association of Clinical Biochemistry - John King Award
  • 2013: European Calcified Tissue Society (ECTS) - Anniversary Travel Grant
  • 2008: University of Glasgow - Lorimer Bursary in Anatomy
  • 2008: Glasgow Cardiovascular Research Centre - Wellcome Trust Vacation Scholarship