Dr Angie Sin

  • Research Associate (School of Cardiovascular & Metabolic Health)

telephone: +441413306388
email: Angie.Sin@glasgow.ac.uk

Import to contacts

Biography

I am an MBBS/PhD scientist with multidisciplinary research capacity and expertise. My career goal is to develop a research career at the interface between basic science and clinical medicine by applying my background in medicine complemented with my broad-based research skills. Over the years, my research focus has always been clinically driven with emphasis on unravelling the molecular mechanisms underlying disease progression and the development of novel therapeutic strategies. I have worked on a wide range of cutting-edge research projects such as the elucidation of signaling pathways to identify novel therapeutic targets for cardiac hypertrophy, targeted gene repair for rare genetic disorders using mouse- and patient-derived induced pluripotent stem cells in combination with the CRISPR/Cas9 gene-editing and piggyBac technologies, fluorescence polarisation-based high throughput assay for drug screening, CRISPR-generated cell model for functional studies of collagen IV deficiency and drug validation of PROTACs using cancer cell lines.

Research interests

Research Theme:CardiacCardiac

  • Phosphodiesterase-mediated cAMP signalling
  • Drug discovery
  • CRISPR-Cas9 gene editing
  • Induced pluripotent stem cells
  • 3D cell cultures
  • Rare Diseases

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2006
Number of items: 24.

2025

Shakya, A. et al. (2025) Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders. Journal of Translational Autoimmunity, 11, 100329. (doi: 10.1016/j.jtauto.2025.100329) (PMID:41278249) (PMCID:PMC12637402)

Cooke, S. F. et al. (2025) Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells. Molecular Therapy Oncology, 33(3), 201029. (doi: 10.1016/j.omton.2025.201029) (PMID:40896364) (PMCID:PMC12395054)

Montezano, A. C. et al. (2025) Ang-(1-7) and ET-1 interplay through Mas and ETB receptor interaction defines a novel vasoprotective mechanism. Hypertension, 82(2), pp. 267-281. (doi: 10.1161/HYPERTENSIONAHA.124.22693) (PMID:39633565)

2024

Main, Alice, Mary, Sheon ORCID logoORCID: https://orcid.org/0000-0001-9392-3020, Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Wright, Tom A., Ling, Jiayue, Blair, Connor M., Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741, Fuller, Will ORCID logoORCID: https://orcid.org/0000-0002-5883-4433 and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

Sin, Y. Y. et al. (2024) Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS Journal, 292(13), pp. 3360-3377. (doi: 10.1111/febs.17359) (PMID:39673076) (PMCID:PMC12220845)

McNeilly, S. et al. (2024) Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage. EBioMedicine, 107, 105315. (doi: 10.1016/j.ebiom.2024.105315) (PMID:39216230) (PMCID:PMC11402910)

Sin, Y. Y. et al. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598(13), pp. 1591-1604. (doi: 10.1002/1873-3468.14902) (PMID:38724485)

Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546) (PMCID:PMC11026450)

2020

Ngandu Mpoyi, E. et al. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts. Biomaterials, 252, 120090. (doi: 10.1016/j.biomaterials.2020.120090) (PMID:32413593)

2019

Gatseva, Anna ORCID logoORCID: https://orcid.org/0000-0003-1601-5277, Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Brezzo, Gaia and Van Agtmael, Tom ORCID logoORCID: https://orcid.org/0000-0003-4282-449X (2019) Basement membrane collagens and disease mechanisms. Essays in Biochemistry, 63(3), pp. 297-312. (doi: 10.1042/EBC20180071) (PMID:31387942) (PMCID:PMC6744580)

2018

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Ballantyne, Laurel L., Richmond, Christopher R. and Funk, Colin D. (2018) Transplantation of gene-edited hepatocyte-like cells modestly improves survival of arginase-1 deficient mice. Molecular Therapy - Nucleic Acids, 10, pp. 122-130. (doi: 10.1016/j.omtn.2017.11.012)

2017

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Price, Phillipe R., Ballantyne, Laurel L. and Funk, Colin D. (2017) Proof-of-concept gene editing for the murine model of inducible arginase-1 deficiency. Scientific Reports, 7, 2585. (doi: 10.1038/s41598-017-02927-2) (PMID:28566761) (PMCID:PMC5451454)

2016

Ballantyne, Laurel L., Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Al-Dirbashi, Osama Y., Li, Xinzhi, Hurlbut, David J. and Funk, Colin D. (2016) Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency. Molecular Genetics and Metabolism Reports, 9, pp. 54-60. (doi: 10.1016/j.ymgmr.2016.10.003) (PMID:27761413) (PMCID:PMC5065044)

2015

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Baron, Garrett, Schulze, Andreas and Funk, Colin D. (2015) Arginase-1 deficiency. Journal of Molecular Medicine, 93(12), pp. 1287-1296. (doi: 10.1007/s00109-015-1354-3) (PMID:26467175)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266 and Baillie, George ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1). Cell Biochemistry and Function, 33(7), pp. 421-426. (doi: 10.1002/cbf.3147) (PMID:26443497) (PMCID:PMC4973849)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Ballantyne, Laurel L., Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, St. Amand, Tim, Si, Joshua, Goossens, Steven, Haenebalcke, Lieven, Haigh, Jody J., Kyriakopoulou, Lianna, Schulze, Andreas and Funk, Colin D. (2015) Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. PLoS ONE, 10(5), e0125967. (doi: 10.1371/journal.pone.0125967) (PMID:25938595) (PMCID:PMC4418594)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Martin, Tamara P. ORCID logoORCID: https://orcid.org/0000-0002-2509-2613, Wills, Lauren, Currie, Susan and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, 16. (doi: 10.1186/s12964-015-0094-x) (PMID:25889640) (PMCID:PMC4356135)

2013

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Ballantyne, Laurel L., Mukherjee, Kamalika, St. Amand, Tim, Kyriakopoulou, Lianna, Schulze, Andreas and Funk, Colin D. (2013) Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. PLoS ONE, 8(11), e80001. (doi: 10.1371/journal.pone.0080001) (PMID:24224027) (PMCID:PMC3817112)

Berthouze-Duquesnes, M., Lucas, A., Saulière, A., Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Laurent, A.C., Galés, C., Baillie, G. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 and Lezoualc'h, F. (2013) Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling. Cellular Signalling, 25(4), pp. 970-980. (doi: 10.1016/j.cellsig.2012.12.007) (PMID:23266473)

2012

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266 and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2012) Protein kinase D in the hypertrophy pathway. Biochemical Society Transactions, 40(1), pp. 287-289. (doi: 10.1042/BST20110626) (PMID:22260707)

2011

Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Edwards, H.V., Li, X., Day, J.P., Christian, F. ORCID logoORCID: https://orcid.org/0000-0001-8208-5930, Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50(5), pp. 872-883. (doi: 10.1016/j.yjmcc.2011.02.006) (PMID:21334344)

Anthony, D.F., Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519, Houslay, M.D. and Baillie, G.S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2011) β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31(5), pp. 1066-1075. (doi: 10.1128/MCB.00883-10) (PMID:21173159) (PMCID:PMC3067824)

2006

Harris, T P, Gomas, K P, Weir, F, Holyoake, A J, McHugh, P, Wu, M, Sin, Y ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Sin, I L and Sin, F Y T (2006) Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men. International Journal of Andrology, 29(3), pp. 421-433. (doi: 10.1111/j.1365-2605.2005.00633.x) (PMID:16487403)

This list was generated on Mon Dec 29 07:20:07 2025 GMT.
Jump to: Articles
Number of items: 24.

Articles

Shakya, A. et al. (2025) Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders. Journal of Translational Autoimmunity, 11, 100329. (doi: 10.1016/j.jtauto.2025.100329) (PMID:41278249) (PMCID:PMC12637402)

Cooke, S. F. et al. (2025) Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells. Molecular Therapy Oncology, 33(3), 201029. (doi: 10.1016/j.omton.2025.201029) (PMID:40896364) (PMCID:PMC12395054)

Montezano, A. C. et al. (2025) Ang-(1-7) and ET-1 interplay through Mas and ETB receptor interaction defines a novel vasoprotective mechanism. Hypertension, 82(2), pp. 267-281. (doi: 10.1161/HYPERTENSIONAHA.124.22693) (PMID:39633565)

Main, Alice, Mary, Sheon ORCID logoORCID: https://orcid.org/0000-0001-9392-3020, Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Wright, Tom A., Ling, Jiayue, Blair, Connor M., Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741, Fuller, Will ORCID logoORCID: https://orcid.org/0000-0002-5883-4433 and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

Sin, Y. Y. et al. (2024) Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS Journal, 292(13), pp. 3360-3377. (doi: 10.1111/febs.17359) (PMID:39673076) (PMCID:PMC12220845)

McNeilly, S. et al. (2024) Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage. EBioMedicine, 107, 105315. (doi: 10.1016/j.ebiom.2024.105315) (PMID:39216230) (PMCID:PMC11402910)

Sin, Y. Y. et al. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598(13), pp. 1591-1604. (doi: 10.1002/1873-3468.14902) (PMID:38724485)

Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546) (PMCID:PMC11026450)

Ngandu Mpoyi, E. et al. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts. Biomaterials, 252, 120090. (doi: 10.1016/j.biomaterials.2020.120090) (PMID:32413593)

Gatseva, Anna ORCID logoORCID: https://orcid.org/0000-0003-1601-5277, Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Brezzo, Gaia and Van Agtmael, Tom ORCID logoORCID: https://orcid.org/0000-0003-4282-449X (2019) Basement membrane collagens and disease mechanisms. Essays in Biochemistry, 63(3), pp. 297-312. (doi: 10.1042/EBC20180071) (PMID:31387942) (PMCID:PMC6744580)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Ballantyne, Laurel L., Richmond, Christopher R. and Funk, Colin D. (2018) Transplantation of gene-edited hepatocyte-like cells modestly improves survival of arginase-1 deficient mice. Molecular Therapy - Nucleic Acids, 10, pp. 122-130. (doi: 10.1016/j.omtn.2017.11.012)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Price, Phillipe R., Ballantyne, Laurel L. and Funk, Colin D. (2017) Proof-of-concept gene editing for the murine model of inducible arginase-1 deficiency. Scientific Reports, 7, 2585. (doi: 10.1038/s41598-017-02927-2) (PMID:28566761) (PMCID:PMC5451454)

Ballantyne, Laurel L., Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Al-Dirbashi, Osama Y., Li, Xinzhi, Hurlbut, David J. and Funk, Colin D. (2016) Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency. Molecular Genetics and Metabolism Reports, 9, pp. 54-60. (doi: 10.1016/j.ymgmr.2016.10.003) (PMID:27761413) (PMCID:PMC5065044)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Baron, Garrett, Schulze, Andreas and Funk, Colin D. (2015) Arginase-1 deficiency. Journal of Molecular Medicine, 93(12), pp. 1287-1296. (doi: 10.1007/s00109-015-1354-3) (PMID:26467175)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266 and Baillie, George ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1). Cell Biochemistry and Function, 33(7), pp. 421-426. (doi: 10.1002/cbf.3147) (PMID:26443497) (PMCID:PMC4973849)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Ballantyne, Laurel L., Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, St. Amand, Tim, Si, Joshua, Goossens, Steven, Haenebalcke, Lieven, Haigh, Jody J., Kyriakopoulou, Lianna, Schulze, Andreas and Funk, Colin D. (2015) Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. PLoS ONE, 10(5), e0125967. (doi: 10.1371/journal.pone.0125967) (PMID:25938595) (PMCID:PMC4418594)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Martin, Tamara P. ORCID logoORCID: https://orcid.org/0000-0002-2509-2613, Wills, Lauren, Currie, Susan and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, 16. (doi: 10.1186/s12964-015-0094-x) (PMID:25889640) (PMCID:PMC4356135)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Ballantyne, Laurel L., Mukherjee, Kamalika, St. Amand, Tim, Kyriakopoulou, Lianna, Schulze, Andreas and Funk, Colin D. (2013) Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. PLoS ONE, 8(11), e80001. (doi: 10.1371/journal.pone.0080001) (PMID:24224027) (PMCID:PMC3817112)

Berthouze-Duquesnes, M., Lucas, A., Saulière, A., Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Laurent, A.C., Galés, C., Baillie, G. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 and Lezoualc'h, F. (2013) Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling. Cellular Signalling, 25(4), pp. 970-980. (doi: 10.1016/j.cellsig.2012.12.007) (PMID:23266473)

Sin, Yuan Yan ORCID logoORCID: https://orcid.org/0000-0001-6537-5266 and Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2012) Protein kinase D in the hypertrophy pathway. Biochemical Society Transactions, 40(1), pp. 287-289. (doi: 10.1042/BST20110626) (PMID:22260707)

Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Edwards, H.V., Li, X., Day, J.P., Christian, F. ORCID logoORCID: https://orcid.org/0000-0001-8208-5930, Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50(5), pp. 872-883. (doi: 10.1016/j.yjmcc.2011.02.006) (PMID:21334344)

Anthony, D.F., Sin, Y.Y. ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519, Houslay, M.D. and Baillie, G.S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 (2011) β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31(5), pp. 1066-1075. (doi: 10.1128/MCB.00883-10) (PMID:21173159) (PMCID:PMC3067824)

Harris, T P, Gomas, K P, Weir, F, Holyoake, A J, McHugh, P, Wu, M, Sin, Y ORCID logoORCID: https://orcid.org/0000-0001-6537-5266, Sin, I L and Sin, F Y T (2006) Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men. International Journal of Andrology, 29(3), pp. 421-433. (doi: 10.1111/j.1365-2605.2005.00633.x) (PMID:16487403)

This list was generated on Mon Dec 29 07:20:07 2025 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Developing 3D culture systems for the validation of phosphodiesteras-4 inhibitors
    Medical Research Council
    2024 - 2025
     

Angie Sin