Dr Peter Hanlon

  • Clinical Senior Research Fellow (General Practice & Primary Care)

Biography

Dr Peter Hanlon is a General Practitioner and a Clinical Research Fellow based in General Practice and Primary Care. He is interested in using quantitative methods to understand health needs and clinical management of people with multiple long-term health conditions and frailty.

Current Research

In 2019 Peter was awarded a Medical Research Council Clinical Research Training Fellowship entitled "Understanding prevalence and impact of frailty in chronic illness and implications for clinical management". This project seeks to understand how current evidence for managing long-term conditions is best applied to people living with frailty.

Background and Training

Peter graduated from University of Edinburgh with MBChB in 2011, having completed an intercalated BMedSci in Immunology in 2008. He completed Membership of the Royal College of Physicians in 2014 and an MSc in Internal Medicine (with distinction) in 2015. He completed clinical training in General Practice in 2018, and holds diplomas in Geriatric Medicine, Child Health, and Obstetrics and Gynaecology. 

In 2016 Peter joined the University of Glasgow as a SCREDS Clinical Lecturer in General Practice and Primary Care. He has worked with a group studying multimorbidity and treatment burden using UK Biobank. He has also studied chronic disease management for marginalised patient groups. 

Clinical work

Peter works as a General Practitioner at Doune Health Centre.

Research interests

  • Frailty
  • Multimorbidity
  • Polypharmacy
  • Chronic disease management

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013
Number of items: 66.

2024

Mayne, K. J., Hanlon, P. and Lees, J. (2024) Detecting and managing the patient with CKD in primary care: a review of the latest guidelines. Diabetes, Obesity and Metabolism, (Accepted for Publication)

Politis, M., Crawford, L. , Jani, B. D. , Nicholl, B. I. , Lewsey, J. , McAllister, D. A. , Mair, F. S. and Hanlon, P. (2024) An observational analysis of frailty in combination with loneliness or social isolation and their association with socioeconomic deprivation, hospitalisation and mortality among UK Biobank participants. Scientific Reports, 14, 7258. (doi: 10.1038/s41598-024-57366-7)

Hanlon, P. , Wightman, H., Politis, M., Kirkpatrick, S., Jones, C. , Andrew, M. K., Vetrano, D. L., Dent, E. and Hoogendijk, E. O. (2024) The relationship between frailty and social vulnerability: a systematic review. Lancet Healthy Longevity, 5(3), e214-e226. (doi: 10.1016/S2666-7568(23)00263-5)

Hanlon, P. , Welsh, S. A. and Evans, N. R. (2024) Constructing a quality frailty index: you get out what you put in. Age and Ageing, 53(1), afad248. (doi: 10.1093/ageing/afad248) (PMID:38266125)

2023

Crowther, J. , Butterly, E. W., Hannigan, L. J. , Guthrie, B., Wild, S., Mair, F. S. , Hanlon, P. , Chadwick, F. J. and McAllister, D. (2023) Correlations between comorbidities in trials and the community: an individual-level participant data meta-analysis. Journal of Multimorbidity and Comorbidity, 13, pp. 1-9. (doi: 10.1177/26335565231213571) (PMID:37953975) (PMCID:PMC10637135)

Dent, E. et al. (2023) Recent developments in frailty identification, management, risk factors and prevention: a narrative review of leading journals in geriatrics and gerontology. Ageing Research Reviews, 91, 102082. (doi: 10.1016/j.arr.2023.102082) (PMID:37797723)

Jani, B. D. , Sullivan, M. K. , Hanlon, P. , Nicholl, B. I. , Lees, J. S. , Brown, L., MacDonald, S. , Mark, P. B. , Mair, F. S. and Sullivan, F. M. (2023) Personalised lung cancer risk stratification and lung cancer screening: do general practice electronic medical records have a role? British Journal of Cancer, (doi: 10.1038/s41416-023-02467-9) (PMID:37880510) (Early Online Publication)

Hanlon, P. , Burton, J. K. , Quinn, T. J. , Mair, F. S. , McAllister, D. , Lewsey, J. and Gallacher, K. I. (2023) Prevalence, measurement and implications of frailty in stroke survivors: an analysis of three global aging cohorts. International Journal of Stroke, 18(6), pp. 720-727. (doi: 10.1177/17474930231151847) (PMID:36621981) (PMCID:PMC10311928)

Wightman, H., Quinn, T. J. , Mair, F. S. , Lewsey, J. , McAllister, D. A. and Hanlon, P. (2023) Frailty in randomised controlled trials for dementia or mild cognitive impairment measured via the frailty index: prevalence and prediction of serious adverse events and attrition. Alzheimer's Research and Therapy, 15, 110. (doi: 10.1186/s13195-023-01260-3) (PMID:37312157) (PMCID:PMC10262528)

Hanlon, P. et al. (2023) Treatment effect modification due to comorbidity: individual participant data meta-analyses of 120 randomised controlled trials. PLoS Medicine, 20(6), e1004176. (doi: 10.1371/journal.pmed.1004176) (PMID:37279199) (PMCID:PMC10243630)

Hanlon, P. , Guo, X., McGhee, E., Lewsey, J. , McAllister, D. and Mair, F. S. (2023) Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD. npj Primary Care Respiratory Medicine, 33, 1. (doi: 10.1038/s41533-022-00324-5) (PMID:36604427) (PMCID:PMC9816100)

Butterly, E. W. et al. (2023) Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: an individual participant data meta-analysis. PLoS Medicine, 20(1), e1004154. (doi: 10.1371/journal.pmed.1004154) (PMID:36649256) (PMCID:PMC9844862)

Nguyen, T. N. et al. (2023) Multimorbidity and blood pressure control in patients attending primary care in Canada. Journal of Primary Care and Community Health, 14, pp. 1-9. (doi: 10.1177/21501319231215025) (PMID:38097504) (PMCID:PMC10725138)

2022

Sullivan, M. K. et al. (2022) The presence and impact of multimorbidity clusters on adverse outcomes across the spectrum of kidney function. BMC Medicine, 20, 420. (doi: 10.1186/s12916-022-02628-2) (PMID:36320059) (PMCID:PMC9623942)

Hanlon, P. , Butterly, E., Shah, A. S. V., Hannigan, L. J. , Wild, S. H., Guthrie, B., Mair, F. S. , Dias, S., Welton, N. J. and McAllister, D. A. (2022) Assessing trial representativeness using Serious Adverse Events: An observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data. BMC Medicine, 20, 410. (doi: 10.1186/s12916-022-02594-9) (PMID:36303169) (PMCID:PMC9615407)

Butterly, E. et al. (2022) Calibrating a network meta-analysis of diabetes trials of sodium glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor analogues and dipeptidyl peptidase-4 inhibitors to a representative routine population: a systematic review protocol. BMJ Open, 12(10), e066491. (doi: 10.1136/bmjopen-2022-066491) (PMID:36302574) (PMCID:PMC9621152)

Hanlon, P. , Morrison, H., Morton, F. , Jani, B. D. , Siebert, S. , Lewsey, J. , McAllister, D. and Mair, F. S. (2022) Frailty in people with rheumatoid arthritis: a systematic review of observational studies. Wellcome Open Research, 6, 244. (doi: 10.12688/wellcomeopenres.17208.2)

Hanlon, P. , Lewsey, J. , Quint, J. K., Jani, B. D. , Nicholl, B. I. , McAllister, D. A. and Mair, F. S. (2022) Frailty in COPD: an analysis of prevalence and clinical impact using UK Biobank. BMJ Open Respiratory Research, 9, e001314. (doi: 10.1136/bmjresp-2022-001314) (PMID:35787523) (PMCID:PMC9255399)

Hanlon, P. , Jani, B. D. , Nicholl, B. , Lewsey, J. , McAllister, D. A. and Mair, F. S. (2022) Associations between multimorbidity and adverse health outcomes in UK Biobank and the SAIL Databank: a comparison of longitudinal cohort studies. PLoS Medicine, 19(3), e1003931. (doi: 10.1371/journal.pmed.1003931) (PMID:35255092) (PMCID:PMC8901063)

Hannigan, L. J. , Phillippo, D. M., Hanlon, P. , Moss, L. , Butterly, E. W., Hawkins, N. , Dias, S., Welton, N. J. and McAllister, D. A. (2022) Improving the estimation of subgroup effects for clinical trial participants with multimorbidity by incorporating drug class-level information in Bayesian hierarchical models: a simulation study. Medical Decision Making, 42(2), pp. 228-240. (doi: 10.1177/0272989X211029556) (PMID:34407672) (PMCID:PMC8777306)

Hanlon, P. , Morton, F. , Siebert, S. , Jani, B. D. , Nicholl, B. I. , Lewsey, J. , McAllister, D. and Mair, F. S. (2022) Frailty in rheumatoid arthritis and its relationship with disease activity, hospitalisation and mortality: a longitudinal analysis of the Scottish Early Rheumatoid Arthritis cohort and UK Biobank. RMD Open, 8(1), e002111. (doi: 10.1136/rmdopen-2021-002111) (PMID:35292529) (PMCID:PMC8928366)

Lees, J. S. et al. (2022) Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials. BMJ Medicine, 1(1), e000217. (doi: 10.1136/bmjmed-2022-000217) (PMID:36936559) (PMCID:PMC9978693)

2021

Macpherson, J. M. et al. (2021) Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study. Lancet Regional Health - Europe, 11, 100224. (doi: 10.1016/j.lanepe.2021.100224) (PMID:34917999) (PMCID:PMC8642708)

McCallum, M. , Gray, C. M. , Hanlon, P. , O'Brien, R. and Mercer, S. W. (2021) Exploring the utility of self-determination theory in complex interventions in multimorbidity: a qualitative analysis of patient experiences of the CARE Plus intervention. Chronic Illness, 17(4), pp. 433-450. (doi: 10.1177/1742395319884106) (PMID:31674216)

Sullivan, M. K. et al. (2021) Hospitalisation events in people with chronic kidney disease as a component of multimorbidity: parallel cohort studies in research and routine care settings. BMC Medicine, 19, 278. (doi: 10.1186/s12916-021-02147-6)

Shah, A. S.V. et al. (2021) Effect of vaccination on transmission of SARS-CoV-2. New England Journal of Medicine, 385(18), pp. 1718-1720. (doi: 10.1056/NEJMc2106757) (PMID:34496200) (PMCID:PMC8451182)

Hanlon, P. et al. (2021) Self-management interventions for Type 2 Diabetes: systematic review protocol focusing on patient workload and capacity support. Wellcome Open Research, 6, 257. (doi: 10.12688/wellcomeopenres.17238.1) (PMID:35928807) (PMCID:PMC9308000)

Jani, B. D. et al. (2021) Family history of diabetes and risk of SARS-COV-2 in UK Biobank: a prospective cohort study. Endocrinology, Diabetes and Metabolism, 4(4), e00283. (doi: 10.1002/edm2.283) (PMID:34505416) (PMCID:PMC8420405)

Hanlon, P. , Gray, C. M. , Chng, N. R. and Mercer, S. W. (2021) Does Self-Determination Theory help explain the impact of social prescribing? A qualitative analysis of patients’ experiences of the Glasgow ‘Deep-End’ Community Links Worker intervention. Chronic Illness, 17(3), pp. 173-188. (doi: 10.1177/1742395319845427) (PMID:31053038)

Hanlon, P. , Jani, B. D. , Butterly, E., Nicholl, B. , Lewsey, J. , McAllister, D. A. and Mair, F. S. (2021) An analysis of frailty and multimorbidity in 20,566 UK Biobank participants with type 2 diabetes. Communications Medicine, 1, 28. (doi: 10.1038/s43856-021-00029-9)

Burton, J. K. et al. (2021) Impact of COVID-19 on care-home mortality and life expectancy in Scotland. Age and Ageing, 50(4), pp. 1029-1037. (doi: 10.1093/ageing/afab080) (PMID:33914870) (PMCID:PMC8135527)

Hanlon, P. , Corcoran, N. , Rughani, G., Shah, A. S.V., Mair, F. S. , Guthrie, B., Renton, J. P. and McAllister, D. A. (2021) Observed and expected serious adverse event rates in randomised clinical trials for hypertension: an observational study comparing trials that do and do not focus on older people. Lancet Healthy Longevity, 2(7), e398-e406. (doi: 10.1016/S2666-7568(21)00092-1) (PMID:34240062) (PMCID:PMC8245327)

Hanlon, P. , Blane, D. N. , Macdonald, S. , Mair, F. S. and O'Donnell, C. A. (2021) Our response to rising frailty in younger people must address prevention burden. Lancet Healthy Longevity, 2(5), e245. (doi: 10.1016/S2666-7568(21)00052-0)

Rughani, G., Hanlon, P. , Corcoran, N. and Mair, F. (2021) The readability of general practice websites: a cross-sectional analysis of all general practice websites in Scotland. British Journal of General Practice, 71(706), e391-e398. (doi: 10.3399/BJGP.2020.0820) (PMID:33824159) (PMCID:PMC8049218)

Hanlon, P. et al. (2021) COVID-19 – exploring the implications of long-term condition type and extent of multimorbidity on years of life lost: a modelling study. Wellcome Open Research, 5, 75. (doi: 10.12688/wellcomeopenres.15849.3) (PMID:33709037) (PMCID:PMC7927210)

Jani, B. D. , McQueenie, R., Nicholl, B. I. , Field, R. , Hanlon, P. , Gallacher, K. I. , Mair, F. S. and Lewsey, J. (2021) Association between patterns of alcohol consumption (beverage type, frequency and consumption with food) and risk of adverse health outcomes: a prospective cohort study. BMC Medicine, 19, 8. (doi: 10.1186/s12916-020-01878-2) (PMID:33430840) (PMCID:PMC7802201)

2020

Hanlon, P. , Faure, I., Corcoran, N. , Butterly, E., Lewsey, J. , McAllister, D. and Mair, F. S. (2020) Frailty measurement, prevalence, incidence, and clinical implications in people with diabetes: a systematic review and study-level meta-analysis. Lancet Healthy Longevity, 1(3), e106-e116. (doi: 10.1016/S2666-7568(20)30014-3) (PMID:33313578) (PMCID:PMC7721684)

Petermann-Rocha, F. et al. (2020) Comparison of two different frailty measurements and risk of hospitalisation or death from COVID-19: findings from UK Biobank. BMC Medicine, 18, 355. (doi: 10.1186/s12916-020-01822-4) (PMID:33167965) (PMCID:PMC7652674)

Hanlon, P. , Butterly, E., Lewsey, J. , Siebert, S. , Mair, F. S. and McAllister, D. A. (2020) Identifying frailty in trials: an analysis of individual participant data from trials of novel pharmacological interventions. BMC Medicine, 18, 309. (doi: 10.1186/s12916-020-01752-1) (PMID:33087107) (PMCID:PMC7579922)

Hanlon, P. , Fauré, I., Corcoran, N. , Butterly, E., Lewsey, J. , McAllister, D. A. and Mair, F. S. (2020) The identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol. BMJ Open, 10(9), e037476. (doi: 10.1136/bmjopen-2020-037476) (PMID:32873673) (PMCID:PMC7467518)

Chiang, J. I. et al. (2020) Multimorbidity, mortality, and HbA1c in type 2 diabetes: a cohort study with UK and Taiwanese cohorts. PLoS Medicine, 17(5), e1003094. (doi: 10.1371/journal.pmed.1003094)

Hanlon, P. et al. (2020) Assessing risks of polypharmacy involving medications with anticholinergic properties. Annals of Family Medicine, 18(2), pp. 148-155. (doi: 10.1370/afm.2501) (PMID:32152019) (PMCID:PMC7062487)

Hanlon, P. , McCallum, M. , Jani, B. D. , McQueenie, R., Lee, D. and Mair, F. S. (2020) Association between childhood maltreatment and the prevalence and complexity of multimorbidity: a cross-sectional analysis of 157,357 UK Biobank participants. Journal of Comorbidity, 10, pp. 1-12. (doi: 10.1177/2235042X10944344)

2019

McCallum, M. , Hanlon, P. , Mair, F. S. and McKay, J. (2019) Is there an association between socioeconomic status of General Practice population and postgraduate training practice accreditation? A cross-sectional analysis of Scottish General Practices. Family Practice, 37(2), pp. 200-205. (doi: 10.1093/fampra/cmz071) (PMID:31746981) (PMCID:PMC7094817)

Hanlon, P. , Hannigan, L. , Rodriguez-Perez, J., Fischbacher, C., Welton, N. J., Dias, S., Mair, F. S. , Guthrie, B., Wild, S. and McAllister, D. (2019) Representation of people with comorbidity and multimorbidity in clinical trials of novel drug therapies: an individual-level participant data analysis. BMC Medicine, 17, 201. (doi: 10.1186/s12916-019-1427-1) (PMID:31711480) (PMCID:PMC6849229)

Gallacher, K. I. , Jani, B. D. , Hanlon, P. , Nicholl, B. I. and Mair, F. S. (2019) Multimorbidity in stroke. Stroke, 50(7), pp. 1919-1926. (doi: 10.1161/STROKEAHA.118.020376) (PMID:31233391)

Jani, B. D. , Hanlon, P. , Nicholl, B. I. , McQueenie, R., Gallacher, K. I. , Lee, D. and Mair, F. S. (2019) Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank Cohort. BMC Medicine, 17, 74. (doi: 10.1186/s12916-019-1305-x) (PMID:30967141) (PMCID:PMC6456941)

2018

Jani, B. D. , Nicholl, B. I. , McQueenie, R., Connelly, D. T., Hanlon, P. , Gallacher, K. I. , Lee, D. and Mair, F. S. (2018) Multimorbidity and co-morbidity in atrial fibrillation and effects on survival: findings from UK Biobank cohort. Europace, 20, f329-f336. (doi: 10.1093/europace/eux322) (PMID:29112751) (PMCID:PMC6277149)

Hunt, V., Anderson, D., Lowrie, R., Montgomery Sardar, C. , Ballantyne, S., Bryson, G., Kyle, J. and Hanlon, P. (2018) A non-randomised controlled pilot study of clinical pharmacist collaborative intervention for community dwelling patients with COPD. npj Primary Care Respiratory Medicine, 28(1), 38. (doi: 10.1038/s41533-018-0105-7) (PMID:30305634) (PMCID:PMC6180130)

Hanlon, P. , Nicholl, B. I. , Jani, B. D. , Lee, D. , McQueenie, R. and Mair, F. S. (2018) Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493,737 UK Biobank participants. Lancet Public Health, 3(7), e323-e332. (doi: 10.1016/S2468-2667(18)30091-4) (PMID:29908859) (PMCID:PMC6028743)

Hanlon, P. , Macdonald, S. , Wood, K., Allan, L. and Cooper, S.-A. (2018) Long-term condition management in adults with intellectual disability in primary care: a systematic review. BJGP Open, 2(1), (doi: 10.3399/bjgpopen18X101445)

Hanlon, P. , Yeoman, L., Gibson, L., Esiovwa, R., Williamson, A. E. , Mair, F. S. and Lowrie, R. (2018) A systematic review of interventions by healthcare professionals to improve management of non-communicable diseases and communicable diseases requiring long-term care in adults who are homeless. BMJ Open, 8(4), e020161. (doi: 10.1136/bmjopen-2017-020161) (PMID:29627814)

Hanlon, P. , Nicholl, B. I. , Jani, B. D. , McQueenie, R., Lee, D. , Gallacher, K. I. and Mair, F. S. (2018) Examining patterns of multimorbidity, polypharmacy and risk of adverse drug reactions in chronic obstructive pulmonary disease: a cross-sectional UK Biobank study. BMJ Open, 8(1), e018404. (doi: 10.1136/bmjopen-2017-018404) (PMID:29332840) (PMCID:PMC5781016)

2017

Hanlon, P. , Yeoman, L., Esiovwa, R., Gibson, L., Williamson, A. E. , Mair, F. S. and Lowrie, R. (2017) Interventions by healthcare professionals to improve management of physical long-term conditions in adults who are homeless: a systematic review protocol. BMJ Open, 7(8), e016756. (doi: 10.1136/bmjopen-2017-016756) (PMID:28827259) (PMCID:PMC5629632)

Hanlon, P. , Daines, L., Campbell, C., McKinstry, B., Weller, D. and Pinnock, H. (2017) Telehealth interventions to support self-management of long-term conditions: a systematic meta-review of diabetes, heart failure, asthma, chronic obstructive pulmonary disease and cancer. Journal of Medical Internet Research, 19(5), e172. (doi: 10.2196/jmir.6688) (PMID:28526671) (PMCID:PMC5451641)

2016

O'Connor, S., Hanlon, P. , O'Donnell, C. A. , Garcia, S., Glanville, J. and Mair, F. S. (2016) Understanding factors affecting patient and public engagement and recruitment to digital health interventions: a systematic review of qualitative studies. BMC Medical Informatics and Decision Making, 16, 120. (doi: 10.1186/s12911-016-0359-3) (PMID:27630020) (PMCID:PMC5024516)

O'Connor, S., Hanlon, P. , O'Donnell, C. A. , Garcia, S., Glanville, J. and Mair, F. S. (2016) Barriers and facilitators to patient and public engagement and recruitment to digital health interventions: protocol of a systematic review of qualitative studies. BMJ Open, 6(9), e010895. (doi: 10.1136/bmjopen-2015-010895) (PMID:27591017) (PMCID:PMC5020860)

Hanlon, P. and Fenning, S. J. (2016) Palliative medicine and the diagnostic process: who is prematurely closing the door on whom? BMJ Supportive and Palliative Care, 001174. (doi: 10.1136/bmjspcare-2016-001174) (PMID:27235392)

Fenning, S. J. and Hanlon, P. G. (2016) Improving care of the dying adult: the great challenge to which we all must rise. BMJ Supportive and Palliative Care, 6(1), pp. 11-12. (doi: 10.1136/bmjspcare-2015-001028) (PMID:26566654)

McLean, G., Murray, E., Band, R., Saunderson, K., Hanlon, P. , Little, P., McManus, R. J., Yardley, L. and Mair, F. S. (2016) Digital Interventions to promote self-management in adults with hypertension: protocol for systematic review and meta-analysis. JMIR Research Protocols, 4(4), e133. (doi: 10.2196/resprot.4648) (PMID:26589728)

McLean, G., Band, R., Saunderson, K., Hanlon, P. , Murray, E., Little, P., McManus, R. J., Yardley, L. and Mair, F. S. (2016) Digital interventions to promote self-management in adults with hypertension systematic review and meta-analysis. Journal of Hypertension, 34(4), pp. 600-612. (doi: 10.1097/HJH.0000000000000859) (PMID:26845284)

McLean, G., Murray, E., Band, R., Moffat, K. R., Hanlon, P. , Bruton, A., Thomas, M., Yardley, L. and Mair, F. S. (2016) Interactive digital interventions to promote self-management in adults with asthma: systematic review and meta-analysis. BMC Pulmonary Medicine, 16, 83. (doi: 10.1186/s12890-016-0248-7) (PMID:27215329) (PMCID:PMC4876566)

2015

Ball, R. J., Avenell, A., Aucott, L., Hanlon, P. and Vickers, M. A. (2015) Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis. Arthritis Research and Therapy, 17, 274. (doi: 10.1186/s13075-015-0755-6) (PMID:26416719) (PMCID:PMC4587583)

Hanlon, P. , Avenell, A., Aucott, L. and Vickers, M. A. (2015) Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus. Arthritis Research and Therapy, 16, R3. (doi: 10.1186/ar4429) (PMID:24387619) (PMCID:PMC3978841)

2013

Ramsay, G., Parnaby, C., MacKay, C., Hanlon, P. , Ong, S. and Loudon, M. (2013) Analysis of outcome using a levator sparing technique of abdominoperineal excision of rectum and anus. Cylindrical ELAPE is not necessary in all patients. European Journal of Surgical Oncology, 39(11), pp. 1219-1224. (doi: 10.1016/j.ejso.2013.08.004) (PMID:23973512)

Nair, H. et al. (2013) Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet, 381(9875), pp. 1380-1390. (doi: 10.1016/S0140-6736(12)61901-1) (PMID:23369797) (PMCID:PMC3986472)

This list was generated on Thu Apr 18 15:18:56 2024 BST.
Jump to: Articles
Number of items: 66.

Articles

Mayne, K. J., Hanlon, P. and Lees, J. (2024) Detecting and managing the patient with CKD in primary care: a review of the latest guidelines. Diabetes, Obesity and Metabolism, (Accepted for Publication)

Politis, M., Crawford, L. , Jani, B. D. , Nicholl, B. I. , Lewsey, J. , McAllister, D. A. , Mair, F. S. and Hanlon, P. (2024) An observational analysis of frailty in combination with loneliness or social isolation and their association with socioeconomic deprivation, hospitalisation and mortality among UK Biobank participants. Scientific Reports, 14, 7258. (doi: 10.1038/s41598-024-57366-7)

Hanlon, P. , Wightman, H., Politis, M., Kirkpatrick, S., Jones, C. , Andrew, M. K., Vetrano, D. L., Dent, E. and Hoogendijk, E. O. (2024) The relationship between frailty and social vulnerability: a systematic review. Lancet Healthy Longevity, 5(3), e214-e226. (doi: 10.1016/S2666-7568(23)00263-5)

Hanlon, P. , Welsh, S. A. and Evans, N. R. (2024) Constructing a quality frailty index: you get out what you put in. Age and Ageing, 53(1), afad248. (doi: 10.1093/ageing/afad248) (PMID:38266125)

Crowther, J. , Butterly, E. W., Hannigan, L. J. , Guthrie, B., Wild, S., Mair, F. S. , Hanlon, P. , Chadwick, F. J. and McAllister, D. (2023) Correlations between comorbidities in trials and the community: an individual-level participant data meta-analysis. Journal of Multimorbidity and Comorbidity, 13, pp. 1-9. (doi: 10.1177/26335565231213571) (PMID:37953975) (PMCID:PMC10637135)

Dent, E. et al. (2023) Recent developments in frailty identification, management, risk factors and prevention: a narrative review of leading journals in geriatrics and gerontology. Ageing Research Reviews, 91, 102082. (doi: 10.1016/j.arr.2023.102082) (PMID:37797723)

Jani, B. D. , Sullivan, M. K. , Hanlon, P. , Nicholl, B. I. , Lees, J. S. , Brown, L., MacDonald, S. , Mark, P. B. , Mair, F. S. and Sullivan, F. M. (2023) Personalised lung cancer risk stratification and lung cancer screening: do general practice electronic medical records have a role? British Journal of Cancer, (doi: 10.1038/s41416-023-02467-9) (PMID:37880510) (Early Online Publication)

Hanlon, P. , Burton, J. K. , Quinn, T. J. , Mair, F. S. , McAllister, D. , Lewsey, J. and Gallacher, K. I. (2023) Prevalence, measurement and implications of frailty in stroke survivors: an analysis of three global aging cohorts. International Journal of Stroke, 18(6), pp. 720-727. (doi: 10.1177/17474930231151847) (PMID:36621981) (PMCID:PMC10311928)

Wightman, H., Quinn, T. J. , Mair, F. S. , Lewsey, J. , McAllister, D. A. and Hanlon, P. (2023) Frailty in randomised controlled trials for dementia or mild cognitive impairment measured via the frailty index: prevalence and prediction of serious adverse events and attrition. Alzheimer's Research and Therapy, 15, 110. (doi: 10.1186/s13195-023-01260-3) (PMID:37312157) (PMCID:PMC10262528)

Hanlon, P. et al. (2023) Treatment effect modification due to comorbidity: individual participant data meta-analyses of 120 randomised controlled trials. PLoS Medicine, 20(6), e1004176. (doi: 10.1371/journal.pmed.1004176) (PMID:37279199) (PMCID:PMC10243630)

Hanlon, P. , Guo, X., McGhee, E., Lewsey, J. , McAllister, D. and Mair, F. S. (2023) Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD. npj Primary Care Respiratory Medicine, 33, 1. (doi: 10.1038/s41533-022-00324-5) (PMID:36604427) (PMCID:PMC9816100)

Butterly, E. W. et al. (2023) Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: an individual participant data meta-analysis. PLoS Medicine, 20(1), e1004154. (doi: 10.1371/journal.pmed.1004154) (PMID:36649256) (PMCID:PMC9844862)

Nguyen, T. N. et al. (2023) Multimorbidity and blood pressure control in patients attending primary care in Canada. Journal of Primary Care and Community Health, 14, pp. 1-9. (doi: 10.1177/21501319231215025) (PMID:38097504) (PMCID:PMC10725138)

Sullivan, M. K. et al. (2022) The presence and impact of multimorbidity clusters on adverse outcomes across the spectrum of kidney function. BMC Medicine, 20, 420. (doi: 10.1186/s12916-022-02628-2) (PMID:36320059) (PMCID:PMC9623942)

Hanlon, P. , Butterly, E., Shah, A. S. V., Hannigan, L. J. , Wild, S. H., Guthrie, B., Mair, F. S. , Dias, S., Welton, N. J. and McAllister, D. A. (2022) Assessing trial representativeness using Serious Adverse Events: An observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data. BMC Medicine, 20, 410. (doi: 10.1186/s12916-022-02594-9) (PMID:36303169) (PMCID:PMC9615407)

Butterly, E. et al. (2022) Calibrating a network meta-analysis of diabetes trials of sodium glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor analogues and dipeptidyl peptidase-4 inhibitors to a representative routine population: a systematic review protocol. BMJ Open, 12(10), e066491. (doi: 10.1136/bmjopen-2022-066491) (PMID:36302574) (PMCID:PMC9621152)

Hanlon, P. , Morrison, H., Morton, F. , Jani, B. D. , Siebert, S. , Lewsey, J. , McAllister, D. and Mair, F. S. (2022) Frailty in people with rheumatoid arthritis: a systematic review of observational studies. Wellcome Open Research, 6, 244. (doi: 10.12688/wellcomeopenres.17208.2)

Hanlon, P. , Lewsey, J. , Quint, J. K., Jani, B. D. , Nicholl, B. I. , McAllister, D. A. and Mair, F. S. (2022) Frailty in COPD: an analysis of prevalence and clinical impact using UK Biobank. BMJ Open Respiratory Research, 9, e001314. (doi: 10.1136/bmjresp-2022-001314) (PMID:35787523) (PMCID:PMC9255399)

Hanlon, P. , Jani, B. D. , Nicholl, B. , Lewsey, J. , McAllister, D. A. and Mair, F. S. (2022) Associations between multimorbidity and adverse health outcomes in UK Biobank and the SAIL Databank: a comparison of longitudinal cohort studies. PLoS Medicine, 19(3), e1003931. (doi: 10.1371/journal.pmed.1003931) (PMID:35255092) (PMCID:PMC8901063)

Hannigan, L. J. , Phillippo, D. M., Hanlon, P. , Moss, L. , Butterly, E. W., Hawkins, N. , Dias, S., Welton, N. J. and McAllister, D. A. (2022) Improving the estimation of subgroup effects for clinical trial participants with multimorbidity by incorporating drug class-level information in Bayesian hierarchical models: a simulation study. Medical Decision Making, 42(2), pp. 228-240. (doi: 10.1177/0272989X211029556) (PMID:34407672) (PMCID:PMC8777306)

Hanlon, P. , Morton, F. , Siebert, S. , Jani, B. D. , Nicholl, B. I. , Lewsey, J. , McAllister, D. and Mair, F. S. (2022) Frailty in rheumatoid arthritis and its relationship with disease activity, hospitalisation and mortality: a longitudinal analysis of the Scottish Early Rheumatoid Arthritis cohort and UK Biobank. RMD Open, 8(1), e002111. (doi: 10.1136/rmdopen-2021-002111) (PMID:35292529) (PMCID:PMC8928366)

Lees, J. S. et al. (2022) Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials. BMJ Medicine, 1(1), e000217. (doi: 10.1136/bmjmed-2022-000217) (PMID:36936559) (PMCID:PMC9978693)

Macpherson, J. M. et al. (2021) Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study. Lancet Regional Health - Europe, 11, 100224. (doi: 10.1016/j.lanepe.2021.100224) (PMID:34917999) (PMCID:PMC8642708)

McCallum, M. , Gray, C. M. , Hanlon, P. , O'Brien, R. and Mercer, S. W. (2021) Exploring the utility of self-determination theory in complex interventions in multimorbidity: a qualitative analysis of patient experiences of the CARE Plus intervention. Chronic Illness, 17(4), pp. 433-450. (doi: 10.1177/1742395319884106) (PMID:31674216)

Sullivan, M. K. et al. (2021) Hospitalisation events in people with chronic kidney disease as a component of multimorbidity: parallel cohort studies in research and routine care settings. BMC Medicine, 19, 278. (doi: 10.1186/s12916-021-02147-6)

Shah, A. S.V. et al. (2021) Effect of vaccination on transmission of SARS-CoV-2. New England Journal of Medicine, 385(18), pp. 1718-1720. (doi: 10.1056/NEJMc2106757) (PMID:34496200) (PMCID:PMC8451182)

Hanlon, P. et al. (2021) Self-management interventions for Type 2 Diabetes: systematic review protocol focusing on patient workload and capacity support. Wellcome Open Research, 6, 257. (doi: 10.12688/wellcomeopenres.17238.1) (PMID:35928807) (PMCID:PMC9308000)

Jani, B. D. et al. (2021) Family history of diabetes and risk of SARS-COV-2 in UK Biobank: a prospective cohort study. Endocrinology, Diabetes and Metabolism, 4(4), e00283. (doi: 10.1002/edm2.283) (PMID:34505416) (PMCID:PMC8420405)

Hanlon, P. , Gray, C. M. , Chng, N. R. and Mercer, S. W. (2021) Does Self-Determination Theory help explain the impact of social prescribing? A qualitative analysis of patients’ experiences of the Glasgow ‘Deep-End’ Community Links Worker intervention. Chronic Illness, 17(3), pp. 173-188. (doi: 10.1177/1742395319845427) (PMID:31053038)

Hanlon, P. , Jani, B. D. , Butterly, E., Nicholl, B. , Lewsey, J. , McAllister, D. A. and Mair, F. S. (2021) An analysis of frailty and multimorbidity in 20,566 UK Biobank participants with type 2 diabetes. Communications Medicine, 1, 28. (doi: 10.1038/s43856-021-00029-9)

Burton, J. K. et al. (2021) Impact of COVID-19 on care-home mortality and life expectancy in Scotland. Age and Ageing, 50(4), pp. 1029-1037. (doi: 10.1093/ageing/afab080) (PMID:33914870) (PMCID:PMC8135527)

Hanlon, P. , Corcoran, N. , Rughani, G., Shah, A. S.V., Mair, F. S. , Guthrie, B., Renton, J. P. and McAllister, D. A. (2021) Observed and expected serious adverse event rates in randomised clinical trials for hypertension: an observational study comparing trials that do and do not focus on older people. Lancet Healthy Longevity, 2(7), e398-e406. (doi: 10.1016/S2666-7568(21)00092-1) (PMID:34240062) (PMCID:PMC8245327)

Hanlon, P. , Blane, D. N. , Macdonald, S. , Mair, F. S. and O'Donnell, C. A. (2021) Our response to rising frailty in younger people must address prevention burden. Lancet Healthy Longevity, 2(5), e245. (doi: 10.1016/S2666-7568(21)00052-0)

Rughani, G., Hanlon, P. , Corcoran, N. and Mair, F. (2021) The readability of general practice websites: a cross-sectional analysis of all general practice websites in Scotland. British Journal of General Practice, 71(706), e391-e398. (doi: 10.3399/BJGP.2020.0820) (PMID:33824159) (PMCID:PMC8049218)

Hanlon, P. et al. (2021) COVID-19 – exploring the implications of long-term condition type and extent of multimorbidity on years of life lost: a modelling study. Wellcome Open Research, 5, 75. (doi: 10.12688/wellcomeopenres.15849.3) (PMID:33709037) (PMCID:PMC7927210)

Jani, B. D. , McQueenie, R., Nicholl, B. I. , Field, R. , Hanlon, P. , Gallacher, K. I. , Mair, F. S. and Lewsey, J. (2021) Association between patterns of alcohol consumption (beverage type, frequency and consumption with food) and risk of adverse health outcomes: a prospective cohort study. BMC Medicine, 19, 8. (doi: 10.1186/s12916-020-01878-2) (PMID:33430840) (PMCID:PMC7802201)

Hanlon, P. , Faure, I., Corcoran, N. , Butterly, E., Lewsey, J. , McAllister, D. and Mair, F. S. (2020) Frailty measurement, prevalence, incidence, and clinical implications in people with diabetes: a systematic review and study-level meta-analysis. Lancet Healthy Longevity, 1(3), e106-e116. (doi: 10.1016/S2666-7568(20)30014-3) (PMID:33313578) (PMCID:PMC7721684)

Petermann-Rocha, F. et al. (2020) Comparison of two different frailty measurements and risk of hospitalisation or death from COVID-19: findings from UK Biobank. BMC Medicine, 18, 355. (doi: 10.1186/s12916-020-01822-4) (PMID:33167965) (PMCID:PMC7652674)

Hanlon, P. , Butterly, E., Lewsey, J. , Siebert, S. , Mair, F. S. and McAllister, D. A. (2020) Identifying frailty in trials: an analysis of individual participant data from trials of novel pharmacological interventions. BMC Medicine, 18, 309. (doi: 10.1186/s12916-020-01752-1) (PMID:33087107) (PMCID:PMC7579922)

Hanlon, P. , Fauré, I., Corcoran, N. , Butterly, E., Lewsey, J. , McAllister, D. A. and Mair, F. S. (2020) The identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol. BMJ Open, 10(9), e037476. (doi: 10.1136/bmjopen-2020-037476) (PMID:32873673) (PMCID:PMC7467518)

Chiang, J. I. et al. (2020) Multimorbidity, mortality, and HbA1c in type 2 diabetes: a cohort study with UK and Taiwanese cohorts. PLoS Medicine, 17(5), e1003094. (doi: 10.1371/journal.pmed.1003094)

Hanlon, P. et al. (2020) Assessing risks of polypharmacy involving medications with anticholinergic properties. Annals of Family Medicine, 18(2), pp. 148-155. (doi: 10.1370/afm.2501) (PMID:32152019) (PMCID:PMC7062487)

Hanlon, P. , McCallum, M. , Jani, B. D. , McQueenie, R., Lee, D. and Mair, F. S. (2020) Association between childhood maltreatment and the prevalence and complexity of multimorbidity: a cross-sectional analysis of 157,357 UK Biobank participants. Journal of Comorbidity, 10, pp. 1-12. (doi: 10.1177/2235042X10944344)

McCallum, M. , Hanlon, P. , Mair, F. S. and McKay, J. (2019) Is there an association between socioeconomic status of General Practice population and postgraduate training practice accreditation? A cross-sectional analysis of Scottish General Practices. Family Practice, 37(2), pp. 200-205. (doi: 10.1093/fampra/cmz071) (PMID:31746981) (PMCID:PMC7094817)

Hanlon, P. , Hannigan, L. , Rodriguez-Perez, J., Fischbacher, C., Welton, N. J., Dias, S., Mair, F. S. , Guthrie, B., Wild, S. and McAllister, D. (2019) Representation of people with comorbidity and multimorbidity in clinical trials of novel drug therapies: an individual-level participant data analysis. BMC Medicine, 17, 201. (doi: 10.1186/s12916-019-1427-1) (PMID:31711480) (PMCID:PMC6849229)

Gallacher, K. I. , Jani, B. D. , Hanlon, P. , Nicholl, B. I. and Mair, F. S. (2019) Multimorbidity in stroke. Stroke, 50(7), pp. 1919-1926. (doi: 10.1161/STROKEAHA.118.020376) (PMID:31233391)

Jani, B. D. , Hanlon, P. , Nicholl, B. I. , McQueenie, R., Gallacher, K. I. , Lee, D. and Mair, F. S. (2019) Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank Cohort. BMC Medicine, 17, 74. (doi: 10.1186/s12916-019-1305-x) (PMID:30967141) (PMCID:PMC6456941)

Jani, B. D. , Nicholl, B. I. , McQueenie, R., Connelly, D. T., Hanlon, P. , Gallacher, K. I. , Lee, D. and Mair, F. S. (2018) Multimorbidity and co-morbidity in atrial fibrillation and effects on survival: findings from UK Biobank cohort. Europace, 20, f329-f336. (doi: 10.1093/europace/eux322) (PMID:29112751) (PMCID:PMC6277149)

Hunt, V., Anderson, D., Lowrie, R., Montgomery Sardar, C. , Ballantyne, S., Bryson, G., Kyle, J. and Hanlon, P. (2018) A non-randomised controlled pilot study of clinical pharmacist collaborative intervention for community dwelling patients with COPD. npj Primary Care Respiratory Medicine, 28(1), 38. (doi: 10.1038/s41533-018-0105-7) (PMID:30305634) (PMCID:PMC6180130)

Hanlon, P. , Nicholl, B. I. , Jani, B. D. , Lee, D. , McQueenie, R. and Mair, F. S. (2018) Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493,737 UK Biobank participants. Lancet Public Health, 3(7), e323-e332. (doi: 10.1016/S2468-2667(18)30091-4) (PMID:29908859) (PMCID:PMC6028743)

Hanlon, P. , Macdonald, S. , Wood, K., Allan, L. and Cooper, S.-A. (2018) Long-term condition management in adults with intellectual disability in primary care: a systematic review. BJGP Open, 2(1), (doi: 10.3399/bjgpopen18X101445)

Hanlon, P. , Yeoman, L., Gibson, L., Esiovwa, R., Williamson, A. E. , Mair, F. S. and Lowrie, R. (2018) A systematic review of interventions by healthcare professionals to improve management of non-communicable diseases and communicable diseases requiring long-term care in adults who are homeless. BMJ Open, 8(4), e020161. (doi: 10.1136/bmjopen-2017-020161) (PMID:29627814)

Hanlon, P. , Nicholl, B. I. , Jani, B. D. , McQueenie, R., Lee, D. , Gallacher, K. I. and Mair, F. S. (2018) Examining patterns of multimorbidity, polypharmacy and risk of adverse drug reactions in chronic obstructive pulmonary disease: a cross-sectional UK Biobank study. BMJ Open, 8(1), e018404. (doi: 10.1136/bmjopen-2017-018404) (PMID:29332840) (PMCID:PMC5781016)

Hanlon, P. , Yeoman, L., Esiovwa, R., Gibson, L., Williamson, A. E. , Mair, F. S. and Lowrie, R. (2017) Interventions by healthcare professionals to improve management of physical long-term conditions in adults who are homeless: a systematic review protocol. BMJ Open, 7(8), e016756. (doi: 10.1136/bmjopen-2017-016756) (PMID:28827259) (PMCID:PMC5629632)

Hanlon, P. , Daines, L., Campbell, C., McKinstry, B., Weller, D. and Pinnock, H. (2017) Telehealth interventions to support self-management of long-term conditions: a systematic meta-review of diabetes, heart failure, asthma, chronic obstructive pulmonary disease and cancer. Journal of Medical Internet Research, 19(5), e172. (doi: 10.2196/jmir.6688) (PMID:28526671) (PMCID:PMC5451641)

O'Connor, S., Hanlon, P. , O'Donnell, C. A. , Garcia, S., Glanville, J. and Mair, F. S. (2016) Understanding factors affecting patient and public engagement and recruitment to digital health interventions: a systematic review of qualitative studies. BMC Medical Informatics and Decision Making, 16, 120. (doi: 10.1186/s12911-016-0359-3) (PMID:27630020) (PMCID:PMC5024516)

O'Connor, S., Hanlon, P. , O'Donnell, C. A. , Garcia, S., Glanville, J. and Mair, F. S. (2016) Barriers and facilitators to patient and public engagement and recruitment to digital health interventions: protocol of a systematic review of qualitative studies. BMJ Open, 6(9), e010895. (doi: 10.1136/bmjopen-2015-010895) (PMID:27591017) (PMCID:PMC5020860)

Hanlon, P. and Fenning, S. J. (2016) Palliative medicine and the diagnostic process: who is prematurely closing the door on whom? BMJ Supportive and Palliative Care, 001174. (doi: 10.1136/bmjspcare-2016-001174) (PMID:27235392)

Fenning, S. J. and Hanlon, P. G. (2016) Improving care of the dying adult: the great challenge to which we all must rise. BMJ Supportive and Palliative Care, 6(1), pp. 11-12. (doi: 10.1136/bmjspcare-2015-001028) (PMID:26566654)

McLean, G., Murray, E., Band, R., Saunderson, K., Hanlon, P. , Little, P., McManus, R. J., Yardley, L. and Mair, F. S. (2016) Digital Interventions to promote self-management in adults with hypertension: protocol for systematic review and meta-analysis. JMIR Research Protocols, 4(4), e133. (doi: 10.2196/resprot.4648) (PMID:26589728)

McLean, G., Band, R., Saunderson, K., Hanlon, P. , Murray, E., Little, P., McManus, R. J., Yardley, L. and Mair, F. S. (2016) Digital interventions to promote self-management in adults with hypertension systematic review and meta-analysis. Journal of Hypertension, 34(4), pp. 600-612. (doi: 10.1097/HJH.0000000000000859) (PMID:26845284)

McLean, G., Murray, E., Band, R., Moffat, K. R., Hanlon, P. , Bruton, A., Thomas, M., Yardley, L. and Mair, F. S. (2016) Interactive digital interventions to promote self-management in adults with asthma: systematic review and meta-analysis. BMC Pulmonary Medicine, 16, 83. (doi: 10.1186/s12890-016-0248-7) (PMID:27215329) (PMCID:PMC4876566)

Ball, R. J., Avenell, A., Aucott, L., Hanlon, P. and Vickers, M. A. (2015) Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis. Arthritis Research and Therapy, 17, 274. (doi: 10.1186/s13075-015-0755-6) (PMID:26416719) (PMCID:PMC4587583)

Hanlon, P. , Avenell, A., Aucott, L. and Vickers, M. A. (2015) Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus. Arthritis Research and Therapy, 16, R3. (doi: 10.1186/ar4429) (PMID:24387619) (PMCID:PMC3978841)

Ramsay, G., Parnaby, C., MacKay, C., Hanlon, P. , Ong, S. and Loudon, M. (2013) Analysis of outcome using a levator sparing technique of abdominoperineal excision of rectum and anus. Cylindrical ELAPE is not necessary in all patients. European Journal of Surgical Oncology, 39(11), pp. 1219-1224. (doi: 10.1016/j.ejso.2013.08.004) (PMID:23973512)

Nair, H. et al. (2013) Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet, 381(9875), pp. 1380-1390. (doi: 10.1016/S0140-6736(12)61901-1) (PMID:23369797) (PMCID:PMC3986472)

This list was generated on Thu Apr 18 15:18:56 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Understanding problematic polypharmacy in people with diabetes
    Diabetes UK
    2024 - 2028
     
  • Enhancing routine healthcare data to compare frailty and multimorbidity in randomised controlled trials versus routine care
    Academy of Medical Sciences
    2023 - 2025
     
  • Assessing frailty and representativeness in randomised controlled trials of glucose lowering therapies for type 2 diabetes
    Tenovus Scotland
    2023 - 2024
     

Supervision

  • McChrystal, Ryan
    Predictors of early trial termination using individual-level participant data and aggregate-level data from multiple trials