Dr Saverio Tardito

  • Honorary Associate Professor (School of Cancer Sciences)

Research interests

Link to research pages

Publications

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Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006 | 2005
Number of items: 39.

2024

Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)

2023

Rattigan, K. M. et al. (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24, e56279. (doi: 10.15252/embr.202256279) (PMID:37489735) (PMCID:PMC10561355)

Rattigan, K. M. et al. (2023) Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature Communications, 14, 4634. (doi: 10.1038/s41467-023-40222-z) (PMID:37591854) (PMCID:PMC10435520)

May, S. et al. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78(5), pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009) (PMID:36702176)

Avellino, Giulia, Deshmukh, Ruhi, Rogers, Stephanie N., Charnock-Jones, D. Stephen, Smith, Gordon C.S., Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Aye, Irving L.M.H. (2023) Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function. American Journal of Physiology: Cell Physiology, 324(4), C878-C885. (doi: 10.1152/ajpcell.00581.2022) (PMID:36878843)

Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)

2022

Taurino, G. et al. (2022) Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis. Molecular Metabolism, 63, 101532. (doi: 10.1016/j.molmet.2022.101532) (PMID:35752287) (PMCID:PMC9254159)

Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4(6), pp. 693-710. (doi: 10.1038/s42255-022-00582-0) (PMID:35760868) (PMCID:PMC9236907)

2021

Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3) (PMID:33414552)

2020

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Patel, R. et al. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80(3), pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684) (PMID:31719098)

2019

Clerc, Isabelle, Moussa, Daouda Abba, Vahlas, Zoi, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Oburoglu, Leal, Hope, Thomas J., Sitbon, Marc, Dardalhon, Valérie, Mongellaz, Cédric and Taylor, Naomi (2019) Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells. Nature Metabolism, 1(7), pp. 717-730. (doi: 10.1038/s42255-019-0084-1) (PMID:32373781) (PMCID:PMC7199465)

Ackermann, Tobias and Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 (2019) Cell culture medium formulation and its implications in cancer metabolism. Trends in Cancer, 5(6), pp. 329-332. (doi: 10.1016/j.trecan.2019.05.004) (PMID:31208694) (PMCID:PMC6557711)

Vande Voorde, Johan, Ackermann, Tobias, Pfetzer, Nadja, Sumpton, David, Mackay, Gillian, Kalna, Gabriela, Nixon, Colin, Blyth, Karen ORCID logoORCID: https://orcid.org/0000-0002-9304-439X, Gottlieb, Eyal ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 and Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 (2019) Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Science Advances, 5(1), eaau7314. (doi: 10.1126/sciadv.aau7314) (PMID:30613774) (PMCID:PMC6314821)

2018

Chiu, Martina, Taurino, Giuseppe, Bianchi, Massimiliano G., Ottaviani, Laura, Andreoli, Roberta, Ciociola, Tecla, Lagrasta, Costanza A M, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Bussolati, Ovidio (2018) Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth. International Journal of Molecular Sciences, 19(4), 1099. (doi: 10.3390/ijms19041099) (PMID:29642388) (PMCID:PMC5979401)

2017

Fack, F. et al. (2017) Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways. EMBO Molecular Medicine, 9(12), pp. 1681-1695. (doi: 10.15252/emmm.201707729) (PMID:29054837) (PMCID:PMC5709746)

Kuntz, Elodie M., Baquero, Pablo, Michie, Alison M. ORCID logoORCID: https://orcid.org/0000-0002-5404-475X, Dunn, Karen, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Holyoake, Tessa L., Helgason, G. Vignir ORCID logoORCID: https://orcid.org/0000-0003-1616-132X and Gottlieb, Eyal ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 (2017) Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells. Nature Medicine, 23(10), pp. 1234-1240. (doi: 10.1038/nm.4399) (PMID:28920959) (PMCID:PMC5657469)

2016

Vazquez, Alexei, Kamphorst, Jurre J. ORCID logoORCID: https://orcid.org/0000-0002-2042-5474, Markert, Elke K., Schug, Zachary T., Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Gottlieb, Eyal ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 (2016) Cancer metabolism at a glance. Journal of Cell Science, 129(18), pp. 3367-3373. (doi: 10.1242/jcs.181016) (PMID:27635066)

2015

Tardito, S. et al. (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology, 17(12), pp. 1556-1568. (doi: 10.1038/ncb3272) (PMID:26595383) (PMCID:PMC4663685)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi: 10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

2014

Chiu, M. et al. (2014) Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. British Journal of Cancer, 111(6), pp. 1159-1167. (doi: 10.1038/bjc.2014.425) (PMID:25072259) (PMCID:PMC4453854)

Oburoglu, L. et al. (2014) Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. Cell Stem Cell, 15(2), pp. 169-184. (doi: 10.1016/j.stem.2014.06.002) (PMID:24953180)

Rizzi, Federica, Naponelli, Valeria, Silva, Alessandro, Modernelli, Alice, Ramazzina, Ileana, Bonacini, Martina, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Gatti, Rita, Uggeri, Jacopo and Bettuzzi, Saverio (2014) Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis. Carcinogenesis, 35(4), pp. 828-839. (doi: 10.1093/carcin/bgt481) (PMID:24343359)

2013

Duran, R.V., MacKenzie, E.D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S. ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Rocha, S., Hall, M.N. and Gottlieb, E. ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 (2013) HIF-independent role of Prolyl Hydroxylases in the cellular response to amino acids. Oncogene, 32(38), pp. 4549-4556. (doi: 10.1038/onc.2012.465) (PMID:23085753) (PMCID:PMC3787797)

2012

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Barilli, Amelia, Bassanetti, Irene, Tegoni, Matteo, Bussolati, Ovidio, Franchi-Gazzola, Renata, Mucchino, Claudio and Marchiò, Luciano (2012) Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation. Journal of Medicinal Chemistry, 55(23), pp. 10448-10459. (doi: 10.1021/jm301053a) (PMID:23170953)

Chiu, Martina, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Barilli, Amelia, Bianchi, Massimiliano G., Dall’Asta, Valeria and Bussolati, Ovidio (2012) Glutamine stimulates mTORC1 independent of the cell content of essential amino acids. Amino Acids, 43(6), pp. 2561-2567. (doi: 10.1007/s00726-012-1312-0) (PMID:22566039)

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Chiu, Martina, Franchi-Gazzola, Renata, Dall’Asta, Valeria, Comi, Paola and Bussolati, Ovidio (2012) The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR. Amino Acids, 42(6), pp. 2507-2512. (doi: 10.1007/s00726-011-0981-4) (PMID:21769496)

Covini, Daniele, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Bussolati, Ovidio, Chiarelli, Laurent R., Pasquetto, Maria V., Digilio, Rita, Valentini, Giovanna and Scotti, Claudia (2012) Expanding targets for a metabolic therapy of cancer: L-asparaginase. Recent Patents on Anti-Cancer Drug Discovery, 7(1), pp. 4-13. (doi: 10.2174/157489212798358001) (PMID:21854356)

2011

Tardito, S. ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Chiu, M., Uggeri, J., Da Ros, F., Zerbini, A., Dall`Asta, V., Missale, G. and Bussolati, O. (2011) L-asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of β-catenin-mutated human hepatocellular carcinoma cells. Current Cancer Drug Targets, 11(8), pp. 929-943. (doi: 10.2174/156800911797264725) (PMID:21834755)

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Bassanetti, Irene, Bignardi, Chiara, Elviri, Lisa, Tegoni, Matteo, Mucchino, Claudio, Bussolati, Ovidio, Franchi-Gazzola, Renata and Marchiò, Luciano (2011) Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells. Journal of the American Chemical Society, 133(16), pp. 6235-6242. (doi: 10.1021/ja109413c) (PMID:21452832)

2010

Bernuizzi, G. et al. (2010) Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma. Blood Transfusion, 8(4), pp. 237-247. (doi: 10.2450/2009.0118-09) (PMID:20967164) (PMCID:PMC2957488)

2009

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Isella, Claudio, Medico, Enzo, Marchiò, Luciano, Bevilacqua, Elena, Hatzoglou, Maria, Bussolati, Ovidio and Franchi-Gazzola, Renata (2009) The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. Journal of Biological Chemistry, 284(36), pp. 24306-24319. (doi: 10.1074/jbc.M109.026583) (PMID:19561079) (PMCID:PMC2782024)

Sperandio, Sabina, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Surzycki, Aleksandra, Latterich, Martin and de Belle, Ian (2009) TOE1 interacts with p53 to modulate its transactivation potential. FEBS Letters, 583(13), pp. 2165-2170. (doi: 10.1016/j.febslet.2009.06.004) (PMID:19508870)

Delferro, Massimiliano, Marchiò, Luciano, Tegoni, Matteo, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Franchi-Gazzola, Renata and Lanfranchi, Maurizio (2009) Synthesis, structural characterisation and solution chemistry of ruthenium(III) triazole-thiadiazine complexes. Dalton Transactions(19), pp. 3766-3773. (doi: 10.1039/B823271G) (PMID:19417942)

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Marchio, Luciano (2009) Copper compounds in anticancer strategies. Current Medicinal Chemistry, 16(11), pp. 1325-1348. (doi: 10.2174/092986709787846532) (PMID:19355889)

2007

Tardito, S. ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Uggeri, J., Bozzetti, C., Bianchi, M.G., Rotoli, B.M., Franchi-Gazzola, R., Gazzola, G.C., Gatti, R. and Bussolati, O. (2007) The inhibition of glutamine synthetase sensitizes human sarcoma cells to l-asparaginase. Cancer Chemotherapy and Pharmacology, 60(5), pp. 751-758. (doi: 10.1007/s00280-007-0421-z) (PMID:17256128)

Tardito, S. et al. (2007) Thioamido coordination in a thioxo-1,2,4-triazole copper(II) complex enhances nonapoptotic programmed cell death associated with copper accumulation and oxidative stress in human cancer cells. Journal of Medicinal Chemistry, 50(8), pp. 1916-1924. (doi: 10.1021/jm061174f) (PMID:17373781)

2006

Tardito, S. ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Bussolati, O., Gaccioli, F., Gatti, R., Guizzardi, S., Uggeri, J., Marchiò, L., Lanfranchi, M. and Franchi-Gazzola, R. (2006) Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. Histochemistry and Cell Biology, 126(4), pp. 473-482. (doi: 10.1007/s00418-006-0183-4) (PMID:16733666)

2005

Gaccioli, Francesca, Franchi-Gazzola, Renata, Lanfranchi, Maurizio, Marchiò, Luciano, Metta, Giuseppe, Pellinghelli, Maria Angela, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Tegoni, Matteo (2005) Synthesis, solution equilibria and antiproliferative activity of copper(II) aminomethyltriazole and aminomethylthioxotriazoline complexes. Journal of Inorganic Biochemistry, 99(8), pp. 1573-1584. (doi: 10.1016/j.jinorgbio.2005.04.017) (PMID:15953645)

This list was generated on Mon Jun 30 04:06:27 2025 BST.
Jump to: Articles
Number of items: 39.

Articles

Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)

Rattigan, K. M. et al. (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24, e56279. (doi: 10.15252/embr.202256279) (PMID:37489735) (PMCID:PMC10561355)

Rattigan, K. M. et al. (2023) Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature Communications, 14, 4634. (doi: 10.1038/s41467-023-40222-z) (PMID:37591854) (PMCID:PMC10435520)

May, S. et al. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78(5), pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009) (PMID:36702176)

Avellino, Giulia, Deshmukh, Ruhi, Rogers, Stephanie N., Charnock-Jones, D. Stephen, Smith, Gordon C.S., Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Aye, Irving L.M.H. (2023) Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function. American Journal of Physiology: Cell Physiology, 324(4), C878-C885. (doi: 10.1152/ajpcell.00581.2022) (PMID:36878843)

Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)

Taurino, G. et al. (2022) Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis. Molecular Metabolism, 63, 101532. (doi: 10.1016/j.molmet.2022.101532) (PMID:35752287) (PMCID:PMC9254159)

Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4(6), pp. 693-710. (doi: 10.1038/s42255-022-00582-0) (PMID:35760868) (PMCID:PMC9236907)

Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3) (PMID:33414552)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Patel, R. et al. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80(3), pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684) (PMID:31719098)

Clerc, Isabelle, Moussa, Daouda Abba, Vahlas, Zoi, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Oburoglu, Leal, Hope, Thomas J., Sitbon, Marc, Dardalhon, Valérie, Mongellaz, Cédric and Taylor, Naomi (2019) Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells. Nature Metabolism, 1(7), pp. 717-730. (doi: 10.1038/s42255-019-0084-1) (PMID:32373781) (PMCID:PMC7199465)

Ackermann, Tobias and Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 (2019) Cell culture medium formulation and its implications in cancer metabolism. Trends in Cancer, 5(6), pp. 329-332. (doi: 10.1016/j.trecan.2019.05.004) (PMID:31208694) (PMCID:PMC6557711)

Vande Voorde, Johan, Ackermann, Tobias, Pfetzer, Nadja, Sumpton, David, Mackay, Gillian, Kalna, Gabriela, Nixon, Colin, Blyth, Karen ORCID logoORCID: https://orcid.org/0000-0002-9304-439X, Gottlieb, Eyal ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 and Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 (2019) Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Science Advances, 5(1), eaau7314. (doi: 10.1126/sciadv.aau7314) (PMID:30613774) (PMCID:PMC6314821)

Chiu, Martina, Taurino, Giuseppe, Bianchi, Massimiliano G., Ottaviani, Laura, Andreoli, Roberta, Ciociola, Tecla, Lagrasta, Costanza A M, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Bussolati, Ovidio (2018) Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth. International Journal of Molecular Sciences, 19(4), 1099. (doi: 10.3390/ijms19041099) (PMID:29642388) (PMCID:PMC5979401)

Fack, F. et al. (2017) Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways. EMBO Molecular Medicine, 9(12), pp. 1681-1695. (doi: 10.15252/emmm.201707729) (PMID:29054837) (PMCID:PMC5709746)

Kuntz, Elodie M., Baquero, Pablo, Michie, Alison M. ORCID logoORCID: https://orcid.org/0000-0002-5404-475X, Dunn, Karen, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Holyoake, Tessa L., Helgason, G. Vignir ORCID logoORCID: https://orcid.org/0000-0003-1616-132X and Gottlieb, Eyal ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 (2017) Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells. Nature Medicine, 23(10), pp. 1234-1240. (doi: 10.1038/nm.4399) (PMID:28920959) (PMCID:PMC5657469)

Vazquez, Alexei, Kamphorst, Jurre J. ORCID logoORCID: https://orcid.org/0000-0002-2042-5474, Markert, Elke K., Schug, Zachary T., Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Gottlieb, Eyal ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 (2016) Cancer metabolism at a glance. Journal of Cell Science, 129(18), pp. 3367-3373. (doi: 10.1242/jcs.181016) (PMID:27635066)

Tardito, S. et al. (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology, 17(12), pp. 1556-1568. (doi: 10.1038/ncb3272) (PMID:26595383) (PMCID:PMC4663685)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi: 10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

Chiu, M. et al. (2014) Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. British Journal of Cancer, 111(6), pp. 1159-1167. (doi: 10.1038/bjc.2014.425) (PMID:25072259) (PMCID:PMC4453854)

Oburoglu, L. et al. (2014) Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. Cell Stem Cell, 15(2), pp. 169-184. (doi: 10.1016/j.stem.2014.06.002) (PMID:24953180)

Rizzi, Federica, Naponelli, Valeria, Silva, Alessandro, Modernelli, Alice, Ramazzina, Ileana, Bonacini, Martina, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Gatti, Rita, Uggeri, Jacopo and Bettuzzi, Saverio (2014) Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis. Carcinogenesis, 35(4), pp. 828-839. (doi: 10.1093/carcin/bgt481) (PMID:24343359)

Duran, R.V., MacKenzie, E.D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S. ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Rocha, S., Hall, M.N. and Gottlieb, E. ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 (2013) HIF-independent role of Prolyl Hydroxylases in the cellular response to amino acids. Oncogene, 32(38), pp. 4549-4556. (doi: 10.1038/onc.2012.465) (PMID:23085753) (PMCID:PMC3787797)

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Barilli, Amelia, Bassanetti, Irene, Tegoni, Matteo, Bussolati, Ovidio, Franchi-Gazzola, Renata, Mucchino, Claudio and Marchiò, Luciano (2012) Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation. Journal of Medicinal Chemistry, 55(23), pp. 10448-10459. (doi: 10.1021/jm301053a) (PMID:23170953)

Chiu, Martina, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Barilli, Amelia, Bianchi, Massimiliano G., Dall’Asta, Valeria and Bussolati, Ovidio (2012) Glutamine stimulates mTORC1 independent of the cell content of essential amino acids. Amino Acids, 43(6), pp. 2561-2567. (doi: 10.1007/s00726-012-1312-0) (PMID:22566039)

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Chiu, Martina, Franchi-Gazzola, Renata, Dall’Asta, Valeria, Comi, Paola and Bussolati, Ovidio (2012) The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR. Amino Acids, 42(6), pp. 2507-2512. (doi: 10.1007/s00726-011-0981-4) (PMID:21769496)

Covini, Daniele, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Bussolati, Ovidio, Chiarelli, Laurent R., Pasquetto, Maria V., Digilio, Rita, Valentini, Giovanna and Scotti, Claudia (2012) Expanding targets for a metabolic therapy of cancer: L-asparaginase. Recent Patents on Anti-Cancer Drug Discovery, 7(1), pp. 4-13. (doi: 10.2174/157489212798358001) (PMID:21854356)

Tardito, S. ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Chiu, M., Uggeri, J., Da Ros, F., Zerbini, A., Dall`Asta, V., Missale, G. and Bussolati, O. (2011) L-asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of β-catenin-mutated human hepatocellular carcinoma cells. Current Cancer Drug Targets, 11(8), pp. 929-943. (doi: 10.2174/156800911797264725) (PMID:21834755)

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Bassanetti, Irene, Bignardi, Chiara, Elviri, Lisa, Tegoni, Matteo, Mucchino, Claudio, Bussolati, Ovidio, Franchi-Gazzola, Renata and Marchiò, Luciano (2011) Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells. Journal of the American Chemical Society, 133(16), pp. 6235-6242. (doi: 10.1021/ja109413c) (PMID:21452832)

Bernuizzi, G. et al. (2010) Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma. Blood Transfusion, 8(4), pp. 237-247. (doi: 10.2450/2009.0118-09) (PMID:20967164) (PMCID:PMC2957488)

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Isella, Claudio, Medico, Enzo, Marchiò, Luciano, Bevilacqua, Elena, Hatzoglou, Maria, Bussolati, Ovidio and Franchi-Gazzola, Renata (2009) The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. Journal of Biological Chemistry, 284(36), pp. 24306-24319. (doi: 10.1074/jbc.M109.026583) (PMID:19561079) (PMCID:PMC2782024)

Sperandio, Sabina, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Surzycki, Aleksandra, Latterich, Martin and de Belle, Ian (2009) TOE1 interacts with p53 to modulate its transactivation potential. FEBS Letters, 583(13), pp. 2165-2170. (doi: 10.1016/j.febslet.2009.06.004) (PMID:19508870)

Delferro, Massimiliano, Marchiò, Luciano, Tegoni, Matteo, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Franchi-Gazzola, Renata and Lanfranchi, Maurizio (2009) Synthesis, structural characterisation and solution chemistry of ruthenium(III) triazole-thiadiazine complexes. Dalton Transactions(19), pp. 3766-3773. (doi: 10.1039/B823271G) (PMID:19417942)

Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Marchio, Luciano (2009) Copper compounds in anticancer strategies. Current Medicinal Chemistry, 16(11), pp. 1325-1348. (doi: 10.2174/092986709787846532) (PMID:19355889)

Tardito, S. ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Uggeri, J., Bozzetti, C., Bianchi, M.G., Rotoli, B.M., Franchi-Gazzola, R., Gazzola, G.C., Gatti, R. and Bussolati, O. (2007) The inhibition of glutamine synthetase sensitizes human sarcoma cells to l-asparaginase. Cancer Chemotherapy and Pharmacology, 60(5), pp. 751-758. (doi: 10.1007/s00280-007-0421-z) (PMID:17256128)

Tardito, S. et al. (2007) Thioamido coordination in a thioxo-1,2,4-triazole copper(II) complex enhances nonapoptotic programmed cell death associated with copper accumulation and oxidative stress in human cancer cells. Journal of Medicinal Chemistry, 50(8), pp. 1916-1924. (doi: 10.1021/jm061174f) (PMID:17373781)

Tardito, S. ORCID logoORCID: https://orcid.org/0000-0002-5294-8683, Bussolati, O., Gaccioli, F., Gatti, R., Guizzardi, S., Uggeri, J., Marchiò, L., Lanfranchi, M. and Franchi-Gazzola, R. (2006) Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. Histochemistry and Cell Biology, 126(4), pp. 473-482. (doi: 10.1007/s00418-006-0183-4) (PMID:16733666)

Gaccioli, Francesca, Franchi-Gazzola, Renata, Lanfranchi, Maurizio, Marchiò, Luciano, Metta, Giuseppe, Pellinghelli, Maria Angela, Tardito, Saverio ORCID logoORCID: https://orcid.org/0000-0002-5294-8683 and Tegoni, Matteo (2005) Synthesis, solution equilibria and antiproliferative activity of copper(II) aminomethyltriazole and aminomethylthioxotriazoline complexes. Journal of Inorganic Biochemistry, 99(8), pp. 1573-1584. (doi: 10.1016/j.jinorgbio.2005.04.017) (PMID:15953645)

This list was generated on Mon Jun 30 04:06:27 2025 BST.