2020

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Patel, R. et al. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80(3), pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684) (PMID:31719098)

2019

Clerc, I., Moussa, D. A., Vahlas, Z., Tardito, S. , Oburoglu, L., Hope, T. J., Sitbon, M., Dardalhon, V., Mongellaz, C. and Taylor, N. (2019) Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells. Nature Metabolism, 1(7), pp. 717-730. (doi: 10.1038/s42255-019-0084-1) (PMID:32373781) (PMCID:PMC7199465)

Ackermann, T. and Tardito, S. (2019) Cell culture medium formulation and its implications in cancer metabolism. Trends in Cancer, 5(6), pp. 329-332. (doi: 10.1016/j.trecan.2019.05.004) (PMID:31208694)

Vande Voorde, J., Ackermann, T., Pfetzer, N., Sumpton, D., Mackay, G., Kalna, G., Nixon, C., Blyth, K. , Gottlieb, E. and Tardito, S. (2019) Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Science Advances, 5(1), eaau7314. (doi: 10.1126/sciadv.aau7314) (PMID:30613774) (PMCID:PMC6314821)

2018

Chiu, M., Taurino, G., Bianchi, M. G., Ottaviani, L., Andreoli, R., Ciociola, T., Lagrasta, C. A. M., Tardito, S. and Bussolati, O. (2018) Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth. International Journal of Molecular Sciences, 19(4), 1099. (doi: 10.3390/ijms19041099) (PMID:29642388)

2017

Fack, F. et al. (2017) Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways. EMBO Molecular Medicine, 9(12), pp. 1681-1695. (doi: 10.15252/emmm.201707729) (PMID:29054837) (PMCID:PMC5709746)

Kuntz, E. M., Baquero, P., Michie, A. M. , Dunn, K., Tardito, S. , Holyoake, T. L., Helgason, G. V. and Gottlieb, E. (2017) Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells. Nature Medicine, 23(10), pp. 1234-1240. (doi: 10.1038/nm.4399) (PMID:28920959) (PMCID:PMC5657469)

2016

Vazquez, A., Kamphorst, J. J. , Markert, E. K., Schug, Z. T., Tardito, S. and Gottlieb, E. (2016) Cancer metabolism at a glance. Journal of Cell Science, 129(18), pp. 3367-3373. (doi: 10.1242/jcs.181016) (PMID:27635066)

2015

Tardito, S. et al. (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology, 17(12), pp. 1556-1568. (doi: 10.1038/ncb3272) (PMID:26595383) (PMCID:PMC4663685)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi: 10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

2014

Chiu, M. et al. (2014) Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. British Journal of Cancer, 111(6), pp. 1159-1167. (doi: 10.1038/bjc.2014.425) (PMID:25072259) (PMCID:PMC4453854)

Oburoglu, L. et al. (2014) Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. Cell Stem Cell, 15(2), pp. 169-184. (doi: 10.1016/j.stem.2014.06.002) (PMID:24953180)

Rizzi, F., Naponelli, V., Silva, A., Modernelli, A., Ramazzina, I., Bonacini, M., Tardito, S. , Gatti, R., Uggeri, J. and Bettuzzi, S. (2014) Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis. Carcinogenesis, 35(4), pp. 828-839. (doi: 10.1093/carcin/bgt481) (PMID:24343359)

2013

Duran, R.V., MacKenzie, E.D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S. , Rocha, S., Hall, M.N. and Gottlieb, E. (2013) HIF-independent role of Prolyl Hydroxylases in the cellular response to amino acids. Oncogene, 32(38), pp. 4549-4556. (doi: 10.1038/onc.2012.465) (PMID:23085753) (PMCID:PMC3787797)

2012

Tardito, S. , Barilli, A., Bassanetti, I., Tegoni, M., Bussolati, O., Franchi-Gazzola, R., Mucchino, C. and Marchiò, L. (2012) Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation. Journal of Medicinal Chemistry, 55(23), pp. 10448-10459. (doi: 10.1021/jm301053a) (PMID:23170953)

Chiu, M., Tardito, S. , Barilli, A., Bianchi, M. G., Dall’Asta, V. and Bussolati, O. (2012) Glutamine stimulates mTORC1 independent of the cell content of essential amino acids. Amino Acids, 43(6), pp. 2561-2567. (doi: 10.1007/s00726-012-1312-0) (PMID:22566039)

Tardito, S. , Chiu, M., Franchi-Gazzola, R., Dall’Asta, V., Comi, P. and Bussolati, O. (2012) The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR. Amino Acids, 42(6), pp. 2507-2512. (doi: 10.1007/s00726-011-0981-4) (PMID:21769496)

Covini, D., Tardito, S. , Bussolati, O., Chiarelli, L. R., Pasquetto, M. V., Digilio, R., Valentini, G. and Scotti, C. (2012) Expanding targets for a metabolic therapy of cancer: L-asparaginase. Recent Patents on Anti-Cancer Drug Discovery, 7(1), pp. 4-13. (doi: 10.2174/157489212798358001) (PMID:21854356)

2011

Tardito, S. , Chiu, M., Uggeri, J., Da Ros, F., Zerbini, A., Dall`Asta, V., Missale, G. and Bussolati, O. (2011) L-asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of β-catenin-mutated human hepatocellular carcinoma cells. Current Cancer Drug Targets, 11(8), pp. 929-943. (doi: 10.2174/156800911797264725) (PMID:21834755)

Tardito, S. , Bassanetti, I., Bignardi, C., Elviri, L., Tegoni, M., Mucchino, C., Bussolati, O., Franchi-Gazzola, R. and Marchiò, L. (2011) Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells. Journal of the American Chemical Society, 133(16), pp. 6235-6242. (doi: 10.1021/ja109413c) (PMID:21452832)

2010

Bernuizzi, G. et al. (2010) Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma. Blood Transfusion, 8(4), pp. 237-247. (doi: 10.2450/2009.0118-09) (PMID:20967164) (PMCID:PMC2957488)

2009

Tardito, S. , Isella, C., Medico, E., Marchiò, L., Bevilacqua, E., Hatzoglou, M., Bussolati, O. and Franchi-Gazzola, R. (2009) The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. Journal of Biological Chemistry, 284(36), pp. 24306-24319. (doi: 10.1074/jbc.M109.026583) (PMID:19561079) (PMCID:PMC2782024)

Sperandio, S., Tardito, S. , Surzycki, A., Latterich, M. and de Belle, I. (2009) TOE1 interacts with p53 to modulate its transactivation potential. FEBS Letters, 583(13), pp. 2165-2170. (doi: 10.1016/j.febslet.2009.06.004) (PMID:19508870)

Delferro, M., Marchiò, L., Tegoni, M., Tardito, S. , Franchi-Gazzola, R. and Lanfranchi, M. (2009) Synthesis, structural characterisation and solution chemistry of ruthenium(III) triazole-thiadiazine complexes. Dalton Transactions(19), pp. 3766-3773. (doi: 10.1039/B823271G) (PMID:19417942)

Tardito, S. and Marchio, L. (2009) Copper compounds in anticancer strategies. Current Medicinal Chemistry, 16(11), pp. 1325-1348. (doi: 10.2174/092986709787846532) (PMID:19355889)

2007

Tardito, S. , Uggeri, J., Bozzetti, C., Bianchi, M.G., Rotoli, B.M., Franchi-Gazzola, R., Gazzola, G.C., Gatti, R. and Bussolati, O. (2007) The inhibition of glutamine synthetase sensitizes human sarcoma cells to l-asparaginase. Cancer Chemotherapy and Pharmacology, 60(5), pp. 751-758. (doi: 10.1007/s00280-007-0421-z) (PMID:17256128)

Tardito, S. et al. (2007) Thioamido coordination in a thioxo-1,2,4-triazole copper(II) complex enhances nonapoptotic programmed cell death associated with copper accumulation and oxidative stress in human cancer cells. Journal of Medicinal Chemistry, 50(8), pp. 1916-1924. (doi: 10.1021/jm061174f) (PMID:17373781)

2006

Tardito, S. , Bussolati, O., Gaccioli, F., Gatti, R., Guizzardi, S., Uggeri, J., Marchiò, L., Lanfranchi, M. and Franchi-Gazzola, R. (2006) Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. Histochemistry and Cell Biology, 126(4), pp. 473-482. (doi: 10.1007/s00418-006-0183-4) (PMID:16733666)

2005

Gaccioli, F., Franchi-Gazzola, R., Lanfranchi, M., Marchiò, L., Metta, G., Pellinghelli, M. A., Tardito, S. and Tegoni, M. (2005) Synthesis, solution equilibria and antiproliferative activity of copper(II) aminomethyltriazole and aminomethylthioxotriazoline complexes. Journal of Inorganic Biochemistry, 99(8), pp. 1573-1584. (doi: 10.1016/j.jinorgbio.2005.04.017) (PMID:15953645)

Articles

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Patel, R. et al. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80(3), pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684) (PMID:31719098)

Clerc, I., Moussa, D. A., Vahlas, Z., Tardito, S. , Oburoglu, L., Hope, T. J., Sitbon, M., Dardalhon, V., Mongellaz, C. and Taylor, N. (2019) Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells. Nature Metabolism, 1(7), pp. 717-730. (doi: 10.1038/s42255-019-0084-1) (PMID:32373781) (PMCID:PMC7199465)

Ackermann, T. and Tardito, S. (2019) Cell culture medium formulation and its implications in cancer metabolism. Trends in Cancer, 5(6), pp. 329-332. (doi: 10.1016/j.trecan.2019.05.004) (PMID:31208694)

Vande Voorde, J., Ackermann, T., Pfetzer, N., Sumpton, D., Mackay, G., Kalna, G., Nixon, C., Blyth, K. , Gottlieb, E. and Tardito, S. (2019) Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Science Advances, 5(1), eaau7314. (doi: 10.1126/sciadv.aau7314) (PMID:30613774) (PMCID:PMC6314821)

Chiu, M., Taurino, G., Bianchi, M. G., Ottaviani, L., Andreoli, R., Ciociola, T., Lagrasta, C. A. M., Tardito, S. and Bussolati, O. (2018) Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth. International Journal of Molecular Sciences, 19(4), 1099. (doi: 10.3390/ijms19041099) (PMID:29642388)

Fack, F. et al. (2017) Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways. EMBO Molecular Medicine, 9(12), pp. 1681-1695. (doi: 10.15252/emmm.201707729) (PMID:29054837) (PMCID:PMC5709746)

Kuntz, E. M., Baquero, P., Michie, A. M. , Dunn, K., Tardito, S. , Holyoake, T. L., Helgason, G. V. and Gottlieb, E. (2017) Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells. Nature Medicine, 23(10), pp. 1234-1240. (doi: 10.1038/nm.4399) (PMID:28920959) (PMCID:PMC5657469)

Vazquez, A., Kamphorst, J. J. , Markert, E. K., Schug, Z. T., Tardito, S. and Gottlieb, E. (2016) Cancer metabolism at a glance. Journal of Cell Science, 129(18), pp. 3367-3373. (doi: 10.1242/jcs.181016) (PMID:27635066)

Tardito, S. et al. (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology, 17(12), pp. 1556-1568. (doi: 10.1038/ncb3272) (PMID:26595383) (PMCID:PMC4663685)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi: 10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

Chiu, M. et al. (2014) Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. British Journal of Cancer, 111(6), pp. 1159-1167. (doi: 10.1038/bjc.2014.425) (PMID:25072259) (PMCID:PMC4453854)

Oburoglu, L. et al. (2014) Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. Cell Stem Cell, 15(2), pp. 169-184. (doi: 10.1016/j.stem.2014.06.002) (PMID:24953180)

Rizzi, F., Naponelli, V., Silva, A., Modernelli, A., Ramazzina, I., Bonacini, M., Tardito, S. , Gatti, R., Uggeri, J. and Bettuzzi, S. (2014) Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis. Carcinogenesis, 35(4), pp. 828-839. (doi: 10.1093/carcin/bgt481) (PMID:24343359)

Duran, R.V., MacKenzie, E.D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S. , Rocha, S., Hall, M.N. and Gottlieb, E. (2013) HIF-independent role of Prolyl Hydroxylases in the cellular response to amino acids. Oncogene, 32(38), pp. 4549-4556. (doi: 10.1038/onc.2012.465) (PMID:23085753) (PMCID:PMC3787797)

Tardito, S. , Barilli, A., Bassanetti, I., Tegoni, M., Bussolati, O., Franchi-Gazzola, R., Mucchino, C. and Marchiò, L. (2012) Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation. Journal of Medicinal Chemistry, 55(23), pp. 10448-10459. (doi: 10.1021/jm301053a) (PMID:23170953)

Chiu, M., Tardito, S. , Barilli, A., Bianchi, M. G., Dall’Asta, V. and Bussolati, O. (2012) Glutamine stimulates mTORC1 independent of the cell content of essential amino acids. Amino Acids, 43(6), pp. 2561-2567. (doi: 10.1007/s00726-012-1312-0) (PMID:22566039)

Tardito, S. , Chiu, M., Franchi-Gazzola, R., Dall’Asta, V., Comi, P. and Bussolati, O. (2012) The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR. Amino Acids, 42(6), pp. 2507-2512. (doi: 10.1007/s00726-011-0981-4) (PMID:21769496)

Covini, D., Tardito, S. , Bussolati, O., Chiarelli, L. R., Pasquetto, M. V., Digilio, R., Valentini, G. and Scotti, C. (2012) Expanding targets for a metabolic therapy of cancer: L-asparaginase. Recent Patents on Anti-Cancer Drug Discovery, 7(1), pp. 4-13. (doi: 10.2174/157489212798358001) (PMID:21854356)

Tardito, S. , Chiu, M., Uggeri, J., Da Ros, F., Zerbini, A., Dall`Asta, V., Missale, G. and Bussolati, O. (2011) L-asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of β-catenin-mutated human hepatocellular carcinoma cells. Current Cancer Drug Targets, 11(8), pp. 929-943. (doi: 10.2174/156800911797264725) (PMID:21834755)

Tardito, S. , Bassanetti, I., Bignardi, C., Elviri, L., Tegoni, M., Mucchino, C., Bussolati, O., Franchi-Gazzola, R. and Marchiò, L. (2011) Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells. Journal of the American Chemical Society, 133(16), pp. 6235-6242. (doi: 10.1021/ja109413c) (PMID:21452832)

Bernuizzi, G. et al. (2010) Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma. Blood Transfusion, 8(4), pp. 237-247. (doi: 10.2450/2009.0118-09) (PMID:20967164) (PMCID:PMC2957488)

Tardito, S. , Isella, C., Medico, E., Marchiò, L., Bevilacqua, E., Hatzoglou, M., Bussolati, O. and Franchi-Gazzola, R. (2009) The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. Journal of Biological Chemistry, 284(36), pp. 24306-24319. (doi: 10.1074/jbc.M109.026583) (PMID:19561079) (PMCID:PMC2782024)

Sperandio, S., Tardito, S. , Surzycki, A., Latterich, M. and de Belle, I. (2009) TOE1 interacts with p53 to modulate its transactivation potential. FEBS Letters, 583(13), pp. 2165-2170. (doi: 10.1016/j.febslet.2009.06.004) (PMID:19508870)

Delferro, M., Marchiò, L., Tegoni, M., Tardito, S. , Franchi-Gazzola, R. and Lanfranchi, M. (2009) Synthesis, structural characterisation and solution chemistry of ruthenium(III) triazole-thiadiazine complexes. Dalton Transactions(19), pp. 3766-3773. (doi: 10.1039/B823271G) (PMID:19417942)

Tardito, S. and Marchio, L. (2009) Copper compounds in anticancer strategies. Current Medicinal Chemistry, 16(11), pp. 1325-1348. (doi: 10.2174/092986709787846532) (PMID:19355889)

Tardito, S. , Uggeri, J., Bozzetti, C., Bianchi, M.G., Rotoli, B.M., Franchi-Gazzola, R., Gazzola, G.C., Gatti, R. and Bussolati, O. (2007) The inhibition of glutamine synthetase sensitizes human sarcoma cells to l-asparaginase. Cancer Chemotherapy and Pharmacology, 60(5), pp. 751-758. (doi: 10.1007/s00280-007-0421-z) (PMID:17256128)

Tardito, S. et al. (2007) Thioamido coordination in a thioxo-1,2,4-triazole copper(II) complex enhances nonapoptotic programmed cell death associated with copper accumulation and oxidative stress in human cancer cells. Journal of Medicinal Chemistry, 50(8), pp. 1916-1924. (doi: 10.1021/jm061174f) (PMID:17373781)

Tardito, S. , Bussolati, O., Gaccioli, F., Gatti, R., Guizzardi, S., Uggeri, J., Marchiò, L., Lanfranchi, M. and Franchi-Gazzola, R. (2006) Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. Histochemistry and Cell Biology, 126(4), pp. 473-482. (doi: 10.1007/s00418-006-0183-4) (PMID:16733666)

Gaccioli, F., Franchi-Gazzola, R., Lanfranchi, M., Marchiò, L., Metta, G., Pellinghelli, M. A., Tardito, S. and Tegoni, M. (2005) Synthesis, solution equilibria and antiproliferative activity of copper(II) aminomethyltriazole and aminomethylthioxotriazoline complexes. Journal of Inorganic Biochemistry, 99(8), pp. 1573-1584. (doi: 10.1016/j.jinorgbio.2005.04.017) (PMID:15953645)