Professor Laura Machesky

  • Professor (Beatson Institute for Cancer Research)
  • Associate Academic (Institute of Molecular Cell and Systems Biology)

Research interests

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating the role of N-WASP in the development and metastasis of colorectal cancer (SCP3 Fellowship 2012)
    Medical Research Council
    2012 - 2015
     

Publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2004 | 2003 | 2001 | 2000 | 1999 | 1998 | 1997
Number of items: 76.

2017

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi:10.1038/ncb3596) (PMID:28846096)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, (doi:10.15252/embj.201694912) (PMID:28694244) (Early Online Publication)

Woodham, E. F. et al. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27(5), pp. 624-637. (doi:10.1016/j.cub.2017.01.033) (PMID:28238662) (PMCID:PMC5344686)

Thomas, S. G., Poulter, N. S., Bem, D., Finney, B., Machesky, L. M. and Watson, S. P. (2017) The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation. Platelets, 28(4), pp. 372-379. (doi:10.1080/09537104.2016.1235688) (PMID:27778524) (PMCID:PMC5274539)

2016

Tyrrell, B. J., Woodham, E. F., Spence, H. J., Strathdee, D., Insall, R. H. and Machesky, L. M. (2016) Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Pigment Cell and Melanoma Research, 29(5), pp. 559-571. (doi:10.1111/pcmr.12506) (PMID:27390154) (PMCID:PMC5082549)

Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi:10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)

García, E., Ragazzini, C., Yu, X., Cuesta-García, E., Bernardino de la Serna, J., Zech, T., Sarrió, D., Machesky, L. M. and Antón, I. M. (2016) WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion. Scientific Reports, 6, 23590. (doi:10.1038/srep23590) (PMID:27009365) (PMCID:PMC4806363)

2015

Ma, Y. and Machesky, L. (2015) Fascin1 in carcinomas: Its regulation and prognostic value. International Journal of Cancer, 137(11), pp. 2534-2544. (doi:10.1002/ijc.29260) (PMID:25302416)

Siebert, S., Machesky, L. M. and Insall, R. H. (2015) Overflow in science and its implications for trust. eLife, 4, e10825. (doi:10.7554/eLife.10825)

Giancotti, F. G., Haynes, C. M., Machesky, L. M., Olson, M. F. and Overholtzer, M. (2015) Alan Hall 1952–2015. Nature Cell Biology, 17(7), pp. 839-840. (doi:10.1038/ncb3190) (PMID:26005836)

Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B., Anderson, K., Critchley, D. R., Machesky, L. and Norman, J. C. (2015) Ligand-occupied integrin internalization links nutrient signaling to invasive migration. Cell Reports, 10(3), pp. 398-413. (doi:10.1016/j.celrep.2014.12.037)

Vijayakumar, V., Monypenny, J., Chen, X. J., Machesky, L. M., Lilla, S., Thrasher, A. J., Anton, I. M., Calle, Y. and Jones, G. E. (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Journal of Cell Science, 128(2), pp. 251-265. (doi:10.1242/jcs.154880)

Lindsay, C. R., Li, A., Faller, W., Ozanne, B., Welch, H., Machesky, L. M. and Sansom, O. (2015) A Rac1-independent role for P-Rex1 in melanoblasts. Journal of Investigative Dermatology, 135(1), pp. 314-318. (doi:10.1038/jid.2014.323)

Ma, Y., Faller, W., Sansom, O., Brown, E. R., Doig, T. N., Melton, D. W. and Machesky, L. (2015) Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma. Melanoma Research, 25(2), pp. 169-172. (doi:10.1097/CMR.0000000000000135) (PMID:25535872)

Morris, H.T. and Machesky, L.M. (2015) Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract. British Journal of Cancer, 112(4), pp. 613-620. (doi:10.1038/bjc.2014.658) (PMID:25611303) (PMCID:PMC4333498)

2014

Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (PMID:25313567) (PMCID:PMC4196730)

García, E., Machesky, L. M., Jones, G. E. and Antón, I. M. (2014) WIP is necessary for matrix invasion by breast cancer cells. European Journal of Cell Biology, 93(10-12), pp. 413-423. (doi:10.1016/j.ejcb.2014.07.008)

Woodham, E. F. and Machesky, L. M. (2014) Polarised cell migration: intrinsic and extrinsic drivers. Current Opinion in Cell Biology, 30, pp. 25-32. (doi:10.1016/j.ceb.2014.05.006)

Li, A. et al. (2014) Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology, 146(5), 1386-1396.e17. (doi:10.1053/j.gastro.2014.01.046)

Tyrrell, B. J., Neilson, M., Insall, R. H. and Machesky, L. M. (2014) Predicting cell shapes in melanomas. Pigment Cell and Melanoma Research, 27(1), pp. 5-6. (doi:10.1111/pcmr.12176) (PMID:24118871)

2013

Schachtner, H., Li, A., Stevenson, D., Calaminus, S. D.J., Thomas, S. G., Watson, S. P., Sixt, M., Wedlich-Soldner, R., Strathdee, D. and Machesky, L. M. (2013) Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo. European Journal of Cell Biology, 91(11-12), pp. 923-929. (doi:10.1016/j.ejcb.2012.04.002)

Futó, K., Bódis, E., Machesky, L.M., Nyitrai, M. and Visegrády, B. (2013) Membrane binding properties of IRSp53-missing in metastasis domain (IMD) protein. Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1831(11), pp. 1651-1655. (doi:10.1016/j.bbalip.2013.07.006)

Schachtner, H., Calaminus, S. D. J., Thomas, S. G. and Machesky, L. M. (2013) Podosomes in adhesion, migration, mechanosensing and matrix remodeling. Cytoskeleton, 70(10), pp. 572-589. (doi:10.1002/cm.21119)

Ampe, C., Machesky, L.M. and Nyitrai, M. (2013) Biophysical approaches for investigation of the cytoskeleton. A special issue stemming from research presented at the 2012 ECF meeting: A FEBS/EMBO workshop lecture course in Pécs, Hungary. Cytoskeleton, 70(10), p. 539. (doi:10.1002/cm.21145)

Sonego, M., Gajendra, S., Parsons, M., Ma, Y., Hobbs, C., Zentar, M.P., Williams, G., Machesky, L.M., Doherty, P. and Lalli, G. (2013) Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain. Journal of Neuroscience, 33(30), pp. 12171-12185. (doi:10.1523/JNEUROSCI.0653-13.2013)

Ma, Y., Li, A., Faller, W.J., Libertini, S., Fiorito, F., Gillespie, D.A., Sansom, O.J., Yamashiro, S. and Machesky, L.M. (2013) Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. Development, 140(10), pp. 2203-2211. (doi:10.1242/dev.089789)

Schachtner, H. et al. (2013) Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood, 121(13), pp. 2542-2552. (doi:10.1182/blood-2012-07-443457)

Zanivan, S. et al. (2013) In Vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Reports, 3(2), pp. 552-566. (doi:10.1016/j.celrep.2013.01.003)

Park, L., Thomason, P.A., Zech, T., King, J.S., Veltman, D.M., Carnell, M., Ura, S., Machesky, L.M. and Insall, R.H. (2013) Cyclical Action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment. Developmental Cell, 24(2), pp. 169-181. (doi:10.1016/j.devcel.2012.12.014)

Tang, H. et al. (2013) Loss of scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Current Biology, 23(2), pp. 107-117. (doi:10.1016/j.cub.2012.11.059)

2012

Calaminus, S. D.J., Guitart, A., Sinclair, A., Schachtner, H., Watson, S. P., Holyoake, T. L., Kranc, K. R. and Machesky, L. M. (2012) Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny. PLoS ONE, 7(12), e51361. (doi:10.1371/journal.pone.0051361)

Machesky, L.M. and Sansom, O.J. (2012) Rac1 in the driver’s seat for melanoma. Pigment Cell and Melanoma Research, 25(6), pp. 762-764. (doi:10.1111/pcmr.12004)

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi:10.1083/jcb.201203025)

Veltman, D. M., King, J. S., Machesky, L. M. and Insall, R. H. (2012) SCAR knockouts in Dictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods. Journal of Cell Biology, 198(4), pp. 501-508. (doi:10.1083/jcb.201205058) (PMID:22891261) (PMCID:PMC3514037)

Maritzen, T., Zech, T., Schmidt, M.R., Krause, E., Machesky, L.M. and Haucke, V. (2012) Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proceedings of the National Academy of Sciences of the United States of America, 109(26), pp. 10382-10387. (doi:10.1073/pnas.1206468109)

Ura, S., Pollitt, A.Y., Veltman, D.M., Morrice, N.A., Machesky, L.M. and Insall, R.H. (2012) Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology, 22(7), pp. 553-561. (doi:10.1016/j.cub.2012.02.020)

Dawson, J.C., Bruche, S., Spence, H.J., Braga, V.M.M. and Machesky, L.M. (2012) Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1. PLoS ONE, 7(3), e31141. (doi:10.1371/journal.pone.0031141)

Dawson, J.C., Timpson, P., Kalna, G. and Machesky, L.M. (2012) Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells. Oncogene, 31(14), pp. 1781-1793. (doi:10.1038/onc.2011.376)

García, E., Jones, G.E., Machesky, L.M. and Antón, I.M. (2012) WIP: WASP-interacting proteins at invadopodia and podosomes. European Journal of Cell Biology, 91(11-12), pp. 869-877. (doi:10.1016/j.ejcb.2012.06.002)

Li, A., Ma, Y., Jin, M., Mason, S., Mort, R.L., Blyth, K., Larue, L., Sansom, O.J. and Machesky, L.M. (2012) Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism. Journal of Investigative Dermatology, 132(11), pp. 2610-2621. (doi:10.1038/jid.2012.186)

Spence, H.J., Timpson, P., Tang, H.R., Insall, R.H. and Machesky, L.M. (2012) Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions. Biochemical Journal, 448(1), pp. 35-42. (doi:10.1042/BJ20112206)

Stevenson, R.P., Veltman, D. and Machesky, L.M. (2012) Actin-bundling proteins in cancer progression at a glance. Journal of Cell Science, 125(5), pp. 1073-1079. (doi:10.1242/​jcs.093799)

Yu, X. and Machesky, L.M. (2012) Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay. PLoS ONE, 7(2), e30605. (doi:10.1371/journal.pone.0030605)

2011

Li, A. et al. (2011) Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell, 21(4), pp. 722-734. (doi:10.1016/j.devcel.2011.07.008)

Thomas, S.G., Calaminus, S.D.J., Machesky, L.M., Alberts, A.S. and Watson, S.P. (2011) G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho Kinase in platelets. Journal of Thrombosis and Haemostasis, 9(8), pp. 1648-1651. (doi:10.1111/j.1538-7836.2011.04357.x)

Carnell, M., Zech, T., Calaminus, S.D., Ura, S., Hagedorn, M., Johnston, S.A., May, R.C., Soldati, T., Machesky, L.M. and Insall, R.H. (2011) Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. Journal of Cell Biology, 193(5), pp. 831-839. (doi:10.1083/jcb.201009119)

Lindsay, C.C.R. et al. (2011) P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications, 2(Art 55), pp. 1-9. (doi:10.1038/ncomms1560)

Ramsay, A.K. et al. (2011) ERK5 signalling in prostate cancer promotes an invasive phenotype. British Journal of Cancer, 104(4), pp. 664-672. (doi:10.1038/sj.bjc.6606062)

Vartiainen, M., Heath, R.J.W., Leong, J.M., Visegrády, B., Machesky, L.M. and Xavier, R.J. (2011) Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3. PLoS Pathogens, 7(4), e1001332. (doi:10.1371/journal.ppat.1001332)

Veltman, D.W., Auciello, G., Spence, H.J., Machesky, L.M., Rappoport, J.Z. and Insall, R.H. (2011) Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. Biochemical Journal, 436(1), pp. 45-52. (doi:10.1042/BJ20101684)

Zech, T., Calaminus, S.D.J., Caswell, P., Spence, H.J., Carnell, M., Insall, R.H., Norman, J. and Machesky, L.M. (2011) The Arp2/3 activator WASH regulates 5 1-integrin-mediated invasive migration. Journal of Cell Science, 124(22), pp. 3753-3759. (doi:10.1242/jcs.080986)

2010

Serrels, B., Sandilands, E., Serrels, A., Baillie, G. , Houslay, M. D., Brunton, V. G., Canel, M., Machesky, L. M., Anderson, K. I. and Frame, M. C. (2010) A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Current Biology, 20(12), pp. 1086-1092. (doi:10.1016/j.cub.2010.04.042)

Brooks, S. P., Coccia, M., Tang, H. R., Kanuga, N., Machesky, L. M., Bailly, M., Cheetham, M. E. and Hardcastle, A. J. (2010) The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology. Human Molecular Genetics, 19(12), pp. 2421-2432. (doi:10.1093/hmg/ddq125)

Li, A., Dawson, J., Forero-Vargas, M., Spence, H., Yu, X., König, I., Anderson, K. and Machesky, L. (2010) The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion. Current Biology, 20(4), pp. 339-345. (doi:10.1016/j.cub.2009.12.035)

Scott, R.W. et al. (2010) LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. Journal of Cell Biology, 191(1), pp. 169-185. (doi:10.1083/jcb.201002041)

Visegrády, B. and Machesky, L.M. (2010) Myopathy-causing actin mutations promote defects in serum-response factor signalling. Biochemical Journal, 427(1), pp. 41-48. (doi:10.1042/BJ20091641)

2009

Insall, R. and Machesky, L.M. (2009) Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks. Developmental Cell, 17(3), pp. 310-322. (doi:10.1016/j.devcel.2009.08.012)

Machesky, L.M. and Tang, H.R. (2009) Actin-Based Protrusions: Promoters or Inhibitors of Cancer Invasion? Cancer Cell, 16(1), pp. 5-7. (doi:10.1016/j.ccr.2009.06.009)

2008

Calaminus, S.D.J., Thomas, S., McCarty, O. J. T., Machesky, L.M. and Watson, S. P. (2008) Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading. Journal of Thrombosis and Haemostasis, 6(11), pp. 1944-1952. (doi:10.1111/j.1538-7836.2008.03141.x)

Heung, M., Visegrady, B., Futterer, K. and Machesky, L. (2008) Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53. European Journal of Cell Biology, 87(8-9), pp. 699-708. (doi:10.1016/j.ejcb.2008.02.010)

Johnston, S.A., Bramble, J.P., Yeung, C.L., Mendes, P.M. and Machesky, L.M. (2008) Arp2/3 complex activity in filopodia of spreading cells. BMC Cell Biology, 9(1), p. 65. (doi:10.1186/1471-2121-9-65)

Machesky, L. (2008) Lamellipodia and filopodia in metastasis and invasion. FEBS Letters, 582(14), pp. 2102-2111. (doi:10.1016/j.febslet.2008.03.039)

Machesky, L., Jurdic, P. and Hinz, B. (2008) Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion. EMBO Reports, 9(2), pp. 139-143. (doi:10.1038/sj.embor.7401162)

Zech, T. and Machesky, L. (2008) Rab5 and Rac Team Up in Cell Motility. Cell, 134(1), pp. 18-20. (doi:10.1016/j.cell.2008.06.039)

2006

Ardern, H., Sandilands, E., Machesky, L.M., Timpson, P., Frame, M.C. and Brunton, V.G. (2006) Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex. Cell Motility and the Cytoskeleton, 63(1), pp. 6-13. (doi:10.1002/cm.20101)

2004

Insall, R. H. and Machesky, L. M. (2004) Regulation of WASP: PIP2 pipped By Toca-1? Cell, 118(2), pp. 140-141. (doi:10.1016/j.cell.2004.07.005) (PMID:15260983)

2003

Anderson, S. I., Behrendt, B., Machesky, L. M., Insall, R. H. and Nash, G. B. (2003) Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. Cell Motility and the Cytoskeleton, 54(2), pp. 135-146. (doi:10.1002/cm.10091) (PMID:12529859)

2001

Insall, R. , Müller-Taubenberger, A., Machesky, L., Köhler, J., Simmeth, E., Atkinson, S. J., Weber, I. and Gerisch, G. (2001) Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis. Cell Motility and the Cytoskeleton, 50(3), pp. 115-128. (doi:10.1002/cm.10005) (PMID:11807934)

Machesky, L. M., Insall, R. H. and Volkman, L. E. (2001) WASP homology sequences in baculoviruses. Trends in Cell Biology, 11(7), pp. 286-287. (doi:10.1016/S0962-8924(01)02009-8) (PMID:11434350)

Insall, R. and Machesky, L. (2001) Cytoskeleton. Encyclopedia of Life Sciences, (doi:10.1038/npg.els.0001252)

2000

Rozelle, A.L., Machesky, L.M., Yamamoto, M., Driessens, M.H.E., Insall, R.H. , Roth, M.G., Luby-Phelps, K., Marriott, G., Hall, A. and Yin, H.L. (2000) Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Current Biology, 10(6), pp. 311-320. (doi:10.1016/S0960-9822(00)00384-5) (PMID:10744973)

1999

Machesky, L. M. and Insall, R. H. (1999) Signaling to actin dynamics. Journal of Cell Biology, 146(2), pp. 267-272. (doi:10.1083/jcb.146.2.267) (PMID:10427083) (PMCID:PMC2156183)

Insall, R. and Machesky, L. (1999) PH domains in WASP – a bug in the system? Trends in Cell Biology, 9(6), p. 211. (doi:10.1016/S0962-8924(99)01569-X) (PMID:10354565)

1998

Machesky, L. M. and Insall, R. H. (1998) Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Current Biology, 8(25), pp. 1347-1356. (doi:10.1016/S0960-9822(98)00015-3) (PMID:9889097)

Machesky, L. M., Insall, R. H. and Kay, R. R. (1998) The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum. Current Biology, 8(10), 607-S4. (doi:10.1016/S0960-9822(98)70233-7) (PMID:9601648)

1997

Tuxworth, R. I., Cheetham, J. L., Machesky, L. M., Spiegelmann, G. B., Weeks, G. and Insall, R. H. (1997) Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. Journal of Cell Biology, 138(3), pp. 605-614. (doi:10.1083/jcb.138.3.605) (PMID:9245789) (PMCID:PMC2141629)

This list was generated on Tue Oct 17 11:08:18 2017 BST.
Jump to: Articles
Number of items: 76.

Articles

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi:10.1038/ncb3596) (PMID:28846096)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, (doi:10.15252/embj.201694912) (PMID:28694244) (Early Online Publication)

Woodham, E. F. et al. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27(5), pp. 624-637. (doi:10.1016/j.cub.2017.01.033) (PMID:28238662) (PMCID:PMC5344686)

Thomas, S. G., Poulter, N. S., Bem, D., Finney, B., Machesky, L. M. and Watson, S. P. (2017) The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation. Platelets, 28(4), pp. 372-379. (doi:10.1080/09537104.2016.1235688) (PMID:27778524) (PMCID:PMC5274539)

Tyrrell, B. J., Woodham, E. F., Spence, H. J., Strathdee, D., Insall, R. H. and Machesky, L. M. (2016) Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Pigment Cell and Melanoma Research, 29(5), pp. 559-571. (doi:10.1111/pcmr.12506) (PMID:27390154) (PMCID:PMC5082549)

Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi:10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)

García, E., Ragazzini, C., Yu, X., Cuesta-García, E., Bernardino de la Serna, J., Zech, T., Sarrió, D., Machesky, L. M. and Antón, I. M. (2016) WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion. Scientific Reports, 6, 23590. (doi:10.1038/srep23590) (PMID:27009365) (PMCID:PMC4806363)

Ma, Y. and Machesky, L. (2015) Fascin1 in carcinomas: Its regulation and prognostic value. International Journal of Cancer, 137(11), pp. 2534-2544. (doi:10.1002/ijc.29260) (PMID:25302416)

Siebert, S., Machesky, L. M. and Insall, R. H. (2015) Overflow in science and its implications for trust. eLife, 4, e10825. (doi:10.7554/eLife.10825)

Giancotti, F. G., Haynes, C. M., Machesky, L. M., Olson, M. F. and Overholtzer, M. (2015) Alan Hall 1952–2015. Nature Cell Biology, 17(7), pp. 839-840. (doi:10.1038/ncb3190) (PMID:26005836)

Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B., Anderson, K., Critchley, D. R., Machesky, L. and Norman, J. C. (2015) Ligand-occupied integrin internalization links nutrient signaling to invasive migration. Cell Reports, 10(3), pp. 398-413. (doi:10.1016/j.celrep.2014.12.037)

Vijayakumar, V., Monypenny, J., Chen, X. J., Machesky, L. M., Lilla, S., Thrasher, A. J., Anton, I. M., Calle, Y. and Jones, G. E. (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Journal of Cell Science, 128(2), pp. 251-265. (doi:10.1242/jcs.154880)

Lindsay, C. R., Li, A., Faller, W., Ozanne, B., Welch, H., Machesky, L. M. and Sansom, O. (2015) A Rac1-independent role for P-Rex1 in melanoblasts. Journal of Investigative Dermatology, 135(1), pp. 314-318. (doi:10.1038/jid.2014.323)

Ma, Y., Faller, W., Sansom, O., Brown, E. R., Doig, T. N., Melton, D. W. and Machesky, L. (2015) Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma. Melanoma Research, 25(2), pp. 169-172. (doi:10.1097/CMR.0000000000000135) (PMID:25535872)

Morris, H.T. and Machesky, L.M. (2015) Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract. British Journal of Cancer, 112(4), pp. 613-620. (doi:10.1038/bjc.2014.658) (PMID:25611303) (PMCID:PMC4333498)

Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (PMID:25313567) (PMCID:PMC4196730)

García, E., Machesky, L. M., Jones, G. E. and Antón, I. M. (2014) WIP is necessary for matrix invasion by breast cancer cells. European Journal of Cell Biology, 93(10-12), pp. 413-423. (doi:10.1016/j.ejcb.2014.07.008)

Woodham, E. F. and Machesky, L. M. (2014) Polarised cell migration: intrinsic and extrinsic drivers. Current Opinion in Cell Biology, 30, pp. 25-32. (doi:10.1016/j.ceb.2014.05.006)

Li, A. et al. (2014) Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology, 146(5), 1386-1396.e17. (doi:10.1053/j.gastro.2014.01.046)

Tyrrell, B. J., Neilson, M., Insall, R. H. and Machesky, L. M. (2014) Predicting cell shapes in melanomas. Pigment Cell and Melanoma Research, 27(1), pp. 5-6. (doi:10.1111/pcmr.12176) (PMID:24118871)

Schachtner, H., Li, A., Stevenson, D., Calaminus, S. D.J., Thomas, S. G., Watson, S. P., Sixt, M., Wedlich-Soldner, R., Strathdee, D. and Machesky, L. M. (2013) Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo. European Journal of Cell Biology, 91(11-12), pp. 923-929. (doi:10.1016/j.ejcb.2012.04.002)

Futó, K., Bódis, E., Machesky, L.M., Nyitrai, M. and Visegrády, B. (2013) Membrane binding properties of IRSp53-missing in metastasis domain (IMD) protein. Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1831(11), pp. 1651-1655. (doi:10.1016/j.bbalip.2013.07.006)

Schachtner, H., Calaminus, S. D. J., Thomas, S. G. and Machesky, L. M. (2013) Podosomes in adhesion, migration, mechanosensing and matrix remodeling. Cytoskeleton, 70(10), pp. 572-589. (doi:10.1002/cm.21119)

Ampe, C., Machesky, L.M. and Nyitrai, M. (2013) Biophysical approaches for investigation of the cytoskeleton. A special issue stemming from research presented at the 2012 ECF meeting: A FEBS/EMBO workshop lecture course in Pécs, Hungary. Cytoskeleton, 70(10), p. 539. (doi:10.1002/cm.21145)

Sonego, M., Gajendra, S., Parsons, M., Ma, Y., Hobbs, C., Zentar, M.P., Williams, G., Machesky, L.M., Doherty, P. and Lalli, G. (2013) Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain. Journal of Neuroscience, 33(30), pp. 12171-12185. (doi:10.1523/JNEUROSCI.0653-13.2013)

Ma, Y., Li, A., Faller, W.J., Libertini, S., Fiorito, F., Gillespie, D.A., Sansom, O.J., Yamashiro, S. and Machesky, L.M. (2013) Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. Development, 140(10), pp. 2203-2211. (doi:10.1242/dev.089789)

Schachtner, H. et al. (2013) Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood, 121(13), pp. 2542-2552. (doi:10.1182/blood-2012-07-443457)

Zanivan, S. et al. (2013) In Vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Reports, 3(2), pp. 552-566. (doi:10.1016/j.celrep.2013.01.003)

Park, L., Thomason, P.A., Zech, T., King, J.S., Veltman, D.M., Carnell, M., Ura, S., Machesky, L.M. and Insall, R.H. (2013) Cyclical Action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment. Developmental Cell, 24(2), pp. 169-181. (doi:10.1016/j.devcel.2012.12.014)

Tang, H. et al. (2013) Loss of scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Current Biology, 23(2), pp. 107-117. (doi:10.1016/j.cub.2012.11.059)

Calaminus, S. D.J., Guitart, A., Sinclair, A., Schachtner, H., Watson, S. P., Holyoake, T. L., Kranc, K. R. and Machesky, L. M. (2012) Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny. PLoS ONE, 7(12), e51361. (doi:10.1371/journal.pone.0051361)

Machesky, L.M. and Sansom, O.J. (2012) Rac1 in the driver’s seat for melanoma. Pigment Cell and Melanoma Research, 25(6), pp. 762-764. (doi:10.1111/pcmr.12004)

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi:10.1083/jcb.201203025)

Veltman, D. M., King, J. S., Machesky, L. M. and Insall, R. H. (2012) SCAR knockouts in Dictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods. Journal of Cell Biology, 198(4), pp. 501-508. (doi:10.1083/jcb.201205058) (PMID:22891261) (PMCID:PMC3514037)

Maritzen, T., Zech, T., Schmidt, M.R., Krause, E., Machesky, L.M. and Haucke, V. (2012) Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proceedings of the National Academy of Sciences of the United States of America, 109(26), pp. 10382-10387. (doi:10.1073/pnas.1206468109)

Ura, S., Pollitt, A.Y., Veltman, D.M., Morrice, N.A., Machesky, L.M. and Insall, R.H. (2012) Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology, 22(7), pp. 553-561. (doi:10.1016/j.cub.2012.02.020)

Dawson, J.C., Bruche, S., Spence, H.J., Braga, V.M.M. and Machesky, L.M. (2012) Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1. PLoS ONE, 7(3), e31141. (doi:10.1371/journal.pone.0031141)

Dawson, J.C., Timpson, P., Kalna, G. and Machesky, L.M. (2012) Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells. Oncogene, 31(14), pp. 1781-1793. (doi:10.1038/onc.2011.376)

García, E., Jones, G.E., Machesky, L.M. and Antón, I.M. (2012) WIP: WASP-interacting proteins at invadopodia and podosomes. European Journal of Cell Biology, 91(11-12), pp. 869-877. (doi:10.1016/j.ejcb.2012.06.002)

Li, A., Ma, Y., Jin, M., Mason, S., Mort, R.L., Blyth, K., Larue, L., Sansom, O.J. and Machesky, L.M. (2012) Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism. Journal of Investigative Dermatology, 132(11), pp. 2610-2621. (doi:10.1038/jid.2012.186)

Spence, H.J., Timpson, P., Tang, H.R., Insall, R.H. and Machesky, L.M. (2012) Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions. Biochemical Journal, 448(1), pp. 35-42. (doi:10.1042/BJ20112206)

Stevenson, R.P., Veltman, D. and Machesky, L.M. (2012) Actin-bundling proteins in cancer progression at a glance. Journal of Cell Science, 125(5), pp. 1073-1079. (doi:10.1242/​jcs.093799)

Yu, X. and Machesky, L.M. (2012) Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay. PLoS ONE, 7(2), e30605. (doi:10.1371/journal.pone.0030605)

Li, A. et al. (2011) Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell, 21(4), pp. 722-734. (doi:10.1016/j.devcel.2011.07.008)

Thomas, S.G., Calaminus, S.D.J., Machesky, L.M., Alberts, A.S. and Watson, S.P. (2011) G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho Kinase in platelets. Journal of Thrombosis and Haemostasis, 9(8), pp. 1648-1651. (doi:10.1111/j.1538-7836.2011.04357.x)

Carnell, M., Zech, T., Calaminus, S.D., Ura, S., Hagedorn, M., Johnston, S.A., May, R.C., Soldati, T., Machesky, L.M. and Insall, R.H. (2011) Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. Journal of Cell Biology, 193(5), pp. 831-839. (doi:10.1083/jcb.201009119)

Lindsay, C.C.R. et al. (2011) P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications, 2(Art 55), pp. 1-9. (doi:10.1038/ncomms1560)

Ramsay, A.K. et al. (2011) ERK5 signalling in prostate cancer promotes an invasive phenotype. British Journal of Cancer, 104(4), pp. 664-672. (doi:10.1038/sj.bjc.6606062)

Vartiainen, M., Heath, R.J.W., Leong, J.M., Visegrády, B., Machesky, L.M. and Xavier, R.J. (2011) Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3. PLoS Pathogens, 7(4), e1001332. (doi:10.1371/journal.ppat.1001332)

Veltman, D.W., Auciello, G., Spence, H.J., Machesky, L.M., Rappoport, J.Z. and Insall, R.H. (2011) Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. Biochemical Journal, 436(1), pp. 45-52. (doi:10.1042/BJ20101684)

Zech, T., Calaminus, S.D.J., Caswell, P., Spence, H.J., Carnell, M., Insall, R.H., Norman, J. and Machesky, L.M. (2011) The Arp2/3 activator WASH regulates 5 1-integrin-mediated invasive migration. Journal of Cell Science, 124(22), pp. 3753-3759. (doi:10.1242/jcs.080986)

Serrels, B., Sandilands, E., Serrels, A., Baillie, G. , Houslay, M. D., Brunton, V. G., Canel, M., Machesky, L. M., Anderson, K. I. and Frame, M. C. (2010) A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Current Biology, 20(12), pp. 1086-1092. (doi:10.1016/j.cub.2010.04.042)

Brooks, S. P., Coccia, M., Tang, H. R., Kanuga, N., Machesky, L. M., Bailly, M., Cheetham, M. E. and Hardcastle, A. J. (2010) The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology. Human Molecular Genetics, 19(12), pp. 2421-2432. (doi:10.1093/hmg/ddq125)

Li, A., Dawson, J., Forero-Vargas, M., Spence, H., Yu, X., König, I., Anderson, K. and Machesky, L. (2010) The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion. Current Biology, 20(4), pp. 339-345. (doi:10.1016/j.cub.2009.12.035)

Scott, R.W. et al. (2010) LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. Journal of Cell Biology, 191(1), pp. 169-185. (doi:10.1083/jcb.201002041)

Visegrády, B. and Machesky, L.M. (2010) Myopathy-causing actin mutations promote defects in serum-response factor signalling. Biochemical Journal, 427(1), pp. 41-48. (doi:10.1042/BJ20091641)

Insall, R. and Machesky, L.M. (2009) Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks. Developmental Cell, 17(3), pp. 310-322. (doi:10.1016/j.devcel.2009.08.012)

Machesky, L.M. and Tang, H.R. (2009) Actin-Based Protrusions: Promoters or Inhibitors of Cancer Invasion? Cancer Cell, 16(1), pp. 5-7. (doi:10.1016/j.ccr.2009.06.009)

Calaminus, S.D.J., Thomas, S., McCarty, O. J. T., Machesky, L.M. and Watson, S. P. (2008) Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading. Journal of Thrombosis and Haemostasis, 6(11), pp. 1944-1952. (doi:10.1111/j.1538-7836.2008.03141.x)

Heung, M., Visegrady, B., Futterer, K. and Machesky, L. (2008) Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53. European Journal of Cell Biology, 87(8-9), pp. 699-708. (doi:10.1016/j.ejcb.2008.02.010)

Johnston, S.A., Bramble, J.P., Yeung, C.L., Mendes, P.M. and Machesky, L.M. (2008) Arp2/3 complex activity in filopodia of spreading cells. BMC Cell Biology, 9(1), p. 65. (doi:10.1186/1471-2121-9-65)

Machesky, L. (2008) Lamellipodia and filopodia in metastasis and invasion. FEBS Letters, 582(14), pp. 2102-2111. (doi:10.1016/j.febslet.2008.03.039)

Machesky, L., Jurdic, P. and Hinz, B. (2008) Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion. EMBO Reports, 9(2), pp. 139-143. (doi:10.1038/sj.embor.7401162)

Zech, T. and Machesky, L. (2008) Rab5 and Rac Team Up in Cell Motility. Cell, 134(1), pp. 18-20. (doi:10.1016/j.cell.2008.06.039)

Ardern, H., Sandilands, E., Machesky, L.M., Timpson, P., Frame, M.C. and Brunton, V.G. (2006) Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex. Cell Motility and the Cytoskeleton, 63(1), pp. 6-13. (doi:10.1002/cm.20101)

Insall, R. H. and Machesky, L. M. (2004) Regulation of WASP: PIP2 pipped By Toca-1? Cell, 118(2), pp. 140-141. (doi:10.1016/j.cell.2004.07.005) (PMID:15260983)

Anderson, S. I., Behrendt, B., Machesky, L. M., Insall, R. H. and Nash, G. B. (2003) Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. Cell Motility and the Cytoskeleton, 54(2), pp. 135-146. (doi:10.1002/cm.10091) (PMID:12529859)

Insall, R. , Müller-Taubenberger, A., Machesky, L., Köhler, J., Simmeth, E., Atkinson, S. J., Weber, I. and Gerisch, G. (2001) Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis. Cell Motility and the Cytoskeleton, 50(3), pp. 115-128. (doi:10.1002/cm.10005) (PMID:11807934)

Machesky, L. M., Insall, R. H. and Volkman, L. E. (2001) WASP homology sequences in baculoviruses. Trends in Cell Biology, 11(7), pp. 286-287. (doi:10.1016/S0962-8924(01)02009-8) (PMID:11434350)

Insall, R. and Machesky, L. (2001) Cytoskeleton. Encyclopedia of Life Sciences, (doi:10.1038/npg.els.0001252)

Rozelle, A.L., Machesky, L.M., Yamamoto, M., Driessens, M.H.E., Insall, R.H. , Roth, M.G., Luby-Phelps, K., Marriott, G., Hall, A. and Yin, H.L. (2000) Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Current Biology, 10(6), pp. 311-320. (doi:10.1016/S0960-9822(00)00384-5) (PMID:10744973)

Machesky, L. M. and Insall, R. H. (1999) Signaling to actin dynamics. Journal of Cell Biology, 146(2), pp. 267-272. (doi:10.1083/jcb.146.2.267) (PMID:10427083) (PMCID:PMC2156183)

Insall, R. and Machesky, L. (1999) PH domains in WASP – a bug in the system? Trends in Cell Biology, 9(6), p. 211. (doi:10.1016/S0962-8924(99)01569-X) (PMID:10354565)

Machesky, L. M. and Insall, R. H. (1998) Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Current Biology, 8(25), pp. 1347-1356. (doi:10.1016/S0960-9822(98)00015-3) (PMID:9889097)

Machesky, L. M., Insall, R. H. and Kay, R. R. (1998) The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum. Current Biology, 8(10), 607-S4. (doi:10.1016/S0960-9822(98)70233-7) (PMID:9601648)

Tuxworth, R. I., Cheetham, J. L., Machesky, L. M., Spiegelmann, G. B., Weeks, G. and Insall, R. H. (1997) Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. Journal of Cell Biology, 138(3), pp. 605-614. (doi:10.1083/jcb.138.3.605) (PMID:9245789) (PMCID:PMC2141629)

This list was generated on Tue Oct 17 11:08:18 2017 BST.